DE69918327D1 - Unterdrückung der abstossung bei xenotransplantation - Google Patents

Unterdrückung der abstossung bei xenotransplantation

Info

Publication number
DE69918327D1
DE69918327D1 DE69918327T DE69918327T DE69918327D1 DE 69918327 D1 DE69918327 D1 DE 69918327D1 DE 69918327 T DE69918327 T DE 69918327T DE 69918327 T DE69918327 T DE 69918327T DE 69918327 D1 DE69918327 D1 DE 69918327D1
Authority
DE
Germany
Prior art keywords
suppression
xenotransplantation
exhaust
relates
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69918327T
Other languages
English (en)
Other versions
DE69918327T2 (de
Inventor
Satyavrat Ramrakha
John George
Dorian Haskard
Ian Lechler
Anthony Dorling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ip2ipo Innovations Ltd
Original Assignee
Imperial College Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial College Innovations Ltd filed Critical Imperial College Innovations Ltd
Application granted granted Critical
Publication of DE69918327D1 publication Critical patent/DE69918327D1/de
Publication of DE69918327T2 publication Critical patent/DE69918327T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2836—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD106
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
    • C07K2317/81—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the endoplasmatic reticulum [ER] or the Golgi apparatus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of High-Frequency Heating Circuits (AREA)
  • Processes For Solid Components From Exhaust (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
DE69918327T 1998-11-20 1999-11-22 Unterdrückung der abstossung bei xenotransplantation Expired - Fee Related DE69918327T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9825555.7A GB9825555D0 (en) 1998-11-20 1998-11-20 Suppression of xenotransplant rejection
GB9825555 1998-11-20
PCT/GB1999/003888 WO2000031126A2 (en) 1998-11-20 1999-11-22 Suppression of xenotransplant rejection

Publications (2)

Publication Number Publication Date
DE69918327D1 true DE69918327D1 (de) 2004-07-29
DE69918327T2 DE69918327T2 (de) 2006-05-11

Family

ID=10842836

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69918327T Expired - Fee Related DE69918327T2 (de) 1998-11-20 1999-11-22 Unterdrückung der abstossung bei xenotransplantation

Country Status (9)

Country Link
US (2) US20050255550A1 (de)
EP (1) EP1131411B1 (de)
JP (1) JP2002531072A (de)
AT (1) ATE269896T1 (de)
AU (1) AU1282900A (de)
DE (1) DE69918327T2 (de)
ES (1) ES2224713T3 (de)
GB (1) GB9825555D0 (de)
WO (1) WO2000031126A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2559720A1 (en) 2004-03-17 2005-09-29 Revivicor, Inc. Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase
ES2679282T3 (es) 2004-10-22 2018-08-23 Revivicor Inc. Porcinos transgénicos que carecen de cadena ligera de inmunoglobulina endógena
WO2008153725A2 (en) 2007-05-25 2008-12-18 North Carolina State University Viral nanoparticle cell-targeted delivery platform
CN103242444A (zh) 2007-10-11 2013-08-14 大学健康网络 调节SIRPα-CD47相互作用以增加造血干细胞植入和用于此的化合物
DK2348827T3 (en) 2008-10-27 2015-07-20 Revivicor Inc IMMUNICIPLY COMPROMATED PETS
CA2757842A1 (en) * 2009-04-09 2010-10-14 The Children's Hospital Of Philadelphia Ligand-specific inhibition of attachment of immune cells to implantable biomaterials
CA2766634A1 (en) 2009-06-22 2011-01-13 Burnham Institute For Medical Research Methods and compositions using peptides and proteins with c-terminal elements
AU2012217792A1 (en) 2011-02-14 2013-08-29 Revivicor, Inc. Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
WO2012118778A1 (en) 2011-02-28 2012-09-07 Sanford-Burnham Medical Research Institute Truncated car peptides and methods and compositions using truncated car peptides
JP6025067B2 (ja) * 2011-03-31 2016-11-16 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 新規心筋細胞マーカー
EP2715291A4 (de) 2011-05-31 2015-10-21 Airware Inc Rekalibrierung von ab-ndir-gassensoren
US10179801B2 (en) 2011-08-26 2019-01-15 Sanford-Burnham Medical Research Institute Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
EP3628047A1 (de) 2017-05-02 2020-04-01 Sanford Burnham Prebys Medical Discovery Institute Tumorassoziiertes monozyten-/makrophagenbindendes peptid und verfahren zur verwendung davon
US20220119450A1 (en) 2019-02-04 2022-04-21 University Of Tartu Bi-specific extracellular matrix binding peptides and methods of use thereof
AU2021385081A1 (en) 2020-11-20 2023-06-29 Revivicor, Inc. Multi-transgenic pigs with growth hormone receptor knockout for xenotransplantation
EP4404740A1 (de) 2021-09-20 2024-07-31 Revivicor Inc. Multitransgene schweine mit zehn genetischen modifikationen zur xenotransplantation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2732546B2 (ja) * 1992-09-02 1998-03-30 アイシス・ファーマシューティカルス・インコーポレーテッド 細胞接着のオリゴヌクレオチド調節
WO1996015780A1 (en) * 1994-11-23 1996-05-30 Isis Pharmaceuticals, Inc. Compositions and methods for preventing and treating allograft rejection
JP2002514895A (ja) * 1995-09-28 2002-05-21 アレクション、ファーマスーティカルズ、インコーポレーテッド ブタ細胞相互作用タンパク質
FR2751346A1 (fr) * 1996-07-19 1998-01-23 Inst Nat Sante Rech Med Procede de preparation d'organes de mammiferes non humains transgeniques en vue de leur transplantation chez l'homme, et sequences nucleotidiques pour la mise en oeuvre de ce procede

Also Published As

Publication number Publication date
JP2002531072A (ja) 2002-09-24
WO2000031126A3 (en) 2000-08-24
AU1282900A (en) 2000-06-13
US20070157328A1 (en) 2007-07-05
DE69918327T2 (de) 2006-05-11
GB9825555D0 (en) 1999-01-13
WO2000031126A2 (en) 2000-06-02
US20050255550A1 (en) 2005-11-17
EP1131411B1 (de) 2004-06-23
ES2224713T3 (es) 2005-03-01
ATE269896T1 (de) 2004-07-15
EP1131411A2 (de) 2001-09-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee