DE69910068D1 - 17beta-acyl-17alpha-propynyl-11beta-arylsteroide und ihre derivate mit agonistischen oder antagonistischen hormonalen aktivitäten - Google Patents

17beta-acyl-17alpha-propynyl-11beta-arylsteroide und ihre derivate mit agonistischen oder antagonistischen hormonalen aktivitäten

Info

Publication number
DE69910068D1
DE69910068D1 DE69910068T DE69910068T DE69910068D1 DE 69910068 D1 DE69910068 D1 DE 69910068D1 DE 69910068 T DE69910068 T DE 69910068T DE 69910068 T DE69910068 T DE 69910068T DE 69910068 D1 DE69910068 D1 DE 69910068D1
Authority
DE
Germany
Prior art keywords
17beta
acyl
propynyl
arylsteroids
11beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69910068T
Other languages
English (en)
Other versions
DE69910068T2 (de
Inventor
Edgar Cook
A Kepler
M O'reilly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RES TRIANGLE INST RES TRIANGLE
Research Triangle Institute
Original Assignee
RES TRIANGLE INST RES TRIANGLE
Research Triangle Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RES TRIANGLE INST RES TRIANGLE, Research Triangle Institute filed Critical RES TRIANGLE INST RES TRIANGLE
Application granted granted Critical
Publication of DE69910068D1 publication Critical patent/DE69910068D1/de
Publication of DE69910068T2 publication Critical patent/DE69910068T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69910068T 1998-12-04 1999-12-03 17beta-acyl-17alpha-propynyl-11beta-arylsteroide und ihre derivate mit agonistischen oder antagonistischen hormonalen aktivitäten Expired - Lifetime DE69910068T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US205395 1998-12-04
US09/205,395 US6172052B1 (en) 1998-12-04 1998-12-04 17β-acyl-17α-propynyl-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
PCT/US1999/028535 WO2000034306A1 (en) 1998-12-04 1999-12-03 17β-ACYL-17α-PROPYNYL-11β-ARYLSTEROIDS AND THEIR DERIVATIVES HAVING AGONIST OR ANTAGONIST HORMONAL PROPERTIES

Publications (2)

Publication Number Publication Date
DE69910068D1 true DE69910068D1 (de) 2003-09-04
DE69910068T2 DE69910068T2 (de) 2004-04-15

Family

ID=22762018

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69910068T Expired - Lifetime DE69910068T2 (de) 1998-12-04 1999-12-03 17beta-acyl-17alpha-propynyl-11beta-arylsteroide und ihre derivate mit agonistischen oder antagonistischen hormonalen aktivitäten

Country Status (14)

Country Link
US (1) US6172052B1 (de)
EP (1) EP1135403B1 (de)
CN (1) CN1348461A (de)
AT (1) ATE246201T1 (de)
AU (1) AU777048B2 (de)
CA (1) CA2358466C (de)
DE (1) DE69910068T2 (de)
DK (1) DK1135403T3 (de)
ES (1) ES2203233T3 (de)
NZ (1) NZ512697A (de)
PT (1) PT1135403E (de)
RU (1) RU2230071C2 (de)
SI (1) SI1135403T1 (de)
WO (1) WO2000034306A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
CA2668824A1 (en) 1996-05-01 1997-11-06 The Government Of The United States Of America, Represented By The Secre Tary Of The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
US6262042B1 (en) * 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
AU4584901A (en) * 2000-03-17 2001-10-15 Us Gov Health & Human Serv Structural modification of 19-norprogesterone i: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
TWI477276B (zh) 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
DE102009034362A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
JP5894143B2 (ja) * 2010-03-22 2016-03-23 リプロス セラピューティクス インコーポレイテッド 抗黄体ホルモンの無毒送達のための組成物および方法
US20130029953A1 (en) * 2011-07-28 2013-01-31 Klaus Nickisch Progesterone antagonists
US9096641B2 (en) * 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
EP2881638A1 (de) 2013-12-09 2015-06-10 HILTI Aktiengesellschaft Vorrichtung zur Durchführung von Rohren oder Kabeln durch eine Gebäudeföffnung
EP3088784A1 (de) 2015-04-27 2016-11-02 Hilti Aktiengesellschaft Brandschutzmanschette
EP3088783A1 (de) 2015-04-27 2016-11-02 Hilti Aktiengesellschaft Brandschutzmanschette
WO2023185673A1 (zh) * 2022-03-31 2023-10-05 成都赛璟生物医药科技有限公司 一种cdk8抑制剂及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047928A (en) * 1986-10-24 1991-09-10 Wiedemer John D Billing system for computer software
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
WO1991001958A2 (de) 1989-08-04 1991-02-21 Schering Aktiengesellschaft Berlin Und Bergkamen 11β-ARYL-GONA-4,9-DIEN-3-ONE
DE4000686A1 (de) * 1990-01-12 1991-07-18 Dornier Gmbh Lindauer Steg-ladensohle fuer eine greifer-webmaschine
FR2659233B1 (fr) 1990-03-06 1994-01-21 Roussel Uclaf Nouvelle utilisation de composes anti-progestomimetiques chez les animaux d'elevage.
US5407928A (en) 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
FR2757399B1 (fr) 1996-12-23 1999-12-17 Hoechst Marion Roussel Inc Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee
US6020328A (en) 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties

Also Published As

Publication number Publication date
DE69910068T2 (de) 2004-04-15
EP1135403A1 (de) 2001-09-26
NZ512697A (en) 2003-01-31
CA2358466C (en) 2008-04-15
EP1135403B1 (de) 2003-07-30
EP1135403A4 (de) 2002-03-27
AU777048B2 (en) 2004-09-30
CN1348461A (zh) 2002-05-08
RU2001118273A (ru) 2004-03-10
AU2036600A (en) 2000-06-26
US6172052B1 (en) 2001-01-09
DK1135403T3 (da) 2003-11-24
WO2000034306A1 (en) 2000-06-15
CA2358466A1 (en) 2000-06-15
ES2203233T3 (es) 2004-04-01
SI1135403T1 (en) 2004-02-29
RU2230071C2 (ru) 2004-06-10
PT1135403E (pt) 2003-12-31
ATE246201T1 (de) 2003-08-15

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