ATE349420T1 - Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung - Google Patents

Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung

Info

Publication number
ATE349420T1
ATE349420T1 AT96940538T AT96940538T ATE349420T1 AT E349420 T1 ATE349420 T1 AT E349420T1 AT 96940538 T AT96940538 T AT 96940538T AT 96940538 T AT96940538 T AT 96940538T AT E349420 T1 ATE349420 T1 AT E349420T1
Authority
AT
Austria
Prior art keywords
agents
radical species
present
azulenyl nitrones
production
Prior art date
Application number
AT96940538T
Other languages
English (en)
Inventor
David A Becker
Original Assignee
Florida Internat University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida Internat University filed Critical Florida Internat University
Application granted granted Critical
Publication of ATE349420T1 publication Critical patent/ATE349420T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/30—Azulenes; Hydrogenated azulenes
AT96940538T 1995-11-17 1996-11-15 Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung ATE349420T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US694995P 1995-11-17 1995-11-17
US2463196P 1996-08-27 1996-08-27

Publications (1)

Publication Number Publication Date
ATE349420T1 true ATE349420T1 (de) 2007-01-15

Family

ID=26676282

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96940538T ATE349420T1 (de) 1995-11-17 1996-11-15 Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung

Country Status (8)

Country Link
US (3) US6083988A (de)
EP (1) EP0888290B1 (de)
JP (1) JP3887020B2 (de)
AT (1) ATE349420T1 (de)
AU (1) AU7739796A (de)
CA (1) CA2235765C (de)
DE (1) DE69636795D1 (de)
WO (1) WO1997019054A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ333705A (en) * 1996-07-19 2000-09-29 Centaur Pharmaceuticals Inc Furan nitrone derivatives and medicaments thereof
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
WO1999036420A1 (en) * 1998-01-16 1999-07-22 Centaur Pharmaceuticals, Inc. Thiophene nitrone compounds
WO1999036415A1 (en) * 1998-01-16 1999-07-22 Centaur Pharmaceuticals, Inc. Thioether furan nitrone compounds
FR2780404B1 (fr) * 1998-06-26 2001-04-13 Adir Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1094106A1 (de) * 1999-10-19 2001-04-25 The Procter & Gamble Company Reinigungsmittelzusammensetzung
US6569826B1 (en) 1999-10-19 2003-05-27 The Procter & Gamble Company Radical scavenger
US6566320B1 (en) 1999-10-19 2003-05-20 The Procter & Gamble Company Bleaching composition containing chromotropic compound
GB0024938D0 (en) * 2000-10-11 2000-11-29 Queen Mary & Westfield College Method of diagnosis
WO2002065993A2 (en) 2001-01-08 2002-08-29 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
US6746808B2 (en) 2001-08-29 2004-06-08 Fuji Xerox Co., Ltd. Image forming color toner, color image forming method and color image forming apparatus
US6762322B1 (en) * 2002-12-20 2004-07-13 Goodyear Tire & Rubber Company Preparation of nitrone derivatives
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
WO2006036768A2 (en) 2004-09-22 2006-04-06 The Florida International University Board Of Trustees Azulenyl nitrone spin trapping agents, methods of making and using same
GB0518890D0 (en) * 2005-09-15 2005-10-26 Ucl Biomedica Plc Method of determining damage to skin
WO2008002614A2 (en) * 2006-06-28 2008-01-03 The Florida International University Board Of Trustees Pseudoazulenyl nitrones
GB0623758D0 (en) * 2006-11-25 2007-01-10 Univ Salford The Free radical trapping
AU2009214727B2 (en) * 2008-02-12 2014-12-11 Tosk, Incorporated Doxorubicin adjuvants to reduce toxicity and methods for using the same
US8313456B2 (en) * 2009-06-30 2012-11-20 Palo Alto Research Center Incorporated Drug-transfer device, drug-delivery system incorporating the same, methods of fabricating the same, and methods of enabling administration of a drug
US9034926B2 (en) 2010-12-30 2015-05-19 Nicholas V. Perricone Topical nitrone spin trap compositions for psoriasis
US9156862B2 (en) * 2011-11-01 2015-10-13 The Florida International University Board Of Trustees Silylated azulenyl nitrone spin traps as chromotropic superoxide detectors
GB201217228D0 (en) * 2012-09-26 2012-11-07 Pepric Nv Methods and systems for determining a particle distribution
WO2014151486A1 (en) * 2013-03-15 2014-09-25 The Florida International University Board Of Trustees Chromotropic detection of ionizing radiation
US11814506B2 (en) 2019-07-02 2023-11-14 Marathon Petroleum Company Lp Modified asphalts with enhanced rheological properties and associated methods

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US35213A (en) * 1862-05-13 Improved hydrant
US35112A (en) * 1862-04-29 Improvement in head-rests for car-seats
US3509215A (en) * 1967-06-15 1970-04-28 Givaudan Corp Acyl indan compounds
US4141995A (en) * 1975-04-17 1979-02-27 Lilly Industries Limited Ketone derivatives
JPS5916867A (ja) * 1982-07-21 1984-01-28 Nippon Chemiphar Co Ltd 新規アズレン誘導体およびその製造法
US4990665A (en) * 1982-11-01 1991-02-05 Microsi, Inc. Diarylnitrones
JPS6197238A (ja) * 1984-10-17 1986-05-15 Ajinomoto Co Inc 新規アズレン誘導体およびその用途
JPS63239248A (ja) * 1986-11-07 1988-10-05 Ajinomoto Co Inc 抗脂血剤
KR960008230B1 (ko) * 1989-10-17 1996-06-21 윌리엄 쥐.씨먼 중추신경계의 산화적 손상에 관련된 질병들을 억제하기 위한 조성물들
USRE35213E (en) 1989-10-17 1996-04-16 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5025032A (en) 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
US5235076A (en) * 1991-05-28 1993-08-10 University Of Hawaii Azulenic retinoid compounds, compositions and methods
US5292746A (en) * 1991-09-12 1994-03-08 Merrell Dow Pharmaceuticals Inc. Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
AU7739796A (en) 1997-06-11
US6291702B1 (en) 2001-09-18
CA2235765C (en) 2006-04-04
EP0888290B1 (de) 2006-12-27
EP0888290A1 (de) 1999-01-07
US6197825B1 (en) 2001-03-06
CA2235765A1 (en) 1997-05-29
JP2000501081A (ja) 2000-02-02
DE69636795D1 (de) 2007-02-08
WO1997019054A1 (en) 1997-05-29
EP0888290A4 (de) 2004-08-18
JP3887020B2 (ja) 2007-02-28
US6083988A (en) 2000-07-04

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