DE69617237T2 - Verwendung von imidazo(a,5-a)quinolonen als neuroprotektive arzneimittel - Google Patents
Verwendung von imidazo(a,5-a)quinolonen als neuroprotektive arzneimittelInfo
- Publication number
- DE69617237T2 DE69617237T2 DE69617237T DE69617237T DE69617237T2 DE 69617237 T2 DE69617237 T2 DE 69617237T2 DE 69617237 T DE69617237 T DE 69617237T DE 69617237 T DE69617237 T DE 69617237T DE 69617237 T2 DE69617237 T2 DE 69617237T2
- Authority
- DE
- Germany
- Prior art keywords
- imidazo
- quinolones
- neuroprotective
- medicinal product
- conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229940126601 medicinal product Drugs 0.000 title 1
- 230000000324 neuroprotective effect Effects 0.000 title 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- OWZFYIIJHLFOIG-UHFFFAOYSA-N imidazo[1,5-a]quinoline Chemical class C1=CC=C2N3C=NC=C3C=CC2=C1 OWZFYIIJHLFOIG-UHFFFAOYSA-N 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24695P | 1995-06-15 | 1995-06-15 | |
PCT/US1996/007952 WO1997000074A1 (en) | 1995-06-15 | 1996-06-03 | USE OF IMIDAZO[1,5-a]QUINOLONES AS NEUROPROTECTIVE AGENTS |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69617237D1 DE69617237D1 (de) | 2002-01-03 |
DE69617237T2 true DE69617237T2 (de) | 2002-06-27 |
Family
ID=21690598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69617237T Expired - Fee Related DE69617237T2 (de) | 1995-06-15 | 1996-06-03 | Verwendung von imidazo(a,5-a)quinolonen als neuroprotektive arzneimittel |
Country Status (10)
Country | Link |
---|---|
US (1) | US5935970A (de) |
EP (1) | EP0833638B1 (de) |
JP (1) | JP2001518056A (de) |
AT (1) | ATE209036T1 (de) |
AU (1) | AU6025996A (de) |
DE (1) | DE69617237T2 (de) |
DK (1) | DK0833638T3 (de) |
ES (1) | ES2167569T3 (de) |
PT (1) | PT833638E (de) |
WO (1) | WO1997000074A1 (de) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3454579A (en) * | 1967-08-17 | 1969-07-08 | American Cyanamid Co | Imidazo(1,5-a)quinolin-1-one and thione derivatives |
US4350814A (en) * | 1979-10-22 | 1982-09-21 | Ici Americas Inc. | Pyrrolo [3,4-c]quinoline compounds |
FR2593179B1 (fr) * | 1986-01-22 | 1988-04-01 | Synthelabo | Derives d'imidazo(1,2-a)quinoleines, leur preparation et leur application en therapeutique |
US5190951A (en) * | 1990-10-19 | 1993-03-02 | Ss Pharmaceutical Co., Ltd. | Quinoline derivatives |
USRE35840E (en) * | 1993-11-19 | 1998-07-07 | Pharmacia & Upjohn Company | Imidazo 1,5-a!quinolines for treatment of anxiety and sleep disorders |
US5580877A (en) * | 1994-04-25 | 1996-12-03 | Merck Sharp & Dohme Ltd. | Pyrazolo-quinoline derivatives for treating cerebral ischemia |
-
1996
- 1996-06-03 WO PCT/US1996/007952 patent/WO1997000074A1/en active IP Right Grant
- 1996-06-03 PT PT96917855T patent/PT833638E/pt unknown
- 1996-06-03 ES ES96917855T patent/ES2167569T3/es not_active Expired - Lifetime
- 1996-06-03 AU AU60259/96A patent/AU6025996A/en not_active Abandoned
- 1996-06-03 US US08/657,119 patent/US5935970A/en not_active Expired - Fee Related
- 1996-06-03 DK DK96917855T patent/DK0833638T3/da active
- 1996-06-03 EP EP96917855A patent/EP0833638B1/de not_active Expired - Lifetime
- 1996-06-03 DE DE69617237T patent/DE69617237T2/de not_active Expired - Fee Related
- 1996-06-03 AT AT96917855T patent/ATE209036T1/de not_active IP Right Cessation
- 1996-06-03 JP JP50309097A patent/JP2001518056A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU6025996A (en) | 1997-01-15 |
ATE209036T1 (de) | 2001-12-15 |
JP2001518056A (ja) | 2001-10-09 |
WO1997000074A1 (en) | 1997-01-03 |
ES2167569T3 (es) | 2002-05-16 |
EP0833638B1 (de) | 2001-11-21 |
DE69617237D1 (de) | 2002-01-03 |
DK0833638T3 (da) | 2002-05-21 |
EP0833638A1 (de) | 1998-04-08 |
US5935970A (en) | 1999-08-10 |
PT833638E (pt) | 2002-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |