DK1510579T3 - Anvendelse af heregulin som en epitelcellevækstfaktor - Google Patents

Anvendelse af heregulin som en epitelcellevækstfaktor

Info

Publication number
DK1510579T3
DK1510579T3 DK04022325T DK04022325T DK1510579T3 DK 1510579 T3 DK1510579 T3 DK 1510579T3 DK 04022325 T DK04022325 T DK 04022325T DK 04022325 T DK04022325 T DK 04022325T DK 1510579 T3 DK1510579 T3 DK 1510579T3
Authority
DK
Denmark
Prior art keywords
cell growth
epithelial cell
heregulin
growth factor
her3
Prior art date
Application number
DK04022325T
Other languages
Danish (da)
English (en)
Inventor
Mark Sliwkowski
Jeffrey A Kern
Original Assignee
Genentech Inc
Univ Iowa Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Univ Iowa Res Found filed Critical Genentech Inc
Application granted granted Critical
Publication of DK1510579T3 publication Critical patent/DK1510579T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK04022325T 1998-02-04 1999-02-03 Anvendelse af heregulin som en epitelcellevækstfaktor DK1510579T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2059898A 1998-02-04 1998-02-04
PCT/US1999/002390 WO1999039729A2 (en) 1998-02-04 1999-02-03 Use of heregulin as an epithelial cell growth factor

Publications (1)

Publication Number Publication Date
DK1510579T3 true DK1510579T3 (da) 2009-11-30

Family

ID=21799510

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04022325T DK1510579T3 (da) 1998-02-04 1999-02-03 Anvendelse af heregulin som en epitelcellevækstfaktor

Country Status (10)

Country Link
US (1) US20020042087A1 (de)
EP (2) EP1053009B1 (de)
JP (1) JP4485051B2 (de)
AT (2) ATE438720T1 (de)
AU (1) AU2581599A (de)
CA (1) CA2318857C (de)
DE (2) DE69941228D1 (de)
DK (1) DK1510579T3 (de)
ES (2) ES2229679T3 (de)
WO (1) WO1999039729A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7396810B1 (en) 2000-08-14 2008-07-08 Oregon Health Sciences University Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
CA2373721C (en) 1999-07-02 2013-10-15 Genentech, Inc. Compounds that bind her2
SG10201405107YA (en) * 2006-02-23 2014-10-30 Viacyte Inc Compositions and methods useful for culturing differentiable cells
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
CN103890007A (zh) * 2011-08-17 2014-06-25 霍夫曼-拉罗奇有限公司 神经调节蛋白抗体及其用途
ES2694153T3 (es) 2011-09-30 2018-12-18 Regeneron Pharmaceuticals, Inc. Anticuerpos anti-ErbB3 y usos de los mismos
US9273143B2 (en) 2011-09-30 2016-03-01 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
EP2727941A1 (de) 2012-11-05 2014-05-07 MAB Discovery GmbH Verfahren zur Herstellung multispezifischer Antikörper
EP2727943A1 (de) 2012-11-05 2014-05-07 MAB Discovery GmbH Trispezifische Antikörper gegen menschliche EGFR, HER2 und HER3
EP2914629A1 (de) 2012-11-05 2015-09-09 MAB Discovery GmbH Verfahren zur herstellung multispezifischer antikörper
EP2727942A1 (de) 2012-11-05 2014-05-07 MAB Discovery GmbH Bispezifische Antikörper gegen menschliche EGFR, HER2 und HER3
EP3247380A1 (de) * 2015-01-20 2017-11-29 Universiteit Antwerpen Neuregulin in der behandlung von fibrotischen erkrankungen
CN113789387B (zh) * 2021-11-15 2022-02-22 中国医学科学院北京协和医院 标志物在诊断腹主动脉瘤中的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
DE3169595D1 (en) 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
EP0088046B1 (de) 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipide in wässriger Phase
EP0102324A3 (de) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
DE3483949D1 (de) 1983-09-26 1991-02-21 Udo Dr Med Ehrenfeld Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr.
EP0143949B1 (de) 1983-11-01 1988-10-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmazeutische Zusammensetzung mit Gehalt an Urokinase
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5367060A (en) * 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin
US5770567A (en) * 1994-11-14 1998-06-23 Genentech, Inc. Sensory and motor neuron derived factor (SMDF)
DK0970207T3 (da) * 1997-02-10 2009-07-13 Genentech Inc Heregulin-varianter

Also Published As

Publication number Publication date
WO1999039729A2 (en) 1999-08-12
EP1510579A3 (de) 2005-05-11
ATE276756T1 (de) 2004-10-15
AU2581599A (en) 1999-08-23
DE69920405T2 (de) 2006-01-05
ES2229679T3 (es) 2005-04-16
CA2318857A1 (en) 1999-08-12
DE69920405D1 (de) 2004-10-28
CA2318857C (en) 2013-09-24
DE69941228D1 (de) 2009-09-17
US20020042087A1 (en) 2002-04-11
WO1999039729A3 (en) 1999-10-14
ES2329467T3 (es) 2009-11-26
JP2002509076A (ja) 2002-03-26
EP1510579A2 (de) 2005-03-02
JP4485051B2 (ja) 2010-06-16
ATE438720T1 (de) 2009-08-15
EP1053009B1 (de) 2004-09-22
EP1510579B1 (de) 2009-08-05
EP1053009A2 (de) 2000-11-22

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