DE69728883D1 - Änderung des zirkadischen rhythmus mit nicht-peptidischen neurokinin-1 rezeptor antagonisten - Google Patents
Änderung des zirkadischen rhythmus mit nicht-peptidischen neurokinin-1 rezeptor antagonistenInfo
- Publication number
- DE69728883D1 DE69728883D1 DE69728883T DE69728883T DE69728883D1 DE 69728883 D1 DE69728883 D1 DE 69728883D1 DE 69728883 T DE69728883 T DE 69728883T DE 69728883 T DE69728883 T DE 69728883T DE 69728883 D1 DE69728883 D1 DE 69728883D1
- Authority
- DE
- Germany
- Prior art keywords
- circadic
- neurokinin
- peptidic
- rhythm
- change
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2192496P | 1996-07-17 | 1996-07-17 | |
US21924P | 1996-07-17 | ||
PCT/US1997/010931 WO1998002158A1 (en) | 1996-07-17 | 1997-07-14 | Alteration of circadian rhythmicity with a tachykinin antagonist |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69728883D1 true DE69728883D1 (de) | 2004-06-03 |
DE69728883T2 DE69728883T2 (de) | 2005-04-07 |
Family
ID=21806880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69728883T Revoked DE69728883T2 (de) | 1996-07-17 | 1997-07-14 | Änderung des zirkadischen rhythmus mit nicht-peptidischen neurokinin-1 rezeptor antagonisten |
Country Status (8)
Country | Link |
---|---|
US (4) | US6274604B1 (de) |
EP (1) | EP0912174B1 (de) |
JP (1) | JP2000514455A (de) |
AT (1) | ATE265209T1 (de) |
AU (1) | AU3716997A (de) |
CA (1) | CA2260269A1 (de) |
DE (1) | DE69728883T2 (de) |
WO (1) | WO1998002158A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0912174B1 (de) * | 1996-07-17 | 2004-04-28 | MERCK & CO., INC. | Änderung des zirkadischen rhythmus mit nicht-peptidischen neurokinin-1 rezeptor antagonisten |
US6271230B1 (en) * | 1997-12-01 | 2001-08-07 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating cognitive disorders |
US7101547B1 (en) * | 1999-01-22 | 2006-09-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance P by using anti-substance P antibodies |
US6573244B1 (en) * | 1999-05-17 | 2003-06-03 | The United States Of America As Represented By The Secretary Of The Army | Previns as specific inhibitors and therapeutic agents for Botulinum toxin B and Tetanus neurotoxins |
AU6527000A (en) | 1999-08-06 | 2001-03-05 | Cook Biotech, Incorporated | Tubular graft construct |
GB9923748D0 (en) | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
AU7788500A (en) * | 1999-10-25 | 2001-05-08 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
DE10001785A1 (de) * | 2000-01-18 | 2001-07-19 | Boehringer Ingelheim Pharma | NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms |
US6458384B2 (en) * | 2000-02-23 | 2002-10-01 | Impetus Ag | Pharmaceutical with predetermined activity profile |
IL144900A (en) * | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
IL149377A (en) * | 2002-04-28 | 2012-10-31 | Neurim Pharma 1991 | Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds |
BR0313503A (pt) | 2002-08-30 | 2005-06-21 | Kyowa Hakko Kogyo Kk | Método de tratamento de sìndrome das pernas inquietas, uso do antagonista de receptor da adenoina a2a, agente terapêutico para sìndrome das pernas inquietas, e, método de tratamento da mioclonia noturna |
US7070568B1 (en) | 2004-03-02 | 2006-07-04 | Pacesetter, Inc. | System and method for diagnosing and tracking congestive heart failure based on the periodicity of Cheyne-Stokes Respiration using an implantable medical device |
US7094207B1 (en) | 2004-03-02 | 2006-08-22 | Pacesetter, Inc. | System and method for diagnosing and tracking congestive heart failure based on the periodicity of cheyne-stokes respiration using an implantable medical device |
US7179229B1 (en) | 2004-04-07 | 2007-02-20 | Pacesetter, Inc. | System and method for apnea detection using blood pressure detected via an implantable medical system |
US7371220B1 (en) | 2004-06-30 | 2008-05-13 | Pacesetter, Inc. | System and method for real-time apnea/hypopnea detection using an implantable medical system |
RU2408591C9 (ru) | 2004-07-01 | 2011-04-27 | Шеринг Корпорейшн | Производные пиперидина, фармацевтическая композиция на их основе и их применение |
US8262578B1 (en) | 2004-11-24 | 2012-09-11 | Pacesetter, Inc. | System and method for detecting physiologic states based on intracardiac electrogram signals while distinguishing cardiac rhythm types |
US7361146B1 (en) | 2004-11-24 | 2008-04-22 | Pacesetter, Inc. | System and method for detecting abnormal respiration via respiratory parameters derived from intracardiac electrogram signals |
US7435221B1 (en) | 2004-11-24 | 2008-10-14 | Pacesetter, Inc. | System and method for detecting abnormal respiration based on intracardiac electrogram signals using a pattern recognition device |
US7354922B2 (en) * | 2004-12-14 | 2008-04-08 | Schering Corporation | Bridged ring NK1 antagonists |
US7538799B2 (en) * | 2005-01-14 | 2009-05-26 | Freescale Semiconductor, Inc. | System and method for flicker detection in digital imaging |
US7404799B1 (en) | 2005-04-05 | 2008-07-29 | Pacesetter, Inc. | System and method for detection of respiration patterns via integration of intracardiac electrogram signals |
US7628757B1 (en) | 2005-05-25 | 2009-12-08 | Pacesetter, Inc. | System and method for impedance-based detection of pulmonary edema and reduced respiration using an implantable medical system |
CA2676357A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
GB0808030D0 (en) | 2008-05-01 | 2008-06-11 | Glaxo Wellcome Mfg Pte Ltd | Novel compounds |
UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
GB0814340D0 (en) | 2008-08-05 | 2008-09-10 | Smithkline Beecham Corp | Anhydrous crystol form fo a pyridine derivative |
BR112012003263A2 (pt) | 2009-08-14 | 2015-09-22 | Opko Health Inc | formulações intravenosas de antagonistas de neuroquinina-1 |
US8844537B1 (en) | 2010-10-13 | 2014-09-30 | Michael T. Abramson | System and method for alleviating sleep apnea |
US20150246140A1 (en) * | 2014-02-10 | 2015-09-03 | California Institute Of Technology | Compositions and methods for modulating sleep and wakefulness |
MX2017002988A (es) * | 2014-09-09 | 2018-02-01 | Torvec Inc | Métodos y aparato para monitorear el nivel de alerta de una persona que utiliza un dispositivo portátil, y proporcionar una notificación. |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5232929A (en) | 1990-11-28 | 1993-08-03 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use |
WO1991012266A1 (en) | 1990-02-15 | 1991-08-22 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compound |
US5242930A (en) | 1991-02-11 | 1993-09-07 | Merck Sharp & Dohme Ltd. | Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy |
US5292726A (en) | 1991-05-22 | 1994-03-08 | Merck & Co., Inc. | N,N-diacylpiperazines |
EP0533280B2 (de) * | 1991-09-20 | 2004-12-01 | Glaxo Group Limited | Neue medizinische Indikation für Tachykinin-Antagonisten |
US5719147A (en) | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
CA2106330A1 (en) | 1992-10-07 | 1994-04-08 | Patrice J. Siret | Antibiotic compounds |
DE69428913T2 (de) | 1993-12-29 | 2002-05-29 | Merck Sharp & Dohme | Substituierte morpholinderivate und ihre verwendung als arzneimittel |
GB9426103D0 (en) | 1994-12-23 | 1995-02-22 | Merck Sharp & Dohme | Therapeutic agents |
US5531244A (en) * | 1995-07-25 | 1996-07-02 | Conval, Inc. | Hemispherical ball valve |
AU1977497A (en) * | 1996-03-01 | 1997-09-16 | Eli Lilly And Company | Methods of treating or preventing sleep apnea |
KR20000022060A (ko) * | 1996-06-21 | 2000-04-25 | 더블유. 지. 콜 | 스피로-피페리딘 유도체 및 치료제로서의 이의 용도 |
GB9613969D0 (en) * | 1996-07-03 | 1996-09-04 | Merck Sharp & Dohme | Therapeutic agents |
EP0912174B1 (de) * | 1996-07-17 | 2004-04-28 | MERCK & CO., INC. | Änderung des zirkadischen rhythmus mit nicht-peptidischen neurokinin-1 rezeptor antagonisten |
US5750549A (en) * | 1996-10-15 | 1998-05-12 | Merck & Co., Inc. | Cycloalkyl tachykinin receptor antagonists |
GB9625843D0 (en) * | 1996-12-12 | 1997-01-29 | Merck & Co Inc | Phenyl spiroethercycloalkyl tachykinn receptor antagonists |
BR9913201A (pt) | 1998-08-25 | 2001-05-08 | Novartis Ag | Uso de antagonista da substância p para o tratamento da sìndrome da fadiga crÈnica e/ou fibromialgia e uso de antagonistas do recptor de nk-1 para tratamento da sìndrome da fadiga crÈnica |
-
1997
- 1997-07-14 EP EP97934005A patent/EP0912174B1/de not_active Revoked
- 1997-07-14 CA CA002260269A patent/CA2260269A1/en not_active Abandoned
- 1997-07-14 AT AT97934005T patent/ATE265209T1/de not_active IP Right Cessation
- 1997-07-14 DE DE69728883T patent/DE69728883T2/de not_active Revoked
- 1997-07-14 JP JP10506025A patent/JP2000514455A/ja active Pending
- 1997-07-14 AU AU37169/97A patent/AU3716997A/en not_active Abandoned
- 1997-07-14 US US09/214,973 patent/US6274604B1/en not_active Expired - Fee Related
- 1997-07-14 WO PCT/US1997/010931 patent/WO1998002158A1/en active IP Right Grant
-
1998
- 1998-12-18 US US09/216,194 patent/US6034105A/en not_active Expired - Fee Related
-
1999
- 1999-12-16 US US09/464,972 patent/US6329401B1/en not_active Expired - Fee Related
-
2001
- 2001-10-16 US US09/978,292 patent/US6525073B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1998002158A1 (en) | 1998-01-22 |
AU3716997A (en) | 1998-02-09 |
US6274604B1 (en) | 2001-08-14 |
US6525073B2 (en) | 2003-02-25 |
US20020035059A1 (en) | 2002-03-21 |
DE69728883T2 (de) | 2005-04-07 |
ATE265209T1 (de) | 2004-05-15 |
EP0912174A1 (de) | 1999-05-06 |
CA2260269A1 (en) | 1998-01-22 |
EP0912174A4 (de) | 2000-12-06 |
EP0912174B1 (de) | 2004-04-28 |
US6034105A (en) | 2000-03-07 |
JP2000514455A (ja) | 2000-10-31 |
US6329401B1 (en) | 2001-12-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee | ||
8331 | Complete revocation | ||
8363 | Opposition against the patent |