DE69605803D1 - Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträger - Google Patents

Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträger

Info

Publication number
DE69605803D1
DE69605803D1 DE69605803T DE69605803T DE69605803D1 DE 69605803 D1 DE69605803 D1 DE 69605803D1 DE 69605803 T DE69605803 T DE 69605803T DE 69605803 T DE69605803 T DE 69605803T DE 69605803 D1 DE69605803 D1 DE 69605803D1
Authority
DE
Germany
Prior art keywords
resolvase
malfunctions
cutting
detection
solid carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69605803T
Other languages
English (en)
Other versions
DE69605803T2 (de
Inventor
Ulf Landegren
Arild Lagerkvist
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69605803D1 publication Critical patent/DE69605803D1/de
Publication of DE69605803T2 publication Critical patent/DE69605803T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Dental Preparations (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69605803T 1995-05-11 1996-05-06 Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträger Expired - Fee Related DE69605803T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43986695A 1995-05-11 1995-05-11
PCT/US1996/006333 WO1996035809A1 (en) 1995-05-11 1996-05-06 Detection of mismatches by resolvase cleavage on a solid support

Publications (2)

Publication Number Publication Date
DE69605803D1 true DE69605803D1 (de) 2000-01-27
DE69605803T2 DE69605803T2 (de) 2000-07-20

Family

ID=23746451

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69605803T Expired - Fee Related DE69605803T2 (de) 1995-05-11 1996-05-06 Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträger

Country Status (7)

Country Link
US (1) US5876941A (de)
EP (1) EP0843736B1 (de)
JP (1) JPH11506316A (de)
AU (1) AU703951B2 (de)
CA (1) CA2220467A1 (de)
DE (1) DE69605803T2 (de)
WO (1) WO1996035809A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851770A (en) * 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
EP0832283A2 (de) * 1995-06-07 1998-04-01 Genzyme Corporation Verfahren zur identifizierung der genetixchen modifikation von dns unter verwendung von dns-sequenzierungund positionklonierung
US5770370A (en) * 1996-06-14 1998-06-23 David Sarnoff Research Center, Inc. Nuclease protection assays
WO1998046793A1 (en) * 1997-04-16 1998-10-22 Trevigen, Inc. Detection and mapping of point mutations using partial digestion
EP0983379A1 (de) * 1997-05-21 2000-03-08 Gesellschaft für biotechnologische Forschung mbH (GBF) Verfahren und kit zur detektion von mutationen in dna's mit hilfe von restriktionsenzymen
EP1053352B1 (de) * 1998-02-04 2002-09-18 Variagenics, Inc. Techniken zu detektion von fehlpaarungen
US6080544A (en) * 1998-02-13 2000-06-27 Ohio State University Methods for identifying nucleic acid mutations using mismatch modification
US20020090639A1 (en) * 1998-02-26 2002-07-11 Mcginnis Ralph Evan Two dimensional linkage study methods and related inventions
SE9802951D0 (sv) * 1998-09-02 1998-09-02 Amersham Pharm Biotech Ab Metod för screening samt verktyg att använda i metoden
US6653077B1 (en) * 1998-09-04 2003-11-25 Lynx Therapeutics, Inc. Method of screening for genetic polymorphism
SE9902741D0 (sv) * 1999-07-19 1999-07-19 Boerries Kemper Method for the enrichment of heteroduplexes and its use in mutation detection
US6524794B1 (en) * 1999-10-29 2003-02-25 Decode Genetics Ehf. Identical-by-descent fragment enrichment
EE200100112A (et) * 2001-02-23 2002-10-15 Tartu Ülikool Meetod DNA järjestuste variatsioonide leidmiseks
WO2003048395A1 (en) * 2001-12-03 2003-06-12 Zymogenetics, Inc. Methods for the selection and cloning of nucleic acid molecules free of unwanted nucleotide sequence alterations
US20040002156A1 (en) * 2002-06-26 2004-01-01 Stratagene Selective cloning of homoduplex nucleic acids
AU2003301503A1 (en) * 2003-12-16 2005-07-14 Centre National De La Recherche Scientifique Methods and compositions for assaying mutations in nucleic acids
WO2010068702A2 (en) * 2008-12-10 2010-06-17 Illumina, Inc. Methods and compositions for hybridizing nucleic acids
US20150184251A1 (en) * 2014-01-02 2015-07-02 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Methods for screening muscle invasive bladder cancer patients for neoadjuvant chemotherapy responsiveness

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032502A (en) * 1988-01-21 1991-07-16 The United States Of America As Represented By The United States Of Energy Purification of polymorphic components of complex genomes
US5217863A (en) * 1988-02-04 1993-06-08 Medical Research Council Detection of mutations in nucleic acids
US4988617A (en) * 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
WO1989009835A1 (en) * 1988-04-08 1989-10-19 The Salk Institute For Biological Studies Ligase-based amplification method
WO1990012115A1 (en) * 1989-03-21 1990-10-18 Collaborative Research, Inc. A dna diagnostic test using an exonuclease activity
US5459039A (en) * 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
AU7762091A (en) * 1990-03-30 1991-10-30 City Of Hope Detection of minimal residual disease in lymphoid malignancies
CA2113716A1 (en) * 1991-07-19 1993-02-04 Robert E. Wagner, Jr. Method for detection of mutations
WO1993020233A1 (en) * 1992-03-27 1993-10-14 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
SE9203320D0 (sv) * 1992-11-06 1992-11-06 Pharmacia Lkb Biotech A method of processing nucleic acid samples
FR2709761B1 (fr) * 1993-09-10 1995-11-24 Pasteur Institut Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases .
WO1995029251A1 (en) * 1994-04-25 1995-11-02 Applied Technology Genetics Corporation Detection of mutation by resolvase cleavage

Also Published As

Publication number Publication date
JPH11506316A (ja) 1999-06-08
EP0843736A4 (de) 1998-12-02
US5876941A (en) 1999-03-02
EP0843736A1 (de) 1998-05-27
EP0843736B1 (de) 1999-12-22
WO1996035809A1 (en) 1996-11-14
DE69605803T2 (de) 2000-07-20
AU5675896A (en) 1996-11-29
AU703951B2 (en) 1999-04-01
CA2220467A1 (en) 1996-11-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee