DE69913727T2 - Verfahren zum Auftragen von Trockenpulver sowie Verabreichungsvorschriften - Google Patents
Verfahren zum Auftragen von Trockenpulver sowie Verabreichungsvorschriften Download PDFInfo
- Publication number
- DE69913727T2 DE69913727T2 DE69913727T DE69913727T DE69913727T2 DE 69913727 T2 DE69913727 T2 DE 69913727T2 DE 69913727 T DE69913727 T DE 69913727T DE 69913727 T DE69913727 T DE 69913727T DE 69913727 T2 DE69913727 T2 DE 69913727T2
- Authority
- DE
- Germany
- Prior art keywords
- particles
- substrate
- inhaler
- medicament
- dry powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
- B05D1/04—Processes for applying liquids or other fluent materials performed by spraying involving the use of an electrostatic field
- B05D1/06—Applying particulate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0043—Non-destructive separation of the package, e.g. peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
- A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/187,092 US6146685A (en) | 1998-11-05 | 1998-11-05 | Method of deposition a dry powder and dispensing device |
PCT/US1999/025051 WO2000027456A1 (en) | 1998-11-05 | 1999-10-25 | Method of depositing a dry powder and dispensing device |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69913727D1 DE69913727D1 (de) | 2004-01-29 |
DE69913727T2 true DE69913727T2 (de) | 2004-10-07 |
Family
ID=22687570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69913727T Expired - Fee Related DE69913727T2 (de) | 1998-11-05 | 1999-10-25 | Verfahren zum Auftragen von Trockenpulver sowie Verabreichungsvorschriften |
Country Status (14)
Country | Link |
---|---|
US (2) | US6146685A (de) |
EP (1) | EP1126891B1 (de) |
JP (1) | JP2002529153A (de) |
KR (1) | KR20010075679A (de) |
CN (1) | CN1332647A (de) |
AT (1) | ATE256482T1 (de) |
AU (1) | AU755755B2 (de) |
CA (1) | CA2347978A1 (de) |
DE (1) | DE69913727T2 (de) |
HU (1) | HUP0104759A3 (de) |
IL (1) | IL142932A0 (de) |
NZ (1) | NZ511414A (de) |
PT (1) | PT1126891E (de) |
WO (1) | WO2000027456A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE512386C2 (sv) * | 1998-07-30 | 2000-03-06 | Microdrug Ag | Förfarande och anordning för klassificering av elektrostatiskt laddat pulverformigt material |
US6146685A (en) * | 1998-11-05 | 2000-11-14 | Delsys Pharmaceutical Corporation | Method of deposition a dry powder and dispensing device |
US6923979B2 (en) * | 1999-04-27 | 2005-08-02 | Microdose Technologies, Inc. | Method for depositing particles onto a substrate using an alternating electric field |
US6435175B1 (en) * | 2000-08-29 | 2002-08-20 | Sensormedics Corporation | Pulmonary drug delivery device |
US7621300B2 (en) * | 2001-04-20 | 2009-11-24 | Glaxo Group Limited | Metering method for particulate material |
US6844048B2 (en) * | 2001-07-11 | 2005-01-18 | Sarnoff Corporation | Substrates for powder deposition containing conductive domains |
US6686207B2 (en) | 2001-10-12 | 2004-02-03 | Massachusetts Institute Of Technology | Manipulating micron scale items |
SE525027C2 (sv) * | 2002-04-12 | 2004-11-16 | Microdrug Ag | Anordning utgörande en pulverlufthyvel |
US7279181B2 (en) * | 2003-06-03 | 2007-10-09 | Ferro Corporation | Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions |
JP2007512898A (ja) * | 2003-12-03 | 2007-05-24 | マイクロドラッグ アクチェンゲゼルシャフト | 湿度に過敏な薬剤向けの予め計量されたドライパウダー吸入器 |
ES2382550T3 (es) * | 2004-09-16 | 2012-06-11 | Giampiero Cossi | Inhalador monodosis desechable para medicamentos en polvo |
GB0605723D0 (en) | 2006-03-23 | 2006-05-03 | 3M Innovative Properties Co | Powder filling processes |
US7976872B2 (en) * | 2006-07-24 | 2011-07-12 | L. Perrigo Company | Method for distributing a pharmaceutically active compound in an excipient |
US7879392B2 (en) * | 2007-10-15 | 2011-02-01 | Kimberly-Clark Worldwide, Inc. | Compositions with elongated particles having varying charges and aspect ratios |
EP2340812A1 (de) | 2009-12-18 | 2011-07-06 | Ferring International Center S.A. | Granulat für pharmazeutische Präparate sowie Verfahren und Vorrichtungen zu ihrer Herstellung |
US9162245B1 (en) * | 2012-03-29 | 2015-10-20 | BTD Wood Powder Coating, Inc. | Powder coating conveyor support |
MX354365B (es) | 2012-07-19 | 2018-02-28 | Adamis Pharmaceuticals Corp | Aparato alimentador de polvo. |
JP5350530B1 (ja) * | 2012-12-07 | 2013-11-27 | ニップファーマ株式会社 | 薬剤吸入デバイス |
CA2904997C (en) | 2013-03-15 | 2022-12-06 | Chris V. Ciancone | Inhaler spacer and storage apparatus |
EP3402558B1 (de) * | 2016-01-11 | 2023-11-29 | Syqe Medical Ltd. | Persönliche verdampfungsvorrichtung |
IT201600093878A1 (it) | 2016-09-19 | 2018-03-19 | Hollycon Italy Pte Ltd S R L | Inalatore monodose a perdere per medicinali in polvere |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA452052A (en) * | 1948-10-19 | Minnesota Mining And Manufacturing Company | Method of and apparatus for applying coating materials | |
FR2044908A5 (de) * | 1969-05-23 | 1971-02-26 | Tunzini Sames | |
US3687705A (en) * | 1970-09-23 | 1972-08-29 | Minnesota Mining & Mfg | Powder spray process |
US4031200A (en) * | 1975-12-15 | 1977-06-21 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4029757A (en) * | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4489672A (en) * | 1981-01-05 | 1984-12-25 | Polaroid Corporation | Apparatus for coating semiconductive material |
US4457256A (en) * | 1981-01-05 | 1984-07-03 | Polaroid Corporation | Precharged web coating apparatus |
US5267555A (en) * | 1988-07-01 | 1993-12-07 | Philip Pajalich | Apparatus and method for ionizing medication containing mists |
US5103763A (en) * | 1989-12-08 | 1992-04-14 | International Business Machines Corporation | Apparatus for formation and electrostatic deposition of charged droplets |
GB2253164B (en) * | 1991-02-22 | 1994-10-05 | Hoechst Uk Ltd | Improvements in or relating to electrostatic coating of substrates of medicinal products |
GB9123953D0 (en) * | 1991-11-12 | 1992-01-02 | Minnesota Mining & Mfg | Inhalation device |
WO1994008599A1 (en) * | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
WO1996010459A2 (en) * | 1994-10-04 | 1996-04-11 | Imperial Chemical Industries Plc | Electrostatic spraying of particulate material |
US5669973A (en) * | 1995-06-06 | 1997-09-23 | David Sarnoff Research Center, Inc. | Apparatus for electrostatically depositing and retaining materials upon a substrate |
US5714007A (en) * | 1995-06-06 | 1998-02-03 | David Sarnoff Research Center, Inc. | Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate |
US5642727A (en) * | 1995-07-25 | 1997-07-01 | David Sarnoff Research Center, Inc. | Inhaler apparatus using a tribo-electric charging technique |
US5875776A (en) * | 1996-04-09 | 1999-03-02 | Vivorx Pharmaceuticals, Inc. | Dry powder inhaler |
US5871010A (en) | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
US5857456A (en) | 1996-06-10 | 1999-01-12 | Sarnoff Corporation | Inhaler apparatus with an electronic means for enhanced release of dry powders |
US5885351A (en) * | 1997-02-18 | 1999-03-23 | Pfs Thermoplastic Powder Coatings, Inc. | Tribocharge applicator device |
US6237590B1 (en) * | 1997-09-18 | 2001-05-29 | Delsys Pharmaceutical Corporation | Dry powder delivery system apparatus |
US6063194A (en) * | 1998-06-10 | 2000-05-16 | Delsys Pharmaceutical Corporation | Dry powder deposition apparatus |
US6146685A (en) * | 1998-11-05 | 2000-11-14 | Delsys Pharmaceutical Corporation | Method of deposition a dry powder and dispensing device |
-
1998
- 1998-11-05 US US09/187,092 patent/US6146685A/en not_active Expired - Fee Related
-
1999
- 1999-10-25 DE DE69913727T patent/DE69913727T2/de not_active Expired - Fee Related
- 1999-10-25 AU AU13228/00A patent/AU755755B2/en not_active Ceased
- 1999-10-25 EP EP99956676A patent/EP1126891B1/de not_active Expired - Lifetime
- 1999-10-25 JP JP2000580683A patent/JP2002529153A/ja active Pending
- 1999-10-25 HU HU0104759A patent/HUP0104759A3/hu unknown
- 1999-10-25 IL IL14293299A patent/IL142932A0/xx unknown
- 1999-10-25 AT AT99956676T patent/ATE256482T1/de not_active IP Right Cessation
- 1999-10-25 PT PT99956676T patent/PT1126891E/pt unknown
- 1999-10-25 CA CA002347978A patent/CA2347978A1/en not_active Abandoned
- 1999-10-25 WO PCT/US1999/025051 patent/WO2000027456A1/en not_active Application Discontinuation
- 1999-10-25 KR KR1020017005579A patent/KR20010075679A/ko not_active Application Discontinuation
- 1999-10-25 CN CN99815357A patent/CN1332647A/zh active Pending
- 1999-10-25 NZ NZ511414A patent/NZ511414A/en unknown
-
2000
- 2000-06-06 US US09/588,090 patent/US6397840B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2002529153A (ja) | 2002-09-10 |
AU755755B2 (en) | 2002-12-19 |
EP1126891A1 (de) | 2001-08-29 |
US6397840B1 (en) | 2002-06-04 |
AU1322800A (en) | 2000-05-29 |
HUP0104759A3 (en) | 2004-03-01 |
HUP0104759A2 (hu) | 2002-03-28 |
PT1126891E (pt) | 2004-03-31 |
CA2347978A1 (en) | 2000-05-18 |
EP1126891B1 (de) | 2003-12-17 |
IL142932A0 (en) | 2002-04-21 |
CN1332647A (zh) | 2002-01-23 |
DE69913727D1 (de) | 2004-01-29 |
ATE256482T1 (de) | 2004-01-15 |
WO2000027456A1 (en) | 2000-05-18 |
NZ511414A (en) | 2003-11-28 |
KR20010075679A (ko) | 2001-08-09 |
US6146685A (en) | 2000-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: SARNOFF CORP., PRINCETON, N.J., US |
|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |