DE69906554T2 - P38 inhibitoren - Google Patents
P38 inhibitoren Download PDFInfo
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- DE69906554T2 DE69906554T2 DE69906554T DE69906554T DE69906554T2 DE 69906554 T2 DE69906554 T2 DE 69906554T2 DE 69906554 T DE69906554 T DE 69906554T DE 69906554 T DE69906554 T DE 69906554T DE 69906554 T2 DE69906554 T2 DE 69906554T2
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10101398P | 1998-09-18 | 1998-09-18 | |
| US101013P | 1998-09-18 | ||
| PCT/US1999/021567 WO2000017204A1 (en) | 1998-09-18 | 1999-09-16 | INHIBITORS OF p38 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69906554D1 DE69906554D1 (de) | 2003-05-08 |
| DE69906554T2 true DE69906554T2 (de) | 2004-07-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69906554T Expired - Lifetime DE69906554T2 (de) | 1998-09-18 | 1999-09-16 | P38 inhibitoren |
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| Country | Link |
|---|---|
| US (2) | US6635644B2 (enExample) |
| EP (1) | EP1114051B1 (enExample) |
| JP (1) | JP2002526501A (enExample) |
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| MY (1) | MY117696A (enExample) |
| PT (1) | PT1114051E (enExample) |
| WO (1) | WO2000017204A1 (enExample) |
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| WO2002014281A1 (en) | 2000-08-11 | 2002-02-21 | Vertex Pharmaceuticals Incorporated | Pyridine derivatives as inhibitors of p38 |
| JP2005500284A (ja) | 2001-06-11 | 2005-01-06 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｐ３８のイソキノリンインヒビター |
| BR0306988A (pt) * | 2002-01-18 | 2004-11-23 | Pharmacia Corp | Piridazinonas substituìdas como inibidores de p38 |
| AU2003245989A1 (en) | 2002-07-09 | 2004-01-23 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
| AU2003262911A1 (en) | 2002-08-29 | 2004-03-19 | Scios Inc. | Methods of promoting osteogenesis |
| ES2401079T3 (es) | 2002-12-20 | 2013-04-16 | Amgen Inc. | Moduladores del asma y de la inflamación alérgica |
| AU2004247626B8 (en) | 2003-05-15 | 2011-05-19 | Arqule, Inc. | Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38 |
| WO2005007632A1 (en) * | 2003-07-18 | 2005-01-27 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| WO2005030091A2 (en) | 2003-09-25 | 2005-04-07 | Scios Inc. | Stents and intra-luminal prostheses containing map kinase inhibitors |
| JP4608888B2 (ja) * | 2004-01-23 | 2011-01-12 | 宇部興産株式会社 | ２−シアノ−２−（４−テトラヒドロピラニル）酢酸エステルの製法 |
| WO2006010082A1 (en) | 2004-07-08 | 2006-01-26 | Arqule, Inc. | 1,4-disubstituted naphtalenes as inhibitors of p38 map kinase |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| US8178672B2 (en) | 2004-10-19 | 2012-05-15 | Arqule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase |
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| US20060178388A1 (en) * | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
| US7759337B2 (en) * | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
| RU2379295C2 (ru) | 2005-07-21 | 2010-01-20 | Ф.Хоффманн-Ля Рош Аг | Производные пиридазинона в качестве агонистов рецептора тиреоидного гормона |
| US7482345B2 (en) | 2005-12-05 | 2009-01-27 | Meng-Hsin Chen | P38 kinase inhibiting agents |
| HUE031972T2 (en) | 2005-12-29 | 2017-08-28 | Celtaxsys Inc | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| US7745449B2 (en) * | 2006-04-21 | 2010-06-29 | Amgen Inc. | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use |
| CA2656507C (en) * | 2006-07-17 | 2012-03-20 | Amgen Inc. | Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors |
| ATE501124T1 (de) * | 2006-09-05 | 2011-03-15 | Amgen Inc | Phthalazin-, aza- und diazaphthalazinverbindungen und anwendungsverfahren |
| CA2665195C (en) * | 2006-10-11 | 2011-08-09 | Amgen Inc. | Imidazo- and triazolo-pyridine compounds and methods of use thereof |
| JP2010522155A (ja) * | 2007-03-20 | 2010-07-01 | カディラ ファーマシューティカルズ リミテッド | Ｐ３８阻害剤 |
| CA2685674C (en) * | 2007-05-07 | 2012-07-17 | Amgen Inc. | Pyrazolo-pyridinone compounds, process for their preparation, and their pharmaceutical use |
| US8022085B2 (en) | 2007-05-07 | 2011-09-20 | Amgen Inc. | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| US8314131B2 (en) * | 2007-09-21 | 2012-11-20 | Amgen Inc. | Triazole fused heteroaryl compounds and methods of use thereof |
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| WO2009117156A1 (en) * | 2008-03-21 | 2009-09-24 | Amgen Inc. | Pyrazolo-pyrazinone compounds and methods of use thereof |
| US8420649B2 (en) | 2008-08-29 | 2013-04-16 | Amgen Inc. | Pyrido[3,2-d]pyridazine-2(1H)-one compounds as p38 modulators and methods of use thereof |
| WO2010025201A1 (en) | 2008-08-29 | 2010-03-04 | Amgen Inc. | Pyridazino- pyridinone compounds for the treatment of protein kinase mediated diseases. |
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| US8772481B2 (en) | 2008-10-10 | 2014-07-08 | Amgen Inc. | Aza- and diaza-phthalazine compounds as P38 map kinase modulators and methods of use thereof |
| JP6093110B2 (ja) | 2008-12-17 | 2017-03-08 | ザ スクリプス リサーチ インスティテュート | 幹細胞の作製と維持 |
| GB0902648D0 (en) | 2009-02-17 | 2009-04-01 | Argenta Discovery Ltd | Pharmaceutical compounds and compositions |
| GB0908317D0 (en) * | 2009-05-14 | 2009-06-24 | Argenta Discovery Ltd | Pharmaceutical compounds and compositions |
| US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| WO2013162027A1 (ja) | 2012-04-27 | 2013-10-31 | 学校法人 慶應義塾 | 神経分化促進剤 |
| CA2905340C (en) | 2013-03-12 | 2022-05-31 | Celtaxsys, Inc. | Low dose oral formulations of acebilustat |
| BR112015022864A8 (pt) | 2013-03-14 | 2019-11-26 | Celtaxsys Inc | composto, composição farmacêutica e uso dos mesmos |
| BR112015022226A2 (pt) | 2013-03-14 | 2017-07-18 | Celtaxsys Inc | inibidores de leucotrieno a4 hidrolase |
| KR20150131211A (ko) | 2013-03-14 | 2015-11-24 | 켈탁시스, 인코퍼레이티드 | 류코트라이엔 a4 가수분해효소의 저해제 |
| CA3003433A1 (en) | 2015-10-27 | 2017-05-04 | Children's Hospital Medical Center | Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| AU2019242628A1 (en) | 2018-03-26 | 2020-09-24 | Clear Creek Bio, Inc. | Compositions and methods for inhibiting dihydroorotate dehydrogenase |
| JP7386815B2 (ja) | 2018-05-31 | 2023-11-27 | セルタクシー、エルエルシー | 呼吸器疾患患者の肺増悪を軽減する方法 |
| US12076315B2 (en) | 2020-03-20 | 2024-09-03 | Clear Creek Bio, Inc. | Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| WO2002014281A1 (en) * | 2000-08-11 | 2002-02-21 | Vertex Pharmaceuticals Incorporated | Pyridine derivatives as inhibitors of p38 |
-
1999
- 1999-09-15 AR ARP990104643A patent/AR023659A1/es unknown
- 1999-09-16 ES ES99948314T patent/ES2192864T3/es not_active Expired - Lifetime
- 1999-09-16 PT PT99948314T patent/PT1114051E/pt unknown
- 1999-09-16 EP EP99948314A patent/EP1114051B1/en not_active Expired - Lifetime
- 1999-09-16 JP JP2000574113A patent/JP2002526501A/ja active Pending
- 1999-09-16 WO PCT/US1999/021567 patent/WO2000017204A1/en not_active Ceased
- 1999-09-16 DK DK99948314T patent/DK1114051T3/da active
- 1999-09-16 AT AT99948314T patent/ATE236167T1/de not_active IP Right Cessation
- 1999-09-16 DE DE69906554T patent/DE69906554T2/de not_active Expired - Lifetime
- 1999-09-16 CA CA002339253A patent/CA2339253C/en not_active Expired - Fee Related
- 1999-09-16 AU AU61521/99A patent/AU761599B2/en not_active Ceased
- 1999-09-17 MY MYPI99004032A patent/MY117696A/en unknown
-
2001
- 2001-03-16 US US09/809,921 patent/US6635644B2/en not_active Expired - Fee Related
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- 2003-09-08 US US10/658,111 patent/US7169779B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20040142927A1 (en) | 2004-07-22 |
| DK1114051T3 (da) | 2003-07-14 |
| CA2339253C (en) | 2009-04-07 |
| PT1114051E (pt) | 2003-07-31 |
| US7169779B2 (en) | 2007-01-30 |
| US20020010170A1 (en) | 2002-01-24 |
| DE69906554D1 (de) | 2003-05-08 |
| WO2000017204A1 (en) | 2000-03-30 |
| AR023659A1 (es) | 2002-09-04 |
| EP1114051A1 (en) | 2001-07-11 |
| AU6152199A (en) | 2000-04-10 |
| JP2002526501A (ja) | 2002-08-20 |
| EP1114051B1 (en) | 2003-04-02 |
| ES2192864T3 (es) | 2003-10-16 |
| MY117696A (en) | 2004-07-31 |
| US6635644B2 (en) | 2003-10-21 |
| CA2339253A1 (en) | 2000-03-30 |
| ATE236167T1 (de) | 2003-04-15 |
| AU761599B2 (en) | 2003-06-05 |
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