DE69730011D1 - Herstellung einer Martix von hoher Dichte, sowie Verfahren zur Wiedergabe für einen fiberoptischen Biosensor - Google Patents

Herstellung einer Martix von hoher Dichte, sowie Verfahren zur Wiedergabe für einen fiberoptischen Biosensor

Info

Publication number
DE69730011D1
DE69730011D1 DE69730011T DE69730011T DE69730011D1 DE 69730011 D1 DE69730011 D1 DE 69730011D1 DE 69730011 T DE69730011 T DE 69730011T DE 69730011 T DE69730011 T DE 69730011T DE 69730011 D1 DE69730011 D1 DE 69730011D1
Authority
DE
Germany
Prior art keywords
fibers
binding
sensor
optical
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69730011T
Other languages
English (en)
Other versions
DE69730011T2 (de
Inventor
Daniel Pinkel
Richard Segraves
Ye Zhai
G Albertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of DE69730011D1 publication Critical patent/DE69730011D1/de
Application granted granted Critical
Publication of DE69730011T2 publication Critical patent/DE69730011T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/04—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G01N2201/0833—Fibre array at detector, resolving

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Plasma & Fusion (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
DE69730011T 1996-01-26 1997-01-24 Herstellung einer Martix von hoher Dichte, sowie Verfahren zur Wiedergabe für einen fiberoptischen Biosensor Expired - Lifetime DE69730011T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US592779 1996-01-26
US08/592,779 US5837196A (en) 1996-01-26 1996-01-26 High density array fabrication and readout method for a fiber optic biosensor
PCT/US1997/001052 WO1997027326A1 (en) 1996-01-26 1997-01-24 High density array fabrication and readout method for a fiber optic biosensor

Publications (2)

Publication Number Publication Date
DE69730011D1 true DE69730011D1 (de) 2004-09-02
DE69730011T2 DE69730011T2 (de) 2005-07-21

Family

ID=24372036

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69730011T Expired - Lifetime DE69730011T2 (de) 1996-01-26 1997-01-24 Herstellung einer Martix von hoher Dichte, sowie Verfahren zur Wiedergabe für einen fiberoptischen Biosensor

Country Status (6)

Country Link
US (1) US5837196A (de)
EP (1) EP0879299B1 (de)
JP (1) JP4029921B2 (de)
AT (1) ATE272212T1 (de)
DE (1) DE69730011T2 (de)
WO (1) WO1997027326A1 (de)

Families Citing this family (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534567B2 (en) * 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
AU755913B2 (en) * 1997-06-18 2003-01-02 Masad Damha Nucleic acid biosensor diagnostics
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
ATE393912T1 (de) * 1998-02-04 2008-05-15 Invitrogen Corp Microarrays und ihre verwendungen
CA2328609A1 (en) 1998-05-16 1999-11-25 Pe Corporation (Ny) Instrument for monitoring polymerase chain reaction of dna
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
AU4833899A (en) * 1998-06-24 2000-01-10 Therasense, Inc. Multi-sensor array for electrochemical recognition of nucleotide sequences and methods
EP2360271A1 (de) 1998-06-24 2011-08-24 Illumina, Inc. Dekodierung von Arraysensoren mit Mikrosphären
US6608671B2 (en) 1998-07-17 2003-08-19 Vertex Pharmaceuticals (San Diego) Llc Detector and screening device for ion channels
US6349160B2 (en) 1998-07-24 2002-02-19 Aurora Biosciences Corporation Detector and screening device for ion channels
IL126727A (en) 1998-10-22 2006-12-31 Given Imaging Ltd A method of bringing a device to the goal
US6129896A (en) * 1998-12-17 2000-10-10 Drawn Optical Components, Inc. Biosensor chip and manufacturing method
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
US6514768B1 (en) * 1999-01-29 2003-02-04 Surmodics, Inc. Replicable probe array
US20030148360A1 (en) * 1999-01-29 2003-08-07 Surmodics, Inc. Replicable probe array
US7097973B1 (en) * 1999-06-14 2006-08-29 Alpha Mos Method for monitoring molecular species within a medium
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6274320B1 (en) * 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
AU7549700A (en) * 1999-11-03 2001-05-14 International Business Machines Corporation Cantilever sensors and transducers
US6254830B1 (en) 1999-11-05 2001-07-03 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Magnetic focusing immunosensor for the detection of pathogens
EE04250B1 (et) * 1999-11-29 2004-02-16 Tartu Ülikool Biosensor ja selle valmistamise meetod
AU2001227020A1 (en) * 2000-01-19 2001-07-31 Given Imaging Ltd. A system for detecting substances
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
EP1305605A2 (de) * 2000-02-28 2003-05-02 Variom Biotechnology AG Bauteil zur interaktionsanalyse mit kooperationseffekte ausbildenden probenmolekülspezies
DE10053393A1 (de) * 2000-02-28 2001-12-20 Origen Biotechnology Ag Verfahren zur Immobilisierung von Nukleinsäuren
EP1299713A1 (de) * 2000-02-28 2003-04-09 Variom Biotechnology AG Bauteil mit einer mehrzahl von fiberelementen und an den fiberelementen immobilisierten probenmolekülen
US6689603B2 (en) 2000-03-17 2004-02-10 Alain Pompidou Device for in situ analysis and/or treatment consisting of a flexible rod and micro system fixed at one end of said flexible rod
FR2806481B1 (fr) * 2000-03-17 2002-10-25 Alain Pompidou Dispositif d'analyse et/ou de traitement in situ constitue d'une tige souple et d'un micro-systeme fixe a une extremite de ladite tige souple
ATE486275T1 (de) * 2000-03-22 2010-11-15 Axela Inc Verfahren und vorrichtung zur bestimmung mehrerer analyten
US7244572B1 (en) 2000-03-24 2007-07-17 Wisys Technology Foundation, Inc. One-dimensional arrays on optical fibers
US7435579B2 (en) * 2000-04-17 2008-10-14 Purdue Research Foundation Biosensor and related method
US7306924B2 (en) * 2000-04-17 2007-12-11 Purdue Research Foundation Biosensor and related method
CA2406133A1 (en) * 2000-04-17 2001-10-25 Rashid Bashir Biosensor and related method
CA2408094A1 (en) * 2000-05-04 2001-11-08 The Center For Blood Research, Inc. Colloid compositions for solid phase biomolecular analytical, preparative and identification systems
JP2004502138A (ja) * 2000-06-28 2004-01-22 イルミナ　インコーポレイテッド ハイブリダイゼーションチャンバーと微小球を利用した複合アレイ
US6980674B2 (en) * 2000-09-01 2005-12-27 Large Scale Proteomics Corp. Reference database
US6539102B1 (en) 2000-09-01 2003-03-25 Large Scale Proteomics Reference database
JP2002098696A (ja) 2000-09-26 2002-04-05 Inst Of Physical & Chemical Res 集積型生体分子センサー
US6706479B2 (en) 2000-10-05 2004-03-16 Virginia Tech Intellectual Properties, Inc. Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips
DE10053472B4 (de) * 2000-10-24 2005-06-09 Origen Biotechnology Ag Vorrichtung und Verfahren zur kombinatorischen Immobilisierung von Probenmolekülen auf Fiberelementen
US20020137074A1 (en) * 2000-11-21 2002-09-26 Piunno Paul A.E. Selectivity of nucleic acid diagnostic and microarray technologies by control of interfacial nucleic acid film chemistry
US20030009293A1 (en) * 2001-01-09 2003-01-09 Anderson Norman G. Reference database
CA2450632A1 (en) * 2001-01-12 2002-07-18 Toray Industries, Inc. Selectively hybridizable substance immobilization fiber, fiber array compsiring bundle of such fibers, selective hybridizing method, device therefor, and base
US7407746B2 (en) * 2001-02-08 2008-08-05 Ngk Insulators, Ltd. Biochip and method for producing the same
US9493806B2 (en) * 2001-06-01 2016-11-15 Colorado State University Research Foundation Enzymatic biosensing systems
US9493805B2 (en) * 2001-06-01 2016-11-15 Colorado State University Research Foundation Enzymatic biosensors with enhanced activity retention for detection of organic compounds
US8323956B2 (en) * 2001-06-01 2012-12-04 Colorado State University Research Foundation Distal tip of biosensor transducer comprising enzyme for deamination
AU2002356499A1 (en) * 2001-06-01 2003-04-01 Colorado State University Research Foundation Optical biosensor with enhanced activity retention for detection of halogenated organic compounds
WO2002102224A2 (en) 2001-06-18 2002-12-27 Given Imaging Ltd. In vivo sensing device with a circuit board having rigid sections and flexible sections
US6662091B2 (en) 2001-06-29 2003-12-09 Battelle Memorial Institute Diagnostics/prognostics using wireless links
CA2452376A1 (en) 2001-07-02 2003-01-16 Battelle Memorial Institute Intelligent microsensor module
AU2002322458A1 (en) 2001-07-13 2003-01-29 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
EP1425090A2 (de) * 2001-09-07 2004-06-09 Corning Incorporated Mikrosäulenbasierte anordnung zur hochdurchsatz analyse
WO2003023400A2 (en) * 2001-09-13 2003-03-20 Axela Biosensors Inc. Method and apparatus for assay based on light diffraction
US7662094B2 (en) 2002-05-14 2010-02-16 Given Imaging Ltd. Optical head assembly with dome, and device for use thereof
US7288368B2 (en) * 2002-06-17 2007-10-30 Stephen Eliot Zweig Membrane receptor reagent and assay
US6790632B2 (en) * 2002-06-17 2004-09-14 Stephen Eliot Zweig Membrane receptor reagent and assay
AU2003249551A1 (en) 2002-08-13 2004-02-25 Given Imaging Ltd. System for in vivo sampling and analysis
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
US20040132112A1 (en) * 2002-08-28 2004-07-08 Kimon Angelides Screening antibodies using an optical fiber array device capable of simultaneously performing multiple functional assays
AU2003269438A1 (en) * 2002-09-30 2004-04-19 Given Imaging Ltd. In-vivo sensing system
AU2003264858A1 (en) * 2002-09-30 2004-04-19 Given Imaging Ltd. Reduced size imaging device
US7866322B2 (en) 2002-10-15 2011-01-11 Given Imaging Ltd. Device, system and method for transfer of signals to a moving device
IL159113A (en) * 2002-11-27 2008-11-26 Given Imaging Ltd Method and device for imaging when the device has a cover made of fibers
JP4549865B2 (ja) * 2002-12-26 2010-09-22 ギブン イメージング リミテッド 生体内画像化装置およびその製造方法
ATE547976T1 (de) 2002-12-26 2012-03-15 Given Imaging Ltd Immobilisierbare in-vivo messvorrichtung
US7887752B2 (en) 2003-01-21 2011-02-15 Illumina, Inc. Chemical reaction monitor
EP1613771B1 (de) * 2003-04-04 2012-03-21 Roche Diagnostics GmbH Verbessertes system für mehrfarbige echtzeit-pcr
CN2662247Y (zh) * 2003-04-25 2004-12-08 谭玉山 基于白光反射干涉频谱变化规律的光纤阵列生物芯片
DE10322443A1 (de) * 2003-05-19 2004-12-30 PRO DESIGN Gesellschaft für Produktentwicklung mbH Multifunktioneller Reader für Biochips
US20050112587A1 (en) * 2003-11-25 2005-05-26 Sherrill James V. Analyzing biological probes
WO2005079474A2 (en) 2004-02-17 2005-09-01 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
DE102004008319B4 (de) * 2004-02-17 2006-11-02 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Kontinuierlich arbeitendes eindimensionales Festphasenreaktor-System
EP1771563A2 (de) 2004-05-28 2007-04-11 Ambion, Inc. VERFAHREN UND ZUSAMMENSETZUNGEN MIT MicroRNA
CA2568413A1 (en) * 2004-05-28 2005-12-15 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
US7596403B2 (en) 2004-06-30 2009-09-29 Given Imaging Ltd. System and method for determining path lengths through a body lumen
US7643865B2 (en) * 2004-06-30 2010-01-05 Given Imaging Ltd. Autonomous in-vivo device
US7697808B2 (en) * 2004-07-27 2010-04-13 Ut-Battelle, Llc Multi-tipped optical component
US7697807B2 (en) * 2006-06-01 2010-04-13 Ut-Battelle, Llc Multi-tipped optical component
US20060095093A1 (en) * 2004-11-04 2006-05-04 Ido Bettesh Apparatus and method for receiving device selection and combining
ES2534304T3 (es) 2004-11-12 2015-04-21 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
US8738106B2 (en) * 2005-01-31 2014-05-27 Given Imaging, Ltd Device, system and method for in vivo analysis
IL174531A0 (en) * 2005-04-06 2006-08-20 Given Imaging Ltd System and method for performing capsule endoscopy diagnosis in remote sites
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US20080103746A1 (en) 2005-11-30 2008-05-01 Searete Llc, A Limited Liability Corporation Systems and methods for pathogen detection and response
US8340944B2 (en) 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US7927787B2 (en) 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
US20080241000A1 (en) * 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for pathogen detection
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US10296720B2 (en) 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
US7827042B2 (en) 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
WO2007063550A2 (en) * 2005-12-02 2007-06-07 Given Imaging Ltd. System and device for in vivo procedures
US20070167834A1 (en) * 2005-12-29 2007-07-19 Amit Pascal In-vivo imaging optical device and method
US20070156051A1 (en) * 2005-12-29 2007-07-05 Amit Pascal Device and method for in-vivo illumination
US9320417B2 (en) 2005-12-29 2016-04-26 Given Imaging Ltd. In-vivo optical imaging device with backscatter blocking
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8663093B2 (en) * 2006-04-03 2014-03-04 Given Imaging Ltd. Device, system and method for in-vivo analysis
EP2487240B1 (de) 2006-09-19 2016-11-16 Interpace Diagnostics, LLC Mikro-RNA, die differentiell in Pankreaserkrankungen exprimiert sind, und ihre Verwendung
CA2663962A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
US10001496B2 (en) 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US8617903B2 (en) * 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US20080180259A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Devices for allergen detection
US20080181816A1 (en) * 2007-01-29 2008-07-31 Searete Llc, A Limited Liability Corporation Systems for allergen detection
JP4912908B2 (ja) * 2007-02-13 2012-04-11 国立大学法人浜松医科大学 バイオセンサ形イメージングファイバ装置
US20090227005A1 (en) * 2007-03-27 2009-09-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods for pathogen detection
US9796998B2 (en) 2007-04-09 2017-10-24 Colorado State University Research Foundation Oxygenase-based biosensing systems for measurement of halogenated alkene concentrations
WO2009029073A1 (en) 2007-08-30 2009-03-05 The Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
EP2990487A1 (de) 2008-05-08 2016-03-02 Asuragen, INC. Zusammensetzungen und verfahren in zusammenhang mit der mirna-modulation von neovaskularisation oder angiogenese
US8515507B2 (en) 2008-06-16 2013-08-20 Given Imaging Ltd. Device and method for detecting in-vivo pathology
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
DK2408905T3 (en) 2009-03-16 2017-08-28 Pangu Biopharma Ltd Compositions and Methods comprising Histidyl-tRNA Synthetase Splicing Variants with Non-Canonical Biological Activities
WO2010120509A2 (en) 2009-03-31 2010-10-21 Atyr Pharma, Inc. Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities
US8516691B2 (en) 2009-06-24 2013-08-27 Given Imaging Ltd. Method of assembly of an in vivo imaging device with a flexible circuit board
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
ES2544635T3 (es) 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
EP2542678B1 (de) 2010-03-04 2017-04-12 InteRNA Technologies B.V. Mirna-molekül, das durch seine quelle definiert ist, und seine therapeutischen verwendungen bei emt assoziierten krebs
EP2563380B1 (de) 2010-04-26 2018-05-30 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten der cysteinyl-trna-synthetase
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ， インコーポレイテッド イソロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8993723B2 (en) 2010-04-28 2015-03-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
CA2800557A1 (en) 2010-04-29 2011-11-03 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy
AU2011248490B2 (en) 2010-04-29 2016-11-10 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
US9068177B2 (en) 2010-04-29 2015-06-30 Atyr Pharma, Inc Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
CA2797393C (en) 2010-04-29 2020-03-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
CN103140233B (zh) 2010-05-03 2017-04-05 Atyr 医药公司 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
WO2011140132A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
WO2011139986A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド ｐ３８ＭＵＬＴＩ−ｔＲＮＡ合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6396656B2 (ja) 2010-05-14 2018-09-26 エータイアー ファーマ， インコーポレイテッド フェニルアラニルβｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6027965B2 (ja) 2010-05-17 2016-11-16 エータイアー ファーマ， インコーポレイテッド ロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP5906237B2 (ja) 2010-06-01 2016-04-20 エータイアー ファーマ， インコーポレイテッド リジルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CA2804599C (en) 2010-07-06 2023-01-31 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
JP6116479B2 (ja) 2010-07-12 2017-04-19 エータイアー ファーマ， インコーポレイテッド グリシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CA2808539C (en) 2010-08-25 2021-05-25 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases
EP2640851A2 (de) 2010-11-17 2013-09-25 Asuragen, Inc. Mirna als biomarker zur unterscheidung zwischen benignen und malignen neoplasien der schilddrüse
US10024797B2 (en) 2010-11-22 2018-07-17 Colorado State University Research Foundation Biosensing systems for measurement of lactose
EP2474617A1 (de) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR zur Behandlung von Neoangiogenese
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
EP2681566A2 (de) 2011-02-28 2014-01-08 University of Iowa Research Foundation Anti-müller-hormon-veränderungen in der schwangerschaft und vorhersage von schwangerschaftsnebenwirkungen und des geschlechts
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
US20140106986A1 (en) 2011-06-01 2014-04-17 Medical Prognosis Institute A/S Methods and devices for prognosis of cancer relapse
WO2013019982A2 (en) 2011-08-02 2013-02-07 Colorado State University Research Foundation Biosensing system with extended lifetime via cofactor recycling
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
EP2771487A1 (de) 2011-10-27 2014-09-03 Asuragen, INC. Mirnas als diagnostische biomarker zur unterscheidung gutartiger von bösartigen tumoren in der schilddrüse
EP2814514B1 (de) 2012-02-16 2017-09-13 Atyr Pharma, Inc. Histidyl-trna-synthetasen zur behandlung von autoimmun- und entzündungserkrankungen
US20150152499A1 (en) 2012-07-03 2015-06-04 Interna Technologies B.V. Diagnostic portfolio and its uses
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
WO2014085434A1 (en) 2012-11-27 2014-06-05 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
EP2971149B1 (de) 2013-03-15 2018-05-09 Baylor Research Institute Marker für mit colitis ulcerosa (uc) assoziierten kolorektalen neoplasien
EP2971132B1 (de) 2013-03-15 2020-05-06 Baylor Research Institute Gewebe- und blutbasierte mirna-biomarker zur diagnose, prognose und vorhersage des metastasepotenzials bei kolorektalkrebs
EP3404116B1 (de) 2013-03-15 2022-10-19 The University of Chicago Verfahren und zusammensetzungen in zusammenhang mit t-zell aktivität
US10392667B2 (en) 2013-06-07 2019-08-27 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients
US9828284B2 (en) 2014-03-28 2017-11-28 Ut-Battelle, Llc Thermal history-based etching
US11214836B2 (en) 2014-07-15 2022-01-04 Ontario Institute For Cancer Research Methods and devices for predicting anthracycline treatment efficacy
JP2018130367A (ja) * 2017-02-16 2018-08-23 キヤノン株式会社 光伝送装置、光伝送方法および被検体情報取得装置
AU2018358016A1 (en) 2017-11-03 2020-05-07 Interna Technologies B.V. MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
JP7566775B2 (ja) 2019-04-12 2024-10-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 筋肉量及び酸化的代謝を増加させるための組成物及び方法
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US4447546A (en) * 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
US4909990A (en) * 1987-09-02 1990-03-20 Myron J. Block Immunoassay apparatus
US5135876A (en) * 1987-09-24 1992-08-04 University Of Utah Method and apparatus for the regulation of complex binding
GB8827853D0 (en) * 1988-11-29 1988-12-29 Ares Serono Res & Dev Ltd Sensor for optical assay
US5194393A (en) * 1989-11-21 1993-03-16 Bayar Aktiengesellschaft Optical biosensor and method of use
US5082630A (en) * 1990-04-30 1992-01-21 The United States Of America As Represented By The United States Department Of Energy Fiber optic detector for immuno-testing
US5047627A (en) * 1990-05-18 1991-09-10 Abbott Laboratories Configuration fiber-optic blood gas sensor bundle and method of making
US5166990A (en) * 1990-08-10 1992-11-24 Puritan-Bennett Corporation Multiple optical fiber event sensor and method of manufacture
US5061857A (en) * 1990-11-09 1991-10-29 The United States Of America As Represented By The Secretary Of The Navy Waveguide-binding sensor for use with assays
USH1398H (en) * 1990-12-28 1995-01-03 Campbell; James R. DNA-based fluourescent sensor
US5244636A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5250264A (en) * 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
JPH0526810A (ja) * 1991-07-23 1993-02-02 Hamamatsu Photonics Kk 微粒子の螢光検出装置
US5304492A (en) * 1991-11-26 1994-04-19 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Spectrophotometer for chemical analyses of fluids
JP3107649B2 (ja) * 1991-12-20 2000-11-13 イビデン株式会社 蛍光免疫測定装置
ATE205542T1 (de) * 1992-03-04 2001-09-15 Univ California Vergleichende genomhybridisierung
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples

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