DE69637571D1 - Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen - Google Patents

Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen

Info

Publication number
DE69637571D1
DE69637571D1 DE69637571T DE69637571T DE69637571D1 DE 69637571 D1 DE69637571 D1 DE 69637571D1 DE 69637571 T DE69637571 T DE 69637571T DE 69637571 T DE69637571 T DE 69637571T DE 69637571 D1 DE69637571 D1 DE 69637571D1
Authority
DE
Germany
Prior art keywords
immune response
presenting cells
antigen
reinforcing
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637571T
Other languages
English (en)
Inventor
Sam D Sanderson
Michael A Hollingsworth
Richard A Tempero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Nebraska
Original Assignee
University of Nebraska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Nebraska filed Critical University of Nebraska
Application granted granted Critical
Publication of DE69637571D1 publication Critical patent/DE69637571D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69637571T 1995-10-20 1996-10-18 Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen Expired - Lifetime DE69637571D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US572795P 1995-10-20 1995-10-20
PCT/US1996/016825 WO1997014426A1 (en) 1995-10-20 1996-10-18 Compositions and methods for enhancing immune responses mediated by antigen-presenting cells

Publications (1)

Publication Number Publication Date
DE69637571D1 true DE69637571D1 (de) 2008-08-07

Family

ID=21717413

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637571T Expired - Lifetime DE69637571D1 (de) 1995-10-20 1996-10-18 Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen

Country Status (9)

Country Link
US (5) US6821517B1 (de)
EP (1) EP0859625B1 (de)
JP (1) JP4125784B2 (de)
AT (1) ATE399022T1 (de)
AU (1) AU703120B2 (de)
CA (1) CA2232344C (de)
DE (1) DE69637571D1 (de)
ES (1) ES2309992T3 (de)
WO (1) WO1997014426A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0859625B1 (de) * 1995-10-20 2008-06-25 University Of Nebraska Board Of Regents Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen
US20080286228A1 (en) * 1995-10-20 2008-11-20 Tarantolo Stefano R Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
GB9930591D0 (en) * 1999-12-23 2000-02-16 Univ London Component for vaccine
US20030138434A1 (en) * 2001-08-13 2003-07-24 Campbell Robert L. Agents for enhancing the immune response
GB0208817D0 (en) * 2002-04-17 2002-05-29 European Molecular Biology Lab Embl Method for producing monoclonal antibodies
US7361742B2 (en) * 2002-12-02 2008-04-22 Resistentia Pharmaceuticals Ab Methods and materials for treating inflammatory conditions
US20080152648A1 (en) * 2006-09-26 2008-06-26 Alexion Pharmaceuticals, Inc. Compositions and methods for enhancing an adjuvant
AU2008280436A1 (en) * 2007-07-24 2009-01-29 Stichting Katholieke Universiteit Radboud University Nijmegen Medical Centre Compositions and methods for generating an immune response in a subject
BRPI0817209A2 (pt) * 2007-09-20 2015-03-10 David Gladstone Inst Composições de polipeptídeo de elemento nuclear intercalado longo e métodos de uso das mesmas
EP2250278B1 (de) * 2008-02-21 2023-04-05 Burnham Institute for Medical Research Verfahren und zusammensetzungen in zusammenhang mit peptiden und proteinen mit c-terminalen elementen
CA2766634A1 (en) 2009-06-22 2011-01-13 Burnham Institute For Medical Research Methods and compositions using peptides and proteins with c-terminal elements
FR2955773B1 (fr) 2010-02-01 2017-05-26 Commissariat A L'energie Atomique Complexe moleculaire de ciblage des antigenes vers les cellules presentatrices d'antigene et ses applications pour la vaccination
WO2012006149A2 (en) * 2010-06-29 2012-01-12 Board Of Regents Of The University Of Nebraska Analogs of c5a and methods of using same
WO2013082535A2 (en) 2011-12-02 2013-06-06 Board Of Regents Of The University Of Nebraska Controlled-release peptide compositions and uses thereof
AU2016228771A1 (en) 2015-03-11 2017-10-26 Board Of Regents Of The University Of Nebraska Conformationally stable analogs of the response selective C5a agonist EP67
US11911464B2 (en) 2018-09-14 2024-02-27 Prommune, Inc. Anti-parasitic immunological compositions
CN111544585A (zh) * 2019-02-11 2020-08-18 北京卡替医疗技术有限公司 一种可助推免疫细胞在体内扩增的佐剂
WO2023133526A2 (en) * 2022-01-06 2023-07-13 Washington University Methods and compositions for enhancement of tumor immunogenicity and stimulating anti-tumor immune responses in an animal

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GB2117514B (en) * 1982-03-29 1985-08-29 East Anglian Regional Health Polyvalent antiglobulin reagent
JPH0788398B2 (ja) * 1983-10-17 1995-09-27 サントリー株式会社 新規生理活性ポリペプチドおよびその製造法
GB2177514B (en) 1985-07-04 1988-07-06 Isc Chemicals Ltd Leak testing of electrical or electronic components
GB8610983D0 (en) * 1986-05-06 1986-06-11 Connaught Lab Enhancement of antigen immunogenicity
DE68924850T2 (de) 1988-06-14 1996-10-10 Cell Med Inc Heterofunktionelle zellular immunologische reagenzien, impfstoffe daraus und verwendungsverfahren.
US5032401A (en) * 1989-06-15 1991-07-16 Alpha Beta Technology Glucan drug delivery system and adjuvant
US5073627A (en) * 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
US5262303A (en) * 1989-10-13 1993-11-16 Trustees Of Boston University Ligand/anti-ligand assays for adherent proteins
US5840840A (en) * 1990-04-17 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Selective RNase cytotoxic reagents
US6248332B1 (en) * 1990-10-05 2001-06-19 Medarex, Inc. Targeted immunostimulation with bispecific reagents
WO1992005793A1 (en) * 1990-10-05 1992-04-16 Medarex, Inc. Targeted immunostimulation with bispecific reagents
JPH07108232B2 (ja) * 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
GB9027767D0 (en) * 1990-12-21 1991-02-13 Cambridge Antibody Tech Binding substances
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
AU671971B2 (en) * 1991-11-29 1996-09-19 Chiron Corporation Anti-cancer immunotherapeutic vector constructs
US5804187A (en) * 1992-11-16 1998-09-08 Cancer Research Fund Of Contra Costa Modified antibodies with human milk fat globule specificity
US5744144A (en) * 1993-07-30 1998-04-28 University Of Pittsburgh University Patent Committee Policy And Procedures Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
AUPM322393A0 (en) * 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
US5614370A (en) * 1994-03-18 1997-03-25 Merck & Co., Inc. Assay to identify human C5a antagonists and agonists
US5696230A (en) 1994-08-31 1997-12-09 The Board Of Regents Of The University Of Nebraska High-affinity response-selective C-terminal analogs of C5a anaphylatoxin
US6086875A (en) * 1995-01-17 2000-07-11 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of immunogens
GB9501079D0 (en) * 1995-01-19 1995-03-08 Bioinvent Int Ab Activation of T-cells
EP0859625B1 (de) * 1995-10-20 2008-06-25 University Of Nebraska Board Of Regents Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen
US6080409A (en) * 1995-12-28 2000-06-27 Dendreon Corporation Immunostimulatory method
FR2775977B1 (fr) * 1998-03-10 2000-06-23 Oreal Composes lipidiques derives des bases sphingoides, leur procede de preparation et leurs utilisations en cosmetique et en dermopharmacie
US20050089524A1 (en) * 2002-03-01 2005-04-28 Sanderson Sam D. Compositions and compounds for use as molecular adjuvant for a nicotine vaccine

Also Published As

Publication number Publication date
CA2232344A1 (en) 1997-04-24
US7291336B2 (en) 2007-11-06
AU7460896A (en) 1997-05-07
US20050025784A1 (en) 2005-02-03
EP0859625B1 (de) 2008-06-25
EP0859625A1 (de) 1998-08-26
JPH11515005A (ja) 1999-12-21
US20070031445A1 (en) 2007-02-08
US6821517B1 (en) 2004-11-23
US7063847B1 (en) 2006-06-20
US7358087B2 (en) 2008-04-15
AU703120B2 (en) 1999-03-18
US20020091234A1 (en) 2002-07-11
CA2232344C (en) 2005-04-05
ES2309992T3 (es) 2008-12-16
WO1997014426A1 (en) 1997-04-24
JP4125784B2 (ja) 2008-07-30
EP0859625A4 (de) 2004-03-03
ATE399022T1 (de) 2008-07-15

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