DE69605803T2 - Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträger - Google Patents
Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträgerInfo
- Publication number
- DE69605803T2 DE69605803T2 DE69605803T DE69605803T DE69605803T2 DE 69605803 T2 DE69605803 T2 DE 69605803T2 DE 69605803 T DE69605803 T DE 69605803T DE 69605803 T DE69605803 T DE 69605803T DE 69605803 T2 DE69605803 T2 DE 69605803T2
- Authority
- DE
- Germany
- Prior art keywords
- resolvase
- malfunctions
- cutting
- detection
- solid carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Dental Preparations (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43986695A | 1995-05-11 | 1995-05-11 | |
PCT/US1996/006333 WO1996035809A1 (en) | 1995-05-11 | 1996-05-06 | Detection of mismatches by resolvase cleavage on a solid support |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69605803D1 DE69605803D1 (de) | 2000-01-27 |
DE69605803T2 true DE69605803T2 (de) | 2000-07-20 |
Family
ID=23746451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69605803T Expired - Fee Related DE69605803T2 (de) | 1995-05-11 | 1996-05-06 | Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträger |
Country Status (7)
Country | Link |
---|---|
US (1) | US5876941A (de) |
EP (1) | EP0843736B1 (de) |
JP (1) | JPH11506316A (de) |
AU (1) | AU703951B2 (de) |
CA (1) | CA2220467A1 (de) |
DE (1) | DE69605803T2 (de) |
WO (1) | WO1996035809A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5851770A (en) * | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
EP0832283A2 (de) * | 1995-06-07 | 1998-04-01 | Genzyme Corporation | Verfahren zur identifizierung der genetixchen modifikation von dns unter verwendung von dns-sequenzierungund positionklonierung |
US5770370A (en) * | 1996-06-14 | 1998-06-23 | David Sarnoff Research Center, Inc. | Nuclease protection assays |
WO1998046793A1 (en) * | 1997-04-16 | 1998-10-22 | Trevigen, Inc. | Detection and mapping of point mutations using partial digestion |
EP0983379A1 (de) * | 1997-05-21 | 2000-03-08 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Verfahren und kit zur detektion von mutationen in dna's mit hilfe von restriktionsenzymen |
EP1053352B1 (de) * | 1998-02-04 | 2002-09-18 | Variagenics, Inc. | Techniken zu detektion von fehlpaarungen |
US6080544A (en) * | 1998-02-13 | 2000-06-27 | Ohio State University | Methods for identifying nucleic acid mutations using mismatch modification |
US20020090639A1 (en) * | 1998-02-26 | 2002-07-11 | Mcginnis Ralph Evan | Two dimensional linkage study methods and related inventions |
SE9802951D0 (sv) * | 1998-09-02 | 1998-09-02 | Amersham Pharm Biotech Ab | Metod för screening samt verktyg att använda i metoden |
US6653077B1 (en) * | 1998-09-04 | 2003-11-25 | Lynx Therapeutics, Inc. | Method of screening for genetic polymorphism |
SE9902741D0 (sv) * | 1999-07-19 | 1999-07-19 | Boerries Kemper | Method for the enrichment of heteroduplexes and its use in mutation detection |
US6524794B1 (en) * | 1999-10-29 | 2003-02-25 | Decode Genetics Ehf. | Identical-by-descent fragment enrichment |
EE200100112A (et) * | 2001-02-23 | 2002-10-15 | Tartu Ülikool | Meetod DNA järjestuste variatsioonide leidmiseks |
WO2003048395A1 (en) * | 2001-12-03 | 2003-06-12 | Zymogenetics, Inc. | Methods for the selection and cloning of nucleic acid molecules free of unwanted nucleotide sequence alterations |
US20040002156A1 (en) * | 2002-06-26 | 2004-01-01 | Stratagene | Selective cloning of homoduplex nucleic acids |
AU2003301503A1 (en) * | 2003-12-16 | 2005-07-14 | Centre National De La Recherche Scientifique | Methods and compositions for assaying mutations in nucleic acids |
WO2010068702A2 (en) * | 2008-12-10 | 2010-06-17 | Illumina, Inc. | Methods and compositions for hybridizing nucleic acids |
US20150184251A1 (en) * | 2014-01-02 | 2015-07-02 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Methods for screening muscle invasive bladder cancer patients for neoadjuvant chemotherapy responsiveness |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5032502A (en) * | 1988-01-21 | 1991-07-16 | The United States Of America As Represented By The United States Of Energy | Purification of polymorphic components of complex genomes |
US5217863A (en) * | 1988-02-04 | 1993-06-08 | Medical Research Council | Detection of mutations in nucleic acids |
US4988617A (en) * | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
WO1989009835A1 (en) * | 1988-04-08 | 1989-10-19 | The Salk Institute For Biological Studies | Ligase-based amplification method |
WO1990012115A1 (en) * | 1989-03-21 | 1990-10-18 | Collaborative Research, Inc. | A dna diagnostic test using an exonuclease activity |
US5459039A (en) * | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
AU7762091A (en) * | 1990-03-30 | 1991-10-30 | City Of Hope | Detection of minimal residual disease in lymphoid malignancies |
CA2113716A1 (en) * | 1991-07-19 | 1993-02-04 | Robert E. Wagner, Jr. | Method for detection of mutations |
WO1993020233A1 (en) * | 1992-03-27 | 1993-10-14 | University Of Maryland At Baltimore | Detection of gene mutations with mismatch repair enzymes |
SE9203320D0 (sv) * | 1992-11-06 | 1992-11-06 | Pharmacia Lkb Biotech | A method of processing nucleic acid samples |
FR2709761B1 (fr) * | 1993-09-10 | 1995-11-24 | Pasteur Institut | Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases . |
WO1995029251A1 (en) * | 1994-04-25 | 1995-11-02 | Applied Technology Genetics Corporation | Detection of mutation by resolvase cleavage |
-
1996
- 1996-05-06 WO PCT/US1996/006333 patent/WO1996035809A1/en active IP Right Grant
- 1996-05-06 DE DE69605803T patent/DE69605803T2/de not_active Expired - Fee Related
- 1996-05-06 AU AU56758/96A patent/AU703951B2/en not_active Ceased
- 1996-05-06 EP EP96913940A patent/EP0843736B1/de not_active Expired - Lifetime
- 1996-05-06 CA CA002220467A patent/CA2220467A1/en not_active Abandoned
- 1996-05-06 JP JP8534151A patent/JPH11506316A/ja active Pending
-
1997
- 1997-06-24 US US08/881,621 patent/US5876941A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH11506316A (ja) | 1999-06-08 |
EP0843736A4 (de) | 1998-12-02 |
US5876941A (en) | 1999-03-02 |
EP0843736A1 (de) | 1998-05-27 |
EP0843736B1 (de) | 1999-12-22 |
WO1996035809A1 (en) | 1996-11-14 |
DE69605803D1 (de) | 2000-01-27 |
AU5675896A (en) | 1996-11-29 |
AU703951B2 (en) | 1999-04-01 |
CA2220467A1 (en) | 1996-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |