DE69731213T2 - 2-methoxyestradiol-induzierte apoptosis in krebszellen - Google Patents
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US688613 | 1996-07-30 | ||
| US08/688,613 US5958892A (en) | 1996-07-30 | 1996-07-30 | 2-methoxyestradiol-induced apoptosis in cancer cells |
| PCT/US1997/012998 WO1998004291A1 (en) | 1996-07-30 | 1997-07-24 | 2-methoxyestradiol-induced apoptosis in cancer cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69731213D1 DE69731213D1 (de) | 2004-11-18 |
| DE69731213T2 true DE69731213T2 (de) | 2006-02-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69731213T Expired - Fee Related DE69731213T2 (de) | 1996-07-30 | 1997-07-24 | 2-methoxyestradiol-induzierte apoptosis in krebszellen |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5958892A (enExample) |
| EP (1) | EP0921821B1 (enExample) |
| JP (1) | JP2000517299A (enExample) |
| AT (1) | ATE279212T1 (enExample) |
| AU (1) | AU723401B2 (enExample) |
| CA (1) | CA2262533A1 (enExample) |
| DE (1) | DE69731213T2 (enExample) |
| WO (1) | WO1998004291A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5504074A (en) * | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
| US20040214807A1 (en) * | 1993-08-06 | 2004-10-28 | D'amato Robert J. | Estrogenic compounds as anti-mitotic agents |
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| US20030064949A1 (en) * | 1998-02-17 | 2003-04-03 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| US20030060434A1 (en) * | 1997-02-18 | 2003-03-27 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| KR20010086073A (ko) * | 1998-12-02 | 2001-09-07 | 데이비드 존 우드 | ｐ53계 단백질의 배좌 안정성을 회복하기 위한 방법 및조성물 |
| US6548541B1 (en) * | 1999-04-21 | 2003-04-15 | Unitech Pharmaceuticals, Inc. | Carboplatin analogs for cancer treatment |
| US6730665B1 (en) | 1999-05-12 | 2004-05-04 | Mayo Foundation For Medical Education And Research | Treatment of bone cancer |
| AU5010500A (en) * | 1999-05-12 | 2000-11-21 | Mayo Foundation For Medical Education And Research | Treatment of bone cancer |
| US7087592B1 (en) * | 1999-08-23 | 2006-08-08 | Entre Med, Inc. | Compositions comprising purified 2-methoxyestradiol and methods of producing same |
| US6518261B2 (en) * | 2000-03-17 | 2003-02-11 | Oncology Sciences Corporation | Use of eugenol in combination with other chemopreventative agents as prophylaxis for cancers |
| US7135581B2 (en) * | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
| US6995278B2 (en) * | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
| US20050192258A1 (en) * | 2000-08-18 | 2005-09-01 | Agoston Gregory E. | Antiangiogenic agents |
| US7691567B2 (en) | 2000-10-30 | 2010-04-06 | Board Of Regents, The University Of Texas System | Methods and compositions relating to fortilin, an anti-apoptotic molecule, and modulators of fortilin |
| WO2002062348A1 (en) * | 2001-02-05 | 2002-08-15 | Oncology Sciences Corporation | Eugenol, optionally in combination with 2-methoxyestradiol, as a cancer chemopreventative agent |
| DE60213386T2 (de) * | 2001-03-30 | 2006-11-23 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Geldanamycinderivate zur krebsbehandlung |
| US20030236439A1 (en) * | 2002-01-30 | 2003-12-25 | Gregory Agoston | Non-steroidal analogs of 2-methoxyestradiol |
| WO2003073985A2 (en) * | 2002-03-01 | 2003-09-12 | Entremed, Inc. | New methods of using antiangiogenic agents |
| CA2479665C (en) * | 2002-03-20 | 2011-08-30 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
| BR0312664A (pt) | 2002-07-18 | 2005-05-03 | Helix Biopharma Corp | Composição farmacêutica e uso da enzima urease para a fabricação de um medicamento para o tratamento de células cancerìgenas em um indivìduo |
| KR20050057086A (ko) | 2002-08-28 | 2005-06-16 | 홀리스-에덴 파마슈티칼즈, 인코포레이티드 | 치료적 처치 방법 |
| EP1587519A4 (en) * | 2003-01-10 | 2006-05-31 | Threshold Pharmaceuticals Inc | Treatment of cancer with 2-deoxyglucose |
| US7160908B2 (en) * | 2003-03-04 | 2007-01-09 | Unitech Pharmaceuticals, Inc. | Dynamic anticancer platinum compounds |
| WO2005030120A2 (en) * | 2003-05-28 | 2005-04-07 | Entremed, Inc. | Antiangiogenic agents |
| US20070004689A1 (en) * | 2004-03-12 | 2007-01-04 | Agoston Gregory E | Antiangiogenic agents |
| EP1756139A4 (en) | 2004-03-12 | 2009-07-29 | Entremed Inc | ANTI-ANGIOGENIC AGENTS |
| KR20070057240A (ko) * | 2004-09-13 | 2007-06-04 | 피알 파마슈티칼스, 인크. | 장시간 작용하고 주사가능한 에스트라디올 대사산물의 결정제제 및 이를 사용하는 방법 |
| EP1819343A2 (en) * | 2004-11-29 | 2007-08-22 | EntreMed, Inc. | A method of administering anti-angiogenic agents and a method of treating disease using same |
| WO2007059111A2 (en) * | 2005-11-14 | 2007-05-24 | Entremed, Inc. | Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents |
| US20070176403A1 (en) * | 2006-02-01 | 2007-08-02 | Dennis Calderone | Air adjustable seat |
| WO2007097839A2 (en) * | 2006-02-16 | 2007-08-30 | Massachusetts Eye And Ear Infirmary | Ansamycin analogs or heat shock 90 inhibitors in combination with pdt treatin conditions of the eye |
| CA2646065C (en) * | 2006-03-20 | 2014-01-14 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
| WO2008094665A1 (en) * | 2007-01-31 | 2008-08-07 | Entremed, Inc. | Method of treating amyloidosis mediated diseases |
| WO2008150550A1 (en) * | 2007-06-05 | 2008-12-11 | Cornell University | Compounds for enhancing p21 expression and methods of use thereof |
| KR20090009637A (ko) * | 2007-07-20 | 2009-01-23 | 삼성전자주식회사 | 엠비-오에프디엠 시스템 및 프레임 바운더리 검출 방법 |
| MX388453B (es) * | 2015-10-08 | 2025-03-20 | Univ Utah Res Found | Composiciones para usarse en el tratamiento de cáncer. |
| KR101837735B1 (ko) * | 2016-08-08 | 2018-04-19 | 성균관대학교산학협력단 | TCTP (Translationally controlled tumour protein) 단백질을 포함하는 난모세포(oocytes) 노화 방지 또는 수정능력 개선용 조성물 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5532220A (en) | 1987-08-31 | 1996-07-02 | The Regents Of The University Of California | Genetic mechanisms of tumor suppression |
| EP0440744B1 (en) | 1988-10-31 | 1997-12-10 | The Regents Of The University Of California | Products and methods for controlling the suppression of the neoplastic phenotype |
| US5527676A (en) | 1989-03-29 | 1996-06-18 | The Johns Hopkins University | Detection of loss of the wild-type P53 gene and kits therefor |
| DE69032864T3 (de) | 1989-03-29 | 2013-01-31 | The Johns Hopkins University | Nachweis des Ausfalls des Wildtyps des p53-Gens |
| IE911115A1 (en) | 1990-04-10 | 1991-10-23 | Canji Inc | Gene therapy for cell proliferative diseases |
| US5747469A (en) * | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| US6410010B1 (en) * | 1992-10-13 | 2002-06-25 | Board Of Regents, The University Of Texas System | Recombinant P53 adenovirus compositions |
| DK0648271T3 (da) | 1991-08-20 | 2003-07-21 | Us Gov Health & Human Serv | Adenovirusmedieret overførsel af gener til mave-/tarmkanal |
| FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| DK0931830T3 (da) | 1993-02-16 | 2001-06-11 | Onyx Pharma Inc | Cytopatiske vira til terapi og profylakse af neoplasi |
| FR2704234B1 (fr) | 1993-04-22 | 1995-07-21 | Centre Nat Rech Scient | Virus recombinants, preparation et utilisation en therapie genique. |
| US5643900A (en) | 1993-07-02 | 1997-07-01 | Fotsis; Theodore | Method for treatment of pathological conditions associated with angiogenesis and preparation therefor |
| FI951138L (fi) | 1993-07-13 | 1995-04-13 | Rhone Poulenc Rorer Sa | Puuttellisia adenovirusvektoreita ja niiden käyttö geeniterapiassa |
| US5504074A (en) | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
| FR2712603B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
| FR2712602B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
| FR2716893B1 (fr) | 1994-03-03 | 1996-04-12 | Rhone Poulenc Rorer Sa | Virus recombinants, leur préparation et leur utilisation thérapeutique. |
-
1996
- 1996-07-30 US US08/688,613 patent/US5958892A/en not_active Expired - Fee Related
-
1997
- 1997-07-24 JP JP10508981A patent/JP2000517299A/ja not_active Ceased
- 1997-07-24 EP EP97934286A patent/EP0921821B1/en not_active Expired - Lifetime
- 1997-07-24 CA CA002262533A patent/CA2262533A1/en not_active Abandoned
- 1997-07-24 DE DE69731213T patent/DE69731213T2/de not_active Expired - Fee Related
- 1997-07-24 AU AU37383/97A patent/AU723401B2/en not_active Ceased
- 1997-07-24 WO PCT/US1997/012998 patent/WO1998004291A1/en not_active Ceased
- 1997-07-24 AT AT97934286T patent/ATE279212T1/de not_active IP Right Cessation
-
1999
- 1999-07-09 US US09/351,191 patent/US6410029B1/en not_active Expired - Fee Related
-
2002
- 2002-06-25 US US10/180,893 patent/US20030099614A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE279212T1 (de) | 2004-10-15 |
| JP2000517299A (ja) | 2000-12-26 |
| WO1998004291A1 (en) | 1998-02-05 |
| EP0921821A1 (en) | 1999-06-16 |
| AU723401B2 (en) | 2000-08-24 |
| AU3738397A (en) | 1998-02-20 |
| US20030099614A1 (en) | 2003-05-29 |
| DE69731213D1 (de) | 2004-11-18 |
| EP0921821B1 (en) | 2004-10-13 |
| US6410029B1 (en) | 2002-06-25 |
| US5958892A (en) | 1999-09-28 |
| CA2262533A1 (en) | 1998-02-05 |
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Legal Events
| Date | Code | Title | Description |
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| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |