DE69940318D1 - Polynucleotidkonstrukte und ihre verwendungen - Google Patents

Polynucleotidkonstrukte und ihre verwendungen

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Publication number
DE69940318D1
DE69940318D1 DE69940318T DE69940318T DE69940318D1 DE 69940318 D1 DE69940318 D1 DE 69940318D1 DE 69940318 T DE69940318 T DE 69940318T DE 69940318 T DE69940318 T DE 69940318T DE 69940318 D1 DE69940318 D1 DE 69940318D1
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DE
Germany
Prior art keywords
polynucleotide
repeats
hre
operably linked
hypoxia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69940318T
Other languages
English (en)
Inventor
Katie Mary Binley
Stuart Naylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Biomedica UK Ltd
Original Assignee
Oxford Biomedica UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB1998/002885 external-priority patent/WO1999015684A2/en
Priority claimed from GBGB9901906.9A external-priority patent/GB9901906D0/en
Priority claimed from GBGB9903538.8A external-priority patent/GB9903538D0/en
Application filed by Oxford Biomedica UK Ltd filed Critical Oxford Biomedica UK Ltd
Application granted granted Critical
Publication of DE69940318D1 publication Critical patent/DE69940318D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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DE69940318T 1998-09-23 1999-09-22 Polynucleotidkonstrukte und ihre verwendungen Expired - Fee Related DE69940318D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/GB1998/002885 WO1999015684A2 (en) 1997-09-23 1998-09-23 Expression of genes in hematopoietic stem cells in hischaemic conditions
GBGB9901906.9A GB9901906D0 (en) 1999-01-28 1999-01-28 Polynucleotide constructs and users therof
GBGB9903538.8A GB9903538D0 (en) 1999-02-16 1999-02-16 Polynucleotide constructs and uses therof
PCT/GB1999/003181 WO2000017371A1 (en) 1998-09-23 1999-09-22 Polynucleotide constructs and uses thereof

Publications (1)

Publication Number Publication Date
DE69940318D1 true DE69940318D1 (de) 2009-03-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE69940318T Expired - Fee Related DE69940318D1 (de) 1998-09-23 1999-09-22 Polynucleotidkonstrukte und ihre verwendungen

Country Status (9)

Country Link
EP (1) EP1115877B1 (de)
JP (1) JP2002526083A (de)
KR (1) KR20010084913A (de)
CN (1) CN1319139A (de)
AT (1) ATE420963T1 (de)
AU (1) AU6213099A (de)
DE (1) DE69940318D1 (de)
GB (1) GB2358020A (de)
WO (1) WO2000017371A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE526981T1 (de) 2000-04-12 2011-10-15 Vib Vzw Verwendung von vegf 165 und homologen zur behandlung von neurologischen störungen
US7332179B2 (en) 2003-12-12 2008-02-19 Kimberly-Clark Worldwide, Inc. Tissue products comprising a cleansing composition
WO2005117946A1 (en) 2004-05-27 2005-12-15 Vib Vzw Treatment of amyotrophic lateral sclerosis
WO2012133376A1 (ja) * 2011-03-30 2012-10-04 国立大学法人富山大学 外来遺伝子導入用ベクター及び外来遺伝子が導入されたベクターの製造方法
JP6830949B2 (ja) * 2015-08-03 2021-02-17 リサーチ ファウンデイション オブ ザ シティー ユニヴァーシティ オブ ニューヨーク 嗅覚系における嗅覚受容体の出現を増大させるｄｎａ配列
WO2018151875A2 (en) 2016-12-30 2018-08-23 Research Foundation Of The City University Of New York Biosensor exhibiting sensitivity to trinitrotoluene
MX2019015589A (es) * 2019-12-19 2021-06-21 Centro De Investig Y Asistencia En Tecnologia Y Diseno Del Estado De Jalisco A C Molécula sintética de adn con potenciador autorregulado por hipoxia y/o inflamación para uso como agente terapéutico de enfermedades inflamatorias y degeneración tisular.
AU2021459965A1 (en) * 2021-08-13 2024-02-22 Shanghai Sinobay Biotechnology Co., Ltd. A Hypoxia-triggered Artificial Transcription Factor, A Hypoxia-triggered Transcription Control System and Use Thereof
CN116064675A (zh) * 2022-07-22 2023-05-05 西安电子科技大学 一种重组质粒、重组慢病毒载体、稳转细胞系及其构建方法与应用

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Publication number Priority date Publication date Assignee Title
GB9402857D0 (en) * 1994-02-15 1994-04-06 Isis Innovation Targeting gene therapy
US5834306A (en) * 1994-12-23 1998-11-10 Sri International Tissue specific hypoxia regulated therapeutic constructs
GB2332434B (en) * 1996-10-09 2001-04-04 Oxford Biomedica Ltd Mononuclear phagocytes in therapeutic drug delivery
US5952226A (en) * 1996-11-05 1999-09-14 Modex Therapeutiques Hypoxia responsive EPO producing cells
US5695963A (en) * 1997-01-17 1997-12-09 Board Of Regents, The University Of Texas System Endothelial PAS domain protein
JP2001517453A (ja) * 1997-09-23 2001-10-09 オックスフォード バイオメディカ（ユーケイ）リミテッド 方 法

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GB0105483D0 (en) 2001-04-25
CN1319139A (zh) 2001-10-24
JP2002526083A (ja) 2002-08-20
EP1115877B1 (de) 2009-01-14
KR20010084913A (ko) 2001-09-07
WO2000017371A1 (en) 2000-03-30
GB2358020A (en) 2001-07-11
AU6213099A (en) 2000-04-10
ATE420963T1 (de) 2009-01-15

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