DE69635305T2 - Verwendung eines anti-interleukin-9 antikörpers zur herstellung eines medikamentes zur behandlung von asthma - Google Patents
Verwendung eines anti-interleukin-9 antikörpers zur herstellung eines medikamentes zur behandlung von asthma Download PDFInfo
- Publication number
- DE69635305T2 DE69635305T2 DE69635305T DE69635305T DE69635305T2 DE 69635305 T2 DE69635305 T2 DE 69635305T2 DE 69635305 T DE69635305 T DE 69635305T DE 69635305 T DE69635305 T DE 69635305T DE 69635305 T2 DE69635305 T2 DE 69635305T2
- Authority
- DE
- Germany
- Prior art keywords
- asthma
- interleukin
- receptor
- human
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 20
- 229940118526 interleukin-9 Drugs 0.000 title claims abstract description 12
- 238000002360 preparation method Methods 0.000 title claims abstract description 4
- 208000006673 asthma Diseases 0.000 title claims description 110
- 238000011282 treatment Methods 0.000 title claims description 19
- 108010002335 Interleukin-9 Proteins 0.000 claims abstract description 91
- 102000000585 Interleukin-9 Human genes 0.000 claims abstract description 86
- 108010038414 Interleukin-9 Receptors Proteins 0.000 claims abstract description 29
- 102000010682 Interleukin-9 Receptors Human genes 0.000 claims abstract description 27
- 102000005962 receptors Human genes 0.000 claims abstract description 20
- 108020003175 receptors Proteins 0.000 claims abstract description 20
- 230000027455 binding Effects 0.000 claims abstract description 13
- 239000000427 antigen Substances 0.000 claims description 30
- 108091007433 antigens Proteins 0.000 claims description 30
- 102000036639 antigens Human genes 0.000 claims description 30
- 230000000694 effects Effects 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 7
- 210000003979 eosinophil Anatomy 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 2
- 238000010253 intravenous injection Methods 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 230000010083 bronchial hyperresponsiveness Effects 0.000 abstract description 7
- 230000009467 reduction Effects 0.000 abstract description 2
- 206010003645 Atopy Diseases 0.000 description 49
- 108090000623 proteins and genes Proteins 0.000 description 42
- 210000002966 serum Anatomy 0.000 description 40
- 241001465754 Metazoa Species 0.000 description 31
- 206010066091 Bronchial Hyperreactivity Diseases 0.000 description 30
- 230000036427 bronchial hyperreactivity Effects 0.000 description 30
- 206010020751 Hypersensitivity Diseases 0.000 description 29
- 208000026935 allergic disease Diseases 0.000 description 28
- 210000004027 cell Anatomy 0.000 description 28
- 230000007815 allergy Effects 0.000 description 27
- 241000282414 Homo sapiens Species 0.000 description 24
- 210000000349 chromosome Anatomy 0.000 description 24
- 241001529936 Murinae Species 0.000 description 22
- 230000006870 function Effects 0.000 description 22
- 230000002068 genetic effect Effects 0.000 description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 19
- 208000035475 disorder Diseases 0.000 description 19
- 241000699670 Mus sp. Species 0.000 description 18
- 102000004388 Interleukin-4 Human genes 0.000 description 15
- 108090000978 Interleukin-4 Proteins 0.000 description 15
- 230000004044 response Effects 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 14
- 230000009257 reactivity Effects 0.000 description 13
- 210000001744 T-lymphocyte Anatomy 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 12
- 230000014509 gene expression Effects 0.000 description 12
- 230000001965 increasing effect Effects 0.000 description 12
- 230000004054 inflammatory process Effects 0.000 description 12
- 206010061218 Inflammation Diseases 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 102000004127 Cytokines Human genes 0.000 description 10
- 108090000695 Cytokines Proteins 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 10
- 239000000443 aerosol Substances 0.000 description 9
- 108010002350 Interleukin-2 Proteins 0.000 description 8
- 102000000588 Interleukin-2 Human genes 0.000 description 8
- 101001055219 Homo sapiens Interleukin-9 receptor Proteins 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 210000003719 b-lymphocyte Anatomy 0.000 description 7
- 230000000903 blocking effect Effects 0.000 description 7
- 210000003630 histaminocyte Anatomy 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 6
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 108010029485 Protein Isoforms Proteins 0.000 description 6
- 102000001708 Protein Isoforms Human genes 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 230000018109 developmental process Effects 0.000 description 6
- 238000013507 mapping Methods 0.000 description 6
- 229960002329 methacholine Drugs 0.000 description 6
- 230000003472 neutralizing effect Effects 0.000 description 6
- 230000004043 responsiveness Effects 0.000 description 6
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 239000011534 wash buffer Substances 0.000 description 6
- 101001055216 Homo sapiens Interleukin-9 Proteins 0.000 description 5
- 108010002386 Interleukin-3 Proteins 0.000 description 5
- 102000000646 Interleukin-3 Human genes 0.000 description 5
- 102100039897 Interleukin-5 Human genes 0.000 description 5
- 108010002616 Interleukin-5 Proteins 0.000 description 5
- 239000013566 allergen Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000002759 chromosomal effect Effects 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 230000003828 downregulation Effects 0.000 description 5
- 102000052627 human IL9 Human genes 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 229940028885 interleukin-4 Drugs 0.000 description 5
- NZWOPGCLSHLLPA-UHFFFAOYSA-N methacholine Chemical compound C[N+](C)(C)CC(C)OC(C)=O NZWOPGCLSHLLPA-UHFFFAOYSA-N 0.000 description 5
- 230000035772 mutation Effects 0.000 description 5
- 230000037361 pathway Effects 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 4
- 229930105110 Cyclosporin A Natural products 0.000 description 4
- 108010036949 Cyclosporine Proteins 0.000 description 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 4
- 102000015696 Interleukins Human genes 0.000 description 4
- 108010063738 Interleukins Proteins 0.000 description 4
- 239000000556 agonist Substances 0.000 description 4
- 230000036428 airway hyperreactivity Effects 0.000 description 4
- 230000009285 allergic inflammation Effects 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 4
- 230000003435 bronchoconstrictive effect Effects 0.000 description 4
- 229960001265 ciclosporin Drugs 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 102000014914 Carrier Proteins Human genes 0.000 description 3
- 108010078791 Carrier Proteins Proteins 0.000 description 3
- 206010014950 Eosinophilia Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 3
- 102000009438 IgE Receptors Human genes 0.000 description 3
- 108010073816 IgE Receptors Proteins 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 102000003816 Interleukin-13 Human genes 0.000 description 3
- 108090000176 Interleukin-13 Proteins 0.000 description 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
- 206010035664 Pneumonia Diseases 0.000 description 3
- 206010070834 Sensitisation Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000012512 characterization method Methods 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 229930182912 cyclosporin Natural products 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 210000004969 inflammatory cell Anatomy 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000008506 pathogenesis Effects 0.000 description 3
- 239000000863 peptide conjugate Substances 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 230000026731 phosphorylation Effects 0.000 description 3
- 238000006366 phosphorylation reaction Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 230000008313 sensitization Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 3
- 102000017919 ADRB2 Human genes 0.000 description 2
- 108700028369 Alleles Proteins 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010006482 Bronchospasm Diseases 0.000 description 2
- 108020004635 Complementary DNA Proteins 0.000 description 2
- 102100023226 Early growth response protein 1 Human genes 0.000 description 2
- 108700024394 Exon Proteins 0.000 description 2
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 2
- 102000028180 Glycophorins Human genes 0.000 description 2
- 108091005250 Glycophorins Proteins 0.000 description 2
- 241000243780 Heligmosomoides polygyrus Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101000959437 Homo sapiens Beta-2 adrenergic receptor Proteins 0.000 description 2
- 101001049697 Homo sapiens Early growth response protein 1 Proteins 0.000 description 2
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 description 2
- 101000624643 Homo sapiens M-phase inducer phosphatase 3 Proteins 0.000 description 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 2
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 description 2
- 101000580039 Homo sapiens Ras-specific guanine nucleotide-releasing factor 1 Proteins 0.000 description 2
- 102000003814 Interleukin-10 Human genes 0.000 description 2
- 108090000174 Interleukin-10 Proteins 0.000 description 2
- 108091092195 Intron Proteins 0.000 description 2
- 102100023330 M-phase inducer phosphatase 3 Human genes 0.000 description 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 2
- 101100336288 Mus musculus Nr3c1 gene Proteins 0.000 description 2
- 101000874159 Mus musculus Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 description 2
- 208000002200 Respiratory Hypersensitivity Diseases 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 2
- 229960004373 acetylcholine Drugs 0.000 description 2
- 230000010085 airway hyperresponsiveness Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 229940125388 beta agonist Drugs 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000007885 bronchoconstriction Effects 0.000 description 2
- 229940124630 bronchodilator Drugs 0.000 description 2
- 230000020411 cell activation Effects 0.000 description 2
- 230000024245 cell differentiation Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 230000001086 cytosolic effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- FOCAHLGSDWHSAH-UHFFFAOYSA-N difluoromethanethione Chemical compound FC(F)=S FOCAHLGSDWHSAH-UHFFFAOYSA-N 0.000 description 2
- 230000002222 downregulating effect Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001400 expression cloning Methods 0.000 description 2
- 208000024711 extrinsic asthma Diseases 0.000 description 2
- 210000000943 fetal thymocyte Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000012252 genetic analysis Methods 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 238000010562 histological examination Methods 0.000 description 2
- 102000051950 human IL9R Human genes 0.000 description 2
- 210000003917 human chromosome Anatomy 0.000 description 2
- 230000036737 immune function Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 229940100602 interleukin-5 Drugs 0.000 description 2
- 230000004807 localization Effects 0.000 description 2
- 230000004199 lung function Effects 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 230000008774 maternal effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 102000054765 polymorphisms of proteins Human genes 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 210000003765 sex chromosome Anatomy 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000012049 topical pharmaceutical composition Substances 0.000 description 2
- 208000000884 Airway Obstruction Diseases 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 240000002470 Amphicarpaea bracteata Species 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- YXSLJKQTIDHPOT-UHFFFAOYSA-N Atracurium Dibesylate Chemical compound C1=C(OC)C(OC)=CC=C1CC1[N+](CCC(=O)OCCCCCOC(=O)CC[N+]2(C)C(C3=CC(OC)=C(OC)C=C3CC2)CC=2C=C(OC)C(OC)=CC=2)(C)CCC2=CC(OC)=C(OC)C=C21 YXSLJKQTIDHPOT-UHFFFAOYSA-N 0.000 description 1
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 description 1
- 206010065687 Bone loss Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 238000011746 C57BL/6J (JAX™ mouse strain) Methods 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- -1 FGFA Proteins 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 description 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 101001078133 Homo sapiens Integrin alpha-2 Proteins 0.000 description 1
- 101000598002 Homo sapiens Interferon regulatory factor 1 Proteins 0.000 description 1
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 description 1
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 description 1
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 1
- 101000715050 Homo sapiens Thromboxane A2 receptor Proteins 0.000 description 1
- 101001050476 Homo sapiens Tyrosine-protein kinase ITK/TSK Proteins 0.000 description 1
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 description 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 108010001127 Insulin Receptor Proteins 0.000 description 1
- 102100036721 Insulin receptor Human genes 0.000 description 1
- 102100025305 Integrin alpha-2 Human genes 0.000 description 1
- 102100036981 Interferon regulatory factor 1 Human genes 0.000 description 1
- 102000019223 Interleukin-1 receptor Human genes 0.000 description 1
- 108050006617 Interleukin-1 receptor Proteins 0.000 description 1
- 102100036701 Interleukin-12 subunit beta Human genes 0.000 description 1
- 101710187487 Interleukin-12 subunit beta Proteins 0.000 description 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
- 108010038486 Interleukin-4 Receptors Proteins 0.000 description 1
- 102100039078 Interleukin-4 receptor subunit alpha Human genes 0.000 description 1
- 102100026244 Interleukin-9 receptor Human genes 0.000 description 1
- 102100020880 Kit ligand Human genes 0.000 description 1
- 241000222732 Leishmania major Species 0.000 description 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 description 1
- 108060003100 Magainin Proteins 0.000 description 1
- 238000007476 Maximum Likelihood Methods 0.000 description 1
- 206010028116 Mucosal inflammation Diseases 0.000 description 1
- 108091008606 PDGF receptors Proteins 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 241000237988 Patellidae Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 108091008109 Pseudogenes Proteins 0.000 description 1
- 102000057361 Pseudogenes Human genes 0.000 description 1
- 108700005075 Regulator Genes Proteins 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 102000004495 STAT3 Transcription Factor Human genes 0.000 description 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 description 1
- 108010039445 Stem Cell Factor Proteins 0.000 description 1
- 108091081400 Subtelomere Proteins 0.000 description 1
- 230000006052 T cell proliferation Effects 0.000 description 1
- 208000000389 T-cell leukemia Diseases 0.000 description 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 1
- 102000003938 Thromboxane Receptors Human genes 0.000 description 1
- 108090000300 Thromboxane Receptors Proteins 0.000 description 1
- 102100023345 Tyrosine-protein kinase ITK/TSK Human genes 0.000 description 1
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000012387 aerosolization Methods 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 230000008369 airway response Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 210000000612 antigen-presenting cell Anatomy 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 101150010487 are gene Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229960001862 atracurium Drugs 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000037429 base substitution Effects 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 239000004044 bronchoconstricting agent Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 238000001516 cell proliferation assay Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000562 conjugate Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- HDFXRQJQZBPDLF-UHFFFAOYSA-L disodium hydrogen carbonate Chemical compound [Na+].[Na+].OC([O-])=O.OC([O-])=O HDFXRQJQZBPDLF-UHFFFAOYSA-L 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940112141 dry powder inhaler Drugs 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 230000006353 environmental stress Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000001667 episodic effect Effects 0.000 description 1
- 230000000925 erythroid effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 229940126864 fibroblast growth factor Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000004034 genetic regulation Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 230000000971 hippocampal effect Effects 0.000 description 1
- 230000036732 histological change Effects 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000005934 immune activation Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000000367 immunologic factor Substances 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 239000002596 immunotoxin Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 238000002664 inhalation therapy Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003434 inspiratory effect Effects 0.000 description 1
- 230000017076 interleukin-9 production Effects 0.000 description 1
- 108040006862 interleukin-9 receptor activity proteins Proteins 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 208000008585 mastocytosis Diseases 0.000 description 1
- 210000005074 megakaryoblast Anatomy 0.000 description 1
- 210000003593 megakaryocyte Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000002974 pharmacogenomic effect Effects 0.000 description 1
- 230000009120 phenotypic response Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000009325 pulmonary function Effects 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007423 screening assay Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000010473 stable expression Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 108091035539 telomere Proteins 0.000 description 1
- 210000003411 telomere Anatomy 0.000 description 1
- 102000055501 telomere Human genes 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 210000001631 vena cava inferior Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5425—IL-9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US276595P | 1995-08-24 | 1995-08-24 | |
| US2765P | 1995-08-24 | ||
| US2380096P | 1996-08-06 | 1996-08-06 | |
| US23800P | 1996-08-06 | ||
| PCT/US1996/012757 WO1997008321A1 (en) | 1995-08-24 | 1996-08-23 | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69635305D1 DE69635305D1 (de) | 2006-03-02 |
| DE69635305T2 true DE69635305T2 (de) | 2006-07-06 |
Family
ID=26670837
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69638281T Expired - Lifetime DE69638281D1 (de) | 1995-08-24 | 1996-08-23 | Anti-Interleukin-9 Antikörper oder Anti-Interleukin-9 Rezeptor Antikörper zur Behandlung von bronchialem Hyperreaktionsvermögen |
| DE69635305T Expired - Lifetime DE69635305T2 (de) | 1995-08-24 | 1996-08-23 | Verwendung eines anti-interleukin-9 antikörpers zur herstellung eines medikamentes zur behandlung von asthma |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69638281T Expired - Lifetime DE69638281D1 (de) | 1995-08-24 | 1996-08-23 | Anti-Interleukin-9 Antikörper oder Anti-Interleukin-9 Rezeptor Antikörper zur Behandlung von bronchialem Hyperreaktionsvermögen |
Country Status (10)
| Country | Link |
|---|---|
| EP (3) | EP1632248B8 (enExample) |
| JP (3) | JP3948495B2 (enExample) |
| AT (2) | ATE484294T1 (enExample) |
| AU (1) | AU6895696A (enExample) |
| CA (2) | CA2666298A1 (enExample) |
| DE (2) | DE69638281D1 (enExample) |
| DK (2) | DK0846173T3 (enExample) |
| ES (2) | ES2249786T3 (enExample) |
| PT (1) | PT1632248E (enExample) |
| WO (1) | WO1997008321A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830454A (en) * | 1996-08-30 | 1998-11-03 | Ludwig Institute For Cancer Research | Method for treating cell mediated autoimmune disorders using interleukin-9 |
| EP1471144B1 (en) * | 1996-12-02 | 2010-06-23 | Genaera Corporation | Biological variability of asthma associated factor AAF2 (IL-9 receptor) useful in treating and diagnosing atopic allergies including asthma and related disorders |
| ATE471982T1 (de) * | 1996-12-02 | 2010-07-15 | Genaera Corp | Biologische variabilität von asthma-assoziiertem faktor 2 aaf2 (il-9 rezeptor) nützlich für die behandlung und diagnose von atopischen allergien wie asthma und asthma-ähnlichen erkrankungen |
| WO1998027997A1 (en) * | 1996-12-20 | 1998-07-02 | Magainin Pharmaceuticals Inc. | A method for diagnosis and treatment of inflammatory bowel diseases including crohn's disease and chronic ulcerative colitis |
| CA2302936A1 (en) * | 1997-09-19 | 1999-04-01 | Magainin Pharmaceuticals, Inc. | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
| EP1015492A2 (en) * | 1997-09-19 | 2000-07-05 | Magainin Pharmaceuticals Inc. | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
| JP2002542814A (ja) * | 1999-05-01 | 2002-12-17 | ジェネーラ コーポレーション | 喘息および関連する障害を含むアトピー性のアレルギーを処置するための標的としての喘息に関連する因子 |
| US20010034062A1 (en) * | 2000-02-09 | 2001-10-25 | Scott Koenig | Antibody gene therapy with adeno-associated viral vectors |
| ATE470858T1 (de) * | 2001-02-22 | 2010-06-15 | Univ New York State Res Found | Opiatrezeptoren |
| ATE540695T1 (de) | 2001-06-08 | 2012-01-15 | Genaera Corp | Verfahren zur modulation von il-13 |
| EP1617805A4 (en) * | 2003-04-11 | 2012-07-04 | Medimmune Llc | METHODS FOR PREVENTING OR TREATING RESPIRATORY CONDITIONS |
| EP1771565B1 (en) | 2004-07-20 | 2012-09-05 | The Feinstein Institute for Medical Research | Rage protein derivatives |
| US7635754B2 (en) * | 2004-09-22 | 2009-12-22 | Aerovance, Inc. | Interleukin-9 and interleukin-4 chimeric antagonist muteins and methods of using same |
| WO2006138429A2 (en) | 2005-06-16 | 2006-12-28 | The Feinstein Institute For Medical Research | Antibodies against hmgb1 and fragments thereof |
| WO2008039941A2 (en) | 2006-09-27 | 2008-04-03 | The Government Of The Usa As Represented By The Secretary Of The Dpt. Of Health And Human Services | Scgb3a2 as a growth factor and anti-apoptotic agent |
| JP5564167B2 (ja) * | 2008-05-22 | 2014-07-30 | 日本たばこ産業株式会社 | 苦味マスキング剤及び苦味低減方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208218A (en) * | 1988-09-19 | 1993-05-04 | Ludwig Institute For Cancer Research | T cell growth factor glycoproteins |
| US5414071A (en) | 1989-05-23 | 1995-05-09 | Genetics Institute, Inc. | Human cytokine IL-9 |
| US5132109A (en) * | 1990-10-05 | 1992-07-21 | Ludwig Institute For Cancer Research | Method for inhibiting production of ige and method for enhancing production of igg using interleukin 9 and inhibitors thereof |
| WO1995027052A1 (en) | 1994-03-30 | 1995-10-12 | University Of Maryland At Baltimore | Human interleukin variants generated by alternative splicing |
-
1996
- 1996-08-23 ES ES96929657T patent/ES2249786T3/es not_active Expired - Lifetime
- 1996-08-23 JP JP51028397A patent/JP3948495B2/ja not_active Expired - Fee Related
- 1996-08-23 WO PCT/US1996/012757 patent/WO1997008321A1/en not_active Ceased
- 1996-08-23 EP EP05009688A patent/EP1632248B8/en not_active Expired - Lifetime
- 1996-08-23 EP EP96929657A patent/EP0846173B1/en not_active Expired - Lifetime
- 1996-08-23 DE DE69638281T patent/DE69638281D1/de not_active Expired - Lifetime
- 1996-08-23 AT AT05009688T patent/ATE484294T1/de active
- 1996-08-23 AU AU68956/96A patent/AU6895696A/en not_active Abandoned
- 1996-08-23 CA CA002666298A patent/CA2666298A1/en not_active Abandoned
- 1996-08-23 AT AT96929657T patent/ATE307203T1/de active
- 1996-08-23 EP EP10004496A patent/EP2241329A3/en not_active Withdrawn
- 1996-08-23 DK DK96929657T patent/DK0846173T3/da active
- 1996-08-23 DK DK05009688.2T patent/DK1632248T3/da active
- 1996-08-23 CA CA002230240A patent/CA2230240C/en not_active Expired - Lifetime
- 1996-08-23 DE DE69635305T patent/DE69635305T2/de not_active Expired - Lifetime
- 1996-08-23 PT PT05009688T patent/PT1632248E/pt unknown
- 1996-08-23 ES ES05009688T patent/ES2354360T3/es not_active Expired - Lifetime
-
2007
- 2007-01-09 JP JP2007001870A patent/JP4813380B2/ja not_active Expired - Fee Related
-
2011
- 2011-02-28 JP JP2011043283A patent/JP2011152135A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE69638281D1 (de) | 2010-11-25 |
| JP2011152135A (ja) | 2011-08-11 |
| DK1632248T3 (da) | 2011-01-24 |
| JP4813380B2 (ja) | 2011-11-09 |
| DE69635305D1 (de) | 2006-03-02 |
| EP1632248B1 (en) | 2010-10-13 |
| EP0846173A1 (en) | 1998-06-10 |
| WO1997008321A1 (en) | 1997-03-06 |
| EP0846173B1 (en) | 2005-10-19 |
| ES2354360T3 (es) | 2011-03-14 |
| EP2241329A3 (en) | 2011-03-09 |
| ATE307203T1 (de) | 2005-11-15 |
| EP1632248B8 (en) | 2010-12-29 |
| EP1632248A1 (en) | 2006-03-08 |
| EP2241329A2 (en) | 2010-10-20 |
| CA2230240A1 (en) | 1997-03-06 |
| JPH11514851A (ja) | 1999-12-21 |
| ATE484294T1 (de) | 2010-10-15 |
| ES2249786T3 (es) | 2006-04-01 |
| CA2230240C (en) | 2009-08-18 |
| DK0846173T3 (da) | 2006-01-16 |
| CA2666298A1 (en) | 1997-03-06 |
| PT1632248E (pt) | 2010-12-28 |
| JP2007169287A (ja) | 2007-07-05 |
| AU6895696A (en) | 1997-03-19 |
| JP3948495B2 (ja) | 2007-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6261559B1 (en) | Methods of treating asthma with interleukin-9 antibodies | |
| DE69635305T2 (de) | Verwendung eines anti-interleukin-9 antikörpers zur herstellung eines medikamentes zur behandlung von asthma | |
| DE3853636T3 (de) | Antigene epitope, die sich ausschliesslich auf ige-tragenden b-lymphocyten befinden. | |
| US6716603B2 (en) | Nucleic acids encoding a chloride channel protein | |
| DE69933115T2 (de) | Verwendung eines antagonisten antikörpers gegen den entzündungsmediator oncostatin m (osm) | |
| US6664227B1 (en) | Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains | |
| DE69933696T2 (de) | Cytokinrezeptor-kette | |
| AU760274B2 (en) | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders | |
| Madej et al. | Expression of vascular adhesion protein-1 in atopic eczema | |
| DE69937057T2 (de) | Verwendung von basiliximab zur behandlung von rheumatoider arthritis und hauterkrankungen | |
| AU752735B2 (en) | Asthma and related disorders | |
| AU2007202406B2 (en) | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders | |
| AU2011265475A1 (en) | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders | |
| HK1138294A (en) | Treatment of fibrosis by antagonism of il-13 and/or il-13 receptor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: GRAF VON STOSCH PATENTANWALTSGESELLSCHAFT MBH, 805 |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: LIGAND PHARMACEUTICALS INC. (N. D. GES. D. STA, US |