DE69636795D1 - Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung - Google Patents

Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung

Info

Publication number
DE69636795D1
DE69636795D1 DE69636795T DE69636795T DE69636795D1 DE 69636795 D1 DE69636795 D1 DE 69636795D1 DE 69636795 T DE69636795 T DE 69636795T DE 69636795 T DE69636795 T DE 69636795T DE 69636795 D1 DE69636795 D1 DE 69636795D1
Authority
DE
Germany
Prior art keywords
agents
radical species
present
fanger
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69636795T
Other languages
English (en)
Inventor
A Becker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida International University FIU
Original Assignee
Florida International University FIU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida International University FIU filed Critical Florida International University FIU
Application granted granted Critical
Publication of DE69636795D1 publication Critical patent/DE69636795D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/30—Azulenes; Hydrogenated azulenes
DE69636795T 1995-11-17 1996-11-15 Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung Expired - Lifetime DE69636795D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US694995P 1995-11-17 1995-11-17
US2463196P 1996-08-27 1996-08-27
PCT/US1996/018570 WO1997019054A1 (en) 1995-11-17 1996-11-15 Azulenyl nitrone spin trapping agents, methods of making and using same

Publications (1)

Publication Number Publication Date
DE69636795D1 true DE69636795D1 (de) 2007-02-08

Family

ID=26676282

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69636795T Expired - Lifetime DE69636795D1 (de) 1995-11-17 1996-11-15 Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung

Country Status (8)

Country Link
US (3) US6083988A (de)
EP (1) EP0888290B1 (de)
JP (1) JP3887020B2 (de)
AT (1) ATE349420T1 (de)
AU (1) AU7739796A (de)
CA (1) CA2235765C (de)
DE (1) DE69636795D1 (de)
WO (1) WO1997019054A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000067915A (ko) * 1996-07-19 2000-11-25 센토르 파마슈티칼스, 인크. 푸란 니트론 화합물
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) * 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
WO1999036415A1 (en) * 1998-01-16 1999-07-22 Centaur Pharmaceuticals, Inc. Thioether furan nitrone compounds
ATE228123T1 (de) * 1998-01-16 2002-12-15 Centaur Pharmaceuticals Inc Thiophennitronderivate
FR2780404B1 (fr) * 1998-06-26 2001-04-13 Adir Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1094106A1 (de) * 1999-10-19 2001-04-25 The Procter & Gamble Company Reinigungsmittelzusammensetzung
US6566320B1 (en) 1999-10-19 2003-05-20 The Procter & Gamble Company Bleaching composition containing chromotropic compound
US6569826B1 (en) 1999-10-19 2003-05-27 The Procter & Gamble Company Radical scavenger
GB0024938D0 (en) * 2000-10-11 2000-11-29 Queen Mary & Westfield College Method of diagnosis
WO2002065993A2 (en) 2001-01-08 2002-08-29 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
US6746808B2 (en) 2001-08-29 2004-06-08 Fuji Xerox Co., Ltd. Image forming color toner, color image forming method and color image forming apparatus
US6762322B1 (en) * 2002-12-20 2004-07-13 Goodyear Tire & Rubber Company Preparation of nitrone derivatives
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
US7910729B2 (en) 2004-09-22 2011-03-22 The Florida International University Board Of Trustees Azulenyl nitrone spin trapping agents, methods of making and using same
GB0518890D0 (en) * 2005-09-15 2005-10-26 Ucl Biomedica Plc Method of determining damage to skin
US8278451B2 (en) 2006-06-28 2012-10-02 The Florida International University Board Of Trustees Pseudoazulenyl nitrones
GB0623758D0 (en) * 2006-11-25 2007-01-10 Univ Salford The Free radical trapping
EP2242360B1 (de) * 2008-02-12 2015-04-08 Tosk, Inc. Doxorubicin-hilfsstoffe zur toxizitätsminderung und anwendungsverfahren dafür
US8313456B2 (en) * 2009-06-30 2012-11-20 Palo Alto Research Center Incorporated Drug-transfer device, drug-delivery system incorporating the same, methods of fabricating the same, and methods of enabling administration of a drug
US9034926B2 (en) 2010-12-30 2015-05-19 Nicholas V. Perricone Topical nitrone spin trap compositions for psoriasis
WO2013067084A1 (en) * 2011-11-01 2013-05-10 The Florida International University Board Of Trustees Silylated azulenyl nitrone spin traps as chromotropic superoxide detectors
GB201217228D0 (en) * 2012-09-26 2012-11-07 Pepric Nv Methods and systems for determining a particle distribution
US9971038B2 (en) 2013-03-15 2018-05-15 The Florida International University Board Of Trustees Chromotropic detection of ionizing radiation
US11814506B2 (en) 2019-07-02 2023-11-14 Marathon Petroleum Company Lp Modified asphalts with enhanced rheological properties and associated methods

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US35213A (en) * 1862-05-13 Improved hydrant
US35112A (en) * 1862-04-29 Improvement in head-rests for car-seats
US3509215A (en) * 1967-06-15 1970-04-28 Givaudan Corp Acyl indan compounds
US4141995A (en) * 1975-04-17 1979-02-27 Lilly Industries Limited Ketone derivatives
JPS5916867A (ja) * 1982-07-21 1984-01-28 Nippon Chemiphar Co Ltd 新規アズレン誘導体およびその製造法
US4990665A (en) * 1982-11-01 1991-02-05 Microsi, Inc. Diarylnitrones
JPS6197238A (ja) * 1984-10-17 1986-05-15 Ajinomoto Co Inc 新規アズレン誘導体およびその用途
JPS63239248A (ja) * 1986-11-07 1988-10-05 Ajinomoto Co Inc 抗脂血剤
WO1991005552A1 (en) * 1989-10-17 1991-05-02 Oklahoma Medical Research Foundation Method and compositions for inhibition of disorders associated with oxidative damage
USRE35213E (en) 1989-10-17 1996-04-16 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5025032A (en) * 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
US5235076A (en) * 1991-05-28 1993-08-10 University Of Hawaii Azulenic retinoid compounds, compositions and methods
US5292746A (en) * 1991-09-12 1994-03-08 Merrell Dow Pharmaceuticals Inc. Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
EP0888290B1 (de) 2006-12-27
CA2235765C (en) 2006-04-04
EP0888290A1 (de) 1999-01-07
CA2235765A1 (en) 1997-05-29
ATE349420T1 (de) 2007-01-15
US6197825B1 (en) 2001-03-06
WO1997019054A1 (en) 1997-05-29
US6291702B1 (en) 2001-09-18
AU7739796A (en) 1997-06-11
JP2000501081A (ja) 2000-02-02
EP0888290A4 (de) 2004-08-18
JP3887020B2 (ja) 2007-02-28
US6083988A (en) 2000-07-04

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