DE69841374D1 - 3-o-sulfamatsteroidderivate als hemmer von estronsulfatase - Google Patents

3-o-sulfamatsteroidderivate als hemmer von estronsulfatase

Info

Publication number
DE69841374D1
DE69841374D1 DE69841374T DE69841374T DE69841374D1 DE 69841374 D1 DE69841374 D1 DE 69841374D1 DE 69841374 T DE69841374 T DE 69841374T DE 69841374 T DE69841374 T DE 69841374T DE 69841374 D1 DE69841374 D1 DE 69841374D1
Authority
DE
Germany
Prior art keywords
estronsulfatase
inhibitors
steroid derivatives
sulfamate
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69841374T
Other languages
German (de)
English (en)
Inventor
Michael John Reed
Barry Victor Potter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterix Ltd
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Application granted granted Critical
Publication of DE69841374D1 publication Critical patent/DE69841374D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69841374T 1997-12-04 1998-12-03 3-o-sulfamatsteroidderivate als hemmer von estronsulfatase Expired - Lifetime DE69841374D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9725749A GB2331987B (en) 1997-12-04 1997-12-04 Polycyclic sulphamate inhibitors of oestrone sulphatase
PCT/GB1998/003620 WO1999027936A1 (en) 1997-12-04 1998-12-03 Steroid 3-o-sulphamate derivatives as inhibitors of oestrone sulphatase

Publications (1)

Publication Number Publication Date
DE69841374D1 true DE69841374D1 (de) 2010-01-21

Family

ID=10823155

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69841374T Expired - Lifetime DE69841374D1 (de) 1997-12-04 1998-12-03 3-o-sulfamatsteroidderivate als hemmer von estronsulfatase

Country Status (9)

Country Link
US (1) US6670353B2 (https=)
EP (1) EP1051178B1 (https=)
JP (1) JP2001524525A (https=)
AT (1) ATE451107T1 (https=)
AU (1) AU1345899A (https=)
DE (1) DE69841374D1 (https=)
ES (1) ES2337427T3 (https=)
GB (1) GB2331987B (https=)
WO (1) WO1999027936A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
GB2331987B (en) 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
AU783910B2 (en) 1999-04-30 2005-12-22 Sterix Limited Use of estrone derivatives as antitumour agents
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
AU2190601A (en) * 1999-12-13 2001-06-25 Sterix Limited Halogenated sulphamate-, phosphonate-, thiophosphonate-, sulphonate- and sulphonamide- compounds as inhibitors of steroid sulphatase
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
US6953785B2 (en) 2000-04-24 2005-10-11 Kyowa Hakko Kogyo Co., Ltd. Estra-1,3,5(10)-triene derivatives
GB0025788D0 (en) * 2000-10-20 2000-12-06 Sterix Ltd Use
GB0306717D0 (en) * 2003-03-24 2003-04-30 Sterix Ltd Compound
GB0306718D0 (en) 2003-03-24 2003-04-30 Sterix Ltd Compound
ES2339450T3 (es) * 2003-03-24 2010-05-20 Sterix Limited Derivados de estrogenos como inhibidores de esteroide sulfatasa.
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
EP2149371A1 (en) * 2008-07-28 2010-02-03 PregLem S.A. Use of steroid sulfatase inhibitors for the treatment of preterm labor

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1398026A (en) * 1972-11-10 1975-06-18 Jenapharm Veb Steroid esters
DE3046719C2 (de) * 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
US5273993A (en) * 1989-06-12 1993-12-28 A. H. Robins Company, Incorporated Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9118465D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5556847A (en) * 1994-10-27 1996-09-17 Duquesne University Of The Holy Ghost Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5567831A (en) * 1995-08-16 1996-10-22 Duguesne University Of The Holy Ghost Non-steroidal sulfatase inhibitor compounds and their method of use
JP2000506161A (ja) * 1996-03-05 2000-05-23 インペリアル カレッジ オブ サイエンス テクノロジー アンド メディシン スルファメート基を有する化合物
US5763492A (en) 1996-10-01 1998-06-09 Duguesne University Of The Holy Ghost Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors
GB2331987B (en) 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same

Also Published As

Publication number Publication date
AU1345899A (en) 1999-06-16
EP1051178B1 (en) 2009-12-09
GB2331987A9 (en) 1900-01-01
WO1999027936A1 (en) 1999-06-10
ES2337427T3 (es) 2010-04-23
EP1051178A1 (en) 2000-11-15
US20020198396A1 (en) 2002-12-26
US6670353B2 (en) 2003-12-30
GB2331987B (en) 2002-11-27
ATE451107T1 (de) 2009-12-15
GB9725749D0 (en) 1998-02-04
GB2331987A (en) 1999-06-09
JP2001524525A (ja) 2001-12-04

Similar Documents

Publication Publication Date Title
DE69841374D1 (de) 3-o-sulfamatsteroidderivate als hemmer von estronsulfatase
ES2085876T3 (es) Derivado de bifenilmetano, su utilizacion y composiciones farmacologicas que contienen el mismo.
IL125752A0 (en) Non-steroidal polycyclic ring sulphamate derivatives their preparation and their use as oestrone sulphatase inhibitors
ES2195970T3 (es) L-ribavirina y usos de la misma.
DE69516866D1 (de) Stereochemische wortmanninderivate
ATE238790T1 (de) Verwendung von pramipexole als neuroschutzmittel
ES2114487B1 (es) Mezcla estabilizante sinergistica.
BR9807638A (pt) Compostos antiinflamatórios
NO940635D0 (no) Steroidsulfataseinhibitorer
TR200002224T2 (tr) Matris-bozucu metalloproteinasları inhibe eden sülfonilamino türevleri.
GB2331988B (en) Polycyclic sulphamate inhibitors or oestrone sulphatase
DE69739051D1 (de) Östrogen-Sulfamate als Sulfataseinhibitoren
ES2138247T3 (es) Composicion y uso.
BR9711586A (pt) Compostos e uso dos mesmo
BG104117A (en) Universally applicable blood plasma
NO20002676L (no) Androgene steroidforbindelser og en fremgangsmÕte for fremstilling og anvendelse av samme
TR200001288T2 (tr) Östrojen yoksunluğu sendromunun tedavisinde faydalı 2-arilbenzo (b) tiyofenler.
BR9509741A (pt) Composto e uso de composto
TR199701298T1 (xx) Tetralinler.
ES2059779T3 (es) Compuestos anti-androgenos.
ES2149448T3 (es) Agentes terapeuticos y analiticos.
ATE145213T1 (de) Kardioaktive steroide
DK0640092T3 (da) Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer
DE69020520D1 (de) 2,19-Methylenoxy- und 2,19-methylenthiogebrückte Steroide und ihre Verwendung als Inhibitoren von Aromatase und 19-Hydroxylase.
ATE124952T1 (de) Haloethyl substituierte enzymhemmende steroiden.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition