DE69712621T2 - Verfahren und vorrichtung zur untersuchung von teilchen durch dielektrophorese - Google Patents

Verfahren und vorrichtung zur untersuchung von teilchen durch dielektrophorese

Info

Publication number
DE69712621T2
DE69712621T2 DE69712621T DE69712621T DE69712621T2 DE 69712621 T2 DE69712621 T2 DE 69712621T2 DE 69712621 T DE69712621 T DE 69712621T DE 69712621 T DE69712621 T DE 69712621T DE 69712621 T2 DE69712621 T2 DE 69712621T2
Authority
DE
Germany
Prior art keywords
particles
behavior
dielectrophoresis
different
spectrum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69712621T
Other languages
English (en)
Other versions
DE69712621D1 (de
Inventor
Ronald Pethig
Hendricus Markx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
BTG International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BTG International Ltd filed Critical BTG International Ltd
Application granted granted Critical
Publication of DE69712621D1 publication Critical patent/DE69712621D1/de
Publication of DE69712621T2 publication Critical patent/DE69712621T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00Separating dispersed particles from liquids by electrostatic effect
    • B03C5/005Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
DE69712621T 1996-07-26 1997-07-28 Verfahren und vorrichtung zur untersuchung von teilchen durch dielektrophorese Expired - Lifetime DE69712621T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9615775.5A GB9615775D0 (en) 1996-07-26 1996-07-26 Apparatus and method for characterising particles using dielectrophoresis
PCT/GB1997/002011 WO1998004355A1 (en) 1996-07-26 1997-07-28 Apparatus and method for testing particles using dielectrophoresis

Publications (2)

Publication Number Publication Date
DE69712621D1 DE69712621D1 (de) 2002-06-20
DE69712621T2 true DE69712621T2 (de) 2002-11-07

Family

ID=10797580

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69712621T Expired - Lifetime DE69712621T2 (de) 1996-07-26 1997-07-28 Verfahren und vorrichtung zur untersuchung von teilchen durch dielektrophorese

Country Status (8)

Country Link
US (1) US6264815B1 (de)
EP (1) EP0914211B1 (de)
JP (1) JP4105767B2 (de)
AT (1) ATE217544T1 (de)
DE (1) DE69712621T2 (de)
DK (1) DK0914211T3 (de)
GB (1) GB9615775D0 (de)
WO (1) WO1998004355A1 (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403367B1 (en) * 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US7857957B2 (en) 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US5748088A (en) * 1996-11-27 1998-05-05 Afilani; Thomas L. Device and method using dielectrokinesis to locate entities
US20030102218A1 (en) * 1997-07-28 2003-06-05 Kiely James Dillon Head-disk stiction reduction
DE19823047C1 (de) * 1998-05-22 1999-08-26 Fuhr Verfahren und Vorrichtung zur Permeation biologischer Objekte
DE19860117A1 (de) * 1998-12-23 2000-07-13 Evotec Biosystems Ag Elektrodenanordnung zur dielektrophoretischen Partikelablenkung
ATE253410T1 (de) 1998-06-26 2003-11-15 Evotec Ag Elektrodenanordnung zur dielektrophoretischen partikelablenkung
EP1144092A4 (de) * 1998-12-23 2002-10-29 Nanogen Inc Integriertes tragbares system zur biologischen detektion
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
CN1181337C (zh) 2000-08-08 2004-12-22 清华大学 微流体系统中实体分子的操纵方法及相关试剂盒
US6942776B2 (en) * 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
GB9916850D0 (en) * 1999-07-20 1999-09-22 Univ Wales Bangor Dielectrophoretic apparatus & method
GB9916851D0 (en) * 1999-07-20 1999-09-22 Univ Wales Bangor Manipulation of particles in liquid media
GB2358473B (en) * 2000-01-22 2003-10-08 Cell Analysis Ltd Methods and apparatus for detecting microscopic bodies
JP4587112B2 (ja) * 2000-04-13 2010-11-24 和光純薬工業株式会社 誘電泳動装置及び物質の分離方法
GB2361883B (en) * 2000-05-03 2003-05-28 Cell Analysis Ltd Method and apparatus for analysing low concentrations of particles
WO2001098765A1 (en) 2000-06-21 2001-12-27 Bioarray Solutions, Ltd. Multianalyte molecular analysis
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
CN100495030C (zh) 2000-09-30 2009-06-03 清华大学 多力操纵装置及其应用
WO2002075276A2 (en) * 2001-03-15 2002-09-26 The Regents Of The University Of California Positioning of organic and inorganic objects by electrophoretic forces including for microlens alignment
US7419574B2 (en) * 2001-06-20 2008-09-02 Cummings Eric B Dielectrophoresis device and method having non-uniform arrays for manipulating particles
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
ES2661167T3 (es) 2001-10-15 2018-03-27 Bioarray Solutions Ltd. Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
US6703819B2 (en) 2001-12-03 2004-03-09 Board Of Regents, The University Of Texas System Particle impedance sensor
US6637257B2 (en) * 2002-01-02 2003-10-28 Integrated Sensing Systems Micromachined fluid analysis device and method
US20030209438A1 (en) * 2002-05-09 2003-11-13 Vincent Bressler Particle characterization using gravity in opposition to an induced force
US20040011652A1 (en) * 2002-07-16 2004-01-22 Bressler Vincent Edward Separation of particles using multiple conductive layers
US20040060820A1 (en) * 2002-10-01 2004-04-01 Bressler Vincent Edward Characterization of particles by position in an electric field
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US7063777B2 (en) * 2002-12-12 2006-06-20 Aura Biosystems Inc. Dielectrophoretic particle profiling system and method
US7105081B2 (en) * 2002-12-20 2006-09-12 Board Of Regents, The University Of Texas System Methods and apparatus for electrosmear analysis
JP4128084B2 (ja) * 2003-01-07 2008-07-30 クラスターテクノロジー株式会社 試料の特性化方法およびその装置
WO2004074913A2 (en) * 2003-02-19 2004-09-02 Bioarray Solutions Ltd. A dynamically configurable electrode formed of pixels
US7169282B2 (en) * 2003-05-13 2007-01-30 Aura Biosystems Inc. Dielectrophoresis apparatus
US7156970B2 (en) * 2003-06-12 2007-01-02 Palo Alto Research Center Incorporated Distributed multi-segmented reconfigurable traveling wave grids for separation of proteins in gel electrophoresis
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US7595279B2 (en) 2003-09-22 2009-09-29 Bioarray Solutions Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US7347923B2 (en) * 2003-10-03 2008-03-25 Sandia Corporation Dielectrophoresis device and method having insulating ridges for manipulating particles
CA2544041C (en) 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US7384791B2 (en) * 2004-01-21 2008-06-10 Hewlett-Packard Development Company, L.P. Method of analyzing blood
US7390388B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells on a biodevice
US7390387B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells in series
US7160425B2 (en) * 2004-03-25 2007-01-09 Hewlett-Packard Development Company, L.P. Cell transporter for a biodevice
EP1765501A1 (de) 2004-05-28 2007-03-28 Board of Regents, The University of Texas System Programmierbare fluidverarbeiter
ITBO20040420A1 (it) 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
ITBO20050481A1 (it) 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
JP2009014342A (ja) * 2005-10-19 2009-01-22 Sharp Corp 誘電泳動チップおよび誘電泳動装置並びに誘電泳動システム
WO2007046484A1 (ja) * 2005-10-19 2007-04-26 Sharp Kabushiki Kaisha 誘電泳動チップおよび誘電泳動装置並びに誘電泳動システム
ITBO20050646A1 (it) 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
US8262886B2 (en) 2006-02-10 2012-09-11 Kochi University Of Technology Apparatus for analyzing characteristics of particulate with dielectrophoresis of particulate by applying angle-modulated wave and method for the same
WO2007105578A1 (ja) * 2006-03-10 2007-09-20 Cluster Technology Co., Ltd. 誘電泳動による微粒子の状態の測定方法
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
EP2042239A1 (de) * 2007-09-10 2009-04-01 Koninklijke Philips Electronics N.V. Dielektrophoretische Vorrichtung und entsprechendes Verfahren für Zellmembran-Studien
WO2009037804A1 (ja) * 2007-09-18 2009-03-26 Panasonic Corporation 微粒子測定装置および微粒子測定方法
KR101162434B1 (ko) 2007-10-05 2012-07-04 고쿠리츠 다이가쿠 호진 큐슈 코교 다이가쿠 유전 영동 장치
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
CA2720324C (en) * 2008-04-03 2016-08-23 The Regents Of The University Of California Ex-vivo multi-dimensional system for the separation and isolation of cells, vesicles, nanoparticles and biomarkers
CN101281163B (zh) * 2008-04-28 2012-06-27 中央民族大学 用于确定多种细胞介电响应和分离条件的检测系统
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
DK2408562T3 (en) 2009-03-17 2018-06-06 Menarini Silicon Biosystems Spa Microfluidic device for isolating cells
JP2010252785A (ja) 2009-03-31 2010-11-11 Kanagawa Acad Of Sci & Technol 細胞濃縮分離装置
JP5471228B2 (ja) * 2009-09-17 2014-04-16 パナソニック株式会社 微生物濃度調整装置
IT1403518B1 (it) 2010-12-22 2013-10-31 Silicon Biosystems Spa Dispositivo microfluidico per la manipolazione di particelle
ITTO20110990A1 (it) 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
US11198126B2 (en) 2011-10-31 2021-12-14 Fluid-Screen, Inc. Apparatus for pathogen detection
ITBO20110766A1 (it) 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
US8932815B2 (en) 2012-04-16 2015-01-13 Biological Dynamics, Inc. Nucleic acid sample preparation
EP2839035B1 (de) 2012-04-16 2020-11-25 Biological Dynamics, Inc. Nukleinsäureproben-präparation
KR101501983B1 (ko) * 2013-06-05 2015-03-13 한국항공대학교산학협력단 음의 유전 영동력 기반의 고효율 다단 세포 분리장치
WO2014200774A2 (en) * 2013-06-14 2014-12-18 Nanophoretics Llc Method and apparatus for identifying objects in a plurality of objects using dielectrophoresis
CA2925112A1 (en) 2013-10-04 2015-04-09 Michigan Technological University Methods and systems for identifying a particle using dielectrophoresis
MX2016013216A (es) 2014-04-08 2017-05-01 Biological dynamics inc Dispositivos mejorados para la separacion de materiales biologicos.
WO2016070100A1 (en) * 2014-10-31 2016-05-06 The Regents Of The University Of California Neural circuit probe
EP3361231B1 (de) * 2015-10-07 2021-02-17 AFI Corporation Inspektionsvorrichtung, inspektionssystem und inspektionsverfahren
CA3018900A1 (en) 2016-03-24 2017-09-28 Biological Dynamics, Inc. Disposable fluidic cartridge and components
EP3442711B1 (de) 2016-04-15 2020-12-09 Fluid-Screen, Inc. Analytnachweisverfahren und -vorrichtungen mit dielektrophorese und elektroosmose
CA3041777A1 (en) 2016-10-31 2018-05-03 Mekonos Limited An array of needle manipulators for biological cell injection
SG11201903750RA (en) * 2016-10-31 2019-05-30 Mekonos Ltd Improved sensing for automated biological cell injection
EP3622084A4 (de) 2017-05-08 2021-02-17 Biological Dynamics, Inc. Verfahren und systeme zur verarbeitung von analytinformationen
CN116121340A (zh) 2017-12-19 2023-05-16 生物动力学公司 用于从生物样品中检测多种分析物的方法和装置
CN117065932A (zh) 2018-04-02 2023-11-17 生物动力学公司 介电材料
WO2021097035A1 (en) 2019-11-13 2021-05-20 Fluid-Screen, Inc. An apparatus and methods to rapidly detect, separate, purify, and quantify various viruses from cells, cultured medium and other fluids
CA3161454A1 (en) 2019-11-13 2021-05-20 Fluid-Screen, Inc. Methods and apparatus for detection of bacteria in a sample using dielectrophoresis
WO2024015006A1 (en) * 2022-07-12 2024-01-18 Nocoli Ab Method and system for characterizing organic live particle types in water

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4326934A (en) 1979-12-31 1982-04-27 Pohl Herbert A Continuous dielectrophoretic cell classification method
US4956065A (en) 1988-11-03 1990-09-11 Kaler Karen V I S Method and apparatus for three dimensional dynamic dielectric levitation
GB9002092D0 (en) * 1990-01-30 1990-03-28 P & B Sciences Ltd Manipulation of solid,semi-solid or liquid materials
DE4034697A1 (de) * 1990-10-31 1992-05-14 Fraunhofer Ges Forschung Verfahren zur handhabung mikroskopisch kleiner, dielektrischer teilchen und vorrichtung zur durchfuehrung des verfahrens
DE4143573C2 (de) * 1991-08-19 1996-07-04 Fraunhofer Ges Forschung Vorrichtung zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter, dielektrischer Teilchen
US5489506A (en) * 1992-10-26 1996-02-06 Biolife Systems, Inc. Dielectrophoretic cell stream sorter
GB9306729D0 (en) 1993-03-31 1993-05-26 British Tech Group Improvements in separators

Also Published As

Publication number Publication date
ATE217544T1 (de) 2002-06-15
EP0914211B1 (de) 2002-05-15
DK0914211T3 (da) 2002-08-19
US6264815B1 (en) 2001-07-24
EP0914211A1 (de) 1999-05-12
JP4105767B2 (ja) 2008-06-25
DE69712621D1 (de) 2002-06-20
GB9615775D0 (en) 1996-09-04
JP2001500252A (ja) 2001-01-09
WO1998004355A1 (en) 1998-02-05

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