DE69820671T2 - Zubereitung zur nasalen verabreichung enthaltend vibrio cholera zonula occludens toxin als absorptionsvermittler - Google Patents
Zubereitung zur nasalen verabreichung enthaltend vibrio cholera zonula occludens toxin als absorptionsvermittler Download PDFInfo
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- DE69820671T2 DE69820671T2 DE69820671T DE69820671T DE69820671T2 DE 69820671 T2 DE69820671 T2 DE 69820671T2 DE 69820671 T DE69820671 T DE 69820671T DE 69820671 T DE69820671 T DE 69820671T DE 69820671 T2 DE69820671 T2 DE 69820671T2
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- zonula occludens
- nasal dosage
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
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- Immunology (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/781,057 US5908825A (en) | 1997-01-09 | 1997-01-09 | Dosage composition for nasal delivery and method of use of the same |
| US781057 | 1997-01-09 | ||
| PCT/US1998/000019 WO1998030211A1 (en) | 1997-01-09 | 1998-01-09 | Dosage composition for nasal delivery and method of use of the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69820671D1 DE69820671D1 (de) | 2004-01-29 |
| DE69820671T2 true DE69820671T2 (de) | 2004-09-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69820671T Expired - Fee Related DE69820671T2 (de) | 1997-01-09 | 1998-01-09 | Zubereitung zur nasalen verabreichung enthaltend vibrio cholera zonula occludens toxin als absorptionsvermittler |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5908825A (enExample) |
| EP (1) | EP1028715B1 (enExample) |
| JP (2) | JP2001524940A (enExample) |
| AT (1) | ATE256460T1 (enExample) |
| AU (1) | AU5906398A (enExample) |
| CA (1) | CA2277824C (enExample) |
| DE (1) | DE69820671T2 (enExample) |
| ES (1) | ES2213267T3 (enExample) |
| WO (1) | WO1998030211A1 (enExample) |
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| GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
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| US6818222B1 (en) * | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| ATE252889T1 (de) | 1998-08-19 | 2003-11-15 | Skyepharma Canada Inc | Injizierbare wässerige propofoldispersionen |
| US7176279B2 (en) * | 2000-06-28 | 2007-02-13 | Palatin Technologies, Inc. | Cyclic peptide compositions and methods for treatment of sexual dysfunction |
| US6579968B1 (en) * | 1999-06-29 | 2003-06-17 | Palatin Technologies, Inc. | Compositions and methods for treatment of sexual dysfunction |
| US20030118598A1 (en) * | 2000-02-08 | 2003-06-26 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
| US7780967B2 (en) * | 2000-02-08 | 2010-08-24 | Allergan, Inc. | Reduced toxicity Clostridial toxin pharmaceutical compositions |
| US8632785B2 (en) * | 2000-02-08 | 2014-01-21 | Allergan, Inc. | Clostridial toxin pharmaceutical composition containing a gelatin fragment |
| US20060269575A1 (en) * | 2000-02-08 | 2006-11-30 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions formulated with recombinant albumin |
| CA2494241C (en) * | 2000-02-08 | 2011-06-14 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions |
| US6623765B1 (en) | 2000-08-01 | 2003-09-23 | University Of Florida, Research Foundation, Incorporated | Microemulsion and micelle systems for solubilizing drugs |
| AU2002238106A1 (en) * | 2001-02-13 | 2002-08-28 | Palatin Technologies, Inc. | Melanocortin metallopeptides for treatment of sexual dysfunction |
| US7342089B2 (en) * | 2001-07-11 | 2008-03-11 | Palatin Technologies, Inc. | Cyclic peptides for treatment for cachexia |
| US7345144B2 (en) * | 2001-07-11 | 2008-03-18 | Palatin Technologies, Inc. | Cyclic peptides for treatment of cachexia |
| WO2003072016A2 (en) * | 2001-11-19 | 2003-09-04 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| WO2004005324A2 (en) * | 2002-07-09 | 2004-01-15 | Palatin Technologies, Inc. | Peptide composition for treatment of sexual dysfunction |
| CA2531491A1 (en) * | 2003-07-15 | 2005-02-03 | University Of Maryland, Baltimore | Agonist polypeptide of receptor for zot and zonulin |
| US20060263350A1 (en) * | 2003-09-26 | 2006-11-23 | Fairfield Clinical Trials Llc | Combination antihistamine medication |
| DE10351778A1 (de) | 2003-11-06 | 2005-06-09 | Daimlerchrysler Ag | Verfahren zur Korrespondenzanalyse in Bilddatensätzen |
| US20050143303A1 (en) | 2003-12-26 | 2005-06-30 | Nastech Pharmaceutical Company Inc. | Intranasal administration of glucose-regulating peptides |
| US20060210614A1 (en) * | 2003-12-26 | 2006-09-21 | Nastech Pharmaceutical Company Inc. | Method of treatment of a metabolic disease using intranasal administration of exendin peptide |
| US20080318837A1 (en) * | 2003-12-26 | 2008-12-25 | Nastech Pharmaceutical Company Inc. | Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide |
| US20060074025A1 (en) * | 2003-12-26 | 2006-04-06 | Nastech Pharmaceutical Company Inc. | Therapeutic formulations for transmucosal administration that increase glucagon-like peptide-1 bioavailability |
| US6974187B2 (en) * | 2004-01-28 | 2005-12-13 | Tachi-S Co., Ltd. | Vehicle seat structure |
| WO2006088491A2 (en) * | 2004-06-29 | 2006-08-24 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
| TW200637573A (en) * | 2005-01-14 | 2006-11-01 | Univ Maryland | Peptide for delivery of mucosal vaccines |
| TW200716159A (en) * | 2005-06-09 | 2007-05-01 | Univ Maryland | Method of use of antagonists of zonulin to prevent the loss of or to regenerate pancreatic cells |
| US7754691B1 (en) | 2005-07-07 | 2010-07-13 | Palatin Technologies, Inc. | Linear melanocortin receptor-specific peptides for cachexia |
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| EP1959987A2 (en) * | 2005-12-08 | 2008-08-27 | Nastech Pharmaceutical Company Inc. | Mucosal delivery of stabilized formulations of exendin |
| US20070232537A1 (en) * | 2005-12-19 | 2007-10-04 | Nastech Pharmaceutical Company Inc. | Intranasal pyy formulations with improved transmucosal pharmacokinetics |
| BRPI0707616A2 (pt) | 2006-02-09 | 2011-05-10 | Alba Therapuetics Corp | formulaÇÕes para um efetor de junÇço oclusiva |
| US7795221B2 (en) * | 2006-03-30 | 2010-09-14 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
| EP2001518B1 (en) | 2006-03-30 | 2013-07-10 | Palatin Technologies, Inc. | Cyclic natriuretic peptide constructs |
| US8580746B2 (en) * | 2006-03-30 | 2013-11-12 | Palatin Technologies, Inc. | Amide linkage cyclic natriuretic peptide constructs |
| US8728491B2 (en) * | 2007-05-07 | 2014-05-20 | Alba Therapeutics Corporation | Transcutaneous delivery of therapeutic agents |
| WO2009015382A2 (en) | 2007-07-26 | 2009-01-29 | Alba Therapeutics Corporation | Novel peptides that enhance tight junction permeability |
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| WO2010065801A1 (en) | 2008-12-04 | 2010-06-10 | Palatin Technologies, Inc. | Amine substituted piperazine melanocortin receptor-specific compounds |
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| US9717867B2 (en) | 2009-02-27 | 2017-08-01 | Pari GmbH Spezialisten für effektive Inhalation | Method for operating an aerosol inhalation device and aerosol inhalation device |
| CA2761607C (en) | 2009-06-08 | 2018-09-04 | Yi-Qun Shi | Melanocortin receptor-specific peptides |
| EP2380618A1 (en) * | 2010-04-26 | 2011-10-26 | PARI Pharma GmbH | Operating method for an aerosol delivery device and aerosol delivery device |
| EP2814501A4 (en) | 2012-03-13 | 2016-03-02 | Tensive Controls Inc | MELANOCORTINANALOGA WITH INCREASED EFFECTIVENESS AND TRANSPORTATION OF THEREOF |
| CA2875384A1 (en) | 2013-12-20 | 2015-06-20 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
| US10085937B2 (en) | 2014-03-14 | 2018-10-02 | Adapt Pharma Limited | Nasal drug products and methods of their use |
| RU2016136714A (ru) | 2014-03-14 | 2018-04-19 | ОПИАНТ ФАРМАСЮТИКАЛС, Инк. | Назальные готовые лекарственные формы и способы их применения |
| US9480644B2 (en) | 2014-03-14 | 2016-11-01 | Opiant Pharmaceuticals, Inc. | Nasal drug products and methods of their use |
| US9561177B2 (en) | 2014-03-14 | 2017-02-07 | Adapt Pharma Limited | Nasal drug products and methods of their use |
| WO2016044683A1 (en) | 2014-09-19 | 2016-03-24 | Tensive Controls, Inc. | Anti-microbial peptides |
| US11590209B2 (en) | 2020-01-21 | 2023-02-28 | Palatin Technologies, Inc. | Use of bremelanotide in patients with controlled hypertension |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5470729A (en) * | 1983-03-04 | 1995-11-28 | University Of Maryland At Baltimore | Method of isolating restriction fragment deletions in Vibrio cholerae, and products thereof |
| US5665389A (en) * | 1995-05-24 | 1997-09-09 | University Of Maryland At Baltimore | Oral dosage composition for intestinal delivery and method of treating diabetes |
| US5945510A (en) * | 1997-05-21 | 1999-08-31 | University Of Maryland, Baltimore | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
-
1997
- 1997-01-09 US US08/781,057 patent/US5908825A/en not_active Expired - Lifetime
-
1998
- 1998-01-09 EP EP98902381A patent/EP1028715B1/en not_active Expired - Lifetime
- 1998-01-09 ES ES98902381T patent/ES2213267T3/es not_active Expired - Lifetime
- 1998-01-09 CA CA002277824A patent/CA2277824C/en not_active Expired - Fee Related
- 1998-01-09 DE DE69820671T patent/DE69820671T2/de not_active Expired - Fee Related
- 1998-01-09 AT AT98902381T patent/ATE256460T1/de not_active IP Right Cessation
- 1998-01-09 JP JP53097398A patent/JP2001524940A/ja not_active Ceased
- 1998-01-09 AU AU59063/98A patent/AU5906398A/en not_active Abandoned
- 1998-01-09 WO PCT/US1998/000019 patent/WO1998030211A1/en not_active Ceased
-
2005
- 2005-10-11 JP JP2005297014A patent/JP2006028199A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69820671D1 (de) | 2004-01-29 |
| JP2006028199A (ja) | 2006-02-02 |
| ES2213267T3 (es) | 2004-08-16 |
| EP1028715A4 (en) | 2001-10-10 |
| WO1998030211A1 (en) | 1998-07-16 |
| ATE256460T1 (de) | 2004-01-15 |
| EP1028715A1 (en) | 2000-08-23 |
| JP2001524940A (ja) | 2001-12-04 |
| AU5906398A (en) | 1998-08-03 |
| EP1028715B1 (en) | 2003-12-17 |
| CA2277824C (en) | 2006-11-07 |
| US5908825A (en) | 1999-06-01 |
| CA2277824A1 (en) | 1998-07-16 |
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Owner name: UNIVERSITY OF MARYLAND, BALTIMORE, BALTIMORE, MD., |
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| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |