DE69813729D1 - Verfahren zur Herstellung von 1-(9'H-Carbazol-4'yloxy)-3-2''-(2'''-methoxy-phenoxy)ethyl)-amino)-2-ol (Carvedilol) und Zwischenverbindungen - Google Patents

Verfahren zur Herstellung von 1-(9'H-Carbazol-4'yloxy)-3-2''-(2'''-methoxy-phenoxy)ethyl)-amino)-2-ol (Carvedilol) und Zwischenverbindungen

Info

Publication number
DE69813729D1
DE69813729D1 DE69813729T DE69813729T DE69813729D1 DE 69813729 D1 DE69813729 D1 DE 69813729D1 DE 69813729 T DE69813729 T DE 69813729T DE 69813729 T DE69813729 T DE 69813729T DE 69813729 D1 DE69813729 D1 DE 69813729D1
Authority
DE
Germany
Prior art keywords
carvedilol
carbazol
yloxy
phenoxy
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69813729T
Other languages
English (en)
Other versions
DE69813729T3 (de
DE69813729T2 (de
Inventor
Zoltan Ratkai
Dr Barkoczy
Dr Simig
Dr Gregor
Gyoergyi Donath Vereczkey
Norbert Nemeth
Dr Nagy
Judit Cselenyak
Tibor Szabo
Laszlo Balazs
Imre Doman
Dr Greff
Dr Seres
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9702209A external-priority patent/HU9702209D0/hu
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of DE69813729D1 publication Critical patent/DE69813729D1/de
Application granted granted Critical
Publication of DE69813729T2 publication Critical patent/DE69813729T2/de
Publication of DE69813729T3 publication Critical patent/DE69813729T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69813729T 1997-11-24 1998-11-24 Verfahren zur Herstellung von 1-(9'H-Carbazol-4'yloxy)-3-2''-(2'''-methoxy-phenoxy)ethyl)-amino)-2-ol (Carvedilol) und Zwischenverbindungen Expired - Lifetime DE69813729T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU9702209 1997-11-24
HU9702209A HU9702209D0 (en) 1997-11-24 1997-11-24 Process for producing pharmaceutical product
HU9802180A HU227441B1 (en) 1997-11-24 1998-10-01 Process for producing carvedilol, enantiomers and salts thereof
HU9802180 1998-10-01

Publications (3)

Publication Number Publication Date
DE69813729D1 true DE69813729D1 (de) 2003-05-28
DE69813729T2 DE69813729T2 (de) 2004-02-05
DE69813729T3 DE69813729T3 (de) 2006-11-30

Family

ID=89997149

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69813729T Expired - Lifetime DE69813729T3 (de) 1997-11-24 1998-11-24 Verfahren zur Herstellung von 1-(9'H-Carbazol-4'yloxy)-3-2''-(2'''-methoxy-phenoxy)ethyl)-amino)-2-ol (Carvedilol) und Zwischenverbindungen
DE69823394T Expired - Lifetime DE69823394T2 (de) 1997-11-24 1998-11-24 Verfahren zur Herstellung von 1-(9'H-Carbazol-4'-yloxy)-3-(2''-(2'''-methoxy-phenoxy)-ethyl)amino)-propan-2-ol ( Carvedilol)

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69823394T Expired - Lifetime DE69823394T2 (de) 1997-11-24 1998-11-24 Verfahren zur Herstellung von 1-(9'H-Carbazol-4'-yloxy)-3-(2''-(2'''-methoxy-phenoxy)-ethyl)amino)-propan-2-ol ( Carvedilol)

Country Status (9)

Country Link
EP (3) EP1142874A3 (de)
CZ (2) CZ296521B6 (de)
DE (2) DE69813729T3 (de)
ES (2) ES2196459T5 (de)
HR (1) HRP980590B1 (de)
HU (1) HU227441B1 (de)
PL (1) PL205193B1 (de)
SK (1) SK284109B6 (de)
UA (1) UA57737C2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
DK174645B1 (da) * 2000-05-18 2003-08-04 Gea Farmaceutisk Fabrik As Fremgangsmåde og mellemprodukter til fremstillingen af 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol og syreadditionssalte deraf
MXPA02012795A (es) 2000-06-28 2004-07-30 Teva Pharma Carvedilol.
MXPA04006909A (es) 2002-01-15 2005-04-19 Teva Pharma Solidos cristalinos de carvedilol y procesos para su preparacion.
SK285547B6 (sk) 2002-11-08 2007-03-01 Zentiva, A. S. Spôsob prípravy Carvedilolu
EP1615888A1 (de) 2003-04-21 2006-01-18 Matrix Laboratories Ltd Verfahren zur herstellung von carvedilol form-ii
WO2004113296A1 (en) * 2003-06-20 2004-12-29 Sun Pharmaceutical Industries Limited A process for preparation of 1-[9h-carbazol-4-yloxy]- 3-[{2-(2-(-(methoxy)phenoxy)-ethyl}-amino]-propan-2-ol
GB0411273D0 (en) 2004-05-20 2004-06-23 Cipla Ltd Process and product
WO2006135757A1 (en) * 2005-06-09 2006-12-21 Teva Pharmaceutical Industries Ltd. Crystalline forms of carvedilol and processes for their preparation
KR100746455B1 (ko) * 2006-02-23 2007-08-03 안국약품 주식회사 고광학순도의 키랄 카베딜롤의 제조방법
EP1991527A2 (de) 2006-06-28 2008-11-19 Teva Pharmaceutical Industries Ltd Polymorphe formen von carvedilol-phosphat
CZ302357B6 (cs) * 2007-01-26 2011-03-30 Zentiva, A. S. Zpusob cištení Carvedilolu
WO2009116069A2 (en) * 2008-02-04 2009-09-24 Ipca Laboratories Limited Process for preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(2- methoxyphenoxy) ethyl] amino]-2-propanol
WO2009115906A2 (en) * 2008-03-19 2009-09-24 Cadila Pharmaceuticals Ltd. An improved process for preparation of carvedilol involving halohydrin derivative
WO2009115902A1 (en) * 2008-03-19 2009-09-24 Cadila Pharmaceuticals Ltd. Process for the preparation of carvedilol via silyl protection of substituted amine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3319027A1 (de) † 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten
DE3540149A1 (de) † 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Verwendung von 1-(benztriazol-4-yloxy)3-(2-(2-methoxyphenoxy) -ethylamino)-2-propanol als antiglaukommittel, optisch aktive r und s isomere dieser substanz, verfahren zur herstellung derselben sowie arzneimittel, die diese substanzen enthalten
US5053514A (en) † 1988-08-10 1991-10-01 Otsuka Pharmaceutical Company, Limited Cardiotonics

Also Published As

Publication number Publication date
EP1142873A2 (de) 2001-10-10
SK156098A3 (en) 1999-06-11
HRP980590A2 (en) 1999-10-31
EP1142873A3 (de) 2003-09-10
PL329828A1 (en) 1999-06-07
DE69823394T2 (de) 2005-05-04
EP1142874A3 (de) 2003-10-22
SK284109B6 (sk) 2004-09-08
DE69813729T3 (de) 2006-11-30
EP0918055B1 (de) 2003-04-23
PL205193B1 (pl) 2010-03-31
ES2196459T5 (es) 2006-12-01
HU9802180D0 (en) 1998-11-30
EP1142874A2 (de) 2001-10-10
DE69813729T2 (de) 2004-02-05
HUP9802180A1 (hu) 2000-12-28
DE69823394D1 (de) 2004-05-27
CZ297445B6 (cs) 2006-12-13
ES2221875T3 (es) 2005-01-16
EP0918055A1 (de) 1999-05-26
HU227441B1 (en) 2011-06-28
EP1142873B1 (de) 2004-04-21
ES2196459T3 (es) 2003-12-16
HRP980590B1 (en) 2003-12-31
EP0918055B2 (de) 2006-04-26
CZ356198A3 (cs) 1999-06-16
CZ296521B6 (cs) 2006-04-12
UA57737C2 (uk) 2003-07-15

Similar Documents

Publication Publication Date Title
DE69813729D1 (de) Verfahren zur Herstellung von 1-(9'H-Carbazol-4'yloxy)-3-2''-(2'''-methoxy-phenoxy)ethyl)-amino)-2-ol (Carvedilol) und Zwischenverbindungen
DE69414176D1 (de) Verfahren zur Herstellung von N-Acyl-N,N',N'-Ethylendiamintriessigsäurederivaten
DE59408268D1 (de) Verfahren zur Herstellung von N-(2-Hydroxyethyl)-piperazin
DE69509624D1 (de) Verfahren zur Herstellung von 1-(2'-Deoxy-2',2'-difluoro-D-ribofuranosyl)-4-amino-pyrimidin-2-on-hydrochlorid
DE69604712D1 (de) Alpha-Aluminiumoxid und Verfahren zur dessen Herstellung
DE69618363D1 (de) Verfahren zur Herstellung von Epsilon-Caprolactam und Epsilon-Caprolactam-Vorläufern
DE69124769D1 (de) Verfahren zur Herstellung von (1'R,3S)-3-(1'-hydroxy-ethyl)-Azetidin-2-on und deren Derivaten
BG102697A (en) Combined preparation containing (4-trifluoromethyl)-analide of 5-methyloxazole-4-carboxylic acid and amide of n-(4-trifluoromethylphenyl)-2-cyan-3-hydroxycrotonic acid
DE59504187D1 (de) Verfahren zur Herstellung von ultrareinem Bisphenol-A und dessen Verwendung
DE59601745D1 (de) Verfahren zur Herstellung von 3-Aminomethyl-3,5,5-trimethylcyclohexylamin
IL131850A0 (en) Process and intermediates for the preparation of 4'-trifluoromethyl-biphenyl-2-carboxylic acid (1, 2, 3, 4-tetrahydro-isoquinolin-6-yl)-amide
DE59602691D1 (de) Herstellung von primären Guerbetaminen
DE69713040D1 (de) Verfahren zur Herstellung von Cyclopropylacetylen und dessen Derivaten
DE59207939D1 (de) Verfahren zur Herstellung von 2,2-Difluorbenzo(1,3) dioxol-carbaldehyden und neuen Zwischenprodukten
DE59606657D1 (de) Verfahren zur Herstellung von Poly-o-hydroxyamiden und Poly-o-mercaptoamiden
DE59607664D1 (de) Verfahren zur Herstellung von 2,4,4,7-Tetramethyl-oct-6-en-3-on und dessen Verwendung als Riechstoff
DE59407076D1 (de) Verfahren zur Herstellung von mehrfach fluorierten Nitrobenzolen
DE59500920D1 (de) Verfahren zur Herstellung von 3-Aminomethyl-3,5,5-trimethylcyclohexylamin
DE69700756D1 (de) Verfahren zur Herstellung und Verwendung von Alkylenoxysilan-Zusammensetzungen
DE69424475D1 (de) Verfahren zur Herstellung von 1-(2'-deoxy-beta-D-erythropentofuranosyl)-5-trifluormethyluracil Derivaten
DE69840863D1 (de) Verfahren zur Herstellung von 2,6-Diaminopurin-2'deoxyribosid und 2'-Deoxyguanosin
DE69606384D1 (de) Verfahren zur Herstellung von N-monosubstituierten Hydroxylaminen
DE69804920D1 (de) Verfahren zur Herstellung von Furopyridin-Derivaten und Zwischenprodukten
DE69628060D1 (de) Verfahren zur Herstellung von Difluormethan und Difluorchlormethan
DE69802329D1 (de) Verfahren zur Herstellung von 3,4 disubstituirten Dinitroanilinen

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
R082 Change of representative

Ref document number: 918055

Country of ref document: EP

Representative=s name: STOLMAR & PARTNER, DE