DE69909273D1 - Phosphat-vermittelte cyclisierung - Google Patents

Phosphat-vermittelte cyclisierung

Info

Publication number
DE69909273D1
DE69909273D1 DE69909273T DE69909273T DE69909273D1 DE 69909273 D1 DE69909273 D1 DE 69909273D1 DE 69909273 T DE69909273 T DE 69909273T DE 69909273 T DE69909273 T DE 69909273T DE 69909273 D1 DE69909273 D1 DE 69909273D1
Authority
DE
Germany
Prior art keywords
phosphate
mediated cyclization
preparation
cyclization
mediated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69909273T
Other languages
English (en)
Other versions
DE69909273T2 (de
Inventor
D Tillyer
M Tschaen
Zhiguo Song
Mangzu Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9810175.1A external-priority patent/GB9810175D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69909273D1 publication Critical patent/DE69909273D1/de
Publication of DE69909273T2 publication Critical patent/DE69909273T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69909273T 1998-04-09 1999-04-05 Phosphat-vermittelte cyclisierung Expired - Fee Related DE69909273T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8125098P 1998-04-09 1998-04-09
US81250P 1998-04-09
GB9810175 1998-05-13
GBGB9810175.1A GB9810175D0 (en) 1998-05-13 1998-05-13 Phosphate-medicated cyclization
PCT/US1999/007467 WO1999052851A1 (en) 1998-04-09 1999-04-05 Phosphate-mediated cyclization

Publications (2)

Publication Number Publication Date
DE69909273D1 true DE69909273D1 (de) 2003-08-07
DE69909273T2 DE69909273T2 (de) 2004-04-22

Family

ID=26313658

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69909273T Expired - Fee Related DE69909273T2 (de) 1998-04-09 1999-04-05 Phosphat-vermittelte cyclisierung

Country Status (7)

Country Link
EP (1) EP1070041B1 (de)
JP (1) JP2002511442A (de)
AT (1) ATE244214T1 (de)
AU (1) AU747645B2 (de)
CA (1) CA2327928A1 (de)
DE (1) DE69909273T2 (de)
WO (1) WO1999052851A1 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE213156T1 (de) * 1993-04-27 2002-02-15 Smithkline Beecham Corp Endothelin-rezeptor-antagonisten
US5389620A (en) * 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
CA2262676A1 (en) * 1996-08-09 1998-02-19 Merck & Co., Inc. Stereoselective deoxygenation reaction
US6031101A (en) * 1998-04-09 2000-02-29 Merck & Co., Inc. Oxidation process using tempo

Also Published As

Publication number Publication date
JP2002511442A (ja) 2002-04-16
CA2327928A1 (en) 1999-10-21
EP1070041B1 (de) 2003-07-02
EP1070041A1 (de) 2001-01-24
EP1070041A4 (de) 2001-05-16
DE69909273T2 (de) 2004-04-22
AU747645B2 (en) 2002-05-16
WO1999052851A1 (en) 1999-10-21
ATE244214T1 (de) 2003-07-15
AU3383299A (en) 1999-11-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee