DE69811492D1 - Benzonaphthyridine - Google Patents

Benzonaphthyridine

Info

Publication number
DE69811492D1
DE69811492D1 DE69811492T DE69811492T DE69811492D1 DE 69811492 D1 DE69811492 D1 DE 69811492D1 DE 69811492 T DE69811492 T DE 69811492T DE 69811492 T DE69811492 T DE 69811492T DE 69811492 D1 DE69811492 D1 DE 69811492D1
Authority
DE
Germany
Prior art keywords
disorders
hexahydrobenzo
naphthyridine
phenyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69811492T
Other languages
English (en)
Other versions
DE69811492T2 (de
Inventor
Beate Schmidt
Wolf-Ruediger Ulrich
Hermann Amschler
Rolf Beume
Dietrich Haefner
Thomas Baer
Thomas Martin
Ulrich Kilian
Manfrid Eltze
Ursula Brand
Hildegard Boss
Hans-Peter Kley
Christian Schudt
Karl-Josef Goebel
Dieter Flockerzi
Armin Hatzelmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Priority to DE69811492T priority Critical patent/DE69811492T2/de
Publication of DE69811492D1 publication Critical patent/DE69811492D1/de
Application granted granted Critical
Publication of DE69811492T2 publication Critical patent/DE69811492T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69811492T 1997-06-03 1998-05-27 Benzonaphthyridine Expired - Fee Related DE69811492T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69811492T DE69811492T2 (de) 1997-06-03 1998-05-27 Benzonaphthyridine

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP97108892 1997-06-03
DE19723161 1997-06-03
DE19723161 1997-06-03
EP97108892 1997-06-03
PCT/EP1998/003118 WO1998055481A1 (en) 1997-06-03 1998-05-27 Benzonaphthyridine
DE69811492T DE69811492T2 (de) 1997-06-03 1998-05-27 Benzonaphthyridine

Publications (2)

Publication Number Publication Date
DE69811492D1 true DE69811492D1 (de) 2003-03-27
DE69811492T2 DE69811492T2 (de) 2004-02-05

Family

ID=26037086

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69811492T Expired - Fee Related DE69811492T2 (de) 1997-06-03 1998-05-27 Benzonaphthyridine

Country Status (12)

Country Link
US (1) US6384047B1 (de)
EP (1) EP0988302B1 (de)
JP (1) JP2002502403A (de)
AT (1) ATE232864T1 (de)
AU (1) AU8106598A (de)
CA (1) CA2291153A1 (de)
DE (1) DE69811492T2 (de)
DK (1) DK0988302T3 (de)
ES (1) ES2193539T3 (de)
PT (1) PT988302E (de)
SI (1) SI0988302T1 (de)
WO (1) WO1998055481A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR015966A1 (es) * 1997-10-17 2001-05-30 Smithkline Beecham Corp Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
AU2107700A (en) 1999-01-15 2000-08-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides with pde-iv inhibiting activity
SI1147103T1 (en) 1999-01-15 2005-10-31 Altana Pharma Ag Phenantrhridine-n-oxides with pde-iv inhibiting activity
ATE312081T1 (de) 1999-01-15 2005-12-15 Altana Pharma Ag 6-phenylphenanthridine mit pde-iv hemmender wirkung
SI1212089T1 (sl) 1999-08-21 2006-08-31 Altana Pharma Ag Sinergisticna kombinacija roflumilasta in salmeterola
WO2002040450A1 (en) * 2000-11-14 2002-05-23 Altana Pharma Ag (dihydro)isoquinoline derivatives as phosphodiesterase inhibitors
CA2438717C (en) * 2001-02-21 2011-08-30 Altana Pharma Ag 6-phenylbenzonaphthyridines
US7470704B2 (en) * 2002-09-04 2008-12-30 Nycomed Gmbh Benzonaphthyridines
EP1537109B1 (de) * 2002-09-04 2007-04-18 ALTANA Pharma AG Neue benzonaphthyridine
KR101152488B1 (ko) 2004-03-03 2012-07-02 니코메드 게엠베하 신규 히드록시-6-헤테로아릴페난트리딘 및 ｐｄｅ4 억제제로서의 이의 용도
SI1856093T1 (sl) 2005-03-02 2010-03-31 Nycomed Gmbh Hidrokloridna sol R aR bR dimetoksipiridin il etoksi metoksi a b heksahidrofenantridin ola
US9517263B2 (en) * 2009-06-10 2016-12-13 Glaxosmithkline Biologicals Sa Benzonaphthyridine-containing vaccines
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
WO2013109738A1 (en) 2012-01-17 2013-07-25 The Trustees Of Columbia University In The City Of New York Novel phosphodiesterase inhibitors and uses thereof
US10899756B2 (en) 2013-07-17 2021-01-26 The Trustees Of Columbia University In The City Of New York Phosphodiesterase inhibitors and uses thereof
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1361441A (en) 1970-05-13 1974-07-24 Sandoz Ltd Benzonaphthyridine derivatives
DK159431C (da) 1984-05-10 1991-03-18 Byk Gulden Lomberg Chem Fab 6-phenyl-3(2h)-pyridazinoner, fremgangsmaade til fremstilling deraf, laegemidler indeholdende disse samt anvendelse af forbindelserne til fremstilling af laegemidler
EP0247971A3 (de) * 1986-05-29 1990-01-17 Sandoz Ag Pharmazeutische Zusammensetzungen mit, und Verwendung von Cis-6-(4-Acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin
MY105344A (en) * 1990-05-16 1994-09-30 Byk Gulden Lomberg Chemische Fabrik New sulphonyl compounds
WO1993009780A1 (de) * 1991-11-15 1993-05-27 Byk Gulden Lomberg Chemische Fabrik Gmbh Verwendung von sulfonylverbindungen
DE4310050A1 (de) 1992-04-11 1993-10-14 Byk Gulden Lomberg Chem Fab Neue Verwendung von Sulfonylverbindungen

Also Published As

Publication number Publication date
WO1998055481A1 (en) 1998-12-10
CA2291153A1 (en) 1998-12-10
ATE232864T1 (de) 2003-03-15
AU8106598A (en) 1998-12-21
EP0988302A1 (de) 2000-03-29
DK0988302T3 (da) 2003-06-02
JP2002502403A (ja) 2002-01-22
SI0988302T1 (en) 2003-08-31
PT988302E (pt) 2003-07-31
EP0988302B1 (de) 2003-02-19
US6384047B1 (en) 2002-05-07
ES2193539T3 (es) 2003-11-01
DE69811492T2 (de) 2004-02-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NYCOMED GMBH, 78467 KONSTANZ, DE

8339 Ceased/non-payment of the annual fee