DE69721358D1 - Benzothiophene, deren Zusammensetzungen und Verfahren - Google Patents
Benzothiophene, deren Zusammensetzungen und VerfahrenInfo
- Publication number
- DE69721358D1 DE69721358D1 DE69721358T DE69721358T DE69721358D1 DE 69721358 D1 DE69721358 D1 DE 69721358D1 DE 69721358 T DE69721358 T DE 69721358T DE 69721358 T DE69721358 T DE 69721358T DE 69721358 D1 DE69721358 D1 DE 69721358D1
- Authority
- DE
- Germany
- Prior art keywords
- estrogen
- compositions
- benzothiophenes
- processes
- benzoä
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1199096P | 1996-02-21 | 1996-02-21 | |
US11990 | 1996-02-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69721358D1 true DE69721358D1 (de) | 2003-06-05 |
DE69721358T2 DE69721358T2 (de) | 2004-04-08 |
Family
ID=21752855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69721358T Expired - Fee Related DE69721358T2 (de) | 1996-02-21 | 1997-02-19 | Benzothiophene, deren Zusammensetzungen und Verfahren |
Country Status (9)
Country | Link |
---|---|
US (1) | US6432982B1 (de) |
EP (1) | EP0791590B1 (de) |
JP (1) | JP2000505453A (de) |
AT (1) | ATE239009T1 (de) |
AU (1) | AU1959697A (de) |
CA (1) | CA2247130A1 (de) |
DE (1) | DE69721358T2 (de) |
ES (1) | ES2197301T3 (de) |
WO (1) | WO1997030985A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465445B1 (en) | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
EP1401446B1 (de) | 2001-05-22 | 2005-02-09 | Eli Lilly And Company | Tetrahydrochinolin-derivate zur behandlung von krankheiten ausgelöst durch zu hohem oder zu niedrigem oestrogenspiegel |
JP2004531562A (ja) | 2001-05-22 | 2004-10-14 | イーライ・リリー・アンド・カンパニー | 2−置換1,2,3,4−テトラヒドロキノリンおよびその誘導体、組成物ならびに方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862232A (en) | 1963-07-03 | 1975-01-21 | Upjohn Co | 1-(p-hydroxyphenyl)-2-phenyl-6-(2-diethylaminoethoxy)-3,4-dihydronaphthalene and the salts thereof |
US3293263A (en) | 1963-12-09 | 1966-12-20 | Upjohn Co | Diphenylbenzocycloalkenes |
US3320271A (en) | 1964-06-01 | 1967-05-16 | Upjohn Co | 1, 2-diphenyl-3, 4-dihydronaphthalenes and 2, 3-diphenylindenes |
GB1138163A (en) | 1965-05-21 | 1968-12-27 | Bristol Myers Co | Benzothiophene derivatives having anti-fertility properties |
US4133814A (en) | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4358593A (en) | 1981-04-03 | 1982-11-09 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes |
NZ200204A (en) | 1981-04-03 | 1985-05-31 | Lilly Co Eli | Benzothiophene derivatives and process for preparation |
US4418068A (en) | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
US4380635A (en) | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
FR2665444B1 (fr) | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
DE4117512A1 (de) | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
JP3157882B2 (ja) | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
TW366342B (en) | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
US5482949A (en) | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
US5484798A (en) | 1994-09-20 | 1996-01-16 | Eli Lilly And Company | Benzothiopene compounds, compositions, and method of inhibiting restenosis |
US5510357A (en) | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
US6479517B1 (en) * | 1995-02-28 | 2002-11-12 | Eli Lilly And Company | Phosphorous-containing benzothiophenes |
US6395755B1 (en) * | 1995-03-10 | 2002-05-28 | Eli Lilly And Company | Benzothiophene pharmaceutical compounds |
US6417199B1 (en) * | 1995-03-10 | 2002-07-09 | Eli Lilly And Company | 3-benzyl-benzothiophenes |
US5532382A (en) | 1995-03-13 | 1996-07-02 | Eli Lilly And Company | Benzothiophenes substituted at the 3-carbonyl |
CA2223595C (en) * | 1995-06-07 | 2008-08-05 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies with tamoxifen analogues |
US6444688B1 (en) * | 1995-06-07 | 2002-09-03 | Eli Lilly And Company | Compounds and compositions with nitrogen-containing non-basic side chains |
-
1997
- 1997-01-14 US US08/783,160 patent/US6432982B1/en not_active Expired - Fee Related
- 1997-02-13 AU AU19596/97A patent/AU1959697A/en not_active Abandoned
- 1997-02-13 WO PCT/US1997/002373 patent/WO1997030985A1/en active Application Filing
- 1997-02-13 JP JP9530246A patent/JP2000505453A/ja active Pending
- 1997-02-13 CA CA002247130A patent/CA2247130A1/en not_active Abandoned
- 1997-02-19 AT AT97301058T patent/ATE239009T1/de not_active IP Right Cessation
- 1997-02-19 EP EP97301058A patent/EP0791590B1/de not_active Expired - Lifetime
- 1997-02-19 ES ES97301058T patent/ES2197301T3/es not_active Expired - Lifetime
- 1997-02-19 DE DE69721358T patent/DE69721358T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6432982B1 (en) | 2002-08-13 |
EP0791590A1 (de) | 1997-08-27 |
AU1959697A (en) | 1997-09-10 |
WO1997030985A1 (en) | 1997-08-28 |
EP0791590B1 (de) | 2003-05-02 |
JP2000505453A (ja) | 2000-05-09 |
ATE239009T1 (de) | 2003-05-15 |
CA2247130A1 (en) | 1997-08-28 |
ES2197301T3 (es) | 2004-01-01 |
DE69721358T2 (de) | 2004-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |