DE461772C - Process for the production of dosed, ready-to-use dry tuberculin preparations - Google Patents
Process for the production of dosed, ready-to-use dry tuberculin preparationsInfo
- Publication number
- DE461772C DE461772C DEF59836D DEF0059836D DE461772C DE 461772 C DE461772 C DE 461772C DE F59836 D DEF59836 D DE F59836D DE F0059836 D DEF0059836 D DE F0059836D DE 461772 C DE461772 C DE 461772C
- Authority
- DE
- Germany
- Prior art keywords
- tuberculin
- preparations
- production
- ready
- dosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fodder In General (AREA)
Description
Verfahren zur Herstellung von dosiert gebrauchsfertigen Tuberkulintrockenpräparaten. Tuberkulin wird vielfach zu Injektionszwecken in verdünnter Form in den Handel gebracht. Die Beständigkeit derartiger Lösungen ist jedoch nicht sehr groß, so daß man dazu übergegangen ist, Tuberkulin als Trockenpräparat in den Handel zu bringen. Solche Trockenpräparate sind beispielsweise durch Zumischung von Salzen zu Tuberkulinlösungen hergestellt worden (Patent 291 4.05). Derartig hergestellte Tuberkulintrockenpräparate zeigen den Nachteil, daß bei ihrem Auflösen in kleinen Mengen Wasser zwecks Herstellung der gebrauchsfertigen Lösung die Konzentration des zugemischten Salzes eine so erhebliche ist, daß sie Reizwirkung im Körper hervorrufen kann. Wählt man den anderen Weg, die Lösungen mit erheblicher Menge Wasser zu verdünnen, so ergibt sich der Nachteil, daß, da von der so hergestellten Lösung nur ein minimaler Teil zur Anwendung kommt, der übrige, jetzt nicht mehr haltbare Teil unbenutzt weggegossen werden muß.Process for the production of dosed ready-to-use dry tuberculin preparations. In many cases, tuberculin is marketed in a diluted form for injection purposes. However, the stability of such solutions is not very great, so that one can do so has gone over to market tuberculin as a dry preparation. Such Dry preparations can be made, for example, by adding salts to tuberculin solutions (Patent 291 4.05). Dry tuberculin preparations produced in this way show the disadvantage that when they are dissolved in small amounts of water for the purpose of preparation the ready-to-use solution, the concentration of the added salt is so significant is that it can cause irritation in the body. If you choose the other way, diluting the solutions with a considerable amount of water has the disadvantage that, since only a minimal part of the solution prepared in this way is used, the remaining part, which is no longer durable, has to be poured away unused.
Es wurde nun gefunden, daß man bei der Herstellung von Tuberkulintrockenpräparaten diese Übelstände vermeiden kann, wenn man zur Herstellung von derartigen Trockenpräparaten solche festen Stoffe wählt, die neben neutraler Reaktion die Eigenschaft besitzen, in hohen Konzentrationen injiziert werden zu können. Als solche Stoffe kommen beispielsweise Hexamethylentetramin, Harnstoffe, ferner die verschiedenen Zuckerarten, wie Milchzucker, Saccharose, Dextrose, Lävulose, oder höhere Alkohole, wie Mannit usw., in Frage.It has now been found that in the production of tuberculin dry preparations these inconveniences can be avoided if one is involved in the production of such dry preparations selects solid substances which, in addition to a neutral reaction, have the property to be able to be injected in high concentrations. Examples of such substances are Hexamethylenetetramine, urea, as well as the various types of sugar, such as lactose, Sucrose, dextrose, levulose, or higher alcohols such as mannitol, etc., in question.
Beispiel: Alt-Tuberkulin wird zuerst im Vakuum, dann längere Zeit bei 6o° im Verhältnis 1200 mit Hexamethylentetramin unter Einhalten aller zur Sterilität notwendigen Kautelen zusammengebracht und über Schwefelsäure so lange gehalten, bis ein leichtes Zerreiben der Substanz zu einem feinen Pulver möglich ist. Statt Hexamethylentetramin können auch Harnstoffe oder verschiedene Zuckerarten, wie Milchzucker usw., aber auch höhere Alkohole, wie Mannit usw., Verwendung finden. Aus diesem somit geschaffenen Standardtyp von Trockentuberkulin gewinnt man dann vermittels genauer Wägung und Vermischens mit dem jeweiligen Ausgangsmaterial entsprechend den homöopathischen Verdünnungen dauernd haltbare, auch im Tierversuch ausprüfbare, verschiedenprozentige Verreibungen, die die gewünschten Tuberkulindosierungen abgeben. Statt i ;; Alt-Tuberkulin kann auch 1-/2 g zur Gewichtskonstanz eingeengtes Alt-Tuberkulin benutzt werden. Ebenso Perlsucht-Tuberkulin oder andere flüssige Tuberkuline in anderen Formen und in anderen Konzentrationen. Die so gewonnenen Präparate können dann auch noch mit einem der angeführten anderen Stoffe weiterverarbeitet bzw. gemischt werden, beispielsweise Harnstoff-Trocken-Tuberkulin mit Milchzucker oder umgekehrt.Example: Old tuberculin is first placed in a vacuum, then for a longer period of time at 60 ° in the ratio 1200 with hexamethylenetetramine while maintaining all of the sterility brought together the necessary caution and held over sulfuric acid for so long until the substance can be easily ground to a fine powder. Instead of Hexamethylenetetramine can also contain ureas or various types of sugar, such as lactose etc., but also higher alcohols such as mannitol etc., are used. For this The standard type of dry tuberculin thus created is then obtained by means of accurate weighing and mixing with the respective starting material accordingly The homeopathic dilutions are permanently stable and can also be tested in animal experiments, different percentage Triturations that the desired tuberculin dosages hand over. Instead of i ;; Old tuberculin can also be concentrated 1/2 g to maintain weight Old tuberculin can be used. Likewise, pearl addiction tuberculin or other liquids Tuberculins in other forms and in other concentrations. The ones won in this way Preparations can then also be further processed with one of the other substances listed or mixed, for example urea dry tuberculin with lactose or the other way around.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEF59836D DE461772C (en) | 1925-09-22 | 1925-09-22 | Process for the production of dosed, ready-to-use dry tuberculin preparations |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEF59836D DE461772C (en) | 1925-09-22 | 1925-09-22 | Process for the production of dosed, ready-to-use dry tuberculin preparations |
Publications (1)
Publication Number | Publication Date |
---|---|
DE461772C true DE461772C (en) | 1928-06-27 |
Family
ID=7108913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEF59836D Expired DE461772C (en) | 1925-09-22 | 1925-09-22 | Process for the production of dosed, ready-to-use dry tuberculin preparations |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE461772C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE753154C (en) * | 1941-09-30 | 1951-08-02 | Madaus & Co Dr | Process for the production of a dry preparation from blood or serum for therapeutic purposes |
-
1925
- 1925-09-22 DE DEF59836D patent/DE461772C/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE753154C (en) * | 1941-09-30 | 1951-08-02 | Madaus & Co Dr | Process for the production of a dry preparation from blood or serum for therapeutic purposes |
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