DE69920263D1 - Troxerutin mit hohem trihydroxy-ethyl-rutosidegehalt und verfahren zur herstellung - Google Patents

Troxerutin mit hohem trihydroxy-ethyl-rutosidegehalt und verfahren zur herstellung

Info

Publication number
DE69920263D1
DE69920263D1 DE69920263T DE69920263T DE69920263D1 DE 69920263 D1 DE69920263 D1 DE 69920263D1 DE 69920263 T DE69920263 T DE 69920263T DE 69920263 T DE69920263 T DE 69920263T DE 69920263 D1 DE69920263 D1 DE 69920263D1
Authority
DE
Germany
Prior art keywords
troxerutin
wettability
water
enriched
content
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69920263T
Other languages
English (en)
Other versions
DE69920263T2 (de
Inventor
Cyril Estanove
Francois Pruvost
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NEGMA TOUSSUS LE NOBLE LAB
Original Assignee
NEGMA TOUSSUS LE NOBLE LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NEGMA TOUSSUS LE NOBLE LAB filed Critical NEGMA TOUSSUS LE NOBLE LAB
Application granted granted Critical
Publication of DE69920263D1 publication Critical patent/DE69920263D1/de
Publication of DE69920263T2 publication Critical patent/DE69920263T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE69920263T 1998-12-11 1999-12-10 Troxerutin mit hohem trihydroxy-ethyl-rutosidegehalt und verfahren zur herstellung Expired - Fee Related DE69920263T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9815710 1998-12-11
FR9815710A FR2787111B1 (fr) 1998-12-11 1998-12-11 Troxerutine a forte teneur en trihydroxy-ethyl-rutoside, a mouillabilite elevee, et procede de preparation
PCT/FR1999/003100 WO2000035933A1 (fr) 1998-12-11 1999-12-10 Troxerutine a forte teneur en trihydroxy-ethyl-rutoside et procede de preparation

Publications (2)

Publication Number Publication Date
DE69920263D1 true DE69920263D1 (de) 2004-10-21
DE69920263T2 DE69920263T2 (de) 2005-09-29

Family

ID=9533903

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69920263T Expired - Fee Related DE69920263T2 (de) 1998-12-11 1999-12-10 Troxerutin mit hohem trihydroxy-ethyl-rutosidegehalt und verfahren zur herstellung

Country Status (21)

Country Link
US (1) US6855697B1 (de)
EP (1) EP1137653B1 (de)
JP (1) JP2003505338A (de)
KR (1) KR100644478B1 (de)
CN (1) CN1196709C (de)
AT (1) ATE276265T1 (de)
AU (1) AU1569300A (de)
BR (1) BR9916130A (de)
CA (1) CA2354574C (de)
CZ (1) CZ20011998A3 (de)
DE (1) DE69920263T2 (de)
ES (1) ES2229795T3 (de)
FR (1) FR2787111B1 (de)
HU (1) HUP0104689A3 (de)
IL (1) IL143660A0 (de)
PL (1) PL195116B1 (de)
RU (1) RU2242478C2 (de)
SK (1) SK7822001A3 (de)
TR (1) TR200101695T2 (de)
WO (1) WO2000035933A1 (de)
ZA (1) ZA200105072B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1302774C (zh) * 2003-11-07 2007-03-07 邱学良 一种含有曲克芦丁的泡腾片及制法
RU2295970C1 (ru) * 2006-05-23 2007-03-27 Общество С Ограниченной Ответственностью "Сиа Пептайдс" Пептид, повышающий резистентность капилляров, фармацевтическая композиция на его основе и способ ее применения
CN103113437A (zh) * 2013-01-05 2013-05-22 河北联合大学 曲克芦丁的制备方法
CN104177461B (zh) * 2013-05-21 2016-11-09 济南新力特科技有限公司 三羟乙基芦丁的制备方法
JP6234556B2 (ja) * 2014-05-23 2017-11-22 ▲済▼南新力特科技有限公司Ｊｉｎａｎ Ｘｉｎｌｉｔｅ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ トリヒドロキシエチルルトシドの調製方法
CN104628799B (zh) * 2014-12-24 2017-10-03 苏州亚宝药物研发有限公司 一种曲克芦丁中杂质a及其分离方法
CN111333602B (zh) * 2020-04-16 2022-12-16 四川协力制药股份有限公司 一种曲克芦丁生产废弃母液的回收转化工艺
CN112057424B (zh) * 2020-09-18 2022-09-16 开封康诺药业有限公司 一种曲克芦丁冻干粉针剂及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH423808A (fr) * 1964-03-26 1966-11-15 Zyma Sa Procédé pour la préparation d'éthers O-B-hydroxyéthylés de la rutine
FR5072M (de) * 1965-10-25 1967-05-16
CH581127A5 (de) * 1974-04-09 1976-10-29 Zyma Sa
US4153788A (en) * 1974-04-09 1979-05-08 Zyma S.A. Process of preparing mono-O-β-hydroxyethyl-7 rutoside
CS225440B1 (cs) * 1982-04-06 1984-02-13 Frantisek Ing Kvis Způsob přípravy směsi 0-hydroxyethylovaných derivátů rutinu
CN1032658A (zh) * 1987-10-19 1989-05-03 烟台人民制药厂 芦丁羟乙基衍生物的精制方法

Also Published As

Publication number Publication date
CN1196709C (zh) 2005-04-13
FR2787111A1 (fr) 2000-06-16
CN1331697A (zh) 2002-01-16
FR2787111B1 (fr) 2001-02-23
SK7822001A3 (en) 2002-01-07
CZ20011998A3 (cs) 2001-10-17
DE69920263T2 (de) 2005-09-29
RU2242478C2 (ru) 2004-12-20
KR20010101173A (ko) 2001-11-14
TR200101695T2 (tr) 2002-04-22
PL348200A1 (en) 2002-05-06
AU1569300A (en) 2000-07-03
ES2229795T3 (es) 2005-04-16
KR100644478B1 (ko) 2006-11-10
ZA200105072B (en) 2002-12-20
ATE276265T1 (de) 2004-10-15
WO2000035933A1 (fr) 2000-06-22
HUP0104689A2 (hu) 2002-04-29
JP2003505338A (ja) 2003-02-12
IL143660A0 (en) 2002-04-21
HUP0104689A3 (en) 2003-12-29
US6855697B1 (en) 2005-02-15
EP1137653A1 (de) 2001-10-04
BR9916130A (pt) 2001-09-04
CA2354574C (fr) 2009-07-28
PL195116B1 (pl) 2007-08-31
EP1137653B1 (de) 2004-09-15
CA2354574A1 (fr) 2000-06-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee