DE840245C - Process for the preparation of derivatives of physodic acid - Google Patents
Process for the preparation of derivatives of physodic acidInfo
- Publication number
- DE840245C DE840245C DEK7745A DEK0007745A DE840245C DE 840245 C DE840245 C DE 840245C DE K7745 A DEK7745 A DE K7745A DE K0007745 A DEK0007745 A DE K0007745A DE 840245 C DE840245 C DE 840245C
- Authority
- DE
- Germany
- Prior art keywords
- physodic
- acid
- derivatives
- preparation
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung von Derivaten der Physodsäure Die Physodsäure ist ein Didepsid und zeigt eine Reihe eigenartiger Reaktionen; zum Beispiel wird sie durch Alkalien verändert. Auch gelingt es nicht, sie ohne weiteres zu acetylieren. Es wurde nun die Beobachtung gemacht, daß man die Physod-säure unter milden Bedingungen doch acetylieren kann. Die Acetylverbindttng ist in Alkalien löslich. Sie ist antibiotisclt wirksam und eignet sich für therapeutische Ztthereitungen.Process for the preparation of derivatives of physodic acid Physodic acid is a didepside and shows a number of strange reactions; for example will changed them by alkalis. It is also not possible to acetylate them easily. The observation has now been made that the physodic acid can be obtained under mild conditions but can acetylate. The acetyl compound is soluble in alkalis. It is antibiotic effective and suitable for therapeutic mortar preparations.
t.Beispiel 2 g Physodsäure werden in 1s ccm Pyridin gelöst und tnit 3 #I' f?ssigsättreattltydrid versetzt. Es tritt eine leithafte Erwärmung ein. Man kocht nach tstündigem Stehen 2 Stunden auf dem Wasserdantpfltad. Nach dem Vertreiltett des Pyridins kristallisiert <las Acetylierungsprodukt in farblosen Körnchen aus. Nach (lern Umkristallisieren aus Alkohol zeigen diese einen Schmelzpunkt von 173 bis 17j°.Example 2 g of physodic acid are dissolved in 1s ccm of pyridine and tnit 3 #I 'f? Ssättreattltydrid added. Conductive heating occurs. Man after standing for an hour, cooks for 2 hours on the water dipper. According to the distribution table of the pyridine crystallizes <reads the acetylation product in colorless granules. After learning to recrystallize from alcohol, these show a melting point of 173 up to 17j °.
2.Beispie1 2 g Physodsäure werden mit 15 ccm Acetanhydrid gekocht, Dauer 3 Stunden. Man läßt erkalten, gießt das Ganze in Wasser und läßt zur Zersetzung des Essigsäureanhydrids stehen. Es scheidet sich nach etwa 2.4 Stunden ein kristalliner Brei aus, dessen Kristalle nach Umkristallisieren aus Alkohol den Schmelzpunkt von 17--t bis i75° zeizen.2.Beispie1 2 g of physodic acid are boiled with 15 cc of acetic anhydride, Duration 3 hours. Allow to cool, pour the whole thing into water and leave to decompose of acetic anhydride. A crystalline one separates out after about 2.4 hours A pulp whose crystals, after recrystallization from alcohol, have a melting point of 17 - t to i75 ° zeizen.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEK7745A DE840245C (en) | 1950-05-09 | 1950-05-09 | Process for the preparation of derivatives of physodic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEK7745A DE840245C (en) | 1950-05-09 | 1950-05-09 | Process for the preparation of derivatives of physodic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
DE840245C true DE840245C (en) | 1952-05-29 |
Family
ID=7211670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEK7745A Expired DE840245C (en) | 1950-05-09 | 1950-05-09 | Process for the preparation of derivatives of physodic acid |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE840245C (en) |
-
1950
- 1950-05-09 DE DEK7745A patent/DE840245C/en not_active Expired
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