DE69628397T2 - Verfahren zur Reinigung von Tamm-Horsfall-Glykoprotein und Uromodulin - Google Patents

Verfahren zur Reinigung von Tamm-Horsfall-Glykoprotein und Uromodulin

Info

Publication number
DE69628397T2
DE69628397T2 DE69628397T DE69628397T DE69628397T2 DE 69628397 T2 DE69628397 T2 DE 69628397T2 DE 69628397 T DE69628397 T DE 69628397T DE 69628397 T DE69628397 T DE 69628397T DE 69628397 T2 DE69628397 T2 DE 69628397T2
Authority
DE
Germany
Prior art keywords
uromodulin
tamm
purifying
horsfall glycoprotein
horsfall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69628397T
Other languages
English (en)
Other versions
DE69628397D1 (de
Inventor
Hideyuki Kobayashi
Yoshikazu Komurasaki
Keihide Koh
Satoshi Nishimuro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JCR Pharmaceuticals Co Ltd
Original Assignee
JCR Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JCR Pharmaceuticals Co Ltd filed Critical JCR Pharmaceuticals Co Ltd
Publication of DE69628397D1 publication Critical patent/DE69628397D1/de
Application granted granted Critical
Publication of DE69628397T2 publication Critical patent/DE69628397T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/471—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y10S436/814—Pregnancy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
DE69628397T 1995-12-14 1996-12-12 Verfahren zur Reinigung von Tamm-Horsfall-Glykoprotein und Uromodulin Expired - Fee Related DE69628397T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34793995A JP3839509B2 (ja) 1995-12-14 1995-12-14 タム−ホースフォール・グリコプロテインもしくはウロモジュリンの精製法、精製物および両者の識別法

Publications (2)

Publication Number Publication Date
DE69628397D1 DE69628397D1 (de) 2003-07-03
DE69628397T2 true DE69628397T2 (de) 2003-11-27

Family

ID=18393634

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69628397T Expired - Fee Related DE69628397T2 (de) 1995-12-14 1996-12-12 Verfahren zur Reinigung von Tamm-Horsfall-Glykoprotein und Uromodulin

Country Status (7)

Country Link
US (1) US6110688A (de)
EP (1) EP0780398B1 (de)
JP (1) JP3839509B2 (de)
KR (1) KR970042590A (de)
CN (1) CN1165146A (de)
AT (1) ATE241644T1 (de)
DE (1) DE69628397T2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007027614A2 (en) * 2005-08-30 2007-03-08 The Regents Of The University Of California Abnormal glycosylation in tamm-horsfall protein in interstitial cystitis patient
ES2700958T3 (es) 2012-02-09 2019-02-20 Inst Massone S A Glucoproteína de Tamm-Horsfall (THP) como fármaco inmunoestimulante y composiciones para la utilización en un método de tratamiento para inhibir el desarrollo tumoral

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8801383A1 (es) * 1985-06-27 1988-01-01 Biogen Nv Un procedimiento para purificar uromodulina a partir de orina cruda
US4977244A (en) * 1985-06-27 1990-12-11 The United States Of America As Represented By The Department Of Health And Human Services Uromodulin and a process of purifying it
ATE139802T1 (de) * 1989-01-05 1996-07-15 Leti Lab Verwendung von spezifischen eigenschaften der tierallergene und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPH09165398A (ja) 1997-06-24
JP3839509B2 (ja) 2006-11-01
CN1165146A (zh) 1997-11-19
US6110688A (en) 2000-08-29
DE69628397D1 (de) 2003-07-03
KR970042590A (ko) 1997-07-24
ATE241644T1 (de) 2003-06-15
EP0780398B1 (de) 2003-05-28
EP0780398A3 (de) 1998-04-08
EP0780398A2 (de) 1997-06-25

Similar Documents

Publication Publication Date Title
ATE226960T1 (de) Verfahren zur herstellung von cardiodilatin- fragmenten, hochgereinigte cardiodilatin- fragmente und zwischenprodukte zu deren herstellung
DE69618357D1 (de) Verfahren zur Reinigung von Verbrennungsabgasen
DE69632293D1 (de) Verfahren zur Herstellung von Polysiloxan-Polycarbonat-Blockcopolymeren
DE69818304D1 (de) Verfahren zur reduktion von oxiranyl-epothilonen zu olefinischen epothilonen
DE58902183D1 (de) Verfahren zur reinigung von rohem, gasfoermigem chlorwasserstoff.
ATE278785T1 (de) Neues verfahren zur gewinnung und reinigung von fusionsproteinen
ATE206158T1 (de) Verfahren zur herstellung von gereinigtem enzym
DE59603541D1 (de) Verfahren zur Reinigung von Bisphenol-A
DE69504381D1 (de) Verfahren zur Reinigung von Wasserstoffgas
DE69533590D1 (de) Verfahren zur herstellung von feinteiligen festen builderpartikeln
ATE245192T1 (de) Verfahren zur herstellung von gereinigten papillomavirus proteinen
DE69502313T2 (de) Verfahren zur biologischen Reinigung von Gasströmen
DE69601994D1 (de) Verfahren zur Reinigung von Aceton
ATE289289T1 (de) Verfahren zur reinigung von alkanolaminen
ATE239038T1 (de) Methode zur reinigung von keratinocyten- wachstumsfaktoren
DE69628397T2 (de) Verfahren zur Reinigung von Tamm-Horsfall-Glykoprotein und Uromodulin
DE69620539T2 (de) Verfahren zur Reinigung von Thrombomodulin
DE69616385D1 (de) Methode zur reinigung von prozessgasen
ATE173272T1 (de) Verfahren zur reaktivierung von gereinigten membranproteinen
DE50110986D1 (de) Verfahren zur Reinigung von Kerzenfiltern und Membrananlagen
DE69008424D1 (de) Verfahren zur Erzeugung von Nitrobenzolen.
DE69016188T2 (de) Verfahren zur Herstellung von keramischen Verbundkörpern und so hergestellte Körper.
DE69024392D1 (de) Verfahren zur Reinigung von Aussenmembran-Protein von Haemophilus influenza
ATE496939T1 (de) Methode zur reinigung von keratinozyten- wachstumfaktoren
ATE241630T1 (de) Verfahren zur herstellung von ucn-01

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee