DE69906307D1 - Übergangsmetallkomplexe als linkergruppe - Google Patents

Übergangsmetallkomplexe als linkergruppe

Info

Publication number
DE69906307D1
DE69906307D1 DE69906307T DE69906307T DE69906307D1 DE 69906307 D1 DE69906307 D1 DE 69906307D1 DE 69906307 T DE69906307 T DE 69906307T DE 69906307 T DE69906307 T DE 69906307T DE 69906307 D1 DE69906307 D1 DE 69906307D1
Authority
DE
Germany
Prior art keywords
transition metal
metal complexes
left group
synthesis
mps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69906307T
Other languages
English (en)
Other versions
DE69906307T2 (de
Inventor
Alex Christian Comely
Sue Elizabeth Gibson
Neil James Hales
Mark Andrew Peplow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE69906307D1 publication Critical patent/DE69906307D1/de
Application granted granted Critical
Publication of DE69906307T2 publication Critical patent/DE69906307T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B80/00Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00Other general methods
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F11/00Compounds containing elements of Groups 6 or 16 of the Periodic Table
    • C07F11/005Compounds containing elements of Groups 6 or 16 of the Periodic Table compounds without a metal-carbon linkage
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/13Tracers or tags

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DE69906307T 1998-07-31 1999-07-29 Übergangsmetallkomplexe als linkergruppe Expired - Lifetime DE69906307T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9816575.6A GB9816575D0 (en) 1998-07-31 1998-07-31 Novel compounds
GB9816575 1998-07-31
PCT/GB1999/002499 WO2000007966A1 (en) 1998-07-31 1999-07-29 Transition metal complexes as linkers

Publications (2)

Publication Number Publication Date
DE69906307D1 true DE69906307D1 (de) 2003-04-30
DE69906307T2 DE69906307T2 (de) 2004-02-12

Family

ID=10836413

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69906307T Expired - Lifetime DE69906307T2 (de) 1998-07-31 1999-07-29 Übergangsmetallkomplexe als linkergruppe

Country Status (8)

Country Link
US (1) US6821783B1 (de)
EP (1) EP1100759B1 (de)
JP (1) JP2002522403A (de)
AT (1) ATE235444T1 (de)
AU (1) AU5179599A (de)
DE (1) DE69906307T2 (de)
GB (1) GB9816575D0 (de)
WO (1) WO2000007966A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1175427B1 (de) 1999-03-05 2010-08-18 Massachusetts Institute Of Technology Linker zur synthese von oligosacchariden auf festträgern
KR101687771B1 (ko) * 2009-10-15 2017-01-02 한화케미칼 주식회사 탈수소화가능한 지지체에 전이금속을 도입한 지지체-전이금속하이드라이드 복합체의 개선된 제조방법 및 그의 중간체
ES2676174T3 (es) 2011-02-28 2018-07-17 Cadena Bio, Inc. Polímeros que contienen un grupo ácido y su uso como catalizador
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
US9238845B2 (en) 2012-08-24 2016-01-19 Midori Usa, Inc. Methods of producing sugars from biomass feedstocks
MA45328A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Compositions acide nucléique-polypeptide et utilisations de celles-ci
JP2020505330A (ja) 2017-01-06 2020-02-20 アビディティー バイオサイエンシーズ エルエルシー エクソンスキッピングを誘導する核酸ポリペプチド組成物および方法
TWI804499B (zh) 2017-06-23 2023-06-11 美商維洛斯生物公司 Ror1抗體免疫接合物
GB201711809D0 (en) 2017-07-21 2017-09-06 Governors Of The Univ Of Alberta Antisense oligonucleotide
MX2020003596A (es) 2017-10-04 2020-07-22 Avidity Biosciences Inc Composiciones de acido nucleico-polipeptido y usos de las mismos.
AU2018378812A1 (en) 2017-12-06 2020-07-09 Avidity Biosciences, Inc. Compositions and methods of treating muscle atrophy and myotonic dystrophy
SG11202106593UA (en) 2018-12-21 2021-07-29 Avidity Biosciences Inc Anti-transferrin receptor antibodies and uses thereof
CA3127113A1 (en) 2019-01-30 2020-08-06 Dongxu Sun Anti-gal3 antibodies and uses thereof
WO2020247782A1 (en) 2019-06-06 2020-12-10 Avidity Biosciences, Inc. Nucleic acid-polypeptide compositions and uses thereof
IL296387B1 (en) 2020-03-19 2024-04-01 Avidity Biosciences Inc Preparations and methods for the treatment of facial, back and arm muscle atrophy
WO2021195469A1 (en) 2020-03-27 2021-09-30 Avidity Biosciences, Inc. Compositions and methods of treating muscle dystrophy
EP4370555A1 (de) 2021-07-13 2024-05-22 TrueBinding, Inc. Verfahren zur verhinderung von proteinaggregation
KR20240055874A (ko) 2021-09-16 2024-04-29 어비디티 바이오사이언시스 인크. 안면견갑상완 근이영양증을 치료하는 조성물 및 방법
WO2023122347A2 (en) 2021-12-23 2023-06-29 Mirecule, Inc. Compositions for delivery of polynucleotides
WO2024026474A1 (en) 2022-07-29 2024-02-01 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
WO2024107765A2 (en) 2022-11-14 2024-05-23 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057465A (en) * 1997-05-22 2000-05-02 Glaxo Wellcome Inc. Arene-transition metal linkers for solid phase synthesis

Also Published As

Publication number Publication date
JP2002522403A (ja) 2002-07-23
EP1100759B1 (de) 2003-03-26
US6821783B1 (en) 2004-11-23
ATE235444T1 (de) 2003-04-15
GB9816575D0 (en) 1998-09-30
AU5179599A (en) 2000-02-28
DE69906307T2 (de) 2004-02-12
WO2000007966A1 (en) 2000-02-17
EP1100759A1 (de) 2001-05-23

Similar Documents

Publication Publication Date Title
DE69906307D1 (de) Übergangsmetallkomplexe als linkergruppe
DE60213276D1 (de) 1,2,4-thiadiazoliumverbindungen als melanocortinrezeptor-modulatoren
DE60012571D1 (de) Metallkomplexe als hyrdosilylierungskatalysatoren
DE50215029D1 (de) Verbesserte strukturiert-funktionale bindematrices für biomoleküle
WO2002070992A3 (en) Ambulatory navigation system
ATE332906T1 (de) Ruthenium-komplexe als (pre)katalysatoren für metathesereaktionen
ECSP034600A (es) Compuestos de lactama
GB0124627D0 (en) Novel compounds
DE69008371T2 (de) Zusammensetzungen für strapazierfähige, organische Siliciumverbindungen enthaltende Überzüge.
DK1404377T3 (da) Forbedrede chelatorkonjugater
ATE207614T1 (de) Fluoreszenzkorrelationsspektroskopiemodul für ein mikroskop
ID24876A (id) Senyawa-senyawa indola tersubstitusi-2,3 sebagai penghambat cox-2
DK1141297T3 (da) Interleukin-17-beslægtede mammale cytokiner. Polynucleotider, der koder for dem. Anvendelser
ATE471331T1 (de) Neue übergangsmetall-komplexe und deren einsatz in übergangsmetall-katalysierten reaktionen
MXPA02007951A (es) Complejos de vanadio-imido-fosforanoiminato para la polimerizacion de olefinas.
DK1262778T3 (da) Fremgangsmåde til differentieret mærkning ved anvendelse af platinkomplekser
AU2001282297A1 (en) Catalysts
ATE234837T1 (de) 3-bicycloindole als liganden des 5-ht 1d rezeptors
DE69902731D1 (de) Aluminiumlegierung mit hoher Zähigkeit, für Druckgussteile
DE69831085D1 (de) 2,6-dichlor-4-pyridinmethanolderivate als chemikalien für die landwirtschaft
DK1233011T4 (da) Fremgangsmåde til syntese af carbonhydrider i nærværelse af en katalysator, der indeholder et metal fra gruppe VIII på en siliciumdioxid-aluminiumoxid-bærer
ITMI20021743A1 (it) Processo di produzione di fenilalcani utilizzando un catalizzatore contenente almeno un eteropoliacido.
DE29823223U1 (de) Bausatz für Läden, Studios u.a.
ES2177148T3 (es) Difluor-azufre imadazolatos.
WO2003016888A3 (de) Elektrode als probenträger für txrf-messungen