DE69730011D1 - Herstellung einer Martix von hoher Dichte, sowie Verfahren zur Wiedergabe für einen fiberoptischen Biosensor - Google Patents

Herstellung einer Martix von hoher Dichte, sowie Verfahren zur Wiedergabe für einen fiberoptischen Biosensor

Info

Publication number
DE69730011D1
DE69730011D1 DE69730011T DE69730011T DE69730011D1 DE 69730011 D1 DE69730011 D1 DE 69730011D1 DE 69730011 T DE69730011 T DE 69730011T DE 69730011 T DE69730011 T DE 69730011T DE 69730011 D1 DE69730011 D1 DE 69730011D1
Authority
DE
Germany
Prior art keywords
fibers
binding
sensor
optical
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69730011T
Other languages
English (en)
Other versions
DE69730011T2 (de
Inventor
Daniel Pinkel
Richard Segraves
Ye Zhai
G Albertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE69730011D1 publication Critical patent/DE69730011D1/de
Publication of DE69730011T2 publication Critical patent/DE69730011T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/04—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G01N2201/0833—Fibre array at detector, resolving

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Plasma & Fusion (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
DE69730011T 1996-01-26 1997-01-24 Herstellung einer Martix von hoher Dichte, sowie Verfahren zur Wiedergabe für einen fiberoptischen Biosensor Expired - Lifetime DE69730011T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US592779 1996-01-26
US08/592,779 US5837196A (en) 1996-01-26 1996-01-26 High density array fabrication and readout method for a fiber optic biosensor
PCT/US1997/001052 WO1997027326A1 (en) 1996-01-26 1997-01-24 High density array fabrication and readout method for a fiber optic biosensor

Publications (2)

Publication Number Publication Date
DE69730011D1 true DE69730011D1 (de) 2004-09-02
DE69730011T2 DE69730011T2 (de) 2005-07-21

Family

ID=24372036

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69730011T Expired - Lifetime DE69730011T2 (de) 1996-01-26 1997-01-24 Herstellung einer Martix von hoher Dichte, sowie Verfahren zur Wiedergabe für einen fiberoptischen Biosensor

Country Status (6)

Country Link
US (1) US5837196A (de)
EP (1) EP0879299B1 (de)
JP (1) JP4029921B2 (de)
AT (1) ATE272212T1 (de)
DE (1) DE69730011T2 (de)
WO (1) WO1997027326A1 (de)

Families Citing this family (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534567B2 (en) * 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
JP2002511934A (ja) 1997-06-18 2002-04-16 ウルリッヒ・ジェイ・クルール 核酸バイオセンサ診断装置
US7348181B2 (en) * 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
JP2002502977A (ja) * 1998-02-04 2002-01-29 インビトロジェン コーポレイション マイクロアレイとその使用
CA2328609A1 (en) 1998-05-16 1999-11-25 Pe Corporation (Ny) Instrument for monitoring polymerase chain reaction of dna
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
EP1090286A1 (de) * 1998-06-24 2001-04-11 Therasense, Inc. Mehrfacher sensorgruppe zur electrochemischer erkennung von nukleotidsequenzen und verfahren
EP1090293B2 (de) 1998-06-24 2019-01-23 Illumina, Inc. Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US6608671B2 (en) * 1998-07-17 2003-08-19 Vertex Pharmaceuticals (San Diego) Llc Detector and screening device for ion channels
US6349160B2 (en) 1998-07-24 2002-02-19 Aurora Biosciences Corporation Detector and screening device for ion channels
IL126727A (en) 1998-10-22 2006-12-31 Given Imaging Ltd A method of bringing a device to the goal
US6129896A (en) * 1998-12-17 2000-10-10 Drawn Optical Components, Inc. Biosensor chip and manufacturing method
US7612020B2 (en) 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
US6514768B1 (en) * 1999-01-29 2003-02-04 Surmodics, Inc. Replicable probe array
US20030148360A1 (en) * 1999-01-29 2003-08-07 Surmodics, Inc. Replicable probe array
US7097973B1 (en) * 1999-06-14 2006-08-29 Alpha Mos Method for monitoring molecular species within a medium
US6274320B1 (en) * 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
EP1226437B1 (de) * 1999-11-03 2004-08-11 International Business Machines Corporation Sensoren und wandler mit freitragendem ausleger
US6254830B1 (en) 1999-11-05 2001-07-03 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Magnetic focusing immunosensor for the detection of pathogens
EE9900442A (et) * 1999-11-29 2001-08-15 Tartu Ülikool Bioloogiliselt aktiivne materjal
AU2001227020A1 (en) * 2000-01-19 2001-07-31 Given Imaging Ltd. A system for detecting substances
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
DE10053394C2 (de) * 2000-02-28 2003-03-20 Variom Biotechnology Ag Bauteil mit einer Mehrzahl von Fiberelementen und an den Fiberelementen immobilisierten Probenmolekülen
US20030162232A1 (en) * 2000-02-28 2003-08-28 Derya Ozkan Component comprising a plurality of fiber elements and sample molecules that are immobilized on said fiber elements
EP1305605A2 (de) * 2000-02-28 2003-05-02 Variom Biotechnology AG Bauteil zur interaktionsanalyse mit kooperationseffekte ausbildenden probenmolekülspezies
FR2806481B1 (fr) * 2000-03-17 2002-10-25 Alain Pompidou Dispositif d'analyse et/ou de traitement in situ constitue d'une tige souple et d'un micro-systeme fixe a une extremite de ladite tige souple
PT1358481E (pt) 2000-03-17 2004-11-30 Alain Pompidou Dispositivo de analise e/ou de tratamento in situ, constituido por uma haste flexivel e por um microsistema fixo a uma extremidade da referida haste flexivel
CA2403427C (en) * 2000-03-22 2013-04-30 M. Cynthia Goh Method and apparatus for assay for multiple analytes
US7244572B1 (en) 2000-03-24 2007-07-17 Wisys Technology Foundation, Inc. One-dimensional arrays on optical fibers
AU2001252973A1 (en) 2000-04-17 2001-10-30 Purdue Research Foundation Biosensor and related method
US7435579B2 (en) * 2000-04-17 2008-10-14 Purdue Research Foundation Biosensor and related method
US7306924B2 (en) * 2000-04-17 2007-12-11 Purdue Research Foundation Biosensor and related method
ATE418733T1 (de) * 2000-05-04 2009-01-15 Blood Res Center Kolloidzusammensetzungen für festphasen- biomolekulare analytische systeme
AU2001271662B2 (en) * 2000-06-28 2006-07-27 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US6539102B1 (en) * 2000-09-01 2003-03-25 Large Scale Proteomics Reference database
US6980674B2 (en) * 2000-09-01 2005-12-27 Large Scale Proteomics Corp. Reference database
JP2002098696A (ja) 2000-09-26 2002-04-05 Inst Of Physical & Chemical Res 集積型生体分子センサー
US6706479B2 (en) 2000-10-05 2004-03-16 Virginia Tech Intellectual Properties, Inc. Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips
DE10053472B4 (de) * 2000-10-24 2005-06-09 Origen Biotechnology Ag Vorrichtung und Verfahren zur kombinatorischen Immobilisierung von Probenmolekülen auf Fiberelementen
US20020137074A1 (en) * 2000-11-21 2002-09-26 Piunno Paul A.E. Selectivity of nucleic acid diagnostic and microarray technologies by control of interfacial nucleic acid film chemistry
US20030009293A1 (en) * 2001-01-09 2003-01-09 Anderson Norman G. Reference database
CA2450632A1 (en) * 2001-01-12 2002-07-18 Toray Industries, Inc. Selectively hybridizable substance immobilization fiber, fiber array compsiring bundle of such fibers, selective hybridizing method, device therefor, and base
US7407746B2 (en) * 2001-02-08 2008-08-05 Ngk Insulators, Ltd. Biochip and method for producing the same
US8323956B2 (en) * 2001-06-01 2012-12-04 Colorado State University Research Foundation Distal tip of biosensor transducer comprising enzyme for deamination
US9493806B2 (en) * 2001-06-01 2016-11-15 Colorado State University Research Foundation Enzymatic biosensing systems
AU2002356499A1 (en) * 2001-06-01 2003-04-01 Colorado State University Research Foundation Optical biosensor with enhanced activity retention for detection of halogenated organic compounds
US9493805B2 (en) * 2001-06-01 2016-11-15 Colorado State University Research Foundation Enzymatic biosensors with enhanced activity retention for detection of organic compounds
US7998065B2 (en) 2001-06-18 2011-08-16 Given Imaging Ltd. In vivo sensing device with a circuit board having rigid sections and flexible sections
US6662091B2 (en) 2001-06-29 2003-12-09 Battelle Memorial Institute Diagnostics/prognostics using wireless links
US6889165B2 (en) 2001-07-02 2005-05-03 Battelle Memorial Institute Application specific intelligent microsensors
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
WO2003006676A2 (en) 2001-07-13 2003-01-23 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
JP2005528582A (ja) * 2001-09-07 2005-09-22 コーニング インコーポレイテッド ハイスループット分析のためのマイクロカラム・プラットフォームに基づくアレイ
EP1434994A2 (de) * 2001-09-13 2004-07-07 Axela Biosensors Inc. Verfahren und apparat für lichtdiffraktion basiertes testverfahren
US7662094B2 (en) 2002-05-14 2010-02-16 Given Imaging Ltd. Optical head assembly with dome, and device for use thereof
US6790632B2 (en) * 2002-06-17 2004-09-14 Stephen Eliot Zweig Membrane receptor reagent and assay
US7288368B2 (en) * 2002-06-17 2007-10-30 Stephen Eliot Zweig Membrane receptor reagent and assay
DE60332944D1 (de) 2002-08-13 2010-07-22 Given Imaging Ltd System für die probenahme und analyse in vivo
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
US20040132173A1 (en) * 2002-08-28 2004-07-08 Kimon Angelides Optical fiber array device capable of simultaneously performing multiple functional assays
WO2004028336A2 (en) * 2002-09-30 2004-04-08 Given Imaging Ltd. Reduced size imaging device
US8449452B2 (en) * 2002-09-30 2013-05-28 Given Imaging Ltd. In-vivo sensing system
JP4746876B2 (ja) 2002-10-15 2011-08-10 ギブン イメージング リミテッド 移動装置に信号を転送するための装置、システムおよび方法
IL159113A (en) * 2002-11-27 2008-11-26 Given Imaging Ltd Method and device for imaging when the device has a cover made of fibers
JP2006512130A (ja) 2002-12-26 2006-04-13 ギブン・イメージング・リミテツド 不動化可能な生体内センシング装置
WO2004059568A1 (en) * 2002-12-26 2004-07-15 Given Imaging Ltd. In vivo imaging device and method of manufacture thereof
US7887752B2 (en) 2003-01-21 2011-02-15 Illumina, Inc. Chemical reaction monitor
CA2525482C (en) * 2003-04-04 2015-02-17 F. Hoffmann-La Roche Ag Improved system for multicolor real-time pcr comprising 3 to 6 pairs of forester resonance energy transfer (fret) probes
CN2662247Y (zh) * 2003-04-25 2004-12-08 谭玉山 基于白光反射干涉频谱变化规律的光纤阵列生物芯片
DE10322443A1 (de) * 2003-05-19 2004-12-30 PRO DESIGN Gesellschaft für Produktentwicklung mbH Multifunktioneller Reader für Biochips
US20050112587A1 (en) * 2003-11-25 2005-05-26 Sherrill James V. Analyzing biological probes
WO2005079474A2 (en) * 2004-02-17 2005-09-01 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
DE102004008319B4 (de) * 2004-02-17 2006-11-02 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Kontinuierlich arbeitendes eindimensionales Festphasenreaktor-System
JP2008512984A (ja) * 2004-05-28 2008-05-01 ダナ−ファーバー キャンサー インスティチュート，インコーポレイテッド 癌の同定、評価、予防および治療のための組成物、キットおよび方法
EP2471922A1 (de) 2004-05-28 2012-07-04 Asuragen, Inc. Verfahren und Zusammensetzungen mit microRNA
US7643865B2 (en) * 2004-06-30 2010-01-05 Given Imaging Ltd. Autonomous in-vivo device
US7596403B2 (en) 2004-06-30 2009-09-29 Given Imaging Ltd. System and method for determining path lengths through a body lumen
US7697807B2 (en) * 2006-06-01 2010-04-13 Ut-Battelle, Llc Multi-tipped optical component
US7697808B2 (en) * 2004-07-27 2010-04-13 Ut-Battelle, Llc Multi-tipped optical component
US20060095093A1 (en) * 2004-11-04 2006-05-04 Ido Bettesh Apparatus and method for receiving device selection and combining
US8173611B2 (en) 2004-11-12 2012-05-08 Asuragen Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
US8738106B2 (en) * 2005-01-31 2014-05-27 Given Imaging, Ltd Device, system and method for in vivo analysis
IL174531A0 (en) * 2005-04-06 2006-08-20 Given Imaging Ltd System and method for performing capsule endoscopy diagnosis in remote sites
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US8340944B2 (en) 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US7827042B2 (en) 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
US10296720B2 (en) 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
US7927787B2 (en) 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US20080103746A1 (en) 2005-11-30 2008-05-01 Searete Llc, A Limited Liability Corporation Systems and methods for pathogen detection and response
US20080241000A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for pathogen detection
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
US20080312502A1 (en) * 2005-12-02 2008-12-18 Christopher Paul Swain System and Device for in Vivo Procedures
US20070167834A1 (en) * 2005-12-29 2007-07-19 Amit Pascal In-vivo imaging optical device and method
US9320417B2 (en) 2005-12-29 2016-04-26 Given Imaging Ltd. In-vivo optical imaging device with backscatter blocking
US20070156051A1 (en) * 2005-12-29 2007-07-05 Amit Pascal Device and method for in-vivo illumination
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
EP2007433B1 (de) * 2006-04-03 2011-10-26 Given Imaging Ltd. Vorrichtung, system und verfahren zur in-vivo-analyse
CA2663962A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
EP2115138A2 (de) 2006-09-19 2009-11-11 Asuragen, Inc. Bei pankreatischen erkrankungen differentiell exprimierte mikro-rnas und verwendungen davon
US20080181816A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Systems for allergen detection
US8617903B2 (en) * 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US10001496B2 (en) 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US20080180259A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for allergen detection
JP4912908B2 (ja) * 2007-02-13 2012-04-11 国立大学法人浜松医科大学 バイオセンサ形イメージングファイバ装置
US20090215157A1 (en) * 2007-03-27 2009-08-27 Searete Llc Methods for pathogen detection
US9796998B2 (en) 2007-04-09 2017-10-24 Colorado State University Research Foundation Oxygenase-based biosensing systems for measurement of halogenated alkene concentrations
EP2201374B1 (de) * 2007-08-30 2015-10-07 Trustees Of Tufts College Verfahren zur bestimmung der konzentration eines analyten in lösung
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US8515507B2 (en) 2008-06-16 2013-08-20 Given Imaging Ltd. Device and method for detecting in-vivo pathology
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
DK3255146T3 (da) 2009-03-16 2019-08-19 Pangu Biopharma Ltd Præparater og fremgangsmåder omfattende histidyl-tRNA-synthetasesplejsningsvarianter med ikke-kanoniske biologiske aktiviteter
US20100310576A1 (en) 2009-03-31 2010-12-09 Adams Ryan A COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
US8516691B2 (en) 2009-06-24 2013-08-27 Given Imaging Ltd. Method of assembly of an in vivo imaging device with a flexible circuit board
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
ES2544635T3 (es) 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
WO2011108930A1 (en) 2010-03-04 2011-09-09 Interna Technologies Bv A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS DIAGNOSTIC AND THERAPEUTIC USES IN DISEASES OR CONDITIONS ASSOCIATED WITH EMT
US8980253B2 (en) 2010-04-26 2015-03-17 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
CN103096911B (zh) 2010-04-27 2018-05-29 Atyr 医药公司 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
AU2011248489B2 (en) 2010-04-28 2016-10-06 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl tRNA synthetases
EP2563383B1 (de) 2010-04-29 2017-03-01 Atyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von valyl-trna-synthetasen
CN103097523B (zh) 2010-04-29 2016-09-28 Atyr医药公司 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2800557A1 (en) 2010-04-29 2011-11-03 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy
WO2011150279A2 (en) 2010-05-27 2011-12-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
EP2566496B1 (de) 2010-05-03 2018-02-28 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von methionyl-trna-synthetasen
CA2797277C (en) 2010-05-03 2021-02-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
US9034321B2 (en) 2010-05-03 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
CA2798139C (en) 2010-05-04 2019-09-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
CN103200953B (zh) 2010-05-14 2017-02-15 Atyr 医药公司 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN103096914B (zh) 2010-05-17 2015-08-12 Atyr医药公司 与亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
AU2011261486B2 (en) 2010-06-01 2017-02-23 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-tRNA synthetases
NZ605420A (en) 2010-07-06 2015-02-27 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
EP2593125B1 (de) 2010-07-12 2017-11-01 aTyr Pharma, Inc. Innovative erkennung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen in zusammenhang mit proteinfragmenten von glycyl-trna-synthetasen
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
US10150999B2 (en) 2010-11-17 2018-12-11 Interpace Diagnostics, Llc miRNAs as biomarkers for distinguishing benign from malignant thyroid neoplasms
US10024797B2 (en) 2010-11-22 2018-07-17 Colorado State University Research Foundation Biosensing systems for measurement of lactose
EP2474617A1 (de) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR zur Behandlung von Neoangiogenese
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US20140057295A1 (en) 2011-02-28 2014-02-27 Barbara J. Stegmann Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
EP2714927B1 (de) 2011-06-01 2016-08-10 Medical Prognosis Institute A/S Verfahren und vorrichtungen zur prognose eines krebsrezidivs
WO2013019982A2 (en) 2011-08-02 2013-02-07 Colorado State University Research Foundation Biosensing system with extended lifetime via cofactor recycling
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
EP2771487A1 (de) 2011-10-27 2014-09-03 Asuragen, INC. Mirnas als diagnostische biomarker zur unterscheidung gutartiger von bösartigen tumoren in der schilddrüse
KR20140123571A (ko) 2012-02-16 2014-10-22 에이티와이알 파마, 인코포레이티드 자가면역 및 염증성 질환의 치료를 위한 히스티딜­ｔｒｎａ 신테타제
WO2014007623A1 (en) 2012-07-03 2014-01-09 Interna Technologies B.V. Diagnostic portfolio and its uses
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
WO2014085434A1 (en) 2012-11-27 2014-06-05 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
CA2907377A1 (en) 2013-03-15 2014-09-18 Baylor Research Institute Tissue and blood-based mirna biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
EP3366785A3 (de) 2013-03-15 2018-09-19 Baylor Research Institute Marker für mit colitis ulcerosa (uc) assoziierten kolorektalen neoplasien
WO2014144666A2 (en) 2013-03-15 2014-09-18 The University Of Chicago Methods and compositions related to t-cell activity
WO2014195032A1 (en) 2013-06-07 2014-12-11 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients
US9828284B2 (en) 2014-03-28 2017-11-28 Ut-Battelle, Llc Thermal history-based etching
EP3169815B1 (de) 2014-07-15 2020-12-23 Ontario Institute For Cancer Research Verfahren und vorrichtungen zur vorhersage der behandlungswirksamkeit von anthracyclin
JP2018130367A (ja) * 2017-02-16 2018-08-23 キヤノン株式会社 光伝送装置、光伝送方法および被検体情報取得装置
WO2019086603A1 (en) 2017-11-03 2019-05-09 Interna Technologies B.V. Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
EP3952849A4 (de) 2019-04-12 2023-03-01 The Regents Of The University Of California Zusammensetzungen und verfahren zur erhöhung der muskelmasse und des oxidativen stoffwechsels
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US4447546A (en) * 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
US4909990A (en) * 1987-09-02 1990-03-20 Myron J. Block Immunoassay apparatus
US5135876A (en) * 1987-09-24 1992-08-04 University Of Utah Method and apparatus for the regulation of complex binding
GB8827853D0 (en) * 1988-11-29 1988-12-29 Ares Serono Res & Dev Ltd Sensor for optical assay
EP0429907B1 (de) * 1989-11-21 1994-06-01 Bayer Ag Optischer Biosensor
US5082630A (en) * 1990-04-30 1992-01-21 The United States Of America As Represented By The United States Department Of Energy Fiber optic detector for immuno-testing
US5047627A (en) * 1990-05-18 1991-09-10 Abbott Laboratories Configuration fiber-optic blood gas sensor bundle and method of making
US5166990A (en) * 1990-08-10 1992-11-24 Puritan-Bennett Corporation Multiple optical fiber event sensor and method of manufacture
US5061857A (en) * 1990-11-09 1991-10-29 The United States Of America As Represented By The Secretary Of The Navy Waveguide-binding sensor for use with assays
USH1398H (en) * 1990-12-28 1995-01-03 Campbell; James R. DNA-based fluourescent sensor
US5250264A (en) * 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5244636A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
JPH0526810A (ja) * 1991-07-23 1993-02-02 Hamamatsu Photonics Kk 微粒子の螢光検出装置
US5304492A (en) * 1991-11-26 1994-04-19 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Spectrophotometer for chemical analyses of fluids
JP3107649B2 (ja) * 1991-12-20 2000-11-13 イビデン株式会社 蛍光免疫測定装置
ATE205542T1 (de) * 1992-03-04 2001-09-15 Univ California Vergleichende genomhybridisierung
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples

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