DE69941228D1 - Verwendung des Heregulins als Epithelzellenwachstumsfaktor - Google Patents

Verwendung des Heregulins als Epithelzellenwachstumsfaktor

Info

Publication number
DE69941228D1
DE69941228D1 DE69941228T DE69941228T DE69941228D1 DE 69941228 D1 DE69941228 D1 DE 69941228D1 DE 69941228 T DE69941228 T DE 69941228T DE 69941228 T DE69941228 T DE 69941228T DE 69941228 D1 DE69941228 D1 DE 69941228D1
Authority
DE
Germany
Prior art keywords
cell growth
epithelial cell
heregulin
growth factor
her3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69941228T
Other languages
English (en)
Inventor
Mark Sliwkowski
Jeffrey A Kern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Iowa Research Foundation UIRF
Genentech Inc
Original Assignee
University of Iowa Research Foundation UIRF
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Iowa Research Foundation UIRF, Genentech Inc filed Critical University of Iowa Research Foundation UIRF
Application granted granted Critical
Publication of DE69941228D1 publication Critical patent/DE69941228D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
DE69941228T 1998-02-04 1999-02-03 Verwendung des Heregulins als Epithelzellenwachstumsfaktor Expired - Lifetime DE69941228D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2059898A 1998-02-04 1998-02-04

Publications (1)

Publication Number Publication Date
DE69941228D1 true DE69941228D1 (de) 2009-09-17

Family

ID=21799510

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69920405T Expired - Lifetime DE69920405T2 (de) 1998-02-04 1999-02-03 Verwendung des heregulins als epithelzellenwachstumsfaktor
DE69941228T Expired - Lifetime DE69941228D1 (de) 1998-02-04 1999-02-03 Verwendung des Heregulins als Epithelzellenwachstumsfaktor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69920405T Expired - Lifetime DE69920405T2 (de) 1998-02-04 1999-02-03 Verwendung des heregulins als epithelzellenwachstumsfaktor

Country Status (10)

Country Link
US (1) US20020042087A1 (de)
EP (2) EP1510579B1 (de)
JP (1) JP4485051B2 (de)
AT (2) ATE438720T1 (de)
AU (1) AU2581599A (de)
CA (1) CA2318857C (de)
DE (2) DE69920405T2 (de)
DK (1) DK1510579T3 (de)
ES (2) ES2229679T3 (de)
WO (1) WO1999039729A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
US7396810B1 (en) 2000-08-14 2008-07-08 Oregon Health Sciences University Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
EP1189931B1 (de) * 1999-07-02 2006-06-21 Genentech, Inc. An her2 bindende peptidverbindungen
CA2643478C (en) * 2006-02-23 2019-06-18 Novocell, Inc. Compositions and methods useful for culturing differentiable cells
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
KR20140057326A (ko) * 2011-08-17 2014-05-12 제넨테크, 인크. 뉴레귤린 항체 및 그의 용도
US9273143B2 (en) 2011-09-30 2016-03-01 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
EA028879B1 (ru) 2011-09-30 2018-01-31 Ридженерон Фармасьютикалз, Инк. АНТИТЕЛА К ErbB3 И ИХ ПРИМЕНЕНИЕ
EP2727941A1 (de) 2012-11-05 2014-05-07 MAB Discovery GmbH Verfahren zur Herstellung multispezifischer Antikörper
EP2727942A1 (de) 2012-11-05 2014-05-07 MAB Discovery GmbH Bispezifische Antikörper gegen menschliche EGFR, HER2 und HER3
EP2914629A1 (de) 2012-11-05 2015-09-09 MAB Discovery GmbH Verfahren zur herstellung multispezifischer antikörper
EP2727943A1 (de) 2012-11-05 2014-05-07 MAB Discovery GmbH Trispezifische Antikörper gegen menschliche EGFR, HER2 und HER3
US20170333529A1 (en) * 2015-01-20 2017-11-23 Universiteit Antwerpen Neuregulin in the treatment of fibrotic disorders
CN113789387B (zh) * 2021-11-15 2022-02-22 中国医学科学院北京协和医院 标志物在诊断腹主动脉瘤中的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
DE3169595D1 (en) 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
EP0088046B1 (de) 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipide in wässriger Phase
EP0102324A3 (de) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
ATE59966T1 (de) 1983-09-26 1991-02-15 Ehrenfeld Udo Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr.
US4615885A (en) 1983-11-01 1986-10-07 Terumo Kabushiki Kaisha Pharmaceutical composition containing urokinase
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5367060A (en) * 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin
US5770567A (en) * 1994-11-14 1998-06-23 Genentech, Inc. Sensory and motor neuron derived factor (SMDF)
US6387638B1 (en) * 1997-02-10 2002-05-14 Genentech, Inc. Heregulin variants

Also Published As

Publication number Publication date
EP1510579A2 (de) 2005-03-02
ATE438720T1 (de) 2009-08-15
WO1999039729A2 (en) 1999-08-12
AU2581599A (en) 1999-08-23
ES2329467T3 (es) 2009-11-26
CA2318857A1 (en) 1999-08-12
EP1510579A3 (de) 2005-05-11
US20020042087A1 (en) 2002-04-11
EP1053009A2 (de) 2000-11-22
WO1999039729A3 (en) 1999-10-14
ATE276756T1 (de) 2004-10-15
EP1053009B1 (de) 2004-09-22
JP2002509076A (ja) 2002-03-26
EP1510579B1 (de) 2009-08-05
CA2318857C (en) 2013-09-24
DE69920405T2 (de) 2006-01-05
ES2229679T3 (es) 2005-04-16
DK1510579T3 (da) 2009-11-30
DE69920405D1 (de) 2004-10-28
JP4485051B2 (ja) 2010-06-16

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