DE69734238D1 - Automatisierte kalibrierungsvorrichtung für flüssigkeitstrennung/massenspektrometrie - Google Patents

Automatisierte kalibrierungsvorrichtung für flüssigkeitstrennung/massenspektrometrie

Info

Publication number
DE69734238D1
DE69734238D1 DE69734238T DE69734238T DE69734238D1 DE 69734238 D1 DE69734238 D1 DE 69734238D1 DE 69734238 T DE69734238 T DE 69734238T DE 69734238 T DE69734238 T DE 69734238T DE 69734238 D1 DE69734238 D1 DE 69734238D1
Authority
DE
Germany
Prior art keywords
mass spectrometry
liquid separation
calibration device
automated calibration
automated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69734238T
Other languages
English (en)
Other versions
DE69734238T2 (de
Inventor
Steven M Fischer
Robert Nordman
Mark H Werlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Agilent Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agilent Technologies Inc filed Critical Agilent Technologies Inc
Application granted granted Critical
Publication of DE69734238D1 publication Critical patent/DE69734238D1/de
Publication of DE69734238T2 publication Critical patent/DE69734238T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0009—Calibration of the apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
DE69734238T 1996-08-30 1997-07-21 Automatisierte kalibrierungsvorrichtung für flüssigkeitstrennung/massenspektrometrie Expired - Lifetime DE69734238T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/706,390 US5703360A (en) 1996-08-30 1996-08-30 Automated calibrant system for use in a liquid separation/mass spectrometry apparatus
US706390 1996-08-30
PCT/US1997/012726 WO1998009315A1 (en) 1996-08-30 1997-07-21 Automated calibrant system for use in a liquid separation/mass spectrometry apparatus

Publications (2)

Publication Number Publication Date
DE69734238D1 true DE69734238D1 (de) 2005-10-27
DE69734238T2 DE69734238T2 (de) 2006-06-29

Family

ID=24837347

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69734238T Expired - Lifetime DE69734238T2 (de) 1996-08-30 1997-07-21 Automatisierte kalibrierungsvorrichtung für flüssigkeitstrennung/massenspektrometrie

Country Status (4)

Country Link
US (1) US5703360A (de)
EP (1) EP0906638B1 (de)
DE (1) DE69734238T2 (de)
WO (1) WO1998009315A1 (de)

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EP1137046A2 (de) * 2000-03-13 2001-09-26 Agilent Technologies Inc. a Delaware Corporation Herstellung von Hochpräzisionsmultipolen und -filtern
US6727498B2 (en) * 2000-10-04 2004-04-27 University Of South Florida Portable underwater mass spectrometer
US20030196695A1 (en) 2000-11-06 2003-10-23 Nanostream, Inc. Microfluidic flow control devices
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6974951B1 (en) 2001-01-29 2005-12-13 Metara, Inc. Automated in-process ratio mass spectrometry
US7220383B2 (en) 2001-07-13 2007-05-22 Metara, Inc. Method and instrument for automated analysis of fluid-based processing systems
US7531134B1 (en) 2002-03-08 2009-05-12 Metara, Inc. Method and apparatus for automated analysis and characterization of chemical constituents of process solutions
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
WO2004015411A1 (en) 2002-08-08 2004-02-19 Nanostream, Inc. Systems and methods for high-throughput microfluidic sample analysis
US7214320B1 (en) 2002-08-08 2007-05-08 Nanostream, Inc. Systems and methods for high throughput sample analysis
US6987263B2 (en) 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
US7178386B1 (en) 2003-04-10 2007-02-20 Nanostream, Inc. Parallel fluid processing systems and methods
US7385190B2 (en) * 2005-11-16 2008-06-10 Agilent Technologies, Inc. Reference mass introduction via a capillary
FR2910966B1 (fr) * 2006-12-28 2009-04-17 Commissariat Energie Atomique Dispositif de mesures couplees permettant un suivi global et en continu de traces de goudrons presentes dans un flux gazeux
FR2910967B1 (fr) * 2006-12-28 2009-04-03 Commissariat Energie Atomique Dispositif et procede de mesure continue de la concentration en goudrons dans un flux gazeux
ES2436744T3 (es) * 2007-08-24 2014-01-07 Emd Millipore Corporation Sistema para derivar un eluyente de cromatografía de líquidos
EP2181326A2 (de) * 2007-08-24 2010-05-05 Millipore Corporation Verfahren zur erkennung abbaubarer filterelemente in biopharmazeutischen produkten durch flüssigchromatographische massenspektrometrie
US8039789B2 (en) * 2007-11-19 2011-10-18 Illinois Tool Works Inc. Method and apparatus for self calibrating meter movement for ionization power supplies
DE102009017648A1 (de) * 2009-04-16 2010-10-21 Siemens Aktiengesellschaft Gasinjektionssystem und Verfahren zum Betrieb eines Gasinjektionssystems, insbesondere für eine Partikeltherapieanlage
US8373117B2 (en) * 2010-02-26 2013-02-12 Dh Technologies Development Pte. Ltd. Gas delivery system for mass spectrometer reaction and collision cells
EP2539919B1 (de) * 2010-02-26 2018-07-11 Zoex Corporation Gepulste massenkalibrierung eines flugzeit-massenspektrometers
GB201106689D0 (en) * 2011-04-20 2011-06-01 Micromass Ltd Function switching with fast asynchronous acquisition
EP2741312A1 (de) * 2012-12-05 2014-06-11 Tofwerk AG Verfahren zur Kalibrierung von Messungen des Masse-zu-Ladung-Verhältnisses aus einem Spektrometer, das in Fluidverbindung mit einem Analysesystem verbunden ist welches eine zeitlich wechselnde Probe bereitstellt
US8975573B2 (en) * 2013-03-11 2015-03-10 1St Detect Corporation Systems and methods for calibrating mass spectrometers
US9842727B2 (en) 2013-09-20 2017-12-12 Micromass Uk Limited Automated beam check
US9746450B2 (en) * 2014-04-15 2017-08-29 Rosemount Analytical Inc. Online gas chromatograph operation with reduced usage of calibration gas
US9356434B2 (en) 2014-08-15 2016-05-31 Illinois Tool Works Inc. Active ionization control with closed loop feedback and interleaved sampling
US10529548B2 (en) 2015-09-29 2020-01-07 Shimadzu Corporation Liquid sample introduction system for ion source
WO2017056182A1 (ja) 2015-09-29 2017-04-06 株式会社島津製作所 イオン源用液体試料導入システム及び分析システム
JP6455607B2 (ja) * 2015-12-04 2019-01-23 株式会社島津製作所 液体試料分析システム
US11309173B2 (en) * 2017-08-10 2022-04-19 Shimadzu Corporation Liquid sample introduction method and liquid sample introduction device
US10600626B1 (en) 2018-12-14 2020-03-24 Thermos Finnigan Llc Mass calibration device for a mass spectrometer
CN113383232B (zh) * 2019-02-04 2023-09-19 株式会社日立高新技术 液相色谱质量分析装置
US11764049B2 (en) * 2020-04-14 2023-09-19 Waters Technologies Corporation Coaxial introduction of calibrant in a flow path with analyte to an ion source

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US4207465A (en) * 1978-07-03 1980-06-10 Phillips Petroleum Company Isotope analysis with a mass spectrometer using small samples
US4260886A (en) * 1979-09-07 1981-04-07 Rca Corporation Measurement of a gas constituent by a mass spectrometer
US4495414A (en) * 1981-11-30 1985-01-22 V.G. Isogas Limited Automatic mass spectrometer inlet system
GB8720586D0 (en) * 1987-09-02 1987-10-07 Vg Instr Group Apparatus & method
US4866270A (en) * 1987-09-02 1989-09-12 Vg Instruments Group Limited Method and apparatus for the determination of isotopic composition
US4847493A (en) * 1987-10-09 1989-07-11 Masstron, Inc. Calibration of a mass spectrometer
JP2892795B2 (ja) * 1989-09-12 1999-05-17 エーザイ株式会社 高速液体クロマトグラフィー質量分析における移動相の変換方法と装置
US5175431A (en) * 1991-03-22 1992-12-29 Georgia Tech Research Corporation High pressure selected ion chemical ionization interface for connecting a sample source to an analysis device
US5245185A (en) * 1991-11-05 1993-09-14 Georgia Tech Research Corporation Interface device and process to couple planar electrophoresis with spectroscopic methods of detection

Also Published As

Publication number Publication date
EP0906638A1 (de) 1999-04-07
DE69734238T2 (de) 2006-06-29
WO1998009315A1 (en) 1998-03-05
EP0906638B1 (de) 2005-09-21
US5703360A (en) 1997-12-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AGILENT TECHNOLOGIES, INC. (N.D.GES.D. STAATES, US