DE69628033T8 - Verfahren zur in vitro-analyse von toxischen und allergenen substanzen - Google Patents
Verfahren zur in vitro-analyse von toxischen und allergenen substanzen Download PDFInfo
- Publication number
- DE69628033T8 DE69628033T8 DE69628033T DE69628033T DE69628033T8 DE 69628033 T8 DE69628033 T8 DE 69628033T8 DE 69628033 T DE69628033 T DE 69628033T DE 69628033 T DE69628033 T DE 69628033T DE 69628033 T8 DE69628033 T8 DE 69628033T8
- Authority
- DE
- Germany
- Prior art keywords
- cytokines
- class
- pct
- neopterin
- indication
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000126 substance Substances 0.000 title abstract 6
- 230000002009 allergenic effect Effects 0.000 title abstract 2
- 238000000338 in vitro Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 231100000331 toxic Toxicity 0.000 title abstract 2
- 230000002588 toxic effect Effects 0.000 title abstract 2
- 108090000695 Cytokines Proteins 0.000 abstract 6
- 102000004127 Cytokines Human genes 0.000 abstract 6
- BMQYVXCPAOLZOK-UHFFFAOYSA-N Trihydroxypropylpterisin Natural products OCC(O)C(O)C1=CN=C2NC(N)=NC(=O)C2=N1 BMQYVXCPAOLZOK-UHFFFAOYSA-N 0.000 abstract 3
- BMQYVXCPAOLZOK-XINAWCOVSA-N neopterin Chemical compound OC[C@@H](O)[C@@H](O)C1=CN=C2NC(N)=NC(=O)C2=N1 BMQYVXCPAOLZOK-XINAWCOVSA-N 0.000 abstract 3
- 230000003111 delayed effect Effects 0.000 abstract 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 1
- 206010012442 Dermatitis contact Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 210000000601 blood cell Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000007969 cellular immunity Effects 0.000 abstract 1
- 208000010247 contact dermatitis Diseases 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 206010039083 rhinitis Diseases 0.000 abstract 1
- 238000013207 serial dilution Methods 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9502409A SE506533C2 (sv) | 1995-07-03 | 1995-07-03 | En process för in vitro analys av substansers toxiska och allergena egenskaper samt användning av neopterin för att skilja mellan allergiska immunreaktioner |
| SE9502409 | 1995-11-01 | ||
| PCT/SE1996/000902 WO1997016732A1 (en) | 1995-07-03 | 1996-07-03 | A process for in vitro analysis of toxic and allergenic substances |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DE69628033D1 DE69628033D1 (de) | 2003-06-12 |
| DE69628033T2 DE69628033T2 (de) | 2004-04-22 |
| DE69628033T8 true DE69628033T8 (de) | 2005-03-10 |
| DE69628033T3 DE69628033T3 (de) | 2009-11-19 |
Family
ID=20398831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69628033T Expired - Lifetime DE69628033T3 (de) | 1995-07-03 | 1996-07-03 | Verfahren zur in vitro-analyse von toxischen und allergenen substanzen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6046010A (de) |
| EP (1) | EP0866968B2 (de) |
| JP (1) | JP2000500330A (de) |
| AT (1) | ATE239918T1 (de) |
| AU (1) | AU724932B2 (de) |
| CA (1) | CA2236474A1 (de) |
| DE (1) | DE69628033T3 (de) |
| DK (1) | DK0866968T4 (de) |
| ES (1) | ES2198496T5 (de) |
| SE (1) | SE506533C2 (de) |
| WO (1) | WO1997016732A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003512626A (ja) * | 1999-10-15 | 2003-04-02 | ノボザイムス アクティーゼルスカブ | アレルゲン性の評価方法 |
| EP1392871A4 (de) | 2001-05-22 | 2006-04-19 | Gene Logic Inc | Modellierung molekularer toxizität |
| US20030022250A1 (en) * | 2001-05-29 | 2003-01-30 | Dreskin Stephen C. | Functional IgE test methods and compositions |
| US7447594B2 (en) | 2001-07-10 | 2008-11-04 | Ocimum Biosolutions, Inc. | Molecular cardiotoxicology modeling |
| US7469185B2 (en) | 2002-02-04 | 2008-12-23 | Ocimum Biosolutions, Inc. | Primary rat hepatocyte toxicity modeling |
| US20040077104A1 (en) * | 2002-07-09 | 2004-04-22 | Valentino Montegrande | Antigen detection device |
| EP3138566B1 (de) * | 2003-11-17 | 2022-01-26 | BioMarin Pharmaceutical Inc. | Behandlung von phenylketonurie mit bh4 |
| WO2006055511A2 (en) * | 2004-11-17 | 2006-05-26 | Biomarin Pharmaceutical Inc. | Stable tablet formulation of tetrahydrobiopterin |
| AU2006291604A1 (en) | 2005-09-16 | 2007-03-22 | Biovator Technologies Ab | In vitro assay for identification of allergenic proteins |
| EP1905843A1 (de) * | 2006-09-29 | 2008-04-02 | Vlaamse Instelling voor Technologisch Onderzoek | Methode zur Feststellung des allergischen Potentials einer Substanz |
| JP5442185B2 (ja) * | 2007-04-24 | 2014-03-12 | 日本メナード化粧品株式会社 | 感作性物質評価方法 |
| US20100311068A1 (en) | 2007-12-18 | 2010-12-09 | Biovator Technologies Ab | Assay |
| US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
| CN109283210B (zh) * | 2017-07-20 | 2021-02-09 | 郭俊成 | 一种应用植物胶琼脂固化而快速简便检测毒性物质的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4215275A1 (de) * | 1992-05-09 | 1993-11-11 | Merck Patent Gmbh | Mittel und Verfahren zur Behandlung von Körperflüssigkeiten bei der Bestimmung von Neopterin |
-
1995
- 1995-07-03 SE SE9502409A patent/SE506533C2/sv not_active IP Right Cessation
-
1996
- 1996-07-03 WO PCT/SE1996/000902 patent/WO1997016732A1/en active IP Right Grant
- 1996-07-03 EP EP96925215A patent/EP0866968B2/de not_active Expired - Lifetime
- 1996-07-03 ES ES96925215T patent/ES2198496T5/es not_active Expired - Lifetime
- 1996-07-03 JP JP9517257A patent/JP2000500330A/ja active Pending
- 1996-07-03 AT AT96925215T patent/ATE239918T1/de active
- 1996-07-03 DK DK96925215T patent/DK0866968T4/da active
- 1996-07-03 CA CA002236474A patent/CA2236474A1/en not_active Abandoned
- 1996-07-03 AU AU65379/96A patent/AU724932B2/en not_active Ceased
- 1996-07-03 DE DE69628033T patent/DE69628033T3/de not_active Expired - Lifetime
- 1996-07-03 US US09/066,292 patent/US6046010A/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997016732A1 (en) | 1997-05-09 |
| DE69628033T3 (de) | 2009-11-19 |
| SE9502409D0 (sv) | 1995-07-03 |
| AU6537996A (en) | 1997-05-22 |
| ES2198496T3 (es) | 2004-02-01 |
| DE69628033T2 (de) | 2004-04-22 |
| US6046010A (en) | 2000-04-04 |
| SE506533C2 (sv) | 1998-01-12 |
| JP2000500330A (ja) | 2000-01-18 |
| EP0866968B1 (de) | 2003-05-07 |
| ATE239918T1 (de) | 2003-05-15 |
| DK0866968T3 (da) | 2003-09-01 |
| EP0866968A1 (de) | 1998-09-30 |
| DK0866968T4 (da) | 2009-06-22 |
| ES2198496T5 (es) | 2009-10-23 |
| AU724932B2 (en) | 2000-10-05 |
| CA2236474A1 (en) | 1997-05-09 |
| EP0866968B2 (de) | 2009-05-06 |
| SE9502409L (sv) | 1997-05-02 |
| DE69628033D1 (de) | 2003-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BIOVATOR TECHNOLOGIES AB, KALLERED, SE |
|
| 8381 | Inventor (new situation) |
Inventor name: ANDERSSON, BIRGER, STOCKHOLM, SE |
|
| 8363 | Opposition against the patent | ||
| 8380 | Miscellaneous part iii |
Free format text: DIE BEZEICHNUNG IST ZU BERICHTIGEN IN: VERFAHREN ZUR IN-VITRO-ANALYSE VON TOXISCHEN UND ALLERGENEN SUBSTANZEN |
|
| 8366 | Restricted maintained after opposition proceedings |