DE69706828D1 - Verfahren zur herstellung von purinderivaten - Google Patents

Verfahren zur herstellung von purinderivaten

Info

Publication number
DE69706828D1
DE69706828D1 DE69706828T DE69706828T DE69706828D1 DE 69706828 D1 DE69706828 D1 DE 69706828D1 DE 69706828 T DE69706828 T DE 69706828T DE 69706828 T DE69706828 T DE 69706828T DE 69706828 D1 DE69706828 D1 DE 69706828D1
Authority
DE
Germany
Prior art keywords
purine derivatives
producing purine
producing
derivatives
purine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69706828T
Other languages
English (en)
Other versions
DE69706828T2 (de
Inventor
B Arzeno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69706828D1 publication Critical patent/DE69706828D1/de
Publication of DE69706828T2 publication Critical patent/DE69706828T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69706828T 1996-01-26 1997-01-18 Verfahren zur herstellung von purinderivaten Expired - Lifetime DE69706828T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/592,080 US5700936A (en) 1996-01-26 1996-01-26 Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
PCT/EP1997/000229 WO1997027195A1 (en) 1996-01-26 1997-01-18 Process for preparing purine derivatives

Publications (2)

Publication Number Publication Date
DE69706828D1 true DE69706828D1 (de) 2001-10-25
DE69706828T2 DE69706828T2 (de) 2002-04-04

Family

ID=24369201

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69706828T Expired - Lifetime DE69706828T2 (de) 1996-01-26 1997-01-18 Verfahren zur herstellung von purinderivaten

Country Status (7)

Country Link
US (1) US5700936A (de)
EP (1) EP0877746B1 (de)
JP (1) JP4091115B2 (de)
AU (1) AU1592997A (de)
DE (1) DE69706828T2 (de)
ES (1) ES2163117T3 (de)
WO (1) WO1997027195A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
RU2006109365A (ru) * 2003-08-28 2007-10-10 Рэнбакси Лабораториз Лимитед (In) Аморфный гидрохлорид валганцикловира
WO2005092891A2 (en) * 2004-03-29 2005-10-06 Ranbaxy Laboratories Limited Preparation of esters of ganciclovir
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
EP1870411B1 (de) * 2006-06-21 2016-03-16 Fidia Farmaceutici S.p.A. Verfahren zur Herstellung und Reinigung von Valgancyclovir
US20090076040A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched valganciclovir
WO2010036904A2 (en) * 2008-09-26 2010-04-01 Dr. Reddy's Laboratories Ltd. Preparation of valganciclovir and its salts
CN102070635B (zh) * 2009-11-19 2013-01-30 浙江车头制药股份有限公司 一种更昔洛韦缬氨酸酯衍生物的制备方法
US20110207931A1 (en) * 2010-02-23 2011-08-25 Srinivas Katkam Preparation of valganciclovir and its salts
EP2714691B1 (de) 2011-05-31 2016-09-07 Pharmathen S.A. Verfahren zur herstellung von 2-amino-9- ((2-phenyl-1,3-dioxan-5-yloxy)methyl) (-1h-purin-6(9h) -on-verbindung zur herstellung von valganciclovir
CN111763207B (zh) * 2019-04-02 2024-05-10 北京万全德众医药生物技术有限公司 一种盐酸缬更昔洛韦的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
AU569462B2 (en) * 1981-08-11 1988-02-04 Wellcome Foundation Limited, The Antiviral purine derivatives
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
ATE33654T1 (de) * 1982-10-14 1988-05-15 Wellcome Found Antivirale purinderivate.
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
US5043339A (en) * 1988-12-19 1991-08-27 Burroughs Wellcome Co. Antiviral compounds
ATE199719T1 (de) * 1993-06-10 2001-03-15 Rolabo Sl Verfahren zur herstellung von aminosäureester von nukleosid analogen
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables

Also Published As

Publication number Publication date
DE69706828T2 (de) 2002-04-04
EP0877746A1 (de) 1998-11-18
ES2163117T3 (es) 2002-01-16
JP2000503975A (ja) 2000-04-04
WO1997027195A1 (en) 1997-07-31
JP4091115B2 (ja) 2008-05-28
US5700936A (en) 1997-12-23
AU1592997A (en) 1997-08-20
EP0877746B1 (de) 2001-09-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition