DE69839263T2 - Hämoglobin-Mutanten mit verringertem Stickstoff(mon)oxid-Entfernungsvermögen - Google Patents
Hämoglobin-Mutanten mit verringertem Stickstoff(mon)oxid-Entfernungsvermögen Download PDFInfo
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- DE69839263T2 DE69839263T2 DE69839263T DE69839263T DE69839263T2 DE 69839263 T2 DE69839263 T2 DE 69839263T2 DE 69839263 T DE69839263 T DE 69839263T DE 69839263 T DE69839263 T DE 69839263T DE 69839263 T2 DE69839263 T2 DE 69839263T2
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Classifications
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
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| US5798697P | 1997-09-05 | 1997-09-05 | |
| US57986P | 1997-09-05 | ||
| PCT/US1998/008861 WO1998050430A2 (en) | 1997-05-02 | 1998-05-01 | Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging |
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| DE69839263D1 DE69839263D1 (de) | 2008-04-30 |
| DE69839263T2 true DE69839263T2 (de) | 2009-04-30 |
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| EP (1) | EP0979279B1 (https=) |
| JP (2) | JP4512673B2 (https=) |
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| CA (1) | CA2299049C (https=) |
| DE (1) | DE69839263T2 (https=) |
| WO (1) | WO1998050430A2 (https=) |
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| EP2292657A1 (en) | 1999-11-12 | 2011-03-09 | Baxter Biotech Technology S.A.R.L. | Reduced side-effect hemoglobin compositions |
| JP4563679B2 (ja) * | 2001-12-06 | 2010-10-13 | デューク ユニバーシティ | 形成外科における組織弁壊死の予防 |
| DE10224750A1 (de) | 2002-06-04 | 2003-12-24 | Fresenius Medical Care De Gmbh | Vorrichtung zur Behandlung einer medizinischen Flüssigkeit |
| US20070166792A1 (en) * | 2004-09-15 | 2007-07-19 | Olson John S | Increasing hemoglobin and other heme protein production in bacteria by co-expression of heme transport genes |
| US7642233B2 (en) * | 2004-09-15 | 2010-01-05 | William Marsh Rice University | Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein |
| WO2006031993A2 (en) * | 2004-09-15 | 2006-03-23 | William Marsh Rice University | Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein |
| US7935074B2 (en) | 2005-02-28 | 2011-05-03 | Fresenius Medical Care Holdings, Inc. | Cassette system for peritoneal dialysis machine |
| US20060195064A1 (en) * | 2005-02-28 | 2006-08-31 | Fresenius Medical Care Holdings, Inc. | Portable apparatus for peritoneal dialysis therapy |
| US8197231B2 (en) | 2005-07-13 | 2012-06-12 | Purity Solutions Llc | Diaphragm pump and related methods |
| WO2007112570A1 (en) * | 2006-04-03 | 2007-10-11 | Pharmatherm Chemicals Inc. | Thermal extraction method and product |
| DK2463297T3 (en) | 2006-05-22 | 2017-01-09 | Univ California | Oxygen Compositions and Methods |
| US7905990B2 (en) | 2007-11-20 | 2011-03-15 | Ensyn Renewables, Inc. | Rapid thermal conversion of biomass |
| US8192401B2 (en) | 2009-03-20 | 2012-06-05 | Fresenius Medical Care Holdings, Inc. | Medical fluid pump systems and related components and methods |
| CN102497895A (zh) | 2009-07-15 | 2012-06-13 | 弗雷塞尼斯医疗保健控股公司 | 医疗流体盒及相关系统和方法 |
| US8720913B2 (en) * | 2009-08-11 | 2014-05-13 | Fresenius Medical Care Holdings, Inc. | Portable peritoneal dialysis carts and related systems |
| US8499702B2 (en) | 2010-07-15 | 2013-08-06 | Ensyn Renewables, Inc. | Char-handling processes in a pyrolysis system |
| DE102010053973A1 (de) | 2010-12-09 | 2012-06-14 | Fresenius Medical Care Deutschland Gmbh | Medizinisches Gerät mit einer Heizung |
| EP2654825B1 (en) | 2010-12-20 | 2017-08-02 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US9624915B2 (en) | 2011-03-09 | 2017-04-18 | Fresenius Medical Care Holdings, Inc. | Medical fluid delivery sets and related systems and methods |
| CN103648540B (zh) | 2011-04-21 | 2016-06-01 | 弗雷塞尼斯医疗保健控股公司 | 医疗流体泵送系统及相关装置和方法 |
| US9186449B2 (en) | 2011-11-01 | 2015-11-17 | Fresenius Medical Care Holdings, Inc. | Dialysis machine support assemblies and related systems and methods |
| CN104159591A (zh) | 2011-11-07 | 2014-11-19 | 通用医疗公司 | 红细胞的处理 |
| US9109177B2 (en) | 2011-12-12 | 2015-08-18 | Ensyn Renewables, Inc. | Systems and methods for renewable fuel |
| US9610392B2 (en) | 2012-06-08 | 2017-04-04 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| US9500188B2 (en) | 2012-06-11 | 2016-11-22 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassettes and related systems and methods |
| FR3002146B1 (fr) * | 2013-02-15 | 2016-03-04 | Hemarina | Utilisation d'hemoglobine d'annelides pour traiter les cancers |
| US9561323B2 (en) | 2013-03-14 | 2017-02-07 | Fresenius Medical Care Holdings, Inc. | Medical fluid cassette leak detection methods and devices |
| US10117985B2 (en) | 2013-08-21 | 2018-11-06 | Fresenius Medical Care Holdings, Inc. | Determining a volume of medical fluid pumped into or out of a medical fluid cassette |
| US10752672B1 (en) * | 2019-02-01 | 2020-08-25 | Cheer Global Limited | Recombinant hemoglobins and methods of preparation and use thereof |
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| US5449759A (en) | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
| US6022849A (en) * | 1987-05-16 | 2000-02-08 | Baxter Biotech Technology Saarl | Mutant recombinant hemoglobins containing heme pocket mutations |
| GB8711614D0 (en) * | 1987-05-16 | 1987-06-24 | Medical Res Council | Proteins |
| US5599907A (en) | 1989-05-10 | 1997-02-04 | Somatogen, Inc. | Production and use of multimeric hemoglobins |
| US5545727A (en) | 1989-05-10 | 1996-08-13 | Somatogen, Inc. | DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin |
| US5844090A (en) | 1994-05-09 | 1998-12-01 | Somatogen, Inc. | Modified hemoglobin-like compounds |
| US5173426A (en) * | 1989-10-06 | 1992-12-22 | Yale University | DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin |
| WO1995007932A1 (en) | 1993-09-14 | 1995-03-23 | Medical Research Council | Improvements in or relating to haemoglobin |
| US5665869A (en) | 1993-11-15 | 1997-09-09 | Somatogen, Inc. | Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin |
| US5843888A (en) * | 1995-05-01 | 1998-12-01 | Carnegie Mellon University | Low oxygen affinity mutant hemoglobin |
| AU6489996A (en) * | 1995-07-14 | 1997-02-18 | Somatogen, Inc. | Methods for increasing protein expression |
| WO1997015591A1 (en) * | 1995-10-23 | 1997-05-01 | Rice University | Hemoglobin mutants that reduce heme loss |
| WO1997023631A2 (en) | 1995-12-22 | 1997-07-03 | Somatogen, Inc. | Globins containing binding domains |
-
1998
- 1998-05-01 AU AU72758/98A patent/AU750295B2/en not_active Ceased
- 1998-05-01 JP JP54825298A patent/JP4512673B2/ja not_active Expired - Fee Related
- 1998-05-01 CA CA002299049A patent/CA2299049C/en not_active Expired - Fee Related
- 1998-05-01 US US09/403,208 patent/US6455676B1/en not_active Expired - Fee Related
- 1998-05-01 EP EP98920113A patent/EP0979279B1/en not_active Expired - Lifetime
- 1998-05-01 DE DE69839263T patent/DE69839263T2/de not_active Expired - Lifetime
- 1998-05-01 WO PCT/US1998/008861 patent/WO1998050430A2/en not_active Ceased
-
2002
- 2002-03-27 US US10/107,871 patent/US7049406B2/en not_active Expired - Fee Related
-
2008
- 2008-03-31 JP JP2008094054A patent/JP4399634B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6455676B1 (en) | 2002-09-24 |
| JP2002507115A (ja) | 2002-03-05 |
| US20030017537A1 (en) | 2003-01-23 |
| WO1998050430A2 (en) | 1998-11-12 |
| EP0979279B1 (en) | 2008-03-19 |
| AU750295B2 (en) | 2002-07-11 |
| CA2299049C (en) | 2008-07-15 |
| JP4512673B2 (ja) | 2010-07-28 |
| WO1998050430A3 (en) | 1999-04-01 |
| JP2008194051A (ja) | 2008-08-28 |
| DE69839263D1 (de) | 2008-04-30 |
| AU7275898A (en) | 1998-11-27 |
| JP4399634B2 (ja) | 2010-01-20 |
| EP0979279A2 (en) | 2000-02-16 |
| US7049406B2 (en) | 2006-05-23 |
| CA2299049A1 (en) | 1998-11-12 |
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