DE69627652D1 - Verbesserte meningokokken polysaccharid-konjugat vakzine - Google Patents

Verbesserte meningokokken polysaccharid-konjugat vakzine

Info

Publication number
DE69627652D1
DE69627652D1 DE69627652T DE69627652T DE69627652D1 DE 69627652 D1 DE69627652 D1 DE 69627652D1 DE 69627652 T DE69627652 T DE 69627652T DE 69627652 T DE69627652 T DE 69627652T DE 69627652 D1 DE69627652 D1 DE 69627652D1
Authority
DE
Germany
Prior art keywords
group
polysaccharides
acyl derivative
conjugate vaccine
polysaccharide conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69627652T
Other languages
English (en)
Other versions
DE69627652T2 (de
Inventor
J Jennings
Robert Pon
Michele Lussier
Francis Michon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Application granted granted Critical
Publication of DE69627652D1 publication Critical patent/DE69627652D1/de
Publication of DE69627652T2 publication Critical patent/DE69627652T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate
DE69627652T 1995-06-07 1996-06-07 Verbesserte meningokokken polysaccharid-konjugat vakzine Expired - Fee Related DE69627652T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US484569 1995-06-07
US08/484,569 US5811102A (en) 1995-06-07 1995-06-07 Modified meningococcal polysaccharide conjugate vaccines
PCT/CA1996/000379 WO1996040239A1 (en) 1995-06-07 1996-06-07 Modified meningococcal polysaccharide conjugate vaccines

Publications (2)

Publication Number Publication Date
DE69627652D1 true DE69627652D1 (de) 2003-05-28
DE69627652T2 DE69627652T2 (de) 2004-02-12

Family

ID=23924694

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69627652T Expired - Fee Related DE69627652T2 (de) 1995-06-07 1996-06-07 Verbesserte meningokokken polysaccharid-konjugat vakzine

Country Status (18)

Country Link
US (4) US5811102A (de)
EP (1) EP0831898B1 (de)
JP (2) JP4171068B2 (de)
KR (1) KR100452475B1 (de)
CN (1) CN1163270C (de)
AT (1) ATE238064T1 (de)
AU (1) AU706053B2 (de)
BR (1) BR9609229A (de)
CA (1) CA2223567C (de)
CZ (1) CZ391497A3 (de)
DE (1) DE69627652T2 (de)
ES (1) ES2196153T3 (de)
HU (1) HU224972B1 (de)
IL (3) IL118604A0 (de)
NO (1) NO321705B1 (de)
PL (1) PL184125B1 (de)
WO (1) WO1996040239A1 (de)
ZA (1) ZA964823B (de)

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US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
US20030157129A1 (en) * 1995-06-23 2003-08-21 Smithkline Beecham Biologicals S.A. Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein
EP0939647B2 (de) * 1996-08-27 2006-07-12 Chiron Corporation Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung
WO1998008874A1 (en) * 1996-08-27 1998-03-05 Chiron Corporation Monoclonal antibodies that define unique meningococcal b epitopes and their use in the preparation of vaccine compositions
US6299881B1 (en) * 1997-03-24 2001-10-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
EP2226336B1 (de) * 1997-12-23 2016-10-19 Pfizer Ireland Pharmaceuticals Bakterielle Kapsel-Polysaccharide für die Verwendung als Impfstoffe oder als Impfstoffe-Konjugat
AU771330B2 (en) * 1998-08-19 2004-03-18 Baxter Healthcare Sa Immunogenic beta-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an N-acryloylated polysaccharide
US6585973B1 (en) 1998-10-29 2003-07-01 Henry M. Jackson Foundation For The Advancement Of Military Medicine Method for preparing solid phase conjugated vaccine
CA2279134A1 (en) * 1999-07-29 2001-01-29 Tianmin Liu Novel strategy for carbohydrate-based therapeutic vaccines
EP1307221A2 (de) * 2000-07-28 2003-05-07 National Research Council of Canada Modifizierte sialylsäure impfstoffe
GB0024200D0 (en) * 2000-10-03 2000-11-15 Smithkline Beecham Sa Component vaccine
CA2435681C (en) * 2001-01-23 2011-06-21 Aventis Pasteur Multivalent meningococcal polysaccharide-protein conjugate vaccine
DE60235155D1 (de) * 2001-04-17 2010-03-11 Childrens Hosp Oak Res Inst Monoklonale antikörper gegen molekulare mimetika von meningokokken-b-epitopen
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0130215D0 (en) * 2001-12-18 2002-02-06 Glaxosmithkline Biolog Sa Vaccine
US20040096461A1 (en) * 2002-07-30 2004-05-20 Baxter Healthcare Corporation Chimeric multivalent polysaccharide conjugate vaccines
CA2514328C (en) * 2003-01-30 2020-01-14 Chiron Srl Injectable vaccines against multiple meningococcal serogroups
EP2851088A1 (de) * 2003-06-23 2015-03-25 Baxter International Inc. Impfstoffe gegen Gruppe Y Neisseria meningitidis und Meningokkenkombinationen davon
EP1784428A2 (de) * 2004-06-23 2007-05-16 Children's Hospital & Research Center at Oakland Polysaccharidderivate und verwendung bei der induktion einer immunantwort
US8148335B2 (en) 2004-06-23 2012-04-03 Children's Hospital & Research Center Oakland De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy
EP1863536A4 (de) * 2005-03-14 2011-07-20 Univ Alberta Vakzine auf basis synthetischer oligosaccharide gegen candida albicans
US20070184072A1 (en) * 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
US7709001B2 (en) * 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
TR201807355T4 (tr) * 2006-03-22 2018-06-21 Glaxosmithkline Biologicals Sa Meningokokkal konjugatlarla immünizasyon rejimleri.
US10828361B2 (en) * 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
WO2007116409A2 (en) * 2006-04-11 2007-10-18 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Improved vaccines comprising multimeric hsp60 peptide carriers
GB0611914D0 (en) * 2006-06-15 2006-07-26 Teti Giuseppe Peptides that mimic non-human cross-reactive protective epitopes of the group Bmeningococcal capsulsar polysaccharide
ES2387582T3 (es) 2006-09-07 2012-09-26 Glaxosmithkline Biologicals S.A. Vacuna de combinación con cantidades reducidas del antígeno del virus de la polio
EP2170391B1 (de) * 2007-06-20 2017-01-18 Pfizer Ireland Pharmaceuticals Modifizierte polysaccharide für konjugat-impfstoffe
EP2383035A4 (de) 2008-12-03 2017-11-22 Kaneka Corporation Formylgruppenhaltiger poröser träger, adsorbens damit, herstellungsverfahren dafür und verfahren zur herstellung des adsorbens

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4057685A (en) * 1972-02-02 1977-11-08 Abbott Laboratories Chemically modified endotoxin immunizing agent
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4902506A (en) * 1983-07-05 1990-02-20 The University Of Rochester Immunogenic conjugates
US4673574A (en) * 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4619828A (en) * 1982-07-06 1986-10-28 Connaught Laboratories, Inc. Polysaccharide exotoxoid conjugate vaccines
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
US4644059A (en) * 1982-07-06 1987-02-17 Connaught Laboratories, Inc. Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
NZ214503A (en) * 1984-12-20 1990-02-26 Merck & Co Inc Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
US4727136A (en) * 1985-10-01 1988-02-23 Canadian Patents And Development Ltd. Modified meningococcal group B polysaccharide for conjugate vaccine
US5034516A (en) * 1987-08-04 1991-07-23 University Of Ottawa Synthetic antigens of sialic acid and derivatives thereof
AU640118B2 (en) 1988-12-19 1993-08-19 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur Meningococcal class 1 outer-membrane protein vaccine
JP2637845B2 (ja) * 1989-12-14 1997-08-06 ナシヨナル・リサーチ・カウンシル・カナダ 修飾メニンゴコツクス多糖複合ワクチン
FI903414A (fi) 1990-07-06 1992-01-07 Kansanterveyslaitos Produktion av proteiner i grampositiva bakterier.
FR2682388B1 (fr) * 1991-10-10 1995-06-09 Pasteur Merieux Serums Vacc Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal.
US5425946A (en) * 1992-08-31 1995-06-20 North American Vaccine, Inc. Vaccines against group C Neisseria meningitidis
US5780606A (en) * 1995-06-07 1998-07-14 Connaught Laboratories Limited Neisseria meningitidis capsular polysaccharide conjugates
WO1998008874A1 (en) * 1996-08-27 1998-03-05 Chiron Corporation Monoclonal antibodies that define unique meningococcal b epitopes and their use in the preparation of vaccine compositions

Also Published As

Publication number Publication date
US6350449B1 (en) 2002-02-26
KR19990022748A (ko) 1999-03-25
EP0831898B1 (de) 2003-04-23
IL147121A (en) 2009-07-20
CN1163270C (zh) 2004-08-25
HUP9802664A3 (en) 1999-12-28
US6596283B2 (en) 2003-07-22
PL184125B1 (pl) 2002-09-30
PL323862A1 (en) 1998-04-27
ATE238064T1 (de) 2003-05-15
US5969130A (en) 1999-10-19
IL147121A0 (en) 2002-08-14
JP2008285675A (ja) 2008-11-27
HUP9802664A2 (hu) 1999-02-01
JPH11506491A (ja) 1999-06-08
KR100452475B1 (ko) 2004-12-30
CN1187136A (zh) 1998-07-08
US20020031511A1 (en) 2002-03-14
AU706053B2 (en) 1999-06-10
NO975547D0 (no) 1997-12-02
HU224972B1 (en) 2006-04-28
US5811102A (en) 1998-09-22
DE69627652T2 (de) 2004-02-12
JP4171068B2 (ja) 2008-10-22
CZ391497A3 (cs) 1998-05-13
ES2196153T3 (es) 2003-12-16
IL118604A0 (en) 1996-10-16
NO321705B1 (no) 2006-06-26
ZA964823B (en) 1997-08-01
CA2223567A1 (en) 1996-12-19
WO1996040239A1 (en) 1996-12-19
NO975547L (no) 1998-02-09
BR9609229A (pt) 1999-07-27
CA2223567C (en) 2009-02-03
AU5993796A (en) 1996-12-30
EP0831898A1 (de) 1998-04-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee