DE69937806D1 - Methode zum identifizieren von inhibitoren der ipc-synthase - Google Patents
Methode zum identifizieren von inhibitoren der ipc-synthaseInfo
- Publication number
- DE69937806D1 DE69937806D1 DE69937806T DE69937806T DE69937806D1 DE 69937806 D1 DE69937806 D1 DE 69937806D1 DE 69937806 T DE69937806 T DE 69937806T DE 69937806 T DE69937806 T DE 69937806T DE 69937806 D1 DE69937806 D1 DE 69937806D1
- Authority
- DE
- Germany
- Prior art keywords
- ipc synthase
- assay
- test compound
- phytosphingosine
- engineered cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 108010029890 phosphatidylinositol-ceramide phosphoinositol transferase Proteins 0.000 abstract 2
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 abstract 2
- 229940033329 phytosphingosine Drugs 0.000 abstract 2
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000001447 compensatory effect Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 238000007423 screening assay Methods 0.000 abstract 1
- 150000003408 sphingolipids Chemical class 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Semiconductor Lasers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9825055 | 1998-11-17 | ||
| GBGB9825055.8A GB9825055D0 (en) | 1998-11-17 | 1998-11-17 | Method |
| PCT/GB1999/003789 WO2000029590A1 (en) | 1998-11-17 | 1999-11-12 | Method for identifying inhibitors of ipc synthase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69937806D1 true DE69937806D1 (de) | 2008-01-31 |
| DE69937806T2 DE69937806T2 (de) | 2008-12-11 |
Family
ID=10842500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69937806T Expired - Lifetime DE69937806T2 (de) | 1998-11-17 | 1999-11-12 | Methode zum identifizieren von inhibitoren der ipc-synthase |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6808892B1 (de) |
| EP (1) | EP1131449B1 (de) |
| JP (1) | JP2002530084A (de) |
| AT (1) | ATE381621T1 (de) |
| AU (1) | AU1066100A (de) |
| DE (1) | DE69937806T2 (de) |
| ES (1) | ES2297939T3 (de) |
| GB (1) | GB9825055D0 (de) |
| WO (1) | WO2000029590A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7659088B2 (en) * | 2006-05-22 | 2010-02-09 | Aureogen Biosciences, Inc. | Assay for inositol phosphorylceramide synthase activity |
| US11643438B2 (en) | 2018-07-20 | 2023-05-09 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5667986A (en) | 1989-10-18 | 1997-09-16 | Delta Biotechnology Limited | Yeast promoter for expressing heterologous polypeptides |
| GB8923521D0 (en) | 1989-10-18 | 1989-12-06 | Delta Biotechnology Ltd | Yeast promoter |
| EP0644262B1 (de) | 1993-05-24 | 2006-03-15 | Takara Bio Inc. | Kodierung eines Gens für ein die Aureobasidinempfindlichkeit regulierendes Protein |
| GB9510927D0 (en) | 1995-05-31 | 1995-07-26 | Ca Nat Research Council | Plant and seed oil modification |
-
1998
- 1998-11-17 GB GBGB9825055.8A patent/GB9825055D0/en not_active Ceased
-
1999
- 1999-11-12 ES ES99954249T patent/ES2297939T3/es not_active Expired - Lifetime
- 1999-11-12 AT AT99954249T patent/ATE381621T1/de not_active IP Right Cessation
- 1999-11-12 US US09/831,290 patent/US6808892B1/en not_active Expired - Fee Related
- 1999-11-12 EP EP99954249A patent/EP1131449B1/de not_active Expired - Lifetime
- 1999-11-12 AU AU10661/00A patent/AU1066100A/en not_active Abandoned
- 1999-11-12 WO PCT/GB1999/003789 patent/WO2000029590A1/en active IP Right Grant
- 1999-11-12 JP JP2000582572A patent/JP2002530084A/ja active Pending
- 1999-11-12 DE DE69937806T patent/DE69937806T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6808892B1 (en) | 2004-10-26 |
| AU1066100A (en) | 2000-06-05 |
| ATE381621T1 (de) | 2008-01-15 |
| JP2002530084A (ja) | 2002-09-17 |
| WO2000029590A1 (en) | 2000-05-25 |
| DE69937806T2 (de) | 2008-12-11 |
| ES2297939T3 (es) | 2008-05-01 |
| EP1131449B1 (de) | 2007-12-19 |
| GB9825055D0 (en) | 1999-01-13 |
| EP1131449A1 (de) | 2001-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |