ATE256482T1 - Verfahren zum auftragen von trockenpulver sowie verabreichungsvorrichtung - Google Patents

Verfahren zum auftragen von trockenpulver sowie verabreichungsvorrichtung

Info

Publication number
ATE256482T1
ATE256482T1 AT99956676T AT99956676T ATE256482T1 AT E256482 T1 ATE256482 T1 AT E256482T1 AT 99956676 T AT99956676 T AT 99956676T AT 99956676 T AT99956676 T AT 99956676T AT E256482 T1 ATE256482 T1 AT E256482T1
Authority
AT
Austria
Prior art keywords
particles
substrate
inhaler
medicament
dry powder
Prior art date
Application number
AT99956676T
Other languages
English (en)
Inventor
Suggy S Chrai
Joseph Thomas Mcginn
Bawa Singh
Original Assignee
Delsys Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delsys Pharmaceutical Corp filed Critical Delsys Pharmaceutical Corp
Application granted granted Critical
Publication of ATE256482T1 publication Critical patent/ATE256482T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
    • B05D1/04—Processes for applying liquids or other fluent materials performed by spraying involving the use of an electrostatic field
    • B05D1/06—Applying particulate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
AT99956676T 1998-11-05 1999-10-25 Verfahren zum auftragen von trockenpulver sowie verabreichungsvorrichtung ATE256482T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/187,092 US6146685A (en) 1998-11-05 1998-11-05 Method of deposition a dry powder and dispensing device
PCT/US1999/025051 WO2000027456A1 (en) 1998-11-05 1999-10-25 Method of depositing a dry powder and dispensing device

Publications (1)

Publication Number Publication Date
ATE256482T1 true ATE256482T1 (de) 2004-01-15

Family

ID=22687570

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99956676T ATE256482T1 (de) 1998-11-05 1999-10-25 Verfahren zum auftragen von trockenpulver sowie verabreichungsvorrichtung

Country Status (14)

Country Link
US (2) US6146685A (de)
EP (1) EP1126891B1 (de)
JP (1) JP2002529153A (de)
KR (1) KR20010075679A (de)
CN (1) CN1332647A (de)
AT (1) ATE256482T1 (de)
AU (1) AU755755B2 (de)
CA (1) CA2347978A1 (de)
DE (1) DE69913727T2 (de)
HU (1) HUP0104759A3 (de)
IL (1) IL142932A0 (de)
NZ (1) NZ511414A (de)
PT (1) PT1126891E (de)
WO (1) WO2000027456A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE512386C2 (sv) * 1998-07-30 2000-03-06 Microdrug Ag Förfarande och anordning för klassificering av elektrostatiskt laddat pulverformigt material
US6146685A (en) * 1998-11-05 2000-11-14 Delsys Pharmaceutical Corporation Method of deposition a dry powder and dispensing device
US6923979B2 (en) * 1999-04-27 2005-08-02 Microdose Technologies, Inc. Method for depositing particles onto a substrate using an alternating electric field
US6435175B1 (en) * 2000-08-29 2002-08-20 Sensormedics Corporation Pulmonary drug delivery device
EP1390699B1 (de) * 2001-04-20 2007-10-17 Glaxo Group Limited Messmethode für teilchenmaterial
US6844048B2 (en) * 2001-07-11 2005-01-18 Sarnoff Corporation Substrates for powder deposition containing conductive domains
US6686207B2 (en) 2001-10-12 2004-02-03 Massachusetts Institute Of Technology Manipulating micron scale items
SE525027C2 (sv) * 2002-04-12 2004-11-16 Microdrug Ag Anordning utgörande en pulverlufthyvel
WO2004110603A2 (en) * 2003-06-03 2004-12-23 Ferro Corporation Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions
EP1691783B1 (de) * 2003-12-03 2009-11-25 Boehringer Ingelheim International GmbH Vordosierter trockenpulverinhalator für feuchtigkeitsempfindliche medikamente
DK1799289T3 (da) * 2004-09-16 2012-05-29 Giampiero Cossi Engangs-enkeltdosis-inhalator til pulverformede lægemidler
GB0605723D0 (en) 2006-03-23 2006-05-03 3M Innovative Properties Co Powder filling processes
US7976872B2 (en) * 2006-07-24 2011-07-12 L. Perrigo Company Method for distributing a pharmaceutically active compound in an excipient
US7879392B2 (en) * 2007-10-15 2011-02-01 Kimberly-Clark Worldwide, Inc. Compositions with elongated particles having varying charges and aspect ratios
EP2340812A1 (de) 2009-12-18 2011-07-06 Ferring International Center S.A. Granulat für pharmazeutische Präparate sowie Verfahren und Vorrichtungen zu ihrer Herstellung
US9162245B1 (en) * 2012-03-29 2015-10-20 BTD Wood Powder Coating, Inc. Powder coating conveyor support
US10370183B2 (en) 2012-07-19 2019-08-06 Adamis Pharmaceuticals Corporation Powder feeding apparatus
JP5350530B1 (ja) * 2012-12-07 2013-11-27 ニップファーマ株式会社 薬剤吸入デバイス
EP2968800B1 (de) 2013-03-15 2017-12-20 Chris V. Ciancone Inhalator-abstandshalter und speichervorrichtung
EP3402558B1 (de) * 2016-01-11 2023-11-29 Syqe Medical Ltd. Persönliche verdampfungsvorrichtung
IT201600093878A1 (it) 2016-09-19 2018-03-19 Hollycon Italy Pte Ltd S R L Inalatore monodose a perdere per medicinali in polvere

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA452052A (en) * 1948-10-19 Minnesota Mining And Manufacturing Company Method of and apparatus for applying coating materials
FR2044908A5 (de) * 1969-05-23 1971-02-26 Tunzini Sames
US3687705A (en) * 1970-09-23 1972-08-29 Minnesota Mining & Mfg Powder spray process
US4029757A (en) * 1975-12-15 1977-06-14 Hoffmann-La Roche Inc. Manufacture of pharmaceutical unit dosage forms
US4031200A (en) * 1975-12-15 1977-06-21 Hoffmann-La Roche Inc. Manufacture of pharmaceutical unit dosage forms
US4489672A (en) * 1981-01-05 1984-12-25 Polaroid Corporation Apparatus for coating semiconductive material
US4457256A (en) * 1981-01-05 1984-07-03 Polaroid Corporation Precharged web coating apparatus
US5267555A (en) * 1988-07-01 1993-12-07 Philip Pajalich Apparatus and method for ionizing medication containing mists
US5103763A (en) * 1989-12-08 1992-04-14 International Business Machines Corporation Apparatus for formation and electrostatic deposition of charged droplets
GB2253164B (en) * 1991-02-22 1994-10-05 Hoechst Uk Ltd Improvements in or relating to electrostatic coating of substrates of medicinal products
GB9123953D0 (en) * 1991-11-12 1992-01-02 Minnesota Mining & Mfg Inhalation device
WO1994008599A1 (en) * 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery
PT776253E (pt) * 1994-10-04 2001-04-30 Procter & Gamble Pulverizacao electrostatica de material em particulas
US5714007A (en) * 1995-06-06 1998-02-03 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US5669973A (en) * 1995-06-06 1997-09-23 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing and retaining materials upon a substrate
US5642727A (en) * 1995-07-25 1997-07-01 David Sarnoff Research Center, Inc. Inhaler apparatus using a tribo-electric charging technique
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
US5857456A (en) 1996-06-10 1999-01-12 Sarnoff Corporation Inhaler apparatus with an electronic means for enhanced release of dry powders
US5871010A (en) 1996-06-10 1999-02-16 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
US5885351A (en) * 1997-02-18 1999-03-23 Pfs Thermoplastic Powder Coatings, Inc. Tribocharge applicator device
US6237590B1 (en) * 1997-09-18 2001-05-29 Delsys Pharmaceutical Corporation Dry powder delivery system apparatus
US6063194A (en) * 1998-06-10 2000-05-16 Delsys Pharmaceutical Corporation Dry powder deposition apparatus
US6146685A (en) * 1998-11-05 2000-11-14 Delsys Pharmaceutical Corporation Method of deposition a dry powder and dispensing device

Also Published As

Publication number Publication date
PT1126891E (pt) 2004-03-31
CA2347978A1 (en) 2000-05-18
KR20010075679A (ko) 2001-08-09
HUP0104759A2 (hu) 2002-03-28
EP1126891A1 (de) 2001-08-29
AU1322800A (en) 2000-05-29
WO2000027456A1 (en) 2000-05-18
DE69913727D1 (de) 2004-01-29
AU755755B2 (en) 2002-12-19
US6146685A (en) 2000-11-14
JP2002529153A (ja) 2002-09-10
EP1126891B1 (de) 2003-12-17
DE69913727T2 (de) 2004-10-07
CN1332647A (zh) 2002-01-23
IL142932A0 (en) 2002-04-21
NZ511414A (en) 2003-11-28
HUP0104759A3 (en) 2004-03-01
US6397840B1 (en) 2002-06-04

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