DE69738353D1 - Radiometall-bindende peptide analoge - Google Patents
Radiometall-bindende peptide analogeInfo
- Publication number
- DE69738353D1 DE69738353D1 DE69738353T DE69738353T DE69738353D1 DE 69738353 D1 DE69738353 D1 DE 69738353D1 DE 69738353 T DE69738353 T DE 69738353T DE 69738353 T DE69738353 T DE 69738353T DE 69738353 D1 DE69738353 D1 DE 69738353D1
- Authority
- DE
- Germany
- Prior art keywords
- radiometall
- binding peptide
- peptide analog
- peptide
- ligands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2166296P | 1996-07-12 | 1996-07-12 | |
US21662P | 1996-07-12 | ||
PCT/US1997/012084 WO1998002192A1 (en) | 1996-07-12 | 1997-07-11 | Radiometal-binding peptide analogues |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69738353D1 true DE69738353D1 (de) | 2008-01-17 |
DE69738353T2 DE69738353T2 (de) | 2009-09-24 |
Family
ID=21805465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69738353T Expired - Lifetime DE69738353T2 (de) | 1996-07-12 | 1997-07-11 | Radiometall-bindende peptide analoge |
Country Status (8)
Country | Link |
---|---|
US (2) | US6126916A (de) |
EP (1) | EP0975374B1 (de) |
JP (1) | JP3647881B2 (de) |
AT (1) | ATE380038T1 (de) |
AU (1) | AU725827B2 (de) |
DE (1) | DE69738353T2 (de) |
ES (1) | ES2297862T3 (de) |
WO (1) | WO1998002192A1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
US6395255B1 (en) * | 1998-06-15 | 2002-05-28 | Thomas Jefferson University | Radiolabeled vasoactive intestinal peptide analogs for imaging and therapy |
US7833528B2 (en) * | 1998-06-22 | 2010-11-16 | Immunomedics, Inc. | Use of multispecific, non-covalent complexes for targeted delivery of therapeutics |
US7405320B2 (en) | 1998-06-22 | 2008-07-29 | Immunomedics, Inc. | Therapeutic and diagnostic conjugates for use with multispecific antibodies |
US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
US7387772B1 (en) * | 1999-06-22 | 2008-06-17 | Immunimedics, Inc. | Chimeric, human and humanized anti-CSAP monoclonal antibodies |
US7138103B2 (en) | 1998-06-22 | 2006-11-21 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
AU760257B2 (en) * | 1998-12-14 | 2003-05-08 | Palatin Technologies, Inc. | Metallopeptide combinatorial libraries and applications |
AU1623801A (en) * | 1999-11-19 | 2001-05-30 | Palatin Technologies, Inc. | Opioid metallopeptide compositions and methods |
US6693165B2 (en) | 2000-01-18 | 2004-02-17 | Merck & Co., Inc. | Cyclic peptides as potent and selective melanocortin-4 receptor antagonists |
AU2002238106A1 (en) * | 2001-02-13 | 2002-08-28 | Palatin Technologies, Inc. | Melanocortin metallopeptides for treatment of sexual dysfunction |
US7893223B2 (en) | 2001-07-17 | 2011-02-22 | Bracco Imaging S.P.A. | Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy |
WO2003101495A1 (en) * | 2002-05-29 | 2003-12-11 | Immunomedics, Inc. | Methods and compositions for radioimmunotherapy of brain and cns tumors |
US20040022726A1 (en) * | 2002-06-03 | 2004-02-05 | Goldenberg David M. | Methods and compositions for intravesical therapy of bladder cancer |
US20060167229A1 (en) * | 2002-12-18 | 2006-07-27 | Wai Ming Wong | Biologically active peptide conjugates |
AU2003303714B2 (en) * | 2003-01-13 | 2009-02-19 | Bracco Imaging S.P.A. | Improved linkers for radiopharmaceutical compounds |
CA2529027C (en) | 2003-06-13 | 2013-09-10 | Immunomedics, Inc. | D-amino acid peptides |
JP2007524649A (ja) * | 2003-07-29 | 2007-08-30 | イミューノメディクス、インコーポレイテッド | フッ素化炭水化物複合体 |
EP1749026B1 (de) | 2004-05-24 | 2011-11-23 | Institut de Cardiologie de Montréal | Markierte adrenomedullinderivate und deren verwendung zur bilddarstellung und therapie |
WO2005123761A1 (en) * | 2004-06-21 | 2005-12-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | GnRH ANALOGS BACKBONE CYCLIZED THROUGH METAL COMPLEXATION |
BRPI0607486B8 (pt) | 2005-03-03 | 2021-05-25 | Immunomedics Inc | anticorpo humanizado l243 contra hla-dr presente nas células hladr+,composição farmacêutica, kit e uso dos referidos anticorpos. |
EP1700608A1 (de) | 2005-03-10 | 2006-09-13 | Schering AG | Chelate für radioaktiv markierte Konjugate mit einer stabilisierenden Seitenkette |
EP2674440B1 (de) | 2005-12-16 | 2019-07-03 | IBC Pharmaceuticals, Inc. | Polyvalente bioaktive anordnungen auf immunglobulinbasis |
JP5312328B2 (ja) | 2006-09-07 | 2013-10-09 | シーメンス アクチエンゲゼルシヤフト | 減衰調節装置および減衰調節方法 |
CN102143970B (zh) * | 2008-05-27 | 2017-02-08 | 健赞股份有限公司 | α‑促黑素细胞激素的肽类似物 |
TWI394585B (zh) * | 2008-07-25 | 2013-05-01 | Iner Aec Executive Yuan | The magnetic fluid used for the development or treatment of peptides |
US9441013B2 (en) | 2011-05-17 | 2016-09-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Melanocortin 1 receptor ligands and methods of use |
US9290539B2 (en) | 2011-05-17 | 2016-03-22 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Melanotropin ligands for skin care |
US9821023B2 (en) | 2014-06-10 | 2017-11-21 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for the treatment of central nervous system (CNS) disorders and mood disorders |
US20170022252A1 (en) | 2014-06-10 | 2017-01-26 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Novel modulators of melanocortin receptors |
US9814755B2 (en) | 2014-06-10 | 2017-11-14 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for the treatment of depression and anxiety |
BR112017010414A2 (pt) | 2014-11-25 | 2018-05-15 | Bristol-Myers Squibb Company | métodos e composições para radiomarcação com 18f de substâncias biológicas |
US10550157B2 (en) | 2015-10-16 | 2020-02-04 | Arizona Board Of Regent On Behalf Of The University Of Arizona | Compositions and methods for treating central nervous system (CNS) disorders and mood disorders |
LT3458111T (lt) | 2016-05-19 | 2021-05-25 | Bristol-Myers Squibb Company | Pet vizualizacijos imunomoduliatoriai |
WO2017210335A1 (en) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Imaging methods using 18f-radiolabeled biologics |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3162537D1 (en) * | 1980-12-19 | 1984-04-12 | Nihon Mediphysics Co Ltd | 3-aminomethylene-2,4-pentanedione bis(thiosemicarbazone) derivatives, and their production and use |
US4822890A (en) * | 1983-05-20 | 1989-04-18 | Hoffmann-La Roche Inc. | Method for the production of amino terminus protected naturally occurring amino acids |
US5227474A (en) * | 1987-02-13 | 1993-07-13 | Abbott Laboratories | Bifunctional chelating agents |
DE69018226T2 (de) * | 1989-07-20 | 1995-09-21 | Sandoz-Patent-Gmbh, 79539 Loerrach | Markierte polypeptidderivate. |
US5080884A (en) * | 1989-12-12 | 1992-01-14 | Medi-Physics, Inc. | Hydrocarbylphenyl diaminodithiol radionuclide complexes and their use in imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
AU656230B2 (en) * | 1991-10-11 | 1995-01-27 | F. Hoffmann-La Roche Ag | Cyclic vasoactive peptides |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
CA2363780C (en) * | 1993-04-08 | 2003-01-07 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
EP0697884B1 (de) * | 1993-05-14 | 1999-11-17 | Mallinckrodt Inc. | Die vorstufe eines liganden zum einbau in peptide |
US5449761A (en) * | 1993-09-28 | 1995-09-12 | Cytogen Corporation | Metal-binding targeted polypeptide constructs |
US5746996A (en) * | 1994-06-03 | 1998-05-05 | Immunomedics, Inc. | Thiolation of peptides for radionuclide-based radiodetection and radiotherapy |
IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
US5539138A (en) * | 1994-07-28 | 1996-07-23 | Merck Frosst Canada, Inc. | High affinity chelates containing isothiocyanate groups, useful for coupling with peptides and proteins |
US5556939A (en) * | 1994-10-13 | 1996-09-17 | Merck Frosst Canada, Inc. | TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications |
US5753206A (en) * | 1995-06-07 | 1998-05-19 | Immunomedics, Inc. | Radiometal-binding analogues of luteinizing hormone releasing hormone |
-
1997
- 1997-07-11 WO PCT/US1997/012084 patent/WO1998002192A1/en active IP Right Grant
- 1997-07-11 JP JP50617198A patent/JP3647881B2/ja not_active Expired - Fee Related
- 1997-07-11 AT AT97934115T patent/ATE380038T1/de active
- 1997-07-11 ES ES97934115T patent/ES2297862T3/es not_active Expired - Lifetime
- 1997-07-11 AU AU37249/97A patent/AU725827B2/en not_active Ceased
- 1997-07-11 DE DE69738353T patent/DE69738353T2/de not_active Expired - Lifetime
- 1997-07-11 US US08/893,749 patent/US6126916A/en not_active Expired - Lifetime
- 1997-07-11 EP EP97934115A patent/EP0975374B1/de not_active Expired - Lifetime
-
2000
- 2000-10-02 US US09/676,783 patent/US7045503B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1998002192A1 (en) | 1998-01-22 |
US6126916A (en) | 2000-10-03 |
US7045503B1 (en) | 2006-05-16 |
DE69738353T2 (de) | 2009-09-24 |
ES2297862T3 (es) | 2008-05-01 |
JP3647881B2 (ja) | 2005-05-18 |
AU3724997A (en) | 1998-02-09 |
EP0975374A1 (de) | 2000-02-02 |
ATE380038T1 (de) | 2007-12-15 |
AU725827B2 (en) | 2000-10-19 |
JP2000515514A (ja) | 2000-11-21 |
EP0975374B1 (de) | 2007-12-05 |
EP0975374A4 (de) | 2004-05-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |