DE69637324T2 - Behälter für hyperpolarisiertes edelgas mit einer oberfläche beschichtet mit einem modifizierten polymer - Google Patents
Behälter für hyperpolarisiertes edelgas mit einer oberfläche beschichtet mit einem modifizierten polymer Download PDFInfo
- Publication number
- DE69637324T2 DE69637324T2 DE69637324T DE69637324T DE69637324T2 DE 69637324 T2 DE69637324 T2 DE 69637324T2 DE 69637324 T DE69637324 T DE 69637324T DE 69637324 T DE69637324 T DE 69637324T DE 69637324 T2 DE69637324 T2 DE 69637324T2
- Authority
- DE
- Germany
- Prior art keywords
- polymer
- noble gas
- relaxation
- container
- container according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920000642 polymer Polymers 0.000 title claims abstract description 90
- 229910052756 noble gas Inorganic materials 0.000 claims abstract description 89
- 238000000034 method Methods 0.000 claims abstract description 60
- 238000000576 coating method Methods 0.000 claims abstract description 43
- 239000011248 coating agent Substances 0.000 claims abstract description 36
- 230000003993 interaction Effects 0.000 claims abstract description 36
- 230000035699 permeability Effects 0.000 claims abstract description 15
- 230000002829 reductive effect Effects 0.000 claims abstract description 14
- 238000003860 storage Methods 0.000 claims abstract description 7
- 230000002102 hyperpolarization Effects 0.000 claims description 22
- 229920001296 polysiloxane Polymers 0.000 claims description 18
- 150000002835 noble gases Chemical class 0.000 claims description 17
- 150000002430 hydrocarbons Chemical class 0.000 claims description 15
- -1 polysiloxane Polymers 0.000 claims description 15
- 239000004215 Carbon black (E152) Substances 0.000 claims description 13
- 229930195733 hydrocarbon Natural products 0.000 claims description 13
- 230000028161 membrane depolarization Effects 0.000 claims description 11
- 150000004756 silanes Chemical class 0.000 claims description 6
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000011261 inert gas Substances 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 238000006277 sulfonation reaction Methods 0.000 claims description 3
- 230000021523 carboxylation Effects 0.000 claims description 2
- 238000006473 carboxylation reaction Methods 0.000 claims description 2
- 230000026030 halogenation Effects 0.000 claims description 2
- 238000005658 halogenation reaction Methods 0.000 claims description 2
- 150000008282 halocarbons Chemical class 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 abstract description 6
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract description 4
- 229910052805 deuterium Inorganic materials 0.000 abstract description 4
- 230000000670 limiting effect Effects 0.000 abstract description 3
- 230000004048 modification Effects 0.000 abstract description 3
- 238000012986 modification Methods 0.000 abstract description 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000010287 polarization Effects 0.000 description 29
- 230000005291 magnetic effect Effects 0.000 description 25
- 238000005481 NMR spectroscopy Methods 0.000 description 16
- 150000001340 alkali metals Chemical class 0.000 description 15
- 229910052724 xenon Inorganic materials 0.000 description 15
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 15
- 229910052783 alkali metal Inorganic materials 0.000 description 14
- 125000004429 atom Chemical group 0.000 description 13
- 239000007789 gas Substances 0.000 description 13
- 230000008569 process Effects 0.000 description 11
- 238000005086 pumping Methods 0.000 description 10
- 238000001179 sorption measurement Methods 0.000 description 9
- 230000003068 static effect Effects 0.000 description 9
- 230000006872 improvement Effects 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 7
- 239000011521 glass Substances 0.000 description 7
- 230000003287 optical effect Effects 0.000 description 7
- 230000002999 depolarising effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000005283 ground state Effects 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 230000000155 isotopic effect Effects 0.000 description 6
- 238000002595 magnetic resonance imaging Methods 0.000 description 6
- 229910052701 rubidium Inorganic materials 0.000 description 6
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 230000008878 coupling Effects 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 238000005859 coupling reaction Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000005415 magnetization Effects 0.000 description 5
- 230000005298 paramagnetic effect Effects 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229920000098 polyolefin Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 241000239290 Araneae Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000003292 diminished effect Effects 0.000 description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003682 fluorination reaction Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000005297 pyrex Substances 0.000 description 2
- 239000004447 silicone coating Substances 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- IGLNJRXAVVLDKE-NJFSPNSNSA-N Rubidium-87 Chemical compound [87Rb] IGLNJRXAVVLDKE-NJFSPNSNSA-N 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- QXJJQWWVWRCVQT-UHFFFAOYSA-K calcium;sodium;phosphate Chemical compound [Na+].[Ca+2].[O-]P([O-])([O-])=O QXJJQWWVWRCVQT-UHFFFAOYSA-K 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 229920001688 coating polymer Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005314 correlation function Methods 0.000 description 1
- 238000005388 cross polarization Methods 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 125000003963 dichloro group Chemical group Cl* 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- GCSJLQSCSDMKTP-UHFFFAOYSA-N ethenyl(trimethyl)silane Chemical class C[Si](C)(C)C=C GCSJLQSCSDMKTP-UHFFFAOYSA-N 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 125000004437 phosphorous atom Chemical group 0.000 description 1
- 230000010399 physical interaction Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920000306 polymethylpentene Polymers 0.000 description 1
- 239000011116 polymethylpentene Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- IGLNJRXAVVLDKE-IGMARMGPSA-N rubidium-85 atom Chemical compound [85Rb] IGLNJRXAVVLDKE-IGMARMGPSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- KEAYESYHFKHZAL-IGMARMGPSA-N sodium-23 atom Chemical compound [23Na] KEAYESYHFKHZAL-IGMARMGPSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/14—Linings or internal coatings
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B23/00—Noble gases; Compounds thereof
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C1/00—Pressure vessels, e.g. gas cylinder, gas tank, replaceable cartridge
- F17C1/16—Pressure vessels, e.g. gas cylinder, gas tank, replaceable cartridge constructed of plastics materials
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2203/00—Vessel construction, in particular walls or details thereof
- F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
- F17C2203/0602—Wall structures; Special features thereof
- F17C2203/0607—Coatings
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2221/00—Handled fluid, in particular type of fluid
- F17C2221/07—Hyperpolarised gases
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2270/00—Applications
- F17C2270/05—Applications for industrial use
- F17C2270/0527—Superconductors
- F17C2270/0536—Magnetic resonance imaging
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/131—Glass, ceramic, or sintered, fused, fired, or calcined metal oxide or metal carbide containing [e.g., porcelain, brick, cement, etc.]
- Y10T428/1317—Multilayer [continuous layer]
- Y10T428/1321—Polymer or resin containing [i.e., natural or synthetic]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
- Y10T428/31609—Particulate metal or metal compound-containing
- Y10T428/31612—As silicone, silane or siloxane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
- Physical Vapour Deposition (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Inorganic Insulating Materials (AREA)
- Chemically Coating (AREA)
- Paints Or Removers (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Containers Having Bodies Formed In One Piece (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/478,276 US5612103A (en) | 1995-06-07 | 1995-06-07 | Coatings for production of hyperpolarized noble gases |
| US478276 | 1995-06-07 | ||
| PCT/US1996/009402 WO1996039912A1 (en) | 1995-06-07 | 1996-06-07 | Coatings for production of hyperpolarized noble gases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69637324D1 DE69637324D1 (de) | 2007-12-27 |
| DE69637324T2 true DE69637324T2 (de) | 2008-09-18 |
Family
ID=23899257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69637324T Expired - Lifetime DE69637324T2 (de) | 1995-06-07 | 1996-06-07 | Behälter für hyperpolarisiertes edelgas mit einer oberfläche beschichtet mit einem modifizierten polymer |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5612103A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0837641B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP3971799B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN1149165C (cg-RX-API-DMAC10.html) |
| AT (1) | ATE378366T1 (cg-RX-API-DMAC10.html) |
| BR (1) | BR9609064A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2220349C (cg-RX-API-DMAC10.html) |
| DE (1) | DE69637324T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK0837641T3 (cg-RX-API-DMAC10.html) |
| MX (1) | MX9709600A (cg-RX-API-DMAC10.html) |
| NO (1) | NO324090B1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO1996039912A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5642625A (en) * | 1996-03-29 | 1997-07-01 | The Trustees Of Princeton University | High volume hyperpolarizer for spin-polarized noble gas |
| DK1036339T3 (da) | 1997-08-13 | 2006-11-27 | Univ Princeton | Sol-gel-beklædte polarisationsbeholdere |
| AU8910698A (en) | 1997-08-18 | 1999-03-08 | Trustees Of Princeton University, The | Alkali metal hybrid spin-exchange optical pumping |
| HUP0100529A2 (hu) | 1997-11-14 | 2001-06-28 | Weiler, Norbert | Berendezés és eljárás áramló kőzeg célba juttatására |
| US6079213A (en) * | 1997-12-12 | 2000-06-27 | Magnetic Imaging Technologies Incorporated | Methods of collecting, thawing, and extending the useful life of polarized gases and associated accumulators and heating jackets |
| DE69813904T2 (de) | 1997-12-12 | 2004-02-05 | Medi-Physics, Inc. | Verfahren zum sägen und auftauen eines xenon enthaltenden polarisierten gases |
| US6423387B1 (en) | 1998-06-17 | 2002-07-23 | Medi-Physics, Inc. | Resilient containers for hyperpolarized gases and associated methods |
| CA2637700A1 (en) | 1998-06-17 | 1999-12-23 | Medi-Physics, Inc. | Resilient containers for hyperpolarized gases |
| BR9911346A (pt) | 1998-06-17 | 2001-03-13 | Medi Physics Inc | Dispositivo de transporte de gás hiperpolarizado e método de transporte associado |
| US6128918A (en) * | 1998-07-30 | 2000-10-10 | Medi-Physics, Inc. | Containers for hyperpolarized gases and associated methods |
| US6523356B2 (en) | 1998-09-30 | 2003-02-25 | Medi-Physics, Inc. | Meted hyperpolarized noble gas dispensing methods and associated devices |
| US6237363B1 (en) | 1998-09-30 | 2001-05-29 | Medi-Physics, Inc. | Hyperpolarized noble gas extraction methods masking methods and associated transport containers |
| US6286319B1 (en) | 1998-09-30 | 2001-09-11 | Medi-Physics, Inc. | Meted hyperpolarized noble gas dispensing methods and associated devices |
| US6125654A (en) * | 1998-10-16 | 2000-10-03 | Syracuse University | Bulk production and usage of hyperpolarized 129 Xenon |
| US6284222B1 (en) | 1998-11-03 | 2001-09-04 | Medi--Physics, Inc. | Hyperpolarized helium-3 microbubble gas entrapment methods |
| US6566875B1 (en) | 1999-02-23 | 2003-05-20 | Medi-Physics, Inc. | Portable hyperpolarized gas monitoring systems, computer program products, and related methods using NMR and/or MRI during transport |
| DE19927788C2 (de) * | 1999-06-18 | 2003-03-06 | Forschungszentrum Juelich Gmbh | Polarisator für die Polarisation eines Edelgases |
| US6295834B1 (en) | 1999-06-30 | 2001-10-02 | Medi-Physics, Inc. | NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production |
| GB9920758D0 (en) * | 1999-09-03 | 1999-11-03 | Nycomed Amersham Plc | Improved container composition for diagnostic agents |
| DE10000675C2 (de) | 2000-01-11 | 2001-11-15 | Otten Ernst Wilhelm | Lineardurchführung, Vorrichtung und Verfahren zur hochproduktiven Erzeugung von hoch kernspinpolarisiertem Helium-3 Gas |
| US7035518B2 (en) * | 2001-04-13 | 2006-04-25 | Hitachi Cable, Ltd. | Polymer waveguides and process for producing the same |
| US6830818B2 (en) * | 2001-04-13 | 2004-12-14 | Hitachi Cable, Ltd. | Polymer material and polymer film |
| AU2004206557A1 (en) | 2003-01-17 | 2004-08-05 | Medi-Physics Inc. | Method of producing optically pumped hyperpolarized gas |
| EP1620154A1 (en) * | 2003-04-22 | 2006-02-01 | Medi-Physics, Inc. | Mri/nmr-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery |
| WO2009143368A2 (en) * | 2008-05-23 | 2009-11-26 | University Of Utah | Non-cryogenic storage cell for hyperpolarized 129xe |
| US9874622B2 (en) | 2013-09-27 | 2018-01-23 | General Electric Company | Hyperpolarized media transport vessel |
| US10086092B2 (en) | 2014-02-21 | 2018-10-02 | Duke University | Hyperpolarized noble gas production systems with nanocluster suppression, detection and/or filtering and related methods and devices |
| CN104651905B (zh) * | 2015-01-28 | 2017-11-07 | 永保纳米科技(深圳)有限公司 | 一种阳极铝匀染缓染助剂及其操作液，和阳极铝匀染缓染处理工艺 |
| CN112833870B (zh) * | 2020-12-30 | 2023-01-06 | 中国人民解放军国防科技大学 | 核磁共振陀螺中抑制碱金属原子极化磁场影响的有效方法 |
| GB2612838A (en) * | 2021-11-15 | 2023-05-17 | Hyperspin Ltd | Apparatus for pumping hyperpolarised gas and method of handling hyperpolarised gas |
| CN114644322B (zh) * | 2022-04-15 | 2024-02-06 | 宁波诺丁汉大学 | 超极化稀有气体生产设备 |
| US20260118452A1 (en) | 2024-01-10 | 2026-04-30 | Polarean, Inc. | Hyperpolarizers with a load-lock chamber for alkali metal |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657363A (en) * | 1967-09-15 | 1972-04-18 | Us Army | Process for the deuteration of the hydroxyl position of organic alcohols |
| US3642851A (en) * | 1968-12-27 | 1972-02-15 | Union Carbide Corp | Preparation of linear halosiloxanes and compounds derived therefrom |
| US3646090A (en) * | 1969-05-29 | 1972-02-29 | Union Carbide Corp | Process for preparing linear chlorine terminated siloxane compounds |
| US3966781A (en) * | 1970-12-17 | 1976-06-29 | Merck Sharp & Dohme (I.A.) Corporation | Deuteration of functional group-containing hydrocarbons |
| US3989705A (en) * | 1974-04-01 | 1976-11-02 | Canadian Patents And Development Limited | Processes for the deuteration and/or tritiation of organic substrates by hydrogen substitution |
| US4586511A (en) * | 1983-03-04 | 1986-05-06 | Children's Hospital Medical Center | Methods and compositions for detecting and imaging a gas in an animal by nuclear magnetic resonance |
| US4882384A (en) * | 1988-02-01 | 1989-11-21 | Shell Oil Company | Modified block copolymers |
| US4914160A (en) * | 1988-06-23 | 1990-04-03 | Hormoz Azizian | Deuteration of unsaturated polymers and copolymers |
| JPH0731545A (ja) * | 1993-07-22 | 1995-02-03 | Toho Kasei Kk | フッ素樹脂塗膜を有する加熱容器 |
| JP2938727B2 (ja) * | 1993-09-14 | 1999-08-25 | 信越化学工業株式会社 | メチルジメトキシシランの保存方法 |
-
1995
- 1995-06-07 US US08/478,276 patent/US5612103A/en not_active Expired - Lifetime
-
1996
- 1996-06-07 WO PCT/US1996/009402 patent/WO1996039912A1/en not_active Ceased
- 1996-06-07 CA CA002220349A patent/CA2220349C/en not_active Expired - Fee Related
- 1996-06-07 EP EP96918293A patent/EP0837641B1/en not_active Expired - Lifetime
- 1996-06-07 AT AT96918293T patent/ATE378366T1/de not_active IP Right Cessation
- 1996-06-07 JP JP50172797A patent/JP3971799B2/ja not_active Expired - Fee Related
- 1996-06-07 DE DE69637324T patent/DE69637324T2/de not_active Expired - Lifetime
- 1996-06-07 BR BR9609064-2A patent/BR9609064A/pt not_active IP Right Cessation
- 1996-06-07 DK DK96918293T patent/DK0837641T3/da active
- 1996-06-07 CN CNB961958804A patent/CN1149165C/zh not_active Expired - Fee Related
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1997
- 1997-12-05 MX MX9709600A patent/MX9709600A/es not_active IP Right Cessation
- 1997-12-05 NO NO19975725A patent/NO324090B1/no not_active IP Right Cessation
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2007
- 2007-03-26 JP JP2007079422A patent/JP4584278B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE378366T1 (de) | 2007-11-15 |
| NO975725L (no) | 1998-02-05 |
| JP4584278B2 (ja) | 2010-11-17 |
| BR9609064A (pt) | 1999-09-21 |
| CA2220349C (en) | 2002-01-22 |
| MX9709600A (es) | 1998-10-31 |
| JPH11508354A (ja) | 1999-07-21 |
| NO975725D0 (no) | 1997-12-05 |
| JP2007292739A (ja) | 2007-11-08 |
| WO1996039912A1 (en) | 1996-12-19 |
| EP0837641A1 (en) | 1998-04-29 |
| CN1149165C (zh) | 2004-05-12 |
| US5612103A (en) | 1997-03-18 |
| CN1192128A (zh) | 1998-09-02 |
| NO324090B1 (no) | 2007-08-13 |
| DK0837641T3 (da) | 2008-03-25 |
| CA2220349A1 (en) | 1996-12-19 |
| EP0837641B1 (en) | 2007-11-14 |
| DE69637324D1 (de) | 2007-12-27 |
| AU6098396A (en) | 1996-12-30 |
| AU695121B2 (en) | 1998-08-06 |
| JP3971799B2 (ja) | 2007-09-05 |
| EP0837641A4 (en) | 2002-07-17 |
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