DE69906307D1 - Übergangsmetallkomplexe als linkergruppe - Google Patents
Übergangsmetallkomplexe als linkergruppeInfo
- Publication number
- DE69906307D1 DE69906307D1 DE69906307T DE69906307T DE69906307D1 DE 69906307 D1 DE69906307 D1 DE 69906307D1 DE 69906307 T DE69906307 T DE 69906307T DE 69906307 T DE69906307 T DE 69906307T DE 69906307 D1 DE69906307 D1 DE 69906307D1
- Authority
- DE
- Germany
- Prior art keywords
- transition metal
- metal complexes
- left group
- synthesis
- mps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229910052723 transition metal Inorganic materials 0.000 title abstract 2
- 150000003624 transition metals Chemical class 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
- C07F11/005—Compounds containing elements of Groups 6 or 16 of the Periodic Table compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/13—Tracers or tags
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Structural Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9816575 | 1998-07-31 | ||
| GBGB9816575.6A GB9816575D0 (en) | 1998-07-31 | 1998-07-31 | Novel compounds |
| PCT/GB1999/002499 WO2000007966A1 (en) | 1998-07-31 | 1999-07-29 | Transition metal complexes as linkers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69906307D1 true DE69906307D1 (de) | 2003-04-30 |
| DE69906307T2 DE69906307T2 (de) | 2004-02-12 |
Family
ID=10836413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69906307T Expired - Lifetime DE69906307T2 (de) | 1998-07-31 | 1999-07-29 | Übergangsmetallkomplexe als linkergruppe |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6821783B1 (de) |
| EP (1) | EP1100759B1 (de) |
| JP (1) | JP2002522403A (de) |
| AT (1) | ATE235444T1 (de) |
| AU (1) | AU5179599A (de) |
| DE (1) | DE69906307T2 (de) |
| GB (1) | GB9816575D0 (de) |
| WO (1) | WO2000007966A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6579725B1 (en) | 1999-03-05 | 2003-06-17 | Massachusetts Institute Of Technology | Linkers for synthesis of oligosaccharides on solid supports |
| KR101687771B1 (ko) * | 2009-10-15 | 2017-01-02 | 한화케미칼 주식회사 | 탈수소화가능한 지지체에 전이금속을 도입한 지지체-전이금속하이드라이드 복합체의 개선된 제조방법 및 그의 중간체 |
| SG192958A1 (en) | 2011-02-28 | 2013-09-30 | Midori Renewables Inc | Polymeric acid catalysts and uses thereof |
| GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| US9238845B2 (en) | 2012-08-24 | 2016-01-19 | Midori Usa, Inc. | Methods of producing sugars from biomass feedstocks |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| CN110381980A (zh) | 2017-01-06 | 2019-10-25 | 艾维迪提生物科学有限责任公司 | 核酸-多肽组合物以及诱导外显子跳读的方法 |
| TWI804499B (zh) | 2017-06-23 | 2023-06-11 | 美商維洛斯生物公司 | Ror1抗體免疫接合物 |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| EP3691657A4 (de) | 2017-10-04 | 2021-07-21 | Avidity Biosciences, Inc. | Nukleinsäurepolypeptidzusammensetzungen und verwendungen davon |
| MX2020005860A (es) | 2017-12-06 | 2020-09-09 | Avidity Biosciences Inc | Composiciones y metodos de tratamiento de atrofia muscular y distrofia miotonica. |
| SG11202106593UA (en) | 2018-12-21 | 2021-07-29 | Avidity Biosciences Inc | Anti-transferrin receptor antibodies and uses thereof |
| AU2020214796A1 (en) | 2019-01-30 | 2021-07-29 | Truebinding, Inc. | Anti-Gal3 antibodies and uses thereof |
| WO2020247782A1 (en) | 2019-06-06 | 2020-12-10 | Avidity Biosciences, Inc. | Nucleic acid-polypeptide compositions and uses thereof |
| US12006499B2 (en) | 2019-06-06 | 2024-06-11 | Avidity Biosciences, Inc. | Una amidites and uses thereof |
| JP2023537798A (ja) | 2020-03-19 | 2023-09-06 | アビディティー バイオサイエンシーズ，インク． | 顔面肩甲上腕型筋ジストロフィーを処置するための組成物および方法 |
| US11446387B2 (en) | 2020-03-27 | 2022-09-20 | Avidity Biosciences, Inc. | Compositions and methods of treating muscle dystrophy |
| EP4370555A1 (de) | 2021-07-13 | 2024-05-22 | TrueBinding, Inc. | Verfahren zur verhinderung von proteinaggregation |
| KR20240055874A (ko) | 2021-09-16 | 2024-04-29 | 어비디티 바이오사이언시스 인크. | 안면견갑상완 근이영양증을 치료하는 조성물 및 방법 |
| CN118660722A (zh) | 2021-12-23 | 2024-09-17 | 米雷楚来有限公司 | 用于递送多核苷酸的组合物 |
| US12071621B2 (en) | 2022-04-05 | 2024-08-27 | Avidity Biosciences, Inc. | Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping |
| WO2024026474A1 (en) | 2022-07-29 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle |
| WO2024107765A2 (en) | 2022-11-14 | 2024-05-23 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057465A (en) * | 1997-05-22 | 2000-05-02 | Glaxo Wellcome Inc. | Arene-transition metal linkers for solid phase synthesis |
-
1998
- 1998-07-31 GB GBGB9816575.6A patent/GB9816575D0/en not_active Ceased
-
1999
- 1999-07-29 AU AU51795/99A patent/AU5179599A/en not_active Abandoned
- 1999-07-29 US US09/744,908 patent/US6821783B1/en not_active Expired - Fee Related
- 1999-07-29 DE DE69906307T patent/DE69906307T2/de not_active Expired - Lifetime
- 1999-07-29 AT AT99936819T patent/ATE235444T1/de not_active IP Right Cessation
- 1999-07-29 WO PCT/GB1999/002499 patent/WO2000007966A1/en active IP Right Grant
- 1999-07-29 JP JP2000563601A patent/JP2002522403A/ja active Pending
- 1999-07-29 EP EP99936819A patent/EP1100759B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE235444T1 (de) | 2003-04-15 |
| US6821783B1 (en) | 2004-11-23 |
| DE69906307T2 (de) | 2004-02-12 |
| EP1100759B1 (de) | 2003-03-26 |
| JP2002522403A (ja) | 2002-07-23 |
| EP1100759A1 (de) | 2001-05-23 |
| AU5179599A (en) | 2000-02-28 |
| GB9816575D0 (en) | 1998-09-30 |
| WO2000007966A1 (en) | 2000-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69906307D1 (de) | Übergangsmetallkomplexe als linkergruppe | |
| DE60213276D1 (de) | 1,2,4-thiadiazoliumverbindungen als melanocortinrezeptor-modulatoren | |
| CR6393A (es) | Moduladores de ccr5 | |
| ATE272066T1 (de) | Metallkomplexe als hyrdosilylierungskatalysatoren | |
| DE50215029D1 (de) | Verbesserte strukturiert-funktionale bindematrices für biomoleküle | |
| WO2002070992A3 (en) | Ambulatory navigation system | |
| ATE332906T1 (de) | Ruthenium-komplexe als (pre)katalysatoren für metathesereaktionen | |
| ECSP034600A (es) | Compuestos de lactama | |
| ATE344254T1 (de) | 1,2,4-thiadiazolverbindungen als melanocortinrezeptor-modulatoren | |
| CY1111492T1 (el) | ΜΙΑ ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ 10,11-ΔΙΥΔΡΟ-10-ΟΞΟ-5Η-ΔΙΒΕΝΖΟ[b,f]ΑΖΕΠΙΝΟ-5-ΚΑΡΒΟΞΑΜΙΔΙΟΥ | |
| DK1404377T3 (da) | Forbedrede chelatorkonjugater | |
| ATE207614T1 (de) | Fluoreszenzkorrelationsspektroskopiemodul für ein mikroskop | |
| ATE471331T1 (de) | Neue übergangsmetall-komplexe und deren einsatz in übergangsmetall-katalysierten reaktionen | |
| ATE227262T1 (de) | Perfluor-n-alkansulfonsäure-derivate | |
| DK1262778T3 (da) | Fremgangsmåde til differentieret mærkning ved anvendelse af platinkomplekser | |
| GB0020613D0 (en) | Catalysts | |
| TR199802532A3 (tr) | Köse veya kol çikmasi gibi, oluklarin bir yerden ötekine geçirilmelerine yarar aksesuar. | |
| ATE234837T1 (de) | 3-bicycloindole als liganden des 5-ht 1d rezeptors | |
| BR0311590A (pt) | Agonistas de brs-3 não-peptìdicos | |
| DE69902731D1 (de) | Aluminiumlegierung mit hoher Zähigkeit, für Druckgussteile | |
| DE60009795D1 (en) | Synthese von 3-amino-2-chlor-4-methylpyridin aus malonsäuresäurenitril und aceton | |
| DK1233011T4 (da) | Fremgangsmåde til syntese af carbonhydrider i nærværelse af en katalysator, der indeholder et metal fra gruppe VIII på en siliciumdioxid-aluminiumoxid-bærer | |
| ITMI20021743A1 (it) | Processo di produzione di fenilalcani utilizzando un catalizzatore contenente almeno un eteropoliacido. | |
| NO20011961L (no) | PRV-1-genet og anvendelsen av dette | |
| BR0104127B1 (pt) | barra de reação múltipla. |