DE69929817D1 - Verfahren zur aktivitätsbestimmung einer substanz mittels eines funktionellen in vitro tests - Google Patents

Verfahren zur aktivitätsbestimmung einer substanz mittels eines funktionellen in vitro tests

Info

Publication number
DE69929817D1
DE69929817D1 DE69929817T DE69929817T DE69929817D1 DE 69929817 D1 DE69929817 D1 DE 69929817D1 DE 69929817 T DE69929817 T DE 69929817T DE 69929817 T DE69929817 T DE 69929817T DE 69929817 D1 DE69929817 D1 DE 69929817D1
Authority
DE
Germany
Prior art keywords
substance
functional
vitro tests
activity determination
absence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69929817T
Other languages
English (en)
Other versions
DE69929817T2 (de
Inventor
Jean-Franupsilonois Bloch
Sandrine Dautel
Daniel Dupret
Jean-Michel Masson
Fabrice Lefevre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proteus SA
Original Assignee
Proteus SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteus SA filed Critical Proteus SA
Publication of DE69929817D1 publication Critical patent/DE69929817D1/de
Application granted granted Critical
Publication of DE69929817T2 publication Critical patent/DE69929817T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69929817T 1998-12-08 1999-12-08 Verfahren zur aktivitätsbestimmung einer substanz mittels eines funktionellen in vitro tests Expired - Lifetime DE69929817T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9815488A FR2786788B1 (fr) 1998-12-08 1998-12-08 Procede de criblage de substances capables de modifier l'activite d'une ou plusieurs proteines cibles ou d'un ensemble cible de proteines exprimees in vitro
FR9815488 1998-12-08
PCT/FR1999/003062 WO2000034514A1 (fr) 1998-12-08 1999-12-08 PROCEDE DE DETERMINATION DE L'ACTIVITE D'UNE SUBSTANCE METTANT EN OEUVRE UN TEST FONCTIONNEL $i(IN VITRO)

Publications (2)

Publication Number Publication Date
DE69929817D1 true DE69929817D1 (de) 2006-04-20
DE69929817T2 DE69929817T2 (de) 2006-12-28

Family

ID=9533725

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69929817T Expired - Lifetime DE69929817T2 (de) 1998-12-08 1999-12-08 Verfahren zur aktivitätsbestimmung einer substanz mittels eines funktionellen in vitro tests

Country Status (9)

Country Link
EP (2) EP1666612A3 (de)
JP (1) JP2002531851A (de)
AT (1) ATE317454T1 (de)
AU (1) AU779179B2 (de)
CA (1) CA2354572A1 (de)
DE (1) DE69929817T2 (de)
FR (1) FR2786788B1 (de)
IL (2) IL143639A0 (de)
WO (1) WO2000034514A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1160332A1 (de) * 2000-05-30 2001-12-05 Amsterdam Support Diagnostics B.V. Verfahren zum Nachweis von enzymatischer Aktivität oder von Resistenz gegen enzymatiche Inhibitoren
EP1229330B1 (de) * 2000-07-26 2007-02-21 Japan Science and Technology Agency Sonde zum analysieren von protein-protein-wechselwirkungen und entsprechendes verfahren dafür
DE10158904A1 (de) * 2001-11-30 2003-06-12 Roche Diagnostics Gmbh Verfahren zur Herstellung von linearen DNA Fragmenten für die in vitro Expression von Proteinen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4557862A (en) * 1983-10-28 1985-12-10 University Patents, Inc. Rhodamine derivatives as fluorogenic substrates for proteinases
WO1992007949A1 (en) * 1990-11-05 1992-05-14 The United States Of America, As Represented By The Secretary Of The Army Method for the in vitro production of protein from a dna sequence without cloning
US5235039A (en) * 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
JPH07184648A (ja) * 1992-02-07 1995-07-25 Kunitada Shimotoono Ｈｃｖプロテイナーゼ活性物質、その製造法並びに同プロテイナーゼおよび同プロテイナーゼ阻害剤のアッセイ法
WO1994005812A1 (en) * 1992-09-02 1994-03-17 The Scripps Research Institute Coupled isothermal polynucleotide amplification and translation system
US5436131A (en) * 1993-04-02 1995-07-25 Merck & Co., Inc. Color screening assay for identifying inhibitor resistant HIV protease mutants
NZ265504A (en) * 1993-04-08 1996-09-25 Res Dev Foundation Cell free engineering and synthesis of protein, using transcription/translation media
GB9320562D0 (en) * 1993-10-06 1993-11-24 Zeneca Ltd Novel assay and applications
US5763198A (en) * 1994-07-22 1998-06-09 Sugen, Inc. Screening assays for compounds
US6063562A (en) * 1994-09-16 2000-05-16 Sepracor, Inc. In vitro method for predicting the evolutionary response of HIV protease to a drug targeted thereagainst
DE19710159A1 (de) * 1997-03-12 1998-10-01 Hoechst Ag In vitro Transkriptionsverfahren zum Screening von Naturstoffen und anderen chemischen Substanzen

Also Published As

Publication number Publication date
JP2002531851A (ja) 2002-09-24
IL143639A0 (en) 2002-04-21
EP1666612A2 (de) 2006-06-07
ATE317454T1 (de) 2006-02-15
AU1510000A (en) 2000-06-26
AU779179B2 (en) 2005-01-13
EP1666612A3 (de) 2006-06-21
FR2786788B1 (fr) 2002-04-19
FR2786788A1 (fr) 2000-06-09
EP1137802B1 (de) 2006-02-08
CA2354572A1 (fr) 2000-06-15
WO2000034514A1 (fr) 2000-06-15
EP1137802A1 (de) 2001-10-04
DE69929817T2 (de) 2006-12-28
IL143639A (en) 2007-08-19

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Legal Events

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8364 No opposition during term of opposition