DE876570C - Process for the production of therapeutically valuable colloid solutions - Google Patents

Process for the production of therapeutically valuable colloid solutions

Info

Publication number
DE876570C
DE876570C DEF2643D DEF0002643D DE876570C DE 876570 C DE876570 C DE 876570C DE F2643 D DEF2643 D DE F2643D DE F0002643 D DEF0002643 D DE F0002643D DE 876570 C DE876570 C DE 876570C
Authority
DE
Germany
Prior art keywords
production
therapeutically valuable
solutions
colloid
colloid solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEF2643D
Other languages
German (de)
Inventor
Gerhard Dr Hecht
Helmut Dr Weese
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DEF2643D priority Critical patent/DE876570C/en
Application granted granted Critical
Publication of DE876570C publication Critical patent/DE876570C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung therapeutisch wertvoller Kolloidlösungen Durch das Patent 738 994 wird ein Verfahren zur Herstellung von als Blutsatzflüssigkeit brauchbaren Infusionslösungen geschützt, bei dem man zu üblichen physiologischen Salzlösungen Polyv inylpyrrolidon in solcher :Menge zusetzt, daß der kolloidosmotische Druck und die Viskosität der entstandenen Lösung denjenigen des Blutplasmas entsprechen.Process for the production of therapeutically valuable colloid solutions Patent 738 994 protects a process for the production of infusion solutions that can be used as blood flow fluids, in which polyvinylpyrrolidone is added to normal physiological saline solutions in such an amount that the colloid osmotic pressure and the viscosity of the resulting solution match that of the Blood plasma.

Es wurde nun gefunden, daß man auch durch Zusatz größerer Mengen von Polyvin.ylpyrrolidon als in dem Patent 738 994 angegeben zu üblichen physiologischen Salzlösungen Lösungen mit wertvollen. therapeutischen Eigenschaften gewinnen kann. Wegen ihres hohen kolloidosmotischen Drucks und ihrer erhöhten Viskosität eignen sie sich zwar nicht mehr als Blutersatzflüssigkeiten. Dagegen haben sie sich bei intravenöser Verabreichung als wirksam erwiesen bei Zuständen, bei denen ein krankhaftes Ausströmen von Blutflüssigkeit aus der Blutbahn droht oder bereits stattgefunden hat. Hierbei verwendet man zweckmäßig Lösungen, die etwa das a- bis 5fache der Polyvinylpyrrolidonmenge enthalten, wie sie bei dem Verfahren nach dem Hauptpatent zugesetzt wird. Beispiel In i 1 Tyrodelösung werden .70 g Polyvinylpyrrolidon von einem mittleren Molekulargewicht 30 000, -das frei vom Monomeren und von, niedrigermolekularen Polymieren sowie von schädlichen Katalysatoren sein muß, gelöst. Die Lösung wird in üblicher Weise sterilisiert. Sie zeigt einen kolloidosmotischen Druck von 8oo mm Wassersäule und eine relative Viskosität von 3,0 gegenüber Wasser.It has now been found that by adding larger amounts of Polyvin.ylpyrrolidon than specified in the patent 738 994 to common physiological saline solutions solutions with valuable. can gain therapeutic properties. Because of their high colloid osmotic pressure and their increased viscosity, they are no longer suitable as blood substitute fluids. On the other hand, when administered intravenously, they have proven to be effective in conditions in which a pathological leakage of blood fluid from the bloodstream is threatened or has already taken place. In this case, it is expedient to use solutions which contain about a to 5 times the amount of polyvinylpyrrolidone that is added in the process according to the main patent. EXAMPLE In i 1 Tyrode solution .70 g of polyvinylpyrrolidone with an average molecular weight of 30,000, which must be free from monomers and from low molecular weight polymers and from harmful catalysts, are dissolved. The solution is sterilized in the usual way. It shows a colloid osmotic pressure of 8oo mm water column and a relative viscosity of 3.0 compared to water.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung therapeutisch wertvoller Kolloidlösungen, dadurch gekennzeichnet, daß in -weiterer Ausbildung des Verfahrens gemäß Patent 738 994 den üblichen physiologischen Salzlösungen so viel Polyvinylpyrrolidon zugesetzt wird, daß der kolloidosmotische Druck und die Viskosität der entstandenen Lösung größer als die des Blutplasmas sind.PATENT CLAIM: Process for the production of therapeutically valuable Colloid solutions, characterized in that in -further development of the process according to patent 738 994 the usual physiological salt solutions as much polyvinylpyrrolidone is added that the colloid osmotic pressure and the viscosity of the resulting Solution are larger than that of the blood plasma.
DEF2643D 1943-02-05 1943-02-05 Process for the production of therapeutically valuable colloid solutions Expired DE876570C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEF2643D DE876570C (en) 1943-02-05 1943-02-05 Process for the production of therapeutically valuable colloid solutions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF2643D DE876570C (en) 1943-02-05 1943-02-05 Process for the production of therapeutically valuable colloid solutions

Publications (1)

Publication Number Publication Date
DE876570C true DE876570C (en) 1953-05-15

Family

ID=7083368

Family Applications (1)

Application Number Title Priority Date Filing Date
DEF2643D Expired DE876570C (en) 1943-02-05 1943-02-05 Process for the production of therapeutically valuable colloid solutions

Country Status (1)

Country Link
DE (1) DE876570C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002804A2 (en) * 1977-12-31 1979-07-11 BASF Aktiengesellschaft Biodegradable vinylpyrrolidone polymers, their preparation and use

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002804A2 (en) * 1977-12-31 1979-07-11 BASF Aktiengesellschaft Biodegradable vinylpyrrolidone polymers, their preparation and use
EP0002804A3 (en) * 1977-12-31 1979-07-25 Basf Aktiengesellschaft Biodegradable vinylpyrrolidone polymers, their preparation and use

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