DE69614417D1 - Merkaptoalkanoyldipeptide Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusmmensetzungen - Google Patents

Merkaptoalkanoyldipeptide Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusmmensetzungen

Info

Publication number
DE69614417D1
DE69614417D1 DE69614417T DE69614417T DE69614417D1 DE 69614417 D1 DE69614417 D1 DE 69614417D1 DE 69614417 T DE69614417 T DE 69614417T DE 69614417 T DE69614417 T DE 69614417T DE 69614417 D1 DE69614417 D1 DE 69614417D1
Authority
DE
Germany
Prior art keywords
alkyl
merkaptoalkanoyldipeptide
derivatives
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69614417T
Other languages
English (en)
Other versions
DE69614417T2 (de
Inventor
Bernard P Roques
Marie-Claude Fournie-Zaluski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Laboratoires Servier SAS
Original Assignee
ADIR SARL
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical ADIR SARL
Application granted granted Critical
Publication of DE69614417D1 publication Critical patent/DE69614417D1/de
Publication of DE69614417T2 publication Critical patent/DE69614417T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69614417T 1995-01-23 1996-01-22 Merkaptoalkanoyldipeptide Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusmmensetzungen Expired - Fee Related DE69614417T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9500694A FR2729668A1 (fr) 1995-01-23 1995-01-23 Nouveaux derives de mercaptoalcanoyldipeptides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE69614417D1 true DE69614417D1 (de) 2001-09-20
DE69614417T2 DE69614417T2 (de) 2002-05-29

Family

ID=9475379

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69614417T Expired - Fee Related DE69614417T2 (de) 1995-01-23 1996-01-22 Merkaptoalkanoyldipeptide Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusmmensetzungen

Country Status (17)

Country Link
US (1) US5741781A (de)
EP (1) EP0723974B1 (de)
JP (1) JPH08325290A (de)
CN (1) CN1137040A (de)
AT (1) ATE204293T1 (de)
AU (1) AU699204B2 (de)
CA (1) CA2167763A1 (de)
DE (1) DE69614417T2 (de)
DK (1) DK0723974T3 (de)
ES (1) ES2162986T3 (de)
FI (1) FI960284A (de)
FR (1) FR2729668A1 (de)
GR (1) GR3037041T3 (de)
NO (1) NO960250L (de)
NZ (1) NZ280870A (de)
PT (1) PT723974E (de)
ZA (1) ZA96516B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2729668A1 (fr) * 1995-01-23 1996-07-26 Adir Nouveaux derives de mercaptoalcanoyldipeptides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
HUP0200662A3 (en) * 1999-03-29 2004-07-28 Bristol Myers Squibb Company P Use of composition containing vasopeptidase to treat angina pectoris
FR2823212B1 (fr) * 2001-04-10 2005-12-02 Inst Nat Sante Rech Med Inhibiteurs de la toxine botulique de type b
FR2931151A1 (fr) * 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
KR101442897B1 (ko) * 2009-05-28 2014-09-23 노파르티스 아게 네프릴리신 억제제로서의 치환된 아미노프로피온산 유도체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3272505D1 (en) * 1981-03-09 1986-09-18 Merck & Co Inc Substituted thiazolidine carboxylic acid analogs and derivatives as antihypertensives
US4560506A (en) * 1984-05-25 1985-12-24 E. R. Squibb & Sons, Inc. Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
AU3494093A (en) * 1993-01-22 1994-08-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-lipophilic aliphatic carbonyl {n-mercaptoacyl-(amino acid or peptide)} compounds as antihypertensive agents
FR2729668A1 (fr) * 1995-01-23 1996-07-26 Adir Nouveaux derives de mercaptoalcanoyldipeptides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ATE204293T1 (de) 2001-09-15
FI960284A0 (fi) 1996-01-19
PT723974E (pt) 2001-11-30
NO960250L (no) 1996-07-24
JPH08325290A (ja) 1996-12-10
CN1137040A (zh) 1996-12-04
DE69614417T2 (de) 2002-05-29
ZA96516B (en) 1996-08-15
EP0723974A1 (de) 1996-07-31
NZ280870A (en) 1997-09-22
FR2729668B1 (de) 1997-02-21
AU4210196A (en) 1996-08-01
NO960250D0 (no) 1996-01-22
AU699204B2 (en) 1998-11-26
US5741781A (en) 1998-04-21
FR2729668A1 (fr) 1996-07-26
EP0723974B1 (de) 2001-08-16
CA2167763A1 (fr) 1996-07-24
FI960284A (fi) 1996-07-24
ES2162986T3 (es) 2002-01-16
GR3037041T3 (en) 2002-01-31
DK0723974T3 (da) 2001-10-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR

Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE M

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR IN

8380 Miscellaneous part iii

Free format text: DER 1.MITANMELDER IST ZU AENDERN IN: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR

8339 Ceased/non-payment of the annual fee