ES2175278T3 - Compuestos de naftofluoreno, intermedios, composiciones y procedimientos. - Google Patents

Compuestos de naftofluoreno, intermedios, composiciones y procedimientos.

Info

Publication number
ES2175278T3
ES2175278T3 ES97307497T ES97307497T ES2175278T3 ES 2175278 T3 ES2175278 T3 ES 2175278T3 ES 97307497 T ES97307497 T ES 97307497T ES 97307497 T ES97307497 T ES 97307497T ES 2175278 T3 ES2175278 T3 ES 2175278T3
Authority
ES
Spain
Prior art keywords
intermediates
compounds
naftofluorene
procedures
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97307497T
Other languages
English (en)
Inventor
Henry Uhlman Bryant
Jeffrey Alan Dodge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2175278T3 publication Critical patent/ES2175278T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/52Ortho- or ortho- and peri-condensed systems containing five condensed rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Thin Film Transistor (AREA)

Abstract

EN LA INVENCION SE PRESENTAN COMPUESTOS DE NAFTOFLUORENO, INTERMEDIOS, FORMULACIONES, PROCESOS Y METODOS PARA INHIBIR LA PERDIDA OSEA O LA RESORCION OSEA, EN PARTICULAR LA OSTEOPOROSIS, Y ESTADOS PATOLOGICOS RELACIONADOS CON TRASTORNOS CARDIOVASCULARES, INCLUIDOS LA HIPERLIPIDEMIA Y EL CANCER DEPENDIENTE DE ESTROGENOS.
ES97307497T 1996-09-26 1997-09-25 Compuestos de naftofluoreno, intermedios, composiciones y procedimientos. Expired - Lifetime ES2175278T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2671596P 1996-09-26 1996-09-26

Publications (1)

Publication Number Publication Date
ES2175278T3 true ES2175278T3 (es) 2002-11-16

Family

ID=21833411

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97307497T Expired - Lifetime ES2175278T3 (es) 1996-09-26 1997-09-25 Compuestos de naftofluoreno, intermedios, composiciones y procedimientos.

Country Status (9)

Country Link
US (2) US5889000A (es)
EP (1) EP0832882B1 (es)
JP (1) JPH10147559A (es)
AT (1) ATE215537T1 (es)
CA (1) CA2214929A1 (es)
DE (1) DE69711528T2 (es)
DK (1) DK0832882T3 (es)
ES (1) ES2175278T3 (es)
PT (1) PT832882E (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1687258A2 (en) * 2003-11-20 2006-08-09 Eli Lilly And Company Vitamin d receptor modulators
WO2005051898A2 (en) * 2003-11-20 2005-06-09 Eli Lilly And Company Vitamin d receptor modulators

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274213A (en) * 1961-09-05 1966-09-20 Upjohn Co Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
GB1138163A (en) * 1965-05-21 1968-12-27 Bristol Myers Co Benzothiophene derivatives having anti-fertility properties
US3394125A (en) * 1965-10-23 1968-07-23 Bristol Myers Co 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group
US3974186A (en) * 1970-05-14 1976-08-10 Richardson-Merrell Inc. Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones
CH564513A5 (en) * 1971-05-24 1975-07-31 Richardson Merrell Inc Basically substd fluoranthene derivs - with antiviral activity
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4230862A (en) * 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
EP0065962A1 (en) * 1980-12-03 1982-12-08 Peabody Abc Corporation Coupling for mine ventilation conduits
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
NZ200204A (en) * 1981-04-03 1985-05-31 Lilly Co Eli Benzothiophene derivatives and process for preparation
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
DE3121175A1 (de) * 1981-05-27 1982-12-16 Klinge Pharma GmbH, 8000 München Erythro-1,2,3-triphenyl-1-pentanon-derivate sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO1989002893A1 (en) * 1987-09-30 1989-04-06 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzothiophene derivatives
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US5147880A (en) * 1991-07-22 1992-09-15 Eli Lilly And Company Benzo[a]fluorene compounds
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
GB9220735D0 (en) * 1992-10-02 1992-11-18 British Tech Group Heterocyclic amines
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US7501441B1 (en) * 1994-09-20 2009-03-10 Eli Lilly And Company Naphthyl compounds, intermediates, processes, compositions, and methods
US5998401A (en) * 1995-02-28 1999-12-07 Eli Lilly And Company Naphthyl compounds, intermediates, compositions, and methods
GB2303628A (en) * 1995-07-27 1997-02-26 Lilly Co Eli 5-Hydroxy- and 5-phenyl-substituted 1-[4-(aminoalkoxy)phenyl]-2-phenylbenzene derivatives for the treatment of post menopausal symptoms and intermediates
US5811421A (en) * 1995-07-31 1998-09-22 Eli Lilly And Company Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods

Also Published As

Publication number Publication date
DE69711528T2 (de) 2002-10-31
ATE215537T1 (de) 2002-04-15
EP0832882A2 (en) 1998-04-01
EP0832882A3 (en) 1998-06-17
DK0832882T3 (da) 2002-06-17
US5889000A (en) 1999-03-30
DE69711528D1 (de) 2002-05-08
CA2214929A1 (en) 1998-03-26
EP0832882B1 (en) 2002-04-03
US5959103A (en) 1999-09-28
JPH10147559A (ja) 1998-06-02
PT832882E (pt) 2002-08-30

Similar Documents

Publication Publication Date Title
DE69905476D1 (en) Phosphonsaürederivate als ptp-1b-inhibitoren
DE60223923D1 (de) Prodrugs von gaba-analoga, zusammensetzungen und ihre verwendungszwecke
PL1663185T3 (pl) Zapobieganie i leczenie utraty kości wywołanej przez zapalenie i/lub za pośrednictwem układu odpornościowego
GB9722520D0 (en) Compounds
IL142900A0 (en) Compositions and methods for the prevention or treatment of cancer and bone loss associated with cancer
DE69730796D1 (de) Naphthylverbindungen, Zusammensetzungen und Verfahren
DE69731043D1 (de) Benzo[B]thiophen-Verbindungen, Zwischenprodukte, Verfahren und Zusammensetzungen
DE69724062D1 (de) Benzothiophenderivate, Zwischenprodukte, Verfahren, Zubereitungen und Methoden
ZA9810215B (en) 2-Aryl-3-Aroylbenzo[b]thiophenes useful for the treatment of estrogen deprivation syndrome.
ATE248830T1 (de) Substituierte 2,3-aryl-benzothiophene und ihre östrogene aktivität
ATE245637T1 (de) Benzothiophenverbindungen, zubereitungen und verfahren
DE69727529D1 (de) Benzothiophenverbindungen, Zwischenprodukte, Zusammensetzungen und Methode
DE69723188D1 (de) Benzo[B]indeno[2,1-D]thiophenverbindungen, Zwischenprodukte, Verfahren, Zusammensetzungen und Methoden
ES2175278T3 (es) Compuestos de naftofluoreno, intermedios, composiciones y procedimientos.
DE69723187D1 (de) Dihydrobenzofluorenverbindungen, Zwischenprodukte, Zusammensetzungen und Methode
ES2175279T3 (es) Compuestos de tetrahidrobenzo(a)fluoreno y procedimientos de uso.
DE69723790D1 (de) Dihydrobenzo(b)indeno(2,1-D)thiophen-Derivate, Zwischenprodukte, Verfahren, Zubereitungen und Methoden

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 832882

Country of ref document: ES