DE69535785D1 - Tumornekrosefaktor-rezeptor-assoziierte faktoren - Google Patents

Tumornekrosefaktor-rezeptor-assoziierte faktoren

Info

Publication number
DE69535785D1
DE69535785D1 DE69535785T DE69535785T DE69535785D1 DE 69535785 D1 DE69535785 D1 DE 69535785D1 DE 69535785 T DE69535785 T DE 69535785T DE 69535785 T DE69535785 T DE 69535785T DE 69535785 D1 DE69535785 D1 DE 69535785D1
Authority
DE
Germany
Prior art keywords
factor receptor
receptor associated
associated factors
nuclear factor
tnf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69535785T
Other languages
English (en)
Inventor
David V Goeddel
Mike Rothe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/446,915 external-priority patent/US5741667A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69535785D1 publication Critical patent/DE69535785D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
DE69535785T 1994-05-27 1995-05-25 Tumornekrosefaktor-rezeptor-assoziierte faktoren Expired - Fee Related DE69535785D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/250,858 US5708142A (en) 1994-05-27 1994-05-27 Tumor necrosis factor receptor-associated factors
US08/331,394 US5670319A (en) 1994-05-27 1994-10-28 Assay for tumor necrosis factor receptor-associated factors
US08/446,915 US5741667A (en) 1994-05-27 1995-05-22 Tumor necrosis factor receptor-associated factors
PCT/US1995/006639 WO1995033051A1 (en) 1994-05-27 1995-05-25 Tumor necrosis factor receptor-associated factors

Publications (1)

Publication Number Publication Date
DE69535785D1 true DE69535785D1 (de) 2008-08-21

Family

ID=22949430

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535785T Expired - Fee Related DE69535785D1 (de) 1994-05-27 1995-05-25 Tumornekrosefaktor-rezeptor-assoziierte faktoren

Country Status (8)

Country Link
US (6) US5708142A (de)
EP (1) EP2011873A3 (de)
JP (2) JP4187263B2 (de)
AT (1) ATE400652T1 (de)
DE (1) DE69535785D1 (de)
DK (1) DK0760851T3 (de)
ES (1) ES2310413T3 (de)
PT (1) PT760851E (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5708142A (en) * 1994-05-27 1998-01-13 Genentech, Inc. Tumor necrosis factor receptor-associated factors
US6355780B1 (en) * 1995-02-22 2002-03-12 Yeda Research And Development Co. Ltd. Antibodies to the death domain motifs of regulatory proteins
WO1997046684A1 (en) * 1996-06-06 1997-12-11 University Of Massachusetts Non-activated receptor complex proteins and uses thereof
JP4138013B2 (ja) 1996-12-23 2008-08-20 イミュネックス・コーポレーション Tnfスーパーファミリーのメンバーであるnf−kappa bの受容体アクティベーターに対するリガンド
US6271349B1 (en) 1996-12-23 2001-08-07 Immunex Corporation Receptor activator of NF-κB
US6143507A (en) * 1998-10-29 2000-11-07 Boehringer Ingelheim Pharmaceuticals, Inc. High throughput compatible assay for receptor-TRAF interactions
US6627199B1 (en) * 1999-07-09 2003-09-30 Amgen Inc Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
CN103232539B (zh) 2001-06-26 2015-06-03 安姆根弗里蒙特公司 抗opgl抗体
EP1499350A4 (de) * 2001-08-31 2006-02-08 Agensys Inc Nukleinsäure und zugehöriges protein mit der bezeichnung 205p1b5 zur verwendung bei der behandlung und zum nachweis von krebs
US7387271B2 (en) * 2002-12-30 2008-06-17 3M Innovative Properties Company Immunostimulatory combinations
WO2005021578A2 (en) * 2004-08-25 2005-03-10 Amprotein Corporation A novel chimeric polypeptide and use thereof
WO2006109044A2 (en) * 2005-04-11 2006-10-19 Yale University Selective modulation of tumour necrosis factor receptors in therapy
US20100034808A1 (en) * 2006-11-21 2010-02-11 Toru Nakazawa Compositions and methods for preserving cells of the eye
AR066016A1 (es) * 2007-04-11 2009-07-15 Alcon Res Ltd Uso de un inhibidor del tnf alfa junto con una antihistamina para tratar la rinitis alergica y la conjuntivitis alergica
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
JP5721722B2 (ja) * 2009-10-01 2015-05-20 アルコン リサーチ, リミテッド オロパタジン組成物およびその使用

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3691016A (en) 1970-04-17 1972-09-12 Monsanto Co Process for the preparation of insoluble enzymes
CA1023287A (en) 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Process for the preparation of carrier-bound proteins
GB1479268A (en) 1973-07-05 1977-07-13 Beecham Group Ltd Pharmaceutical compositions
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US3959642A (en) 1975-02-06 1976-05-25 Lawrence Peska Associates, Inc. Incense lamp
US4195128A (en) 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
US4330440A (en) 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
CA1093991A (en) 1977-02-17 1981-01-20 Hideo Hirohara Enzyme immobilization with pullulan gel
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4229537A (en) 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
DE3169595D1 (en) 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
JPS58118008A (ja) 1982-01-06 1983-07-13 Nec Corp デ−タ処理装置
EP0088046B1 (de) 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipide in wässriger Phase
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
EP0102324A3 (de) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
ATE59966T1 (de) 1983-09-26 1991-02-15 Ehrenfeld Udo Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr.
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4615885A (en) 1983-11-01 1986-10-07 Terumo Kabushiki Kaisha Pharmaceutical composition containing urokinase
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
EP0206448B1 (de) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
EP0272253A4 (de) 1986-03-07 1990-02-05 Massachusetts Inst Technology Verfahren zur verbesserung der glykoproteinstabilität.
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
DE3613167A1 (de) * 1986-04-18 1987-10-29 Basf Ag Verwendung von tnf zur herstellung von arzneimitteln
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
EP0266032A1 (de) 1986-08-29 1988-05-04 Beecham Group Plc Modifiziertes fibrinolytisches Enzym
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
PT88641B (pt) 1987-10-02 1993-04-30 Genentech Inc Metodo para a preparacao de uma variante de adesao
GB8724885D0 (en) 1987-10-23 1987-11-25 Binns M M Fowlpox virus promotors
EP0321196A3 (de) 1987-12-18 1990-07-18 Mycogen Plant Science, Inc. Transkriptionsaktivator des 780 T-DNA-Gens
EP0435911B1 (de) 1988-09-23 1996-03-13 Cetus Oncology Corporation Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
JPH04502011A (ja) 1988-11-23 1992-04-09 ジェネンテク,インコーポレイテッド ポリペプチド誘導体
EP0402226A1 (de) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformationsvektoren für Hefe Yarrowia
CA2062795A1 (en) 1989-06-29 1990-12-30 Michael W. Fanger Bispecific reagents for aids therapy
US5395760A (en) * 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
DE10399023I2 (de) * 1989-09-12 2006-11-23 Ahp Mfg B V TFN-bindende Proteine
AU639047B2 (en) 1989-11-22 1993-07-15 Genentech Inc. Latency associated peptide and uses therefor
WO1992000373A1 (en) 1990-06-29 1992-01-09 Biosource Genetics Corporation Melanin production by transformed microorganisms
EP0590058B1 (de) 1991-06-14 2003-11-26 Genentech, Inc. Humanisierter Heregulin Antikörper
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5708142A (en) * 1994-05-27 1998-01-13 Genentech, Inc. Tumor necrosis factor receptor-associated factors
US5741667A (en) * 1994-05-27 1998-04-21 Genentech, Inc. Tumor necrosis factor receptor-associated factors
IL114418A0 (en) * 1994-07-07 1995-10-31 Res Dev Foundation Tumor necrosis factor receptor-II associated protein kinase and methods for its use
AU2307697A (en) 1996-04-11 1997-10-29 Mochida Pharmaceutical Co., Ltd. Novel signal transducer

Also Published As

Publication number Publication date
US5670319A (en) 1997-09-23
US20070243202A1 (en) 2007-10-18
US5869612A (en) 1999-02-09
ES2310413T3 (es) 2009-01-01
US20030120043A1 (en) 2003-06-26
DK0760851T3 (da) 2008-11-10
EP2011873A2 (de) 2009-01-07
JP4187263B2 (ja) 2008-11-26
ATE400652T1 (de) 2008-07-15
PT760851E (pt) 2008-10-21
US7754858B2 (en) 2010-07-13
EP2011873A3 (de) 2009-07-01
US5708142A (en) 1998-01-13
US7244836B2 (en) 2007-07-17
JP2010131018A (ja) 2010-06-17
US6500922B1 (en) 2002-12-31

Similar Documents

Publication Publication Date Title
DE69535785D1 (de) Tumornekrosefaktor-rezeptor-assoziierte faktoren
DE69807074D1 (de) Substituierte 1,2,4-triazolo[3,4,-a]phthalazin-derivate als gaba-alpha 5-liganden
DE69016784T2 (de) Filterplatte, filterplattenelement und filter, der dieselben enthält.
ATE307204T1 (de) Tumor-nekrose-faktor ähnliches ligand
DE58906242D1 (de) 2,3-difluorbenzolderivate und ihre verwendung als komponenten flüssigkristalliner medien.
DE69005583D1 (de) Perfluoro-N,N,N',N'-tetrapropyldiaminopropan und seine Verwendung in Dampfphase-Heizung.
MX9605579A (es) Factores asociados con el receptor del factor de la necrosis tumoral.
ATE114655T1 (de) 1-methyl-3,5,7-triaza-1-azoniatrizyklodekansalz und deren verwendung bei der bekämpfung von microorganismen und korrosion.
DK0606869T3 (da) Promotorsekvens for p55-receptoren for tumornekrosefaktor
AU676621B2 (en) Ladle for filtering liquid metal on a filter medium with improved heating
Yates The slurry-phase Fischer-Tropsch synthesis
ATE66218T1 (de) 5-heterocyclisch substituierte-3h-1,2,4-triazol-3-thione und ihre verwendung als antidepressiva.
Adra X chromosome inactivation and the phosphoglycerate kinase gene family.
Stuart Para-statal organizations in the voluntary sector.
DE59008358D1 (de) 2,5-disubstituierte heterocyclen und flüssigkristallines medium.
IT8722543V0 (it) Cerotto, in particolare per l'impiego in corrispondenza di zone articolari.
Erasmo The death of Turnus in the" Aeneid".
Mocsary Arpadhon: The largest rural Hungarian settlement in the United States
FR2677655B1 (fr) Dispersions d'agents epaississants, procedes pour les preparer et leur utilisation.
Keller An analysis of housing and housing opportunity sites in the central waterfront of San Francisco, California
Järviö et al. Public Services
Izaurralde Analysis of the spectral characteristics of selected agroecological resource areas in the province of Alberta
World Health Organization Report of the first meeting of the Global Collaboration for the Development of Pesticides for Public Health (GCDPP), WHO/HQ, Geneva, 14-15 October 1998
ES1024206Y (es) Barbacoa perfeccionada.
Dombi Analysis of the factors determining Rumanian nationality policy towards ethnic Hungarians under the Communist regime.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee