DE69725467D1 - Phenylethylamin-derivate - Google Patents

Phenylethylamin-derivate

Info

Publication number
DE69725467D1
DE69725467D1 DE69725467T DE69725467T DE69725467D1 DE 69725467 D1 DE69725467 D1 DE 69725467D1 DE 69725467 T DE69725467 T DE 69725467T DE 69725467 T DE69725467 T DE 69725467T DE 69725467 D1 DE69725467 D1 DE 69725467D1
Authority
DE
Germany
Prior art keywords
dementia
alkyl
hydrogen
compounds
directed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69725467T
Other languages
English (en)
Other versions
DE69725467T2 (de
Inventor
Michael Chorev
Tamar Goren
Yacov Herzig
Jeffrey Sterling
Marta Weinstock-Rosin
B Youdim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Technion Research and Development Foundation Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Teva Pharmaceutical Industries Ltd
Technion Research and Development Foundation Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11985296A external-priority patent/IL119852A0/xx
Priority claimed from IL12050997A external-priority patent/IL120509A0/xx
Application filed by Teva Pharmaceutical Industries Ltd, Technion Research and Development Foundation Ltd, Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Teva Pharmaceutical Industries Ltd
Publication of DE69725467D1 publication Critical patent/DE69725467D1/de
Application granted granted Critical
Publication of DE69725467T2 publication Critical patent/DE69725467T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69725467T 1996-12-18 1997-12-18 Phenylethylamin-derivate Expired - Lifetime DE69725467T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL11985296A IL119852A0 (en) 1996-12-18 1996-12-18 Phenylethylamine derivatives
IL11985296 1996-12-18
IL12050997A IL120509A0 (en) 1997-03-24 1997-03-24 Phenylethylamine derivatives
IL12050997 1997-03-24
PCT/US1997/023897 WO1998026775A1 (en) 1996-12-18 1997-12-18 Phenylethylamine derivatives

Publications (2)

Publication Number Publication Date
DE69725467D1 true DE69725467D1 (de) 2003-11-13
DE69725467T2 DE69725467T2 (de) 2004-07-22

Family

ID=26323337

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69725467T Expired - Lifetime DE69725467T2 (de) 1996-12-18 1997-12-18 Phenylethylamin-derivate

Country Status (12)

Country Link
EP (1) EP0951284B1 (de)
JP (1) JP4116085B2 (de)
AT (1) ATE251456T1 (de)
AU (1) AU5620998A (de)
CA (1) CA2275371C (de)
DE (1) DE69725467T2 (de)
DK (1) DK0951284T3 (de)
ES (1) ES2208967T3 (de)
HK (1) HK1022838A1 (de)
HU (1) HU226526B1 (de)
PT (1) PT951284E (de)
WO (1) WO1998026775A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
EP1686973A4 (de) * 2003-11-25 2009-03-25 Technion Res & Dev Foundation Zusammensetzungen und verfahren zur behandlung von kardiovaskulären erkrankungen und krankheiten
US8097608B2 (en) 2003-11-25 2012-01-17 Technion Research And Development Foundation Ltd. Methods for treatment of cardiovascular disorders and diseases
CA2592969A1 (en) * 2005-01-13 2006-07-20 F. Hoffmann-La Roche Ag New one-step synthesis of useful disubstituted amines
US8022104B2 (en) 2005-02-24 2011-09-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Formulations of ladostigil tartrate
ES2632638T3 (es) 2005-12-09 2017-09-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Ladostigilo de baja dosis para el tratamiento de la deficiencia cognitiva
TW200744576A (en) 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
US20240124411A1 (en) * 2021-08-23 2024-04-18 Alexander Shulgin Research Institute, Inc. Deuterated Empathogens
CA3229910A1 (en) * 2021-08-23 2023-03-02 Alexander Shulgin Research Institute, Inc. Fluorinated empathogens

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6408165A (de) * 1964-07-17 1966-01-18
US3507962A (en) * 1969-05-09 1970-04-21 Thompson Chem Co Hayward Controlling leafminer insects with selected carbamate insecticides,including 3,5-dimethyl-4-dimethylamino-methyl phenyl-n-methylcarbamate
IL74497A (en) * 1985-03-05 1990-02-09 Proterra Ag Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives
NL195004C (nl) * 1987-03-04 2003-11-04 Novartis Ag Fenylcarbamaat bevattend farmaceutisch preparaat.

Also Published As

Publication number Publication date
DK0951284T3 (da) 2004-02-16
CA2275371A1 (en) 1998-06-25
HK1022838A1 (en) 2000-08-25
ATE251456T1 (de) 2003-10-15
EP0951284A1 (de) 1999-10-27
HU226526B1 (en) 2009-03-30
CA2275371C (en) 2008-07-29
AU5620998A (en) 1998-07-15
EP0951284B1 (de) 2003-10-08
ES2208967T3 (es) 2004-06-16
HUP0003180A3 (en) 2002-11-28
HUP0003180A2 (hu) 2001-01-29
WO1998026775A1 (en) 1998-06-25
JP2001506655A (ja) 2001-05-22
PT951284E (pt) 2003-12-31
DE69725467T2 (de) 2004-07-22
EP0951284A4 (de) 2002-03-20
JP4116085B2 (ja) 2008-07-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition