DE69722247D1 - Pharmazeutische tablette mit verzögerter freisetzung, enthaltend eine matrix aus quervernetzter amylose und hydroxypropyl methylzellulose - Google Patents

Pharmazeutische tablette mit verzögerter freisetzung, enthaltend eine matrix aus quervernetzter amylose und hydroxypropyl methylzellulose

Info

Publication number
DE69722247D1
DE69722247D1 DE69722247T DE69722247T DE69722247D1 DE 69722247 D1 DE69722247 D1 DE 69722247D1 DE 69722247 T DE69722247 T DE 69722247T DE 69722247 T DE69722247 T DE 69722247T DE 69722247 D1 DE69722247 D1 DE 69722247D1
Authority
DE
Germany
Prior art keywords
cross
matrix
methyl cellulose
delayed release
hydroxypropyl methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69722247T
Other languages
English (en)
Other versions
DE69722247T2 (de
Inventor
Francois Chouinard
Wilfrid Jacques
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labopharm Inc
Original Assignee
Labopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Inc filed Critical Labopharm Inc
Publication of DE69722247D1 publication Critical patent/DE69722247D1/de
Application granted granted Critical
Publication of DE69722247T2 publication Critical patent/DE69722247T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69722247T 1996-04-10 1997-04-04 Pharmazeutische tablette mit verzögerter freisetzung, enthaltend eine matrix aus quervernetzter amylose und hydroxypropyl methylzellulose Expired - Lifetime DE69722247T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA002173818A CA2173818A1 (fr) 1996-04-10 1996-04-10 Comprime pharmaceutique a liberation controlee contenant un support a base d'amylose reticule et d'hydroxypropylmethylcellulose
CA2173818 1996-04-10
PCT/CA1997/000229 WO1997037639A1 (fr) 1996-04-10 1997-04-04 Comprime pharmaceutique a liberation controlee contenant un support a base d'amylose reticule et d'hydroxypropylmethylcellulose

Publications (2)

Publication Number Publication Date
DE69722247D1 true DE69722247D1 (de) 2003-06-26
DE69722247T2 DE69722247T2 (de) 2004-04-01

Family

ID=4157953

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722247T Expired - Lifetime DE69722247T2 (de) 1996-04-10 1997-04-04 Pharmazeutische tablette mit verzögerter freisetzung, enthaltend eine matrix aus quervernetzter amylose und hydroxypropyl methylzellulose

Country Status (22)

Country Link
US (1) US5885615A (de)
EP (1) EP0954290B1 (de)
JP (1) JP4166278B2 (de)
KR (1) KR100439614B1 (de)
CN (1) CN1218396A (de)
AT (1) ATE240719T1 (de)
AU (1) AU711089B2 (de)
BR (1) BR9708772A (de)
CA (1) CA2173818A1 (de)
CZ (1) CZ294342B6 (de)
DE (1) DE69722247T2 (de)
DK (1) DK0954290T3 (de)
ES (1) ES2200166T3 (de)
IL (1) IL126477A (de)
MY (1) MY115535A (de)
NO (1) NO321862B1 (de)
NZ (1) NZ332576A (de)
PL (1) PL187764B1 (de)
PT (1) PT954290E (de)
TR (1) TR199802034T2 (de)
WO (1) WO1997037639A1 (de)
ZA (1) ZA973054B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119660A (en) 1993-05-10 2002-09-12 Euro Celtique Sa Controlled release formulation comprising tramadol
US6197339B1 (en) * 1997-09-30 2001-03-06 Pharmacia & Upjohn Company Sustained release tablet formulation to treat Parkinson's disease
US6284273B1 (en) * 1998-02-24 2001-09-04 Vincent Lenaerts Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds
WO2000033818A1 (en) 1998-12-11 2000-06-15 Nostrum Pharmaceuticals, Inc. Sustained release tablet containing hydrocolloid and cellulose ether
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
EP1174127A1 (de) * 2000-07-21 2002-01-23 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Zuammensetzung zur zielgesteuerten Freigabe eines Wirkstoffs und Verfahren zur Herstellung einer solchen Zusammensetzung
US6673369B2 (en) * 2001-08-29 2004-01-06 Ranbaxy Laboratories Limited Controlled release formulation
EP1485078B1 (de) * 2002-03-15 2012-09-26 Cypress Bioscience, Inc. Milnacipran zur Behandlung von Reizdarmsyndrom
US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
US20060003004A1 (en) * 2002-10-25 2006-01-05 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
DK1558935T3 (da) * 2002-10-25 2008-11-17 Labopharm Inc Præparater med styret afgivelse
MY142195A (en) * 2002-10-25 2010-10-15 Labopharm Inc Controlled-release compositions
US20040132826A1 (en) * 2002-10-25 2004-07-08 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
EP1578281A2 (de) * 2002-11-25 2005-09-28 Boston Scientific Limited Injektionsvorrichtung zur behandlung eines säugetier
AU2004207578B2 (en) * 2003-01-28 2007-06-28 Collegium Pharmaceutical, Inc. Multiparticulate compositions of milnacipran for oral administration
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
AR051654A1 (es) * 2004-11-04 2007-01-31 Astrazeneca Ab Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones
CA2491665A1 (fr) * 2004-12-24 2006-06-24 Louis Cartilier Formulation de comprime pour liberation soutenue de principe actif
WO2007048219A2 (en) * 2005-09-09 2007-05-03 Labopharm Inc. Sustained drug release composition
US8241656B2 (en) * 2005-09-21 2012-08-14 Surmodics, Inc Articles including natural biodegradable polysaccharides and uses thereof
WO2007038126A1 (en) * 2005-09-21 2007-04-05 Surmodics, Inc. In vivo formed matrices including natural biodegradable polysaccharides and ophthalmic uses thereof
US9029427B2 (en) * 2005-11-11 2015-05-12 Asahi Kasei Chemicals Corporation Controlled release solid preparation
US20080154241A1 (en) * 2006-12-07 2008-06-26 Burkstrand Michael J Latent stabilization of bioactive agents releasable from implantable medical articles
CA2723192A1 (en) 2008-05-07 2009-11-12 Surmodics, Inc. Delivery of nucleic acid complexes from particles
ATE550016T1 (de) * 2008-09-04 2012-04-15 Bristol Myers Squibb Co Stabile pharmazeutische zusammensetzung zur optimierten abgabe eines hiv-attachment- inhibitors
KR20110036858A (ko) * 2008-10-27 2011-04-11 알자 코퍼레이션 지속 방출형 경구용 아세트아미노펜/트라마돌 제형
US20100260842A1 (en) * 2009-04-06 2010-10-14 Rashmi Nair Pseudoephedrine pharmaceutical formulations
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065143A (en) * 1960-04-19 1962-11-20 Richardson Merrell Inc Sustained release tablet
US4167558A (en) * 1976-02-13 1979-09-11 Hoffmann-La Roche Inc. Novel sustained release tablet formulations
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4610870A (en) * 1984-10-05 1986-09-09 E. R. Squibb & Sons, Inc. Controlled release formulation
US4734285A (en) * 1985-10-28 1988-03-29 The Dow Chemical Company Sustained release compositions
US4704285A (en) * 1985-11-18 1987-11-03 The Dow Chemical Company Sustained release compositions comprising hydroxypropyl cellulose ethers
US4855143A (en) * 1986-04-04 1989-08-08 Hans Lowey Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics
US4775535A (en) * 1986-04-04 1988-10-04 Hans Lowey Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics
US5603956A (en) * 1990-11-27 1997-02-18 Labopharm Inc. Cross-linked enzymatically controlled drug release
CA2041774C (en) * 1990-11-27 1994-04-19 Mircea A. Mateescu Use of cross-linked amylose as a matrix for the slow release of biologically active compounds
NL9201196A (nl) * 1992-07-03 1994-02-01 Tno Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat.
PL173249B1 (pl) * 1992-07-24 1998-02-27 Labopharm Inc Tabletka o kontrolowanym uwalnianiu leku
US5616343A (en) * 1993-03-25 1997-04-01 Labopharm, Inc. Cross-linked amylose as a binder/disintegrant in tablets
IT1282650B1 (it) * 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici

Also Published As

Publication number Publication date
AU711089B2 (en) 1999-10-07
CN1218396A (zh) 1999-06-02
EP0954290B1 (de) 2003-05-21
DK0954290T3 (da) 2003-09-22
CZ325498A3 (cs) 1999-03-17
CZ294342B6 (cs) 2004-12-15
WO1997037639A1 (fr) 1997-10-16
ES2200166T3 (es) 2004-03-01
KR20000005337A (ko) 2000-01-25
IL126477A (en) 2001-10-31
NZ332576A (en) 2000-03-27
IL126477A0 (en) 1999-08-17
PL187764B1 (pl) 2004-10-29
KR100439614B1 (ko) 2004-10-14
TR199802034T2 (xx) 1999-02-22
JP4166278B2 (ja) 2008-10-15
NO984703L (no) 1998-12-08
US5885615A (en) 1999-03-23
PL329285A1 (en) 1999-03-15
DE69722247T2 (de) 2004-04-01
PT954290E (pt) 2003-10-31
BR9708772A (pt) 2000-01-04
NO321862B1 (no) 2006-07-17
AU2283297A (en) 1997-10-29
MY115535A (en) 2003-07-31
ATE240719T1 (de) 2003-06-15
CA2173818A1 (fr) 1997-10-11
ZA973054B (en) 1998-06-01
NO984703D0 (no) 1998-10-08
EP0954290A1 (de) 1999-11-10
JP2000507561A (ja) 2000-06-20

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