DE69727529D1 - Benzothiophenverbindungen, Zwischenprodukte, Zusammensetzungen und Methode - Google Patents
Benzothiophenverbindungen, Zwischenprodukte, Zusammensetzungen und MethodeInfo
- Publication number
- DE69727529D1 DE69727529D1 DE69727529T DE69727529T DE69727529D1 DE 69727529 D1 DE69727529 D1 DE 69727529D1 DE 69727529 T DE69727529 T DE 69727529T DE 69727529 T DE69727529 T DE 69727529T DE 69727529 D1 DE69727529 D1 DE 69727529D1
- Authority
- DE
- Germany
- Prior art keywords
- intermediates
- compositions
- benzothiophene compounds
- compounds
- benzothiophene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2951996P | 1996-10-24 | 1996-10-24 | |
US29519P | 1996-10-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69727529D1 true DE69727529D1 (de) | 2004-03-18 |
DE69727529T2 DE69727529T2 (de) | 2005-01-05 |
Family
ID=21849446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69727529T Expired - Fee Related DE69727529T2 (de) | 1996-10-24 | 1997-10-22 | Benzothiophenverbindungen, Zwischenprodukte, Zusammensetzungen und Methode |
Country Status (7)
Country | Link |
---|---|
US (1) | US5985897A (de) |
EP (1) | EP0838462B1 (de) |
JP (1) | JPH10130261A (de) |
AT (1) | ATE259361T1 (de) |
CA (1) | CA2216592C (de) |
DE (1) | DE69727529T2 (de) |
ES (1) | ES2213805T3 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136030A (en) * | 1999-01-12 | 2000-10-24 | Purzer Pharmaceutical Co., Ltd. | Process for preparing porous bioceramic materials |
US6894175B1 (en) * | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
EP1401446B1 (de) * | 2001-05-22 | 2005-02-09 | Eli Lilly And Company | Tetrahydrochinolin-derivate zur behandlung von krankheiten ausgelöst durch zu hohem oder zu niedrigem oestrogenspiegel |
JP2004531562A (ja) | 2001-05-22 | 2004-10-14 | イーライ・リリー・アンド・カンパニー | 2−置換1,2,3,4−テトラヒドロキノリンおよびその誘導体、組成物ならびに方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1138163A (en) * | 1965-05-21 | 1968-12-27 | Bristol Myers Co | Benzothiophene derivatives having anti-fertility properties |
US3394125A (en) * | 1965-10-23 | 1968-07-23 | Bristol Myers Co | 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group |
US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
US4358593A (en) * | 1981-04-03 | 1982-11-09 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes |
NZ200204A (en) * | 1981-04-03 | 1985-05-31 | Lilly Co Eli | Benzothiophene derivatives and process for preparation |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
AU621811B2 (en) * | 1987-09-25 | 1992-03-26 | Ciba-Geigy Ag | Diacyl derivatives of 4-(trialkylbenzyl)-piperazinyl compounds |
AU2543388A (en) * | 1987-09-30 | 1989-04-18 | University Of Tennessee Research Corporation, The | Certain 3-substituted 2-alkyl benzothiophene derivatives |
US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
CA2145614A1 (en) * | 1994-03-31 | 1995-10-01 | Jeffrey A. Dodge | Intermediates and processes for preparing benzothiophene compounds |
US7501441B1 (en) * | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
PE44597A1 (es) * | 1995-02-28 | 1997-10-13 | Lilly Co Eli | Compuestos de benzotiofeno, productos intermedios, composiciones y procedimientos |
US6395755B1 (en) * | 1995-03-10 | 2002-05-28 | Eli Lilly And Company | Benzothiophene pharmaceutical compounds |
-
1997
- 1997-09-29 CA CA002216592A patent/CA2216592C/en not_active Expired - Fee Related
- 1997-10-22 ES ES97308414T patent/ES2213805T3/es not_active Expired - Lifetime
- 1997-10-22 DE DE69727529T patent/DE69727529T2/de not_active Expired - Fee Related
- 1997-10-22 EP EP97308414A patent/EP0838462B1/de not_active Expired - Lifetime
- 1997-10-22 AT AT97308414T patent/ATE259361T1/de not_active IP Right Cessation
- 1997-10-22 JP JP9289612A patent/JPH10130261A/ja not_active Withdrawn
- 1997-10-23 US US08/956,087 patent/US5985897A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5985897A (en) | 1999-11-16 |
ATE259361T1 (de) | 2004-02-15 |
CA2216592C (en) | 2006-07-18 |
ES2213805T3 (es) | 2004-09-01 |
DE69727529T2 (de) | 2005-01-05 |
EP0838462B1 (de) | 2004-02-11 |
EP0838462A1 (de) | 1998-04-29 |
JPH10130261A (ja) | 1998-05-19 |
CA2216592A1 (en) | 1998-04-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |