ES2175278T3 - Compuestos de naftofluoreno, intermedios, composiciones y procedimientos. - Google Patents
Compuestos de naftofluoreno, intermedios, composiciones y procedimientos.Info
- Publication number
- ES2175278T3 ES2175278T3 ES97307497T ES97307497T ES2175278T3 ES 2175278 T3 ES2175278 T3 ES 2175278T3 ES 97307497 T ES97307497 T ES 97307497T ES 97307497 T ES97307497 T ES 97307497T ES 2175278 T3 ES2175278 T3 ES 2175278T3
- Authority
- ES
- Spain
- Prior art keywords
- intermediates
- compounds
- naftofluorene
- procedures
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/52—Ortho- or ortho- and peri-condensed systems containing five condensed rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Thin Film Transistor (AREA)
Abstract
EN LA INVENCION SE PRESENTAN COMPUESTOS DE NAFTOFLUORENO, INTERMEDIOS, FORMULACIONES, PROCESOS Y METODOS PARA INHIBIR LA PERDIDA OSEA O LA RESORCION OSEA, EN PARTICULAR LA OSTEOPOROSIS, Y ESTADOS PATOLOGICOS RELACIONADOS CON TRASTORNOS CARDIOVASCULARES, INCLUIDOS LA HIPERLIPIDEMIA Y EL CANCER DEPENDIENTE DE ESTROGENOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2671596P | 1996-09-26 | 1996-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2175278T3 true ES2175278T3 (es) | 2002-11-16 |
Family
ID=21833411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97307497T Expired - Lifetime ES2175278T3 (es) | 1996-09-26 | 1997-09-25 | Compuestos de naftofluoreno, intermedios, composiciones y procedimientos. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5889000A (es) |
EP (1) | EP0832882B1 (es) |
JP (1) | JPH10147559A (es) |
AT (1) | ATE215537T1 (es) |
CA (1) | CA2214929A1 (es) |
DE (1) | DE69711528T2 (es) |
DK (1) | DK0832882T3 (es) |
ES (1) | ES2175278T3 (es) |
PT (1) | PT832882E (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1687258A2 (en) * | 2003-11-20 | 2006-08-09 | Eli Lilly And Company | Vitamin d receptor modulators |
WO2005051898A2 (en) * | 2003-11-20 | 2005-06-09 | Eli Lilly And Company | Vitamin d receptor modulators |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274213A (en) * | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
GB1138163A (en) * | 1965-05-21 | 1968-12-27 | Bristol Myers Co | Benzothiophene derivatives having anti-fertility properties |
US3394125A (en) * | 1965-10-23 | 1968-07-23 | Bristol Myers Co | 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group |
US3974186A (en) * | 1970-05-14 | 1976-08-10 | Richardson-Merrell Inc. | Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones |
CH564513A5 (en) * | 1971-05-24 | 1975-07-31 | Richardson Merrell Inc | Basically substd fluoranthene derivs - with antiviral activity |
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
EP0065962A1 (en) * | 1980-12-03 | 1982-12-08 | Peabody Abc Corporation | Coupling for mine ventilation conduits |
US4358593A (en) * | 1981-04-03 | 1982-11-09 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes |
NZ200204A (en) * | 1981-04-03 | 1985-05-31 | Lilly Co Eli | Benzothiophene derivatives and process for preparation |
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
DE3121175A1 (de) * | 1981-05-27 | 1982-12-16 | Klinge Pharma GmbH, 8000 München | Erythro-1,2,3-triphenyl-1-pentanon-derivate sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO1989002893A1 (en) * | 1987-09-30 | 1989-04-06 | The University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzothiophene derivatives |
US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
US5147880A (en) * | 1991-07-22 | 1992-09-15 | Eli Lilly And Company | Benzo[a]fluorene compounds |
JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
GB9220735D0 (en) * | 1992-10-02 | 1992-11-18 | British Tech Group | Heterocyclic amines |
US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
US7501441B1 (en) * | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
GB2303628A (en) * | 1995-07-27 | 1997-02-26 | Lilly Co Eli | 5-Hydroxy- and 5-phenyl-substituted 1-[4-(aminoalkoxy)phenyl]-2-phenylbenzene derivatives for the treatment of post menopausal symptoms and intermediates |
US5811421A (en) * | 1995-07-31 | 1998-09-22 | Eli Lilly And Company | Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods |
-
1997
- 1997-09-02 CA CA002214929A patent/CA2214929A1/en not_active Abandoned
- 1997-09-22 US US08/934,988 patent/US5889000A/en not_active Expired - Fee Related
- 1997-09-24 JP JP9258346A patent/JPH10147559A/ja active Pending
- 1997-09-25 DE DE69711528T patent/DE69711528T2/de not_active Expired - Fee Related
- 1997-09-25 ES ES97307497T patent/ES2175278T3/es not_active Expired - Lifetime
- 1997-09-25 AT AT97307497T patent/ATE215537T1/de not_active IP Right Cessation
- 1997-09-25 DK DK97307497T patent/DK0832882T3/da active
- 1997-09-25 PT PT97307497T patent/PT832882E/pt unknown
- 1997-09-25 EP EP97307497A patent/EP0832882B1/en not_active Expired - Lifetime
-
1998
- 1998-09-30 US US09/163,424 patent/US5959103A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69711528T2 (de) | 2002-10-31 |
ATE215537T1 (de) | 2002-04-15 |
EP0832882A2 (en) | 1998-04-01 |
EP0832882A3 (en) | 1998-06-17 |
DK0832882T3 (da) | 2002-06-17 |
US5889000A (en) | 1999-03-30 |
DE69711528D1 (de) | 2002-05-08 |
CA2214929A1 (en) | 1998-03-26 |
EP0832882B1 (en) | 2002-04-03 |
US5959103A (en) | 1999-09-28 |
JPH10147559A (ja) | 1998-06-02 |
PT832882E (pt) | 2002-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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