DE69535921D1 - Alk-7 (aktivin-rezeptor-ähnliche kinase), ein serin/threonin kinase rezeptor - Google Patents
Alk-7 (aktivin-rezeptor-ähnliche kinase), ein serin/threonin kinase rezeptorInfo
- Publication number
- DE69535921D1 DE69535921D1 DE69535921T DE69535921T DE69535921D1 DE 69535921 D1 DE69535921 D1 DE 69535921D1 DE 69535921 T DE69535921 T DE 69535921T DE 69535921 T DE69535921 T DE 69535921T DE 69535921 D1 DE69535921 D1 DE 69535921D1
- Authority
- DE
- Germany
- Prior art keywords
- alk
- nucleic acid
- receptor
- antibodies
- relates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102100034135 Activin receptor type-1C Human genes 0.000 title abstract 9
- 101710173005 Activin receptor type-1C Proteins 0.000 title abstract 9
- 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 title abstract 2
- 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 title abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 6
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 102000005962 receptors Human genes 0.000 abstract 3
- 108020003175 receptors Proteins 0.000 abstract 3
- 108020004711 Nucleic Acid Probes Proteins 0.000 abstract 2
- 239000002853 nucleic acid probe Substances 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000004166 bioassay Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32595694A | 1994-10-20 | 1994-10-20 | |
| US08/341,916 US5614609A (en) | 1994-10-20 | 1994-11-15 | Serine threonine kinase receptor |
| PCT/IB1995/000899 WO1996012805A1 (en) | 1994-10-20 | 1995-10-20 | Alk-7 (activin like kinase), a serine threonine kinase receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69535921D1 true DE69535921D1 (de) | 2009-04-09 |
Family
ID=26985180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69535921T Expired - Lifetime DE69535921D1 (de) | 1994-10-20 | 1995-10-20 | Alk-7 (aktivin-rezeptor-ähnliche kinase), ein serin/threonin kinase rezeptor |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US5614609A (de) |
| EP (1) | EP0788543B1 (de) |
| JP (1) | JPH10510143A (de) |
| AT (1) | ATE423846T1 (de) |
| AU (1) | AU699024B2 (de) |
| CA (1) | CA2203246C (de) |
| DE (1) | DE69535921D1 (de) |
| ES (1) | ES2323158T3 (de) |
| NZ (2) | NZ293687A (de) |
| WO (1) | WO1996012805A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050186593A1 (en) | 1991-05-10 | 2005-08-25 | The Salk Institute For Biological Studies | Cloning and recombinant production of CRF receptor(s) |
| US6162896A (en) * | 1991-05-10 | 2000-12-19 | The Salk Institute For Biological Studies | Recombinant vertebrate activin receptors |
| US6316217B1 (en) * | 1992-11-17 | 2001-11-13 | Ludwig Institute For Cancer Research | Activin receptor-like kinases, proteins having serine threonine kinase domains and polynucleotides encoding same |
| US6692925B1 (en) | 1992-11-17 | 2004-02-17 | Ludwig Institute For Cancer Research | Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use |
| US6818440B2 (en) * | 1997-04-28 | 2004-11-16 | Sugen, Inc. | Diagnosis and treatment of alk-7 related disorders |
| US7166475B2 (en) * | 1999-02-26 | 2007-01-23 | Cyclacel Ltd. | Compositions and methods for monitoring the modification state of a pair of polypeptides |
| US7352901B2 (en) * | 2000-10-23 | 2008-04-01 | Omron Corporation | Contour inspection method and apparatus |
| WO2005077403A1 (en) * | 2004-02-04 | 2005-08-25 | Stryker Corporation | Therapeutic methods using smads |
| WO2005084699A1 (en) * | 2004-03-02 | 2005-09-15 | Acceleron Pharma Inc. | Alk7 and myostatin inhibitors and uses thereof |
| US8410246B2 (en) | 2004-06-17 | 2013-04-02 | Thrasos, Inc. | TDF-related compounds and analogs thereof |
| EP1945258A4 (de) | 2005-09-20 | 2011-08-17 | Thrasos Therapeutics Inc | Mit tdf verwandte verbindungen und analoga davon |
| KR20180002661A (ko) | 2015-04-06 | 2018-01-08 | 악셀레론 파마 인코포레이티드 | ALK7:ActRIIB 이형다합체와 이의 용도 |
| KR102405278B1 (ko) | 2016-04-22 | 2022-06-07 | 악셀레론 파마 인코포레이티드 | Alk7 결합 단백질 및 이들의 용도 |
| AU2018354295A1 (en) * | 2017-10-25 | 2020-04-30 | Acceleron Pharma Inc. | ALK7 binding proteins and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6147500A (ja) * | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (de) * | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimäre Rezeptoren durch Verbindung und Expression von DNS |
| GB8422238D0 (en) * | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) * | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| JPH04503306A (ja) * | 1989-02-01 | 1992-06-18 | ザ・ジェネラル・ホスピタル・コーポレーション | 単純ヘルペスウイルス１型発現ベクター |
| WO1993003743A1 (en) * | 1991-08-16 | 1993-03-04 | The General Hospital Corporation | Method of gene delivery to post-mitotic cells |
| US6316217B1 (en) * | 1992-11-17 | 2001-11-13 | Ludwig Institute For Cancer Research | Activin receptor-like kinases, proteins having serine threonine kinase domains and polynucleotides encoding same |
| DE4331540A1 (de) * | 1993-09-17 | 1995-03-23 | Degussa | Verfahren zur Reinigung von 1-[N·2·-((S)-Ethoxycarbonyl)-3-phenylpropyl)-N·6·-trifluoracetyl]-L-lysyl-L-prolin (Lisinopril(Tfa)ethylester) |
| US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
-
1994
- 1994-11-15 US US08/341,916 patent/US5614609A/en not_active Expired - Lifetime
-
1995
- 1995-10-20 AU AU36180/95A patent/AU699024B2/en not_active Expired
- 1995-10-20 ES ES95933575T patent/ES2323158T3/es not_active Expired - Lifetime
- 1995-10-20 NZ NZ293687A patent/NZ293687A/xx not_active IP Right Cessation
- 1995-10-20 WO PCT/IB1995/000899 patent/WO1996012805A1/en active Application Filing
- 1995-10-20 CA CA002203246A patent/CA2203246C/en not_active Expired - Lifetime
- 1995-10-20 JP JP8513759A patent/JPH10510143A/ja active Pending
- 1995-10-20 EP EP95933575A patent/EP0788543B1/de not_active Expired - Lifetime
- 1995-10-20 AT AT95933575T patent/ATE423846T1/de not_active IP Right Cessation
- 1995-10-20 NZ NZ332829A patent/NZ332829A/xx not_active IP Right Cessation
- 1995-10-20 DE DE69535921T patent/DE69535921D1/de not_active Expired - Lifetime
-
1997
- 1997-02-24 US US08/805,169 patent/US5811245A/en not_active Expired - Lifetime
- 1997-02-24 US US08/805,166 patent/US5789565A/en not_active Expired - Lifetime
- 1997-10-24 US US08/957,364 patent/US5976815A/en not_active Expired - Lifetime
- 1997-10-24 US US08/957,365 patent/US5891638A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5891638A (en) | 1999-04-06 |
| CA2203246C (en) | 2008-02-12 |
| US5789565A (en) | 1998-08-04 |
| WO1996012805A1 (en) | 1996-05-02 |
| EP0788543A1 (de) | 1997-08-13 |
| JPH10510143A (ja) | 1998-10-06 |
| ES2323158T3 (es) | 2009-07-07 |
| NZ332829A (en) | 2000-07-28 |
| EP0788543B1 (de) | 2009-02-25 |
| AU699024B2 (en) | 1998-11-19 |
| ATE423846T1 (de) | 2009-03-15 |
| AU3618095A (en) | 1996-05-15 |
| US5614609A (en) | 1997-03-25 |
| US5811245A (en) | 1998-09-22 |
| US5976815A (en) | 1999-11-02 |
| NZ293687A (en) | 1999-05-28 |
| CA2203246A1 (en) | 1996-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |