DE69822934D1 - Chirale Trennung von pharmazeutischen Verbindungen mit geladenen Cyclodextrinen durch Kapillarelektrophorese - Google Patents

Chirale Trennung von pharmazeutischen Verbindungen mit geladenen Cyclodextrinen durch Kapillarelektrophorese

Info

Publication number
DE69822934D1
DE69822934D1 DE69822934T DE69822934T DE69822934D1 DE 69822934 D1 DE69822934 D1 DE 69822934D1 DE 69822934 T DE69822934 T DE 69822934T DE 69822934 T DE69822934 T DE 69822934T DE 69822934 D1 DE69822934 D1 DE 69822934D1
Authority
DE
Germany
Prior art keywords
capillary electrophoresis
pharmaceutical compounds
chiral separation
charged cyclodextrins
cyclodextrins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69822934T
Other languages
English (en)
Other versions
DE69822934T2 (de
Inventor
Fu-Tai A Chen
Gene G Y Shen
Ramon A Evangelista
Chan S Oh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Application granted granted Critical
Publication of DE69822934D1 publication Critical patent/DE69822934D1/de
Publication of DE69822934T2 publication Critical patent/DE69822934T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44747—Composition of gel or of carrier mixture
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31652—Of asbestos
    • Y10T428/31663—As siloxane, silicone or silane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31971—Of carbohydrate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Analytical Chemistry (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
DE1998622934 1997-07-25 1998-07-10 Chirale Trennung von pharmazeutischen Verbindungen mit geladenen Cyclodextrinen durch Kapillarelektrophorese Expired - Lifetime DE69822934T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/910,483 US6316613B1 (en) 1997-07-25 1997-07-25 Chiral separation of pharmaceutical compounds with charged cyclodextrins using capillary electrophoresis
US910483 1997-07-25

Publications (2)

Publication Number Publication Date
DE69822934D1 true DE69822934D1 (de) 2004-05-13
DE69822934T2 DE69822934T2 (de) 2004-08-12

Family

ID=25428852

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1998622934 Expired - Lifetime DE69822934T2 (de) 1997-07-25 1998-07-10 Chirale Trennung von pharmazeutischen Verbindungen mit geladenen Cyclodextrinen durch Kapillarelektrophorese

Country Status (4)

Country Link
US (1) US6316613B1 (de)
EP (1) EP0893453B1 (de)
JP (2) JP4503715B2 (de)
DE (1) DE69822934T2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391862B1 (en) * 1997-10-14 2002-05-21 The Texas A&M University System Chiral resolving agents for enantioseparations
US6544396B1 (en) * 2000-07-20 2003-04-08 Symyx Technologies, Inc. Multiplexed capillary electrophoresis system
DE10042451A1 (de) * 2000-08-29 2002-03-14 Studiengesellschaft Kohle Mbh High-Throughput Verfahren zur Bestimmung der Enantiomereneinheit von chiralen Verbindungen
US20020193345A1 (en) * 2001-05-23 2002-12-19 Gyula Vigh Anionic cyclodextrin compositions having volatile combustion products with halogen, O or S atoms or their combinations as heteroatoms for use with gas-phase or vapor-phase element-specific detectors
CN101039682A (zh) * 2003-10-31 2007-09-19 堪萨斯大学 磺基烷基醚－烷基醚环糊精衍生物
US7883777B2 (en) * 2006-03-23 2011-02-08 Garware Polyester Ltd. Solar energy shielding window film laminates
CN101221147B (zh) * 2007-09-25 2012-01-04 扬子江药业集团有限公司 一种毛细管电泳法检测雷替曲塞对映异构体的方法
US7635773B2 (en) * 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
ES2758446T3 (es) 2012-01-23 2020-05-05 Sage Therapeutics Inc Formulaciones de esteroides neuroactivos que comprenden un complejo de alopregnanolona y sulfobutil éter beta-ciclodextrina
JP6508944B2 (ja) 2012-02-15 2019-05-08 サイデックス・ファーマシューティカルズ・インコーポレイテッド シクロデキストリン誘導体のための製造方法
RU2615385C2 (ru) 2012-02-28 2017-04-04 Сидекс Фармасьютикалс, Инк. Композиции алкилированного циклодекстрина и способы их получения и применения
BR112015003747A2 (pt) 2012-08-21 2017-07-04 Sage Therapeutics Inc métodos de tratamento de epilepsia ou estado de mal epiléptico
CN105073785B (zh) 2012-10-22 2018-08-21 锡德克斯药物公司 烷基化环糊精组合物及其制备和使用方法
CN103063756B (zh) * 2012-11-29 2014-07-30 沈阳化工大学 一种双手性选择剂毛细管电泳法分离抗溃疡药物的方法
PT3183295T (pt) 2014-08-22 2023-11-03 Cydex Pharmaceuticals Inc Composições de ciclodextrina alquilada fracionada e processos para preparação e utilização das mesmas
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
MA45276A (fr) 2015-06-18 2018-04-25 Sage Therapeutics Inc Solutions de stéroïdes neuroactifs et leurs méthodes d'utilisation
US20200276209A1 (en) 2017-09-11 2020-09-03 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
AU2022306038A1 (en) * 2021-07-07 2024-01-25 Terran Biosciences Inc. 3,4-methylenedioxymethamphetamine and related psychedlics and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4020160A (en) * 1975-08-15 1977-04-26 American Cyanamid Company Cyclodextrin sulfate salts as complement inhibitors
US5183809A (en) * 1990-02-15 1993-02-02 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Cyclodextrin polymers and cyclodextrins immobilized on a solid surface
US5658894A (en) * 1989-04-23 1997-08-19 The Trustees Of The University Of Pennsylvania Compositions for inhibiting restenosis
JP2751344B2 (ja) * 1988-03-18 1998-05-18 武田薬品工業株式会社 β―シクロデキストリン硫酸エステル塩の精製方法
JPH07113797A (ja) * 1993-10-13 1995-05-02 Kaken Pharmaceut Co Ltd ヘパリン親和性物質の分離、精製用充填剤
US5840713A (en) * 1995-04-03 1998-11-24 Weisz; Paul B. Therapy for tissue membrane insufficiency

Also Published As

Publication number Publication date
DE69822934T2 (de) 2004-08-12
JPH11100402A (ja) 1999-04-13
JP4503715B2 (ja) 2010-07-14
US6316613B1 (en) 2001-11-13
JP2010132907A (ja) 2010-06-17
EP0893453B1 (de) 2004-04-07
EP0893453A2 (de) 1999-01-27
EP0893453A3 (de) 1999-05-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BECKMAN COULTER, INC., BREA, CALIF., US