DE69620165T2 - Piperazinone als inhibitoren von blutplattchenaggregation - Google Patents
Piperazinone als inhibitoren von blutplattchenaggregationInfo
- Publication number
- DE69620165T2 DE69620165T2 DE69620165T DE69620165T DE69620165T2 DE 69620165 T2 DE69620165 T2 DE 69620165T2 DE 69620165 T DE69620165 T DE 69620165T DE 69620165 T DE69620165 T DE 69620165T DE 69620165 T2 DE69620165 T2 DE 69620165T2
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- piperazinone
- inhibitors
- blood plate
- plate aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 title abstract 2
- 230000002776 aggregation Effects 0.000 title 1
- 238000004220 aggregation Methods 0.000 title 1
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127217 antithrombotic drug Drugs 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002008 hemorrhagic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10191195 | 1995-04-26 | ||
| JP20313295 | 1995-08-09 | ||
| JP7786796 | 1996-03-29 | ||
| PCT/JP1996/001139 WO1996033982A1 (en) | 1995-04-26 | 1996-04-25 | Piperazinones useful as inhibitors of platelet aggregation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69620165D1 DE69620165D1 (de) | 2002-05-02 |
| DE69620165T2 true DE69620165T2 (de) | 2002-10-31 |
Family
ID=27302551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69620165T Expired - Fee Related DE69620165T2 (de) | 1995-04-26 | 1996-04-25 | Piperazinone als inhibitoren von blutplattchenaggregation |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5935963A (de) |
| EP (1) | EP0822931B1 (de) |
| AT (1) | ATE215074T1 (de) |
| AU (1) | AU5514296A (de) |
| CA (1) | CA2216162A1 (de) |
| DE (1) | DE69620165T2 (de) |
| WO (1) | WO1996033982A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
| EP0750913A3 (de) * | 1995-06-30 | 1997-11-05 | Takeda Chemical Industries, Ltd. | Disaccharide enthaltende gefriergetrocknete Zubereitung für pharmazeutische Verwendung |
| US6242600B1 (en) | 1997-03-07 | 2001-06-05 | Takeda Chemical Industries, Ltd. | 2-piperazinone-1-acetic acid derivatives and their use |
| AU7453498A (en) | 1997-05-30 | 1998-12-30 | Takeda Chemical Industries Ltd. | Sulfonamide derivatives, their production and use |
| AU2298899A (en) | 1998-02-05 | 1999-08-23 | Takeda Chemical Industries Ltd. | Sulfonamide derivatives, process for producing the same and utilization thereof |
| WO1999052861A1 (de) * | 1998-04-09 | 1999-10-21 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Neue benzylguanidinderivate für die therapie, in-vivo- und in-vitro-diagnostik |
| EP0950658A1 (de) * | 1998-04-13 | 1999-10-20 | Takeda Chemical Industries, Ltd. | 2-Piperazinone-1-acetic acid dihydrochloridderivat als Hemmer von Plättchenaggregation |
| US6322550B2 (en) | 1998-04-14 | 2001-11-27 | Hisamitsu Pharmaceutical Co., Inc. | Method for transdermal administration of GP IIb/IIIa antagonist |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| CA2462200A1 (en) * | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| JP2013518618A (ja) * | 2010-02-01 | 2013-05-23 | ザ・ホスピタル・フォー・シック・チルドレン | 再狭窄を治療および予防するための遠隔虚血コンディショニング |
| SG10201502031XA (en) | 2010-03-31 | 2015-05-28 | Hospital For Sick Children | Use of remote ischemic conditioning to improve outcome after myocardial infarction |
| EP2555692A2 (de) | 2010-04-08 | 2013-02-13 | The Hospital For Sick Children | Anwendung von ischämischer fernkonditionierung für traumatische läsionen |
| WO2014140832A2 (en) | 2013-03-15 | 2014-09-18 | The Hospital For Sick Children | Treatment of erectile dysfunction using remote ischemic conditioning |
| WO2014167423A2 (en) | 2013-03-15 | 2014-10-16 | The Hospital For Sick Children | Methods for modulating autophagy using remote ischemic conditioning |
| WO2014199239A2 (en) | 2013-03-15 | 2014-12-18 | The Hospital For Sick Children | Methods relating to the use of remote ischemic conditioning |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2945680B2 (ja) * | 1988-09-09 | 1999-09-06 | 旭硝子株式会社 | ペプチド誘導体およびその用途 |
| DE69126871T2 (de) * | 1990-04-06 | 1998-03-12 | Jolla Cancer Res Found | Verfahren und verbindung zur behandlung von thrombose |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| RU2097378C1 (ru) * | 1991-03-26 | 1997-11-27 | Ф.Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ N-АЦИЛ- α -АМИНОКИСЛОТЫ ИЛИ ИХ ФИЗИОЛОГИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ, ПРОСТЫЕ ИЛИ СЛОЖНЫЕ ЭФИРЫ, АМИДЫ ИЛИ ГИДРАТЫ И КОМПОЗИЦИЯ ИНГИБИРУЮЩАЯ СВЯЗЫВАНИЕ АДГЕЗИВНЫХ ПРОТЕИНОВ С ТРОМБОЦИТАМИ И АГРЕГАЦИЮ ТРОМБОЦИТОВ |
| US5545658A (en) * | 1991-03-26 | 1996-08-13 | Hoffman-La Roche Inc. | Amino acid derivatives |
| DE69226077T2 (de) * | 1991-04-05 | 1998-12-03 | Genentech Inc | PLAETTCHENAGGREGATIONSINHIBITOREN MIT HOHER SPEZIFIZITAET ZUM GP IIbIIIa |
| JPH0529858A (ja) * | 1991-07-23 | 1993-02-05 | Canon Inc | 信号処理装置 |
| AU646966B2 (en) * | 1991-08-23 | 1994-03-10 | Takeda Chemical Industries Ltd. | 2-piperazinone compounds, their production and use |
| HUT70045A (en) * | 1993-06-17 | 1995-09-28 | Takeda Chemical Industries Ltd | 2-piperazinone derivatives parmaceutical compositions containing them and process for producing them |
| US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
-
1996
- 1996-04-25 WO PCT/JP1996/001139 patent/WO1996033982A1/en active IP Right Grant
- 1996-04-25 AT AT96912246T patent/ATE215074T1/de active
- 1996-04-25 AU AU55142/96A patent/AU5514296A/en not_active Abandoned
- 1996-04-25 US US08/669,375 patent/US5935963A/en not_active Expired - Fee Related
- 1996-04-25 DE DE69620165T patent/DE69620165T2/de not_active Expired - Fee Related
- 1996-04-25 EP EP96912246A patent/EP0822931B1/de not_active Expired - Lifetime
- 1996-04-25 CA CA002216162A patent/CA2216162A1/en not_active Abandoned
-
1998
- 1998-09-01 US US09/144,995 patent/US6020334A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5935963A (en) | 1999-08-10 |
| EP0822931B1 (de) | 2002-03-27 |
| US6020334A (en) | 2000-02-01 |
| DE69620165D1 (de) | 2002-05-02 |
| EP0822931A1 (de) | 1998-02-11 |
| WO1996033982A1 (en) | 1996-10-31 |
| ATE215074T1 (de) | 2002-04-15 |
| AU5514296A (en) | 1996-11-18 |
| CA2216162A1 (en) | 1996-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP |
|
| 8339 | Ceased/non-payment of the annual fee |