DE69829966D1 - A MONOETHER OF PROBUCOL AND METHODS FOR INHIBITING THE VCAM-1 EXPRESSION - Google Patents

A MONOETHER OF PROBUCOL AND METHODS FOR INHIBITING THE VCAM-1 EXPRESSION

Info

Publication number
DE69829966D1
DE69829966D1 DE69829966T DE69829966T DE69829966D1 DE 69829966 D1 DE69829966 D1 DE 69829966D1 DE 69829966 T DE69829966 T DE 69829966T DE 69829966 T DE69829966 T DE 69829966T DE 69829966 D1 DE69829966 D1 DE 69829966D1
Authority
DE
Germany
Prior art keywords
vcam
expression
methods
monoether
probucol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69829966T
Other languages
German (de)
Other versions
DE69829966T2 (en
Inventor
K Somers
K Hoong
Q Meng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Atherogenics Inc
Original Assignee
Atherogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atherogenics Inc filed Critical Atherogenics Inc
Application granted granted Critical
Publication of DE69829966D1 publication Critical patent/DE69829966D1/en
Publication of DE69829966T2 publication Critical patent/DE69829966T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/21—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with the sulfur atom of the thio group bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.
DE69829966T 1997-05-14 1998-05-14 A MONOETHER OF PROBUCOL AND METHODS FOR INHIBITING THE VCAM-1 EXPRESSION Expired - Fee Related DE69829966T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4702097P 1997-05-14 1997-05-14
US47020P 1997-05-14
PCT/US1998/009781 WO1998051662A2 (en) 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of vcam-1

Publications (2)

Publication Number Publication Date
DE69829966D1 true DE69829966D1 (en) 2005-06-02
DE69829966T2 DE69829966T2 (en) 2006-02-09

Family

ID=21946634

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69837295T Expired - Lifetime DE69837295T2 (en) 1997-05-14 1998-05-14 Succinic acid ester of probucol to inhibit the expression of VCAM-1
DE69829966T Expired - Fee Related DE69829966T2 (en) 1997-05-14 1998-05-14 A MONOETHER OF PROBUCOL AND METHODS FOR INHIBITING THE VCAM-1 EXPRESSION
DE69831566T Expired - Fee Related DE69831566T2 (en) 1997-05-14 1998-05-14 PROBUCOL MONOESTER FOR THE TREATMENT OF CIRCULAR AND INFLAMMATORY DISEASES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69837295T Expired - Lifetime DE69837295T2 (en) 1997-05-14 1998-05-14 Succinic acid ester of probucol to inhibit the expression of VCAM-1

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69831566T Expired - Fee Related DE69831566T2 (en) 1997-05-14 1998-05-14 PROBUCOL MONOESTER FOR THE TREATMENT OF CIRCULAR AND INFLAMMATORY DISEASES

Country Status (26)

Country Link
US (9) US6121319A (en)
EP (2) EP0981343B1 (en)
JP (4) JP3930056B2 (en)
KR (5) KR100953990B1 (en)
CN (7) CN101284808A (en)
AT (3) ATE294158T1 (en)
AU (2) AU750041B2 (en)
BR (2) BR9809793A (en)
CA (3) CA2292388C (en)
CY (1) CY1107645T1 (en)
CZ (4) CZ301985B6 (en)
DE (3) DE69837295T2 (en)
DK (2) DK0981343T3 (en)
EA (5) EA012847B1 (en)
ES (3) ES2248901T3 (en)
HK (2) HK1024629A1 (en)
HU (2) HUP0004592A3 (en)
ID (2) ID23877A (en)
IL (7) IL164568A0 (en)
NO (3) NO316221B1 (en)
NZ (2) NZ528906A (en)
PL (2) PL207885B1 (en)
PT (1) PT1464639E (en)
SK (4) SK286392B6 (en)
TR (2) TR199902803T2 (en)
WO (2) WO1998051662A2 (en)

Families Citing this family (133)

* Cited by examiner, ā€  Cited by third party
Publication number Priority date Publication date Assignee Title
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
ATE294158T1 (en) * 1997-05-14 2005-05-15 Atherogenics Inc A MONOETHER OF PROBUCOL AND METHODS OF INHIBITING VCAM-1 EXPRESSION
US6852878B2 (en) * 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
EP1019034A2 (en) 1997-07-01 2000-07-19 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
AU9454098A (en) * 1997-09-24 1999-04-12 Nova Molecular, Inc. Methods for increasing apoe levels for the treatment of neurodegenerative disease
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
CO5170498A1 (en) * 1999-05-28 2002-06-27 Abbott Lab BIARIL SULFONAMIDS ARE USEFUL AS CELL PROLIFERATION INHIBITORS
US7361684B2 (en) * 1999-06-28 2008-04-22 Massachusetts Institute Of Technology Screening of compounds for treatment of atherosclerosis and heart attack
US6403637B1 (en) * 1999-08-09 2002-06-11 Univ Saint Louis Methods of modulating matrix metalloproteinase activity and uses thereof
WO2001070757A2 (en) * 2000-03-21 2001-09-27 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of vcam-1
US6881860B2 (en) 2000-04-11 2005-04-19 Atherogenics, Inc. Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality
US6323359B1 (en) * 2000-05-02 2001-11-27 Salsbury Chemicals, Inc. Process for preparing probucol derivatives
US6670355B2 (en) 2000-06-16 2003-12-30 Wyeth Method of treating cardiovascular disease
CN1447804A (en) * 2000-06-20 2003-10-08 é˜æē‰¹ē½—吉尼克ę–Æ公åø 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
AUPQ872800A0 (en) * 2000-07-12 2000-08-03 Heart Research Institute, The Compositions and methods for treating cardiovascular disorders
AU2002248910A1 (en) 2000-11-17 2002-05-27 Idenix (Cayman) Limited Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrmidines
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
EP1911462A3 (en) 2001-01-26 2011-11-30 Schering Corporation Compositions comprising a sterol absorption inhibitor
CA2444429A1 (en) * 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
CA2464717A1 (en) * 2001-10-25 2003-05-15 Atherogenics, Inc. Compounds and methods for treating transplant rejection
CN100482645C (en) * 2001-11-09 2009-04-29 é˜æē‰¹ē½—吉尼克ę–Æ公åø Methods of reversing and preventing cardiovascular pathologies
BR0215240A (en) 2001-12-19 2004-10-26 Atherogenics Inc Calcium derivatives and their use in treating diseases
US6939554B2 (en) * 2002-02-05 2005-09-06 Michigan Biotechnology Institute Antimicrobial polymer
ITMI20020597A1 (en) * 2002-03-22 2003-09-22 Nicox Sa DERIVATIVES OF THE PROBUCLE
US7208467B2 (en) 2002-06-07 2007-04-24 Monty Krieger Lipid-altering compositions for the treatment of infertility
US6960683B2 (en) * 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
AU2003266165A1 (en) * 2002-09-13 2004-04-30 Hossein Dovlatabadi Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
CA2501685A1 (en) * 2002-10-08 2004-04-22 Massachusetts Institute Of Technology Compounds for modulation of cholesterol transport
AU2002953533A0 (en) * 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
EP1594824A4 (en) * 2003-01-13 2007-04-04 Atherogenics Inc Process of preparing esters and ethers of probucol and derivatives thereof
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
DE602004016123D1 (en) 2003-03-07 2008-10-09 Schering Corp SUBSTITUTED AZETIDINONE DERIVATIVES, THEIR PHARMACEUTICAL FORMULATIONS AND THEIR USE FOR THE TREATMENT OF HYPERCHOLESTEROLMIA
ATE418551T1 (en) 2003-03-07 2009-01-15 Schering Corp SUBSTITUTED AZETIDINONE DERIVATIVES, THEIR PHARMACEUTICAL FORMULATIONS AND THEIR USE IN THE TREATMENT OF HYPERCHOLESTEROLEMIA
KR100857759B1 (en) * 2003-03-17 2008-09-09 ė‹ˆė½„ ė‹¤ė°”ģ½” ģ‚°źµ ź°€ė¶€ģ‹œķ‚¤ź°€ģ“ģƒ¤ Pharmaceutical compositions of cetp inhibitors
US7173129B2 (en) 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005025492A2 (en) * 2003-07-07 2005-03-24 Emory University Novel compositions, pharmaceutical compositions, and methods for the treatment and prevention of heart disease
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050074443A1 (en) * 2003-10-03 2005-04-07 Treadwell Benjamin V. Methods of attenuating autoimmune disease and compositions useful therefor
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
EP1677804A1 (en) * 2003-10-17 2006-07-12 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
EP1918000A2 (en) 2003-11-05 2008-05-07 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
CA2546495C (en) * 2003-11-14 2012-10-09 Temple University - Of The Commonwealth System Of Higher Education Alpha, beta-unsaturated sulfoxides for treating proliferative disorders
WO2005051900A1 (en) * 2003-11-25 2005-06-09 Novo Nordisk A/S Novel compounds for the treatment of obesity
US20060025481A1 (en) * 2004-02-09 2006-02-02 Strange Matthew L Process for preparation of probucol derivatives and polymorphic forms thereof
US7294736B2 (en) * 2004-04-09 2007-11-13 Cambrex Charles City, Inc. Process for preparation of probucol derivatives
US7271274B2 (en) 2004-04-20 2007-09-18 Ahterogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
WO2005102323A2 (en) 2004-04-20 2005-11-03 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US7183285B2 (en) * 2004-04-29 2007-02-27 Pharmix Corp. Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20050272770A1 (en) * 2004-04-29 2005-12-08 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US7199126B2 (en) * 2004-04-29 2007-04-03 Pharmix Corporation Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20050282883A1 (en) * 2004-04-29 2005-12-22 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20060063828A1 (en) * 2004-06-28 2006-03-23 Weingarten M D 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
CA2571589A1 (en) * 2004-07-01 2006-01-19 Atherogenics, Inc. Compounds and methods for treating diabetic vascular diseases
EP1807070A1 (en) * 2004-09-29 2007-07-18 Schering Corporation Combinations of substituted azetidinones and cb1 antagonists
US20060111436A1 (en) * 2004-11-23 2006-05-25 John Griffin Compositions and treatments for modulating kinase and/or HMG-CoA reductase
AU2005311930B9 (en) 2004-12-03 2009-09-10 Merck Sharp & Dohme Corp. Substituted piperazines as CB1 antagonists
WO2006063408A1 (en) * 2004-12-17 2006-06-22 Stocker Ronald O Compositions and methods for treating cardiovascular disorders
US7345191B2 (en) * 2005-02-26 2008-03-18 Cambrex Charles City, Inc. Process for preparation of probucol derivatives
EP1874725A4 (en) 2005-04-21 2011-04-06 Atherogenics Inc Process for the separation of probucol derivatives
US20070015779A1 (en) * 2005-04-29 2007-01-18 John Griffin Compositions and treatments for inhibiting kinase and/or hmg-coa reductase
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US7767710B2 (en) 2005-05-25 2010-08-03 Calosyn Pharma, Inc. Method for treating osteoarthritis
US20060269579A1 (en) * 2005-05-25 2006-11-30 Musculoskeletal Research Llc Compositions for treating osteoarthritis
KR20080097426A (en) 2006-01-18 2008-11-05 ģ‰ė§ ģ½”ķ¬ė ˆģ“ģ…˜ Cannabinoid receptor modulators
WO2007142581A1 (en) * 2006-06-07 2007-12-13 Astrazeneca Ab Combination product for the treatment or prevention of dyslipidaemia
AU2008230861A1 (en) 2007-03-26 2008-10-02 Salutria Pharmaceuticals, Llc Methods and compositions of derivatives of probucol for the treatment of diabetes
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes
WO2008130616A2 (en) * 2007-04-19 2008-10-30 Schering Corporation Diaryl morpholines as cb1 modulators
WO2008130718A1 (en) 2007-04-23 2008-10-30 Atherogenics, Inc. Sulfonamide containing compounds for treatment of inflammatory disorders
JP2010531354A (en) * 2007-06-26 2010-09-24 ć‚¢ć‚¹ćƒˆćƒ©ć‚¼ćƒć‚« ć‚¢ć‚Æćƒćƒœćƒ©ć‚° Method for isolating a probucol derivative monosubstituted with a carboxy group
CN101790521A (en) * 2007-06-28 2010-07-28 英ē‰¹ē»“ē‰¹å›½é™…č‚”ä»½ęœ‰é™å…¬åø Substituted-piperazinyl as the CB1 antagonist
CA2692268A1 (en) * 2007-06-28 2009-01-08 Intervet International B.V. Substituted piperazines as cb1 antagonists
WO2009042854A1 (en) * 2007-09-26 2009-04-02 Musculoskeletal Research Llc Ion-channel regulator compositions and methods of using same
US9173997B2 (en) 2007-10-02 2015-11-03 Medimop Medical Projects Ltd. External drug pump
US9656019B2 (en) 2007-10-02 2017-05-23 Medimop Medical Projects Ltd. Apparatuses for securing components of a drug delivery system during transport and methods of using same
US10420880B2 (en) 2007-10-02 2019-09-24 West Pharma. Services IL, Ltd. Key for securing components of a drug delivery system during assembly and/or transport and methods of using same
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
US7967795B1 (en) 2010-01-19 2011-06-28 Lamodel Ltd. Cartridge interface assembly with driving plunger
JP2011500727A (en) 2007-10-22 2011-01-06 ć‚·ć‚§ćƒ¼ćƒŖćƒ³ć‚° ć‚³ćƒ¼ćƒćƒ¬ć‚¤ć‚·ćƒ§ćƒ³ Bicyclic heterocyclic derivatives and their use as modulators of GPR119 activity
CN103251631A (en) * 2008-05-13 2013-08-21 ę ¹ę¢…čæŖå”ę²»ē–—å…¬åø Salicylate conjugates useful for treating metabolic disorders
AU2009249237A1 (en) 2008-05-19 2009-11-26 Schering Corporation Bicyclic heterocycle derivatives and use thereof as GPR119 modulators
AU2009270971A1 (en) 2008-07-16 2010-01-21 Schering Corporation Bicyclic Heterocycle Derivatives and use thereof as GPR119 modulators
US9393369B2 (en) 2008-09-15 2016-07-19 Medimop Medical Projects Ltd. Stabilized pen injector
US20100145305A1 (en) * 2008-11-10 2010-06-10 Ruth Alon Low volume accurate injector
US20110243940A1 (en) 2008-12-16 2011-10-06 Schering Corporation Bicyclic pyranone derivatives and methods of use thereof
US20110245209A1 (en) 2008-12-16 2011-10-06 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
US8722882B2 (en) 2008-12-23 2014-05-13 Merck Sharp & Dohme Corp. Pyrimidine derivatives as GPCR modulators for use in the treatment of obesity and diabetes
CA2747809A1 (en) 2008-12-23 2010-07-01 Joel M. Harris Bicyclic heterocycle derivatives and methods of use thereof
WO2010075273A1 (en) 2008-12-23 2010-07-01 Schering Corporation Bicyclic heterocycle derivatives and methods of use thereof
US8152779B2 (en) * 2008-12-30 2012-04-10 Medimop Medical Projects Ltd. Needle assembly for drug pump
BRPI1013878A2 (en) * 2009-03-16 2016-04-05 Genmedica Therapeutics Sl method for treating metabolic disorders, and, compound
WO2010106083A1 (en) * 2009-03-16 2010-09-23 Genmedica Therapeutics Sl Combination therapies for treating metabolic disorders
CA3146333A1 (en) 2009-03-18 2010-09-23 Resverlogix Corp. Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents
AR076024A1 (en) 2009-04-03 2011-05-11 Schering Corp DERIVATIVES OF BRIDGED BICYCLIC HETEROCICLES AND METHODS OF USE OF THE SAME
WO2010114957A1 (en) 2009-04-03 2010-10-07 Schering Corporation Bicyclic piperidine and piperazine derivatives as gpcr modulators for the treatment of obesity, diabetes and other metabolic disorders
PT2437606T (en) 2009-05-18 2016-09-22 Telomerase Activation Sciences Inc Compositions and methods for increasing telomerase activity
US8157769B2 (en) 2009-09-15 2012-04-17 Medimop Medical Projects Ltd. Cartridge insertion assembly for drug delivery system
US10071198B2 (en) 2012-11-02 2018-09-11 West Pharma. Servicees IL, Ltd. Adhesive structure for medical device
US10071196B2 (en) 2012-05-15 2018-09-11 West Pharma. Services IL, Ltd. Method for selectively powering a battery-operated drug-delivery device and device therefor
CA2778684A1 (en) 2009-10-29 2011-05-05 Schering Corporation Bridged bicyclic piperidine derivatives and methods of use thereof
WO2011062889A1 (en) 2009-11-23 2011-05-26 Schering Corporation Pyrimidine ether derivatives and methods of use thereof
EP2504010A4 (en) 2009-11-23 2013-04-17 Merck Sharp & Dohme Fused bicyclic pyrimidine derivatives and methods of use thereof
US9301929B2 (en) 2009-11-24 2016-04-05 Merck Sharp & Dohme Corp. Substituted biaryl derivatives and methods of use thereof
US8348898B2 (en) 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
EP2569031B1 (en) 2010-05-10 2017-10-11 Medimop Medical Projects Ltd. Low volume accurate injector
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
USD702834S1 (en) 2011-03-22 2014-04-15 Medimop Medical Projects Ltd. Cartridge for use in injection device
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
KR20160023638A (en) 2013-02-28 2016-03-03 ķ”„ė ˆģ§€ė˜ķŠø ģ•¤ė“œ ķŽ ė”œģš°ģ¦ˆ ģ˜¤ėøŒ ķ•˜ė°”ė“œ ģ¹¼ė¦¬ģ§€ Methods and compositions for mobilizing stem cells
US9011164B2 (en) 2013-04-30 2015-04-21 Medimop Medical Projects Ltd. Clip contact for easy installation of printed circuit board PCB
US10293120B2 (en) 2015-04-10 2019-05-21 West Pharma. Services IL, Ltd. Redundant injection device status indication
US10149943B2 (en) 2015-05-29 2018-12-11 West Pharma. Services IL, Ltd. Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly
EP3302652B1 (en) 2015-06-04 2023-09-06 Medimop Medical Projects Ltd. Cartridge insertion for drug delivery device
US9987432B2 (en) 2015-09-22 2018-06-05 West Pharma. Services IL, Ltd. Rotation resistant friction adapter for plunger driver of drug delivery device
US10086145B2 (en) 2015-09-22 2018-10-02 West Pharma Services Il, Ltd. Rotation resistant friction adapter for plunger driver of drug delivery device
US10576207B2 (en) 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
CN108430536B (en) 2015-10-09 2022-04-08 č„æ医čÆęœåŠ”ä»„č‰²åˆ—åˆ†å…¬åø Method of filling a custom syringe
EP3405229A1 (en) 2016-01-21 2018-11-28 West Pharma. Services Il, Ltd. Needle insertion and retraction mechanism
JP6885960B2 (en) 2016-01-21 2021-06-16 ć‚¦ć‚§ć‚¹ćƒˆ ćƒ•ć‚”ćƒ¼ćƒž ć‚µćƒ¼ćƒ“ć‚·ćƒ¼ć‚ŗ ć‚¤ć‚¹ćƒ©ć‚Ø惫 ćƒŖ惟惆惃惉 Drug delivery device with visual indicators
CN109219456B (en) 2016-01-21 2020-05-15 č„æ医čÆęœåŠ”ä»„č‰²åˆ—ęœ‰é™å…¬åø Force containment in autoinjectors
US11389597B2 (en) 2016-03-16 2022-07-19 West Pharma. Services IL, Ltd. Staged telescopic screw assembly having different visual indicators
US10376647B2 (en) 2016-03-18 2019-08-13 West Pharma. Services IL, Ltd. Anti-rotation mechanism for telescopic screw assembly
WO2017210448A1 (en) 2016-06-02 2017-12-07 Medimop Medical Projects Ltd. Three position needle retraction
US9650332B1 (en) * 2016-06-16 2017-05-16 Yong Xu Prodrug of probucol and method for preparing the same
JP7059251B2 (en) 2016-08-01 2022-04-25 ć‚¦ć‚§ć‚¹ćƒˆ ćƒ•ć‚”ćƒ¼ćƒž ć‚µćƒ¼ćƒ“ć‚·ćƒ¼ć‚ŗ ć‚¤ć‚¹ćƒ©ć‚Ø惫 ćƒŖ惟惆惃惉 A spring that prevents the door from closing halfway
CN109562229B (en) 2016-08-01 2021-07-13 č„æ医čÆęœåŠ”ä»„č‰²åˆ—ęœ‰é™å…¬åø Anti-rotation medicine barrel pin
CN106905208B (en) * 2017-02-27 2018-09-07 ę±Ÿč„æē‘žé›…čÆäøšęœ‰é™å…¬åø Probucol prodrug and preparation method thereof and pharmaceutical composition
JP6921997B2 (en) 2017-05-30 2021-08-18 ć‚¦ć‚§ć‚¹ćƒˆ ćƒ•ć‚”ćƒ¼ćƒž ć‚µćƒ¼ćƒ“ć‚·ćƒ¼ć‚ŗ ć‚¤ć‚¹ćƒ©ć‚Ø惫 ćƒŖ惟惆惃惉 Modular drive train for wearable syringes
JP7402799B2 (en) 2017-12-22 2023-12-21 ć‚¦ć‚§ć‚¹ćƒˆ ćƒ•ć‚”ćƒ¼ćƒž ć‚µćƒ¼ćƒ“ć‚·ćƒ¼ć‚ŗ ć‚¤ć‚¹ćƒ©ć‚Ø惫 ćƒŖ惟惆惃惉 Syringes available with different cartridge sizes
CN108299263B (en) 2018-01-30 2020-12-01 北äŗ¬å¾·é»˜é«˜ē§‘医čÆꊀęœÆęœ‰é™å…¬åø Probucol derivative and preparation method and application thereof

Family Cites Families (94)

* Cited by examiner, ā€  Cited by third party
Publication number Priority date Publication date Assignee Title
US3179701A (en) * 1962-05-14 1965-04-20 Shell Oil Co (3, 5-dialkyl-4-hydroxyphenyl) (3, 5-dialkyl-4-hydroxybenzyl) sulfides
US4115590A (en) * 1964-02-26 1978-09-19 Ethyl Corporation Binuclear phenols for reducing plasma lipid levels
GB1136539A (en) * 1966-12-13 1968-12-11 Uniroyal Inc Phenolic sulphides
GB1199871A (en) * 1967-05-11 1970-07-22 Consolidation Coal Co Improvements in or relating to Sulfur-Containing Bisphenols
US3485843A (en) * 1967-05-11 1969-12-23 Dow Chemical Co Piperazine adducts of ketone mercaptoles
GB1148550A (en) * 1967-12-02 1969-04-16 Uniroyal Inc Substituted benzylphenyl sulfides and their use as antioxidants
US3479407A (en) * 1968-11-06 1969-11-18 Consolidation Coal Co Sulfurization of 2,6-di-tert-butylphenol
US3576883A (en) * 1969-06-30 1971-04-27 Consolidation Coal Co Alkylidenedithiobisphenols
DE2104524C3 (en) 1970-09-16 1980-08-07 Veb Kombinat Umformtechnik Herbert Warnke Erfurt, Ddr 5000 Erfurt Hydraulic overload protection
FR2130975A5 (en) * 1971-03-29 1972-11-10 Aries Robert Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics
FR2133024A5 (en) * 1971-04-06 1972-11-24 Aries Robert Bis-(4-nicotinoyloxyphenylthio) propanes - with hypocholesterolaemic and hypolipaemic activity
FR2134810A5 (en) * 1971-04-21 1972-12-08 Aries Robert Bis-(3-alkyl-5-t-alkyl-4-(thiazole-5-carboxy)phenylthio) alcanes - - with hypocholesterolaemic and hypolipaemic activity
FR2140769A5 (en) * 1971-06-07 1973-01-19 Aries Robert Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents
FR2140771A5 (en) * 1971-06-07 1973-01-19 Aries Robert Tetralinyl phenoxy alkanoic esters - of bis hydroxyphenylthio alkanes, hypolipemics etc
FR2168137A1 (en) * 1972-01-17 1973-08-31 Dynachim Sarl Bis 4-hydroxyphenylthioalkane esters - with hypocholesterolaemic and hypolipaemic activities
JPS4975552A (en) * 1972-11-20 1974-07-20
US3952064A (en) * 1973-03-12 1976-04-20 Crown Zellerbach Corporation Process for producing mercaptophenols
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
JPS52125170A (en) * 1976-04-12 1977-10-20 Yoshitomi Pharmaceut Ind Ltd Pyridine derivatives
US4968514A (en) * 1984-12-11 1990-11-06 Forbes Polytech, Inc. Beer bottle with fully reacted thermoplastic polyurethane crown capliner
EP0190682B1 (en) * 1985-02-04 1990-09-12 G.D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
US4679520A (en) 1985-06-10 1987-07-14 Harken Olaf T Mainsail reefing and furling device and method
DE3530256A1 (en) 1985-08-23 1987-02-26 Merrell Dow Pharma USE OF PROBUCOL IN THE TREATMENT OF HEART ARRYTHMY
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase
DE3625279A1 (en) 1986-07-25 1988-02-04 Merrell Dow Pharma USE OF PROBUCOL FOR THE PREVENTION AND TREATMENT OF HEART DISEASES
ES2039489T3 (en) * 1987-03-17 1993-10-01 Merrell Dow Pharmaceuticals Inc. THE USE OF ALKYLIDENDITIO-BIS- (SUBSTITUTED) -PHENOLS SUBSTITUTED COMPOUND.
US4975467A (en) 1987-03-17 1990-12-04 Merrell Dow Pharmaceuticals Inc. Method of inhibiting interleukin-1 release and alleviating interleukin-1 mediated conditions
US4752616A (en) * 1987-06-29 1988-06-21 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use
US5066822A (en) 1987-11-13 1991-11-19 Riker Laboratories, Inc Di-t-butylphenols substituted by an alkoxy or benzyloxy group or a benzylthio group
US4968710A (en) 1987-11-13 1990-11-06 Riker Laboratories, Inc. Substituted di-t-butylphenols and anti-allergic use thereof
NZ226621A (en) * 1987-11-13 1991-12-23 Riker Laboratories Inc Di-tert butyl phenols substituted by alkoxy, benzyloxy, or benzylthio groups; pharmaceutical compositions containing them
CH675422A5 (en) 1988-03-31 1990-09-28 Symphar Sa
JP2754039B2 (en) * 1988-06-24 1998-05-20 唩野ē¾©č£½č–¬ę Ŗ式会ē¤¾ Di-tert-butylhydroxyphenylthio derivative
JP2627003B2 (en) * 1989-01-25 1997-07-02 唩野ē¾©č£½č–¬ę Ŗ式会ē¤¾ G-tert-butylhydroxyphenylthio derivative
US5527945A (en) 1989-02-10 1996-06-18 Basf Aktiengesellschaft Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom
JP3065636B2 (en) * 1989-06-29 2000-07-17 唩野ē¾©č£½č–¬ę Ŗ式会ē¤¾ [Di-tert-butyl (hydroxy) phenylthio] substituted hydroxamic acid derivatives
CA2017956A1 (en) * 1989-07-06 1991-01-06 Werner Bollag Use of retinoids
DE3929913A1 (en) 1989-09-08 1991-04-04 Hoechst Ag 4-HYDROXYTETRAHYDROPYRAN-2-ONE AND THE CORRESPONDING DIHYDROXYCARBONSAEUREDERIVATES, SALTS AND ESTERS, PROCESS FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT, PHARMACEUTICAL PREPARATES AND PREPARED PRODUCTS
US5115250A (en) * 1990-01-12 1992-05-19 Hewlett-Packard Company Wiper for ink-jet printhead
US5061734A (en) 1990-05-09 1991-10-29 Merrell Dow Pharmaceuticals Inc. Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis
US5112870A (en) 1990-05-09 1992-05-12 Merrell Dow Pharmaceuticals Inc. Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis
US5298497A (en) * 1990-05-15 1994-03-29 E. R. Squibb & Sons, Inc. Method for preventing onset of hypertension employing a cholesterol lowering drug
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
US5085777A (en) * 1990-08-31 1992-02-04 E. I. Du Pont De Nemours And Company Reverse osmosis membranes of polyamideurethane
FR2666583B1 (en) * 1990-09-06 1994-09-09 Adir NOVEL DERIVATIVES OF SPIRO [4.5] DECANE, THEIR PREPARATION PROCESS AND THEIR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
RU2024509C1 (en) * 1991-05-07 1994-12-15 Š’сŠµŃ€Š¾ŃŃŠøŠ¹ŃŠŗŠøŠ¹ Š½Š°ŃƒŃ‡Š½Ń‹Š¹ цŠµŠ½Ń‚Ń€ ŠæŠ¾ Š±ŠµŠ·Š¾ŠæŠ°ŃŠ½Š¾ŃŃ‚Šø Š±ŠøŠ¾Š»Š¾Š³ŠøчŠµŃŠŗŠø Š°ŠŗтŠøŠ²Š½Ń‹Ń… Š²ŠµŃ‰ŠµŃŃ‚Š² Derivatives of 9-aminoacridine or their salts with organic or inorganic acids showing psychotropic, antiamnestic and lipid-regulating activity
GB9115951D0 (en) 1991-07-24 1991-09-11 Pfizer Ltd Indoles
HU216191B (en) 1992-02-05 1999-05-28 Boehringer Ingelheim Kg Process for preparing novel amidine derivs. pharmaceutical compns. containing them
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
US5310949A (en) 1992-09-02 1994-05-10 Merck & Co., Inc. Cholesterol lowering compounds
GB9220571D0 (en) 1992-09-30 1992-11-11 Ici Plc Quinazoline derivatives
US5380747A (en) * 1992-10-30 1995-01-10 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5807884A (en) * 1992-10-30 1998-09-15 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5821260A (en) * 1992-10-30 1998-10-13 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5662934A (en) * 1993-01-05 1997-09-02 Najarian; Thomas Compositions and methods for lowering cholesterol while maintaining antioxidant levels
US5585235A (en) 1993-04-13 1996-12-17 Diagnescent Technologies, Inc. Fluorescent assay and method that corrects for spectral interference
FR2704224B1 (en) * 1993-04-20 1995-08-25 Adir New acids and substituted isobutyric phenoxy esters.
JPH06312978A (en) * 1993-04-30 1994-11-08 Japan Tobacco Inc New phthalimide derivative having inhibiting activity against phospholipase a2
US5411741A (en) 1993-07-29 1995-05-02 Zaias; Nardo Method and composition for skin depigmentation
GB9320113D0 (en) 1993-09-29 1993-11-17 Zeneca Ltd Tricyclic derivatives
AU681731B2 (en) * 1993-12-10 1997-09-04 Aventis Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5426196A (en) 1993-12-22 1995-06-20 Glaxo Inc. Synthesis of diaryl methanes
JPH07328425A (en) * 1994-06-03 1995-12-19 Toshiba Corp Plasma chemical reaction device
CA2153553A1 (en) 1994-07-13 1996-01-14 Hidekazu Suzuki Stable lipid emulsion
US5635514A (en) * 1994-10-25 1997-06-03 G. D. Searle & Company Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as 5-lipoxgenase inhibitors
US5792787A (en) * 1995-06-07 1998-08-11 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
JPH0959258A (en) * 1995-08-11 1997-03-04 Ono Pharmaceut Co Ltd Guanidyl derivative
FR2738817B1 (en) * 1995-09-14 1997-10-17 Adir NOVEL SUBSTITUTED ALKANOIC 2,2-DIMETHYL-OMEGA-PHENOXY ACIDS AND ESTERS, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1997015546A1 (en) * 1995-10-26 1997-05-01 Nippon Shinyaku Co., Ltd. Carboxylic acid derivatives and pharmaceutical compositions
WO1997026258A1 (en) 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
CA2258822A1 (en) 1996-06-20 1997-12-24 Sean Kerwin Compounds and methods for providing pharmacologically active preparations and uses thereof
CA2271054C (en) * 1996-11-20 2005-12-13 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
AU5959398A (en) 1997-01-09 1998-08-03 Localmed, Inc. Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels
GB9705502D0 (en) 1997-03-17 1997-05-07 Univ Wales Swansea The Chlorination or aromatic compounds and catalysts therefor
JP2001517232A (en) 1997-03-24 2001-10-02 ć‚³ćƒ¼ćƒˆļ¼Œć‚ø惫 Vascular remodeling agent
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
ATE294158T1 (en) * 1997-05-14 2005-05-15 Atherogenics Inc A MONOETHER OF PROBUCOL AND METHODS OF INHIBITING VCAM-1 EXPRESSION
US6852878B2 (en) * 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
EP1019034A2 (en) * 1997-07-01 2000-07-19 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
AU9454098A (en) 1997-09-24 1999-04-12 Nova Molecular, Inc. Methods for increasing apoe levels for the treatment of neurodegenerative disease
AU1387399A (en) 1997-11-10 1999-05-31 Vyrex Corporation Probucol esters and uses thereof
FR2785284B1 (en) 1998-11-02 2000-12-01 Galderma Res & Dev VITAMIN D ANALOGS
DE19850532A1 (en) 1998-11-03 2000-05-04 Nematel Dr Rudolf Eidenschink Bisphenylthio compounds
IL143057A0 (en) * 1998-11-09 2002-04-21 Atherogenics Inc Methods and compositions to lower plasma cholesterol levels
DE69907254T2 (en) 1998-11-23 2004-04-01 Janssen Pharmaceutica N.V. 6-AZAURACIL DERIVATIVES AS IL-5 INHIBITORS
EP1165830B1 (en) 1999-03-10 2017-07-12 University of Pittsburgh of the Commonwealth System of Higher Education Adipose-derived stem cells and lattices
BR0009507A (en) 1999-03-30 2002-01-15 Novartis Ag Phthalazine derivatives for the treatment of inflammatory diseases
US6747061B2 (en) 2000-03-21 2004-06-08 Atherogenics, Inc. N-substituted dithiocarbamates for the treatment of biological disorders
WO2001070757A2 (en) * 2000-03-21 2001-09-27 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of vcam-1
US6323359B1 (en) 2000-05-02 2001-11-27 Salsbury Chemicals, Inc. Process for preparing probucol derivatives
CA2444429A1 (en) 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
CA2447132C (en) 2001-05-14 2008-10-07 Omnova Solutions Inc. Polymeric surfactants derived from cyclic monomers having pendant fluorinated carbon groups
US7187870B2 (en) * 2003-10-15 2007-03-06 Oewaves, Inc. Tunable balanced opto-electronic filters and applications in opto-electronic oscillators

Also Published As

Publication number Publication date
US20020169215A1 (en) 2002-11-14
JP3930056B2 (en) 2007-06-13
CA2289851C (en) 2009-03-10
HUP0004592A3 (en) 2001-12-28
IL178072A0 (en) 2006-12-31
ATE294158T1 (en) 2005-05-15
CN1977836A (en) 2007-06-13
CN1263522A (en) 2000-08-16
KR100882335B1 (en) 2009-02-11
CZ301183B6 (en) 2009-12-02
NO995543D0 (en) 1999-11-12
AU750041B2 (en) 2002-07-11
US6548699B1 (en) 2003-04-15
CN101284808A (en) 2008-10-15
IL132798A (en) 2006-12-31
HUP0004592A2 (en) 2001-06-28
NZ528906A (en) 2005-06-24
US20020177717A1 (en) 2002-11-28
ES2248901T3 (en) 2006-03-16
IL132798A0 (en) 2001-03-19
AU7485198A (en) 1998-12-08
CN1275596C (en) 2006-09-20
CZ301302B6 (en) 2010-01-06
DE69837295D1 (en) 2007-04-19
CN1496740A (en) 2004-05-19
EA009987B1 (en) 2008-04-28
NO995544D0 (en) 1999-11-12
DK1464639T3 (en) 2007-07-09
SK153299A3 (en) 2000-05-16
HUP0004230A2 (en) 2001-06-28
AU7571198A (en) 1998-12-08
NO995544L (en) 2000-01-10
EA199901026A1 (en) 2000-08-28
KR100953990B1 (en) 2010-04-21
NO20032254L (en) 2000-01-10
SK285695B6 (en) 2007-06-07
IL178072A (en) 2010-12-30
US7375252B2 (en) 2008-05-20
KR20070007207A (en) 2007-01-12
SK286766B6 (en) 2009-05-07
ES2241139T3 (en) 2005-10-16
BR9809819A (en) 2001-09-18
IL164568A (en) 2010-05-31
EA009370B1 (en) 2007-12-28
EA200800375A1 (en) 2008-06-30
DE69831566T2 (en) 2006-06-14
PL207885B1 (en) 2011-02-28
ID29158A (en) 2001-08-02
WO1998051289A2 (en) 1998-11-19
ID23877A (en) 2000-05-25
US6121319A (en) 2000-09-19
CA2289851A1 (en) 1998-11-19
EP0994853A2 (en) 2000-04-26
CA2292388C (en) 2004-07-20
CN1496739A (en) 2004-05-19
EA010183B1 (en) 2008-06-30
JP2002503227A (en) 2002-01-29
DE69829966T2 (en) 2006-02-09
CN1200704C (en) 2005-05-11
ATE304350T1 (en) 2005-09-15
AU747801B2 (en) 2002-05-23
DE69837295T2 (en) 2007-11-15
PL194329B1 (en) 2007-05-31
AU747801C (en) 2003-01-30
NO327603B1 (en) 2009-08-31
EA199901027A1 (en) 2000-06-26
EP0981343A2 (en) 2000-03-01
JP2006232848A (en) 2006-09-07
NO316221B1 (en) 2003-12-29
US20020193446A1 (en) 2002-12-19
CZ9904024A3 (en) 2001-10-17
ES2283933T3 (en) 2007-11-01
HUP0004230A3 (en) 2001-12-28
NO20032254D0 (en) 2003-05-19
TR199902803T2 (en) 2000-07-21
DE69831566D1 (en) 2006-01-26
JP2006265257A (en) 2006-10-05
US6602914B2 (en) 2003-08-05
WO1998051289A3 (en) 1999-05-14
IL164568A0 (en) 2005-12-18
JP2001524986A (en) 2001-12-04
HK1025947A1 (en) 2000-12-01
US20050090487A1 (en) 2005-04-28
SK153199A3 (en) 2000-05-16
HK1024629A1 (en) 2000-10-20
IL132797A0 (en) 2001-03-19
US7189870B2 (en) 2007-03-13
EA200601059A1 (en) 2007-02-27
US20080214660A1 (en) 2008-09-04
US6828447B2 (en) 2004-12-07
CN1287783C (en) 2006-12-06
WO1998051662A2 (en) 1998-11-19
EP0981343B1 (en) 2005-09-14
BR9809793A (en) 2000-06-27
CN100453530C (en) 2009-01-21
EA012847B1 (en) 2009-12-30
CZ301985B6 (en) 2010-08-25
PT1464639E (en) 2007-06-15
CZ9904023A3 (en) 2001-07-11
CN1977837B (en) 2010-12-08
KR20010012504A (en) 2001-02-15
SK286674B6 (en) 2009-03-05
CY1107645T1 (en) 2013-04-18
PL336788A1 (en) 2000-07-17
TR199902802T2 (en) 2000-04-21
NO319855B1 (en) 2005-09-26
CA2292388A1 (en) 1998-11-19
US6147250A (en) 2000-11-14
EA200500249A1 (en) 2005-06-30
CN1977837A (en) 2007-06-13
EP0994853B1 (en) 2005-04-27
ATE356113T1 (en) 2007-03-15
WO1998051662A3 (en) 2000-03-02
CN1263462A (en) 2000-08-16
CZ301313B6 (en) 2010-01-13
SK286392B6 (en) 2008-09-05
HU226611B1 (en) 2009-04-28
KR20080066885A (en) 2008-07-16
KR100919883B1 (en) 2009-09-30
KR20010012503A (en) 2001-02-15
US6617352B2 (en) 2003-09-09
CA2428130A1 (en) 1998-11-19
IL175130A (en) 2009-02-11
NO995543L (en) 2000-01-10
NZ501069A (en) 2000-07-28
KR20070008725A (en) 2007-01-17
US20020188118A1 (en) 2002-12-12
DK0981343T3 (en) 2006-01-30
PL343904A1 (en) 2001-09-10

Similar Documents

Publication Publication Date Title
ATE294158T1 (en) A MONOETHER OF PROBUCOL AND METHODS OF INHIBITING VCAM-1 EXPRESSION
NO20030845D0 (en) Selected fused pyrrolocarbazoles
DE69728594D1 (en) Chromium-free composition for the treatment of metal surfaces
DE602004017736D1 (en) USE OF RAPAMYCIN AND ITS DERIVATIVES FOR TREATING BONE LOSS
DE69905476D1 (en) PhosphonsaĆ¼rederivate als ptp-1b-inhibitoren
DE60123238D1 (en) COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
ATE359279T1 (en) MUSK ODORS
DE602004017332D1 (en) NEW CONDENSED N-PYRAZINYL-SULFONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKIN-MEDIATED DISEASES
DE50205466D1 (en) SUBSTITUTED 2,5-DIAMIDOINDOLE AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
TR200200278T2 (en) Calcilitic compositions
ATE330604T1 (en) TREATMENT OF MANIC DISEASES
PT1144348E (en) LTA INHIBITORS, HYDROLASE
DE60111571D1 (en) USE OF ANETHOL DITHIOLETHION FOR THE PREVENTION AND TREATMENT OF TREATMENT TOXICITY
EP1468989A3 (en) Compounds and methods for the inhibition of the expression of VCAM-1
DE69833655D1 (en) METHODS AND COMPOSITIONS FOR THE TREATMENT OF HYPERLIPIDEMIA
ATE546157T1 (en) ANTI-PECAM THERAPY FOR SUPPRESSING METASTASIS

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee